Article
Environmental Sciences
Yidan Liang, Lai Yi, Ping Deng, Liting Wang, Yang Yue, Hui Wang, Li Tian, Jia Xie, Mengyan Chen, Yan Luo, Zhengping Yu, Huifeng Pi, Zhou Zhou
Summary: Rapamycin inhibits cadmium-induced breast cancer cell proliferation and metastasis by directly modulating ACSS2 protein, which serves as a direct target for rapamycin in inhibiting xenobiotic-mediated breast cancer progression.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Chen Chen, Ning Wang, Tingting Huang, Gao Cheng, Yuexia Hu, Bingjie Wang, Ye Zhang, Chunhui Wang
Summary: Chloroprocaine, a local anesthetic, has been found to inhibit proliferation, invasion, and induce apoptosis of breast cancer cells both in vitro and in a mouse model, as well as attenuating tumor growth and metastasis. LINC00494 was identified as a downregulated long noncoding RNA in chloroprocaine-treated breast cancer cells, and its high level was associated with poor outcome in breast cancer patients. LINC00494 acted as a sponge for miR-3619-5p, leading to the upregulation of MED19, and the LINC00494/miR-3619-5p/MED19 axis was involved in the chloroprocaine-mediated inhibition of breast cancer aggressiveness. This study highlights the clinical value of chloroprocaine in breast cancer treatment.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Oncology
Jing Zhang, Jing Hu, Weiwei Li, Chunyan Zhang, Peng Su, Yan Wang, Wei Sun, Xiao Wang, Li Li, Xiaojuan Wu
Summary: BCRP is an independent risk factor for BCa and its expression is regulated by 17 alpha-PG in mPR alpha-positive cells through the PI3K/Akt/mTOR pathway. Rapamycin may enhance the therapeutic effects of certain chemotherapy agents in mPR alpha-positive BCa cells with BCRP overexpression.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xu Li, Shu Zhuo, Yong Suk Cho, Yuchen Liu, Yingzi Yang, Jian Zhu, Jin Jiang
Summary: Hippo signaling inhibits the oncogenic potential of YAP/TAZ-TEAD transcriptional complex, restricting tumor growth. In AR-positive prostate cancer, YAP acts as a tumor suppressor by counteracting TEAD-mediated AR signaling. YAP competes with AR for TEAD binding, disrupting AR-TEAD interaction and preventing TEAD from promoting AR signaling. Targeting the Hippo signaling pathway may provide a therapeutic opportunity to treat therapy resistant AR variants-driven prostate cancer.
Article
Biochemistry & Molecular Biology
Ping Guo, Shijia Zu, Shilong Han, Wendan Yu, Guoqing Xue, Xiaona Lu, Hua Lin, Xinrui Zhao, Haibo Lu, Chunyu Hua, Xinyu Wan, Liyuan Ru, Ziyue Guo, Hanxiao Ge, Kuan Lv, Guohui Zhang, Wuguo Deng, Cheng Luo, Wei Guo
Summary: This study revealed that Bromodomain PHD Finger Transcription Factor (BPTF) promotes colorectal cancer (CRC) progression by targeting Cdc25A under the regulation of c-Myc. Inhibition of BPTF could be a promising strategy for CRC treatment, and the c-Myc/BPTF/Cdc25A signaling axis may serve as candidate biomarkers for CRC diagnosis and prognosis prediction.
Article
Multidisciplinary Sciences
Diego R. Coelho, Flavio R. Palma, Veronica Paviani, Chenxia He, Jeanne M. Danes, Yunping Huang, Juliana C. P. Calado, Peter C. Hart, Cristina M. Furdui, Leslie B. Poole, Matthew J. Schipma, Marcelo G. Bonini
Summary: Acetylation of SOD2 changes its biochemical function from an antioxidant to a demethylase, promoting stem cell gene expression and contributing to tumor progression and metastasis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Xianglan Yi, Liping Lou, Jun Wang, Jing Xiong, Sheng Zhou
Summary: Honokiol enhances doxorubicin sensitivity in breast cancer cells by downregulating miR-188-5p and involving the FBXW7/c-Myc signaling pathway.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Sibylle Loibl, Philip Poortmans, Monica Morrow, Carsten Denkert, Giuseppe Curigliano
Summary: Breast cancer diagnosis and treatment have become increasingly complex, incorporating various biomarkers and neoadjuvant therapies, with de-escalