Article
Food Science & Technology
Yuling Zheng, Jing Xiao, Junqi Wang, Bin Dong, Dawei Guo, Hui Ji, Haifeng Sun, Lin Peng, Shanxiang Jiang, Xiuge Gao
Summary: This study investigates the mechanism of methuosis, a novel cell death phenotype induced by maduramicin. The results suggest that the abnormal enlargement of endosomal compartments and excessive macropinocytosis contribute to maduramicin-induced methuosis. Pharmacological inhibition of macropinocytosis prevents methuosis, and targeting the V0 subunit of V-ATPase can restore endosomal-lysosomal trafficking and prevent methuosis.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Fisheries
Liu Wang, Keisuke Yoshii, Naoya Murase, Hidetoshi Yamada, Yutaka Fukuda, Ikuo Hirono, Hidehiro Kondo
Summary: This study aimed to develop a better immunogenic and protective fish vaccine and compare the effectiveness of poly I:C and formalin-killed cells (FKCs) as adjuvants against pathogen infection. The results showed that co-inoculation with poly I:C and FKC significantly increased the expression levels of specific antibodies and provided better protection compared to FKC vaccine alone.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Oncology
Mariola Gimla, Agnieszka Pyrczak-Felczykowska, Marcelina Malinowska, Aleksandra Hac, Magdalena Narajczyk, Irena Bylinska, Tristan A. Reekie, Anna Herman-Antosiewicz
Summary: UA derivative 5 shows superior activity in inhibiting the growth and proliferation of pancreatic cancer cells. It induces ER stress and calcium ion release, leading to cell vacuolization. In a xenograft model, it effectively suppresses tumor growth without causing toxicity to the kidneys or liver.
CANCER CELL INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Sachin Sharma, Shaikh Maryam Ghufran, Sampa Ghose, Subhrajit Biswas
Summary: In this study, it was found that sorafenib induced cytoplasmic vacuolation in HSCs in a dose and time dependent manner, leading to decreased cell viability. Additionally, sorafenib triggered non-apoptotic cell death in HSCs by inducing ROS and ER stress.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Laura Zein, Simone Fulda, Donat Koegel, Sjoerd J. L. van Wijk
Summary: Autophagy is a conserved catabolic process that plays a crucial role in degrading cellular components, but excessive activation can lead to autophagy-dependent cell death. ADCD is involved in the development of lower organisms and in the response of cancer cells to certain drugs, offering a potential therapeutic option for apoptosis-resistant cancer types. The mechanisms of ADCD are complex and involve mitochondrial and ER-specific killing mechanisms triggered by certain drugs.
Article
Pediatrics
Stephanie Nault, Sophie Tremblay, Roqaya Imane, Sally Al-Omar, Charlene Nadeau, Nathalie Samson, Vincent Creuze, Guy Carrault, Patrick Pladys, Jean-Paul Praud
Summary: This study used a full-term newborn lamb model to investigate the cardiorespiratory consequences of injecting Poly I:C to induce systemic inflammation similar to viral sepsis. The results showed that Poly I:C injection led to a biphasic increase in rectal temperature and heart rate, along with a decrease in heart-rate variability. Interestingly, there was no change in respiratory-rate variability. Additionally, brainstem inflammation was observed in the areas related to cardiorespiratory control centers.
PEDIATRIC RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Shweta Tiwary, Arun Nandwani, Rukshar Khan, Malabika Datta
Summary: GRP75 plays a critical role in mediating ER-mitochondrial interaction, leading to apoptosis in pancreatic islet cells. It is associated with increased mitochondrial Ca2+ transfer, impaired mitochondrial membrane potential, increased ROS production, and enhanced physical coupling between the ER and mitochondria.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Karina S. MacDowell, Eva Munarriz-Cuezva, J. Javier Meana, Juan C. Leza, Jorge E. Ortega
Summary: Emerging evidence suggests that early-life exposure to environmental factors may increase the risk for schizophrenia through inflammatory mechanisms. This study investigated the role of serotonergic and kynurenine pathways in the maternal immune activation (MIA) animal model of schizophrenia, and evaluated the potential reversal by long-term antipsychotic treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Carlos Fernandez Moro, Arun Kumar Selvam, Mehran Ghaderi, Ville N. Pimenoff, Marco Gerling, Bela Bozoky, Soledad Pouso Elduayen, Joakim Dillner, Mikael Bjoernstedt
Summary: This study utilized a whole tissue ex vivo culture model to investigate the impact of sodium selenite on PDAC. The results demonstrated that sodium selenite effectively reduced PDAC cell viability and inhibited tumor cell growth while preserving non-neoplastic tissues. Furthermore, the concentration of sodium selenite used in this study was below the maximum tolerated dose for humans. Transcriptome data analysis revealed the downregulation of genes associated with PDAC growth and metastasis, and the upregulation of cell death-inducing genes.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jung Yoon Jang, Eunok Im, Yung Hyun Choi, Nam Deuk Kim
Summary: Bile acids are important in lipid digestion and absorption, and have been found to be tumor suppressors. This review comprehensively summarizes the literature on bile acid-induced programmed cell death and the development of synthetic bile acid derivatives for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Xiphias Ge Zhu, Aleksey Chudnovskiy, Lou Baudrier, Benjamin Prizer, Yuyang Liu, Benjamin N. Ostendorf, Norihiro Yamaguchi, Abolfozl Arab, Bernardo Tavora, Rebecca Timson, Soren Heissel, Elisa de Stanchina, Henrik Molina, Gabriel D. Victora, Hani Goodarzi, Kivanc Birsoy
Summary: This study reveals that loss of heme synthesis reduces tumor growth in PDAC, and autophagy plays a crucial role in immune evasion of pancreatic tumors.
Article
Plant Sciences
Dahae Lee, Sungyoul Choi, Ki Sung Kang
Summary: This study evaluated the effect of ginsenosides on palmitic acid-induced pancreatic beta-cell death and impairment of glucose-stimulated insulin secretion (GSIS). Protopanaxadiol (PPD) was identified as a potential therapeutic agent, which protected against apoptosis and lipid accumulation. PPD also prevented palmitic acid-induced impairment of insulin secretion.
JOURNAL OF GINSENG RESEARCH
(2023)
Article
Plant Sciences
Karen C. Chamusco, May N. Milazzo, Kanchan S. Bhan, Terry L. Kamps, Prestina Smith, Modupeoluwa Durojaiye, Cristina D. Moreira, Maria Gallo, Christine D. Chase
Summary: Research found that collapse of CMS-S pollen is a programmed cell death event with morphological features similar to apoptosis regulated by mitochondria in animals. Typically, mitochondrial morphology and activity in CMS-S pollen differ significantly from normal pollen, possibly leading to decreased protection against mitochondrial generation of reactive oxygen species.
Article
Oncology
Xinrui Sha, Xia Xu, Shuangye Liao, Hongyuan Chen, Wen Rui
Summary: Honey-processed Astragalus exhibits anti-tumor effects by inducing tumor cell apoptosis, increasing the expression of immunogenic cell death-related molecules, and modulating immune cell activity.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Biochemical Research Methods
Nancy G. Azizian, Delaney K. Sullivan, Litong Nie, Sammy Pardo, Dana Molleur, Junjie Chen, Susan T. Weintraub, Yulin Li
Summary: The study successfully identified the tumor cell proteome in an orthotopic PDAC model using BONCAT and DIA-MS technologies, revealing differences between tumor cells and non-tumor cells. This has important implications for tumorigenesis research and biomarker discovery.
JOURNAL OF PROTEOME RESEARCH
(2021)
