Organelle-specific mechanisms of drug-induced autophagy-dependent cell death

STF-62247 and pimozide induce autophagy and autophagic cell death in mouse embryonic fibroblasts

(2020) Maximilian N. Kinzler et al.   Scientific Reports

Autophagic cell death restricts chromosomal instability during replicative crisis

(2019) Joe Nassour et al.   NATURE

ATL3 Is a Tubular ER-Phagy Receptor for GABARAP-Mediated Selective Autophagy

(2019) Qingzhou Chen et al.   CURRENT BIOLOGY

The Mitochondrion as an Emerging Therapeutic Target in Cancer

(2019) Katherine G. Roth et al.   TRENDS IN MOLECULAR MEDICINE

Cellular quality control by the ubiquitin-proteasome system and autophagy

(2019) Christian Pohl et al.   SCIENCE

AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells

(2018) Nina Meyer et al.   Autophagy

Arsenic trioxide induces autophagic cell death in osteosarcoma cells via the ROS-TFEB signaling pathway

(2018) Bowen Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Induction of peroxisomal changes in oligodendrocytes treated with 7-ketocholesterol: Attenuation by α-tocopherol

(2018) Thomas Nury et al.   BIOCHIMIE

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis

(2018) Matthew D. Smith et al.   DEVELOPMENTAL CELL

A novel role of the mitochondrial permeability transition pore in (−)-gossypol-induced mitochondrial dysfunction

(2018) Verena Warnsmann et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Genotype-Phenotype Relations for the Parkinson's Disease Genes Parkin , PINK1 , DJ1: MDSGene Systematic Review

(2018) Meike Kasten et al.   MOVEMENT DISORDERS

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

No Parkin Zone: Mitophagy without Parkin

(2018) Elodie Villa et al.   TRENDS IN CELL BIOLOGY

Loperamide, pimozide, and STF-62247 trigger autophagy-dependent cell death in glioblastoma cells

(2018) Svenja Zielke et al.   Cell Death & Disease

The Peroxisome-Mitochondria Connection: How and Why?

(2017) Marc Fransen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Helicobacter pylori VacA induces autophagic cell death in gastric epithelial cells via the endoplasmic reticulum stress pathway

(2017) Pan Zhu et al.   Cell Death & Disease

Phosphorylation of the mitochondrial autophagy receptor Nix enhances its interaction with LC3 proteins

(2017) Vladimir V. Rogov et al.   Scientific Reports

The Roles of Mitochondria in Autophagic Cell Death

(2016) Zongyan Chen et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Lysosomal Dysfunction and α-Synuclein Aggregation in Parkinson's Disease: Diagnostic Links

(2016) Tim Moors et al.   MOVEMENT DISORDERS

Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery

(2016) Fiorenza Fumagalli et al.   NATURE CELL BIOLOGY

Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER

(2016) J. Nixon-Abell et al.   SCIENCE

Mitochondrial autophagy: Origins, significance, and role of BNIP3 and NIX

(2015) Paul A. Ney   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulation of endoplasmic reticulum turnover by selective autophagy

(2015) Aliaksandr Khaminets et al.   NATURE

Cell death by autophagy: emerging molecular mechanisms and implications for cancer therapy

(2015) S Fulda et al.   ONCOGENE

Silibinin, a natural flavonoid, induces autophagy via ROS-dependent mitochondrial dysfunction and loss of ATP involving BNIP3 in human MCF7 breast cancer cells

(2015) KAI JIANG et al.   ONCOLOGY REPORTS

Broad targeting of resistance to apoptosis in cancer

(2015) Ramzi M. Mohammad et al.   SEMINARS IN CANCER BIOLOGY

Cellular and metabolic functions for autophagy in cancer cells

(2015) Candia M. Kenific et al.   TRENDS IN CELL BIOLOGY

Lapatinib induces autophagic cell death and inhibits growth of human hepatocellular carcinoma

(2015) Yu-Jen Chen et al.   Oncotarget

A critical role of superoxide anion in selenite-induced mitophagic cell death

(2014) Eun Hee Kim et al.   Autophagy

Bcl-2 Family Proteins Participate in Mitochondrial Quality Control by Regulating Parkin/PINK1-Dependent Mitophagy

(2014) Emilie Hollville et al.   MOLECULAR CELL

Cargo recognition and trafficking in selective autophagy

(2014) Alexandra Stolz et al.   NATURE CELL BIOLOGY

Arsenic trioxide induces autophagy and antitumor effects in Burkitt’s lymphoma Raji cells

(2014) CAI-LI LI et al.   ONCOLOGY REPORTS

Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

(2014) Yvette C. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crosstalk between apoptosis, necrosis and autophagy

(2013) Vassiliki Nikoletopoulou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Chaperone-mediated autophagy: roles in disease and aging

(2013) Ana Maria Cuervo et al.   CELL RESEARCH

Autophagy and Cellular Immune Responses

(2013) Yuting Ma et al.   IMMUNITY

Ganoderma lucidum: A Potential for Biotechnological Production of Anti-Cancer and Immunomodulatory Drugs

(2013) Bojana Boh   Recent Patents on Anti-Cancer Drug Discovery

Peroxisome degradation in mammals: mechanisms of action, recent advances, and perspectives

(2013) Marcus Nordgren et al.   Frontiers in Physiology

Mitochondrial Dysfunction in Cancer

(2013) Michelle L. Boland et al.   Frontiers in Oncology

Andrographolide induces autophagic cell death in human liver cancer cells through cyclophilin D-mediated mitochondrial permeability transition pore

(2012) Wei Chen et al.   CARCINOGENESIS

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

The pathways of mitophagy for quality control and clearance of mitochondria

(2012) G Ashrafi et al.   CELL DEATH AND DIFFERENTIATION

Microtubule-associated Protein 1 Light Chain 3 (LC3) Interacts with Bnip3 Protein to Selectively Remove Endoplasmic Reticulum and Mitochondria via Autophagy

(2012) Rita A. Hanna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NBR1 acts as an autophagy receptor for peroxisomes

(2012) E. Deosaran et al.   JOURNAL OF CELL SCIENCE

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

Autophagy as a new therapeutic target in Duchenne muscular dystrophy

(2012) C De Palma et al.   Cell Death & Disease

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

(2012) C. Kondapalli et al.   Open Biology

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Autophagy induction rescues muscular dystrophy

(2011) Paolo Grumati et al.   Autophagy

Atg1 allows second-signaled autophagic cell death in Dictyostelium

(2011) Marie-Françoise Luciani et al.   Autophagy

Autophagic cell death: Loch Ness monster or endangered species?

(2011) Han-Ming Shen et al.   Autophagy

Bnip3 impairs mitochondrial bioenergetics and stimulates mitochondrial turnover

(2011) S Rikka et al.   CELL DEATH AND DIFFERENTIATION

Microautophagy: lesser-known self-eating

(2011) Wen-wen Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Loperamide

(2011) Claud Regnard et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Recombinant Lz-8 from Ganoderma lucidum induces endoplasmic reticulum stress-mediated autophagic cell death in SGC-7901 human gastric cancer cells

(2011) CHONGYANG LIANG et al.   ONCOLOGY REPORTS

Bnip3 as a Dual Regulator of Mitochondrial Turnover and Cell Death in the Myocardium

(2011) Åsa B. Gustafsson   PEDIATRIC CARDIOLOGY

The ER in 3D: a multifunctional dynamic membrane network

(2011) Jonathan R. Friedman et al.   TRENDS IN CELL BIOLOGY

Peroxisomes Are Signaling Platforms for Antiviral Innate Immunity

(2010) Evelyn Dixit et al.   CELL

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Autophagy is defective in collagen VI muscular dystrophies and its reactivation rescues myofiber degeneration

(2010) Paolo Grumati et al.   NATURE MEDICINE

MnSOD Upregulation Induces Autophagic Programmed Cell Death in Senescent Keratinocytes

(2010) Emeric Deruy et al.   PLoS One

Pleiotropic Actions of Helicobacter pylori Vacuolating Cytotoxin, VacA

(2010) Hajime Isomoto et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Autophagy facilitates oncogene-induced senescence

(2009) Masako Narita et al.   Autophagy

Reactive oxygen species and peroxisomes: Struggling for balance

(2009) Nina A. Bonekamp et al.   BIOFACTORS

Autophagy, Not Apoptosis, Is Essential for Midgut Cell Death in Drosophila

(2009) Donna Denton et al.   CURRENT BIOLOGY

Peripheral ER structure and function

(2009) Amber R English et al.   CURRENT OPINION IN CELL BIOLOGY

Mutations in FAM134B, encoding a newly identified Golgi protein, cause severe sensory and autonomic neuropathy

(2009) Ingo Kurth et al.   NATURE GENETICS

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Autophagy Prevents Hippocampal Pyramidal Neuron Death after Hypoxic-Ischemic Injury

(2008) Masato Koike et al.   AMERICAN JOURNAL OF PATHOLOGY

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Loss of peroxisome function triggers necrosis

(2008) Helmut Jungwirth et al.   FEBS LETTERS

Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes

(2008) P. K. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagic Death of Adult Hippocampal Neural Stem Cells Following Insulin Withdrawal

(2008) Seong-Woon Yu et al.   STEM CELLS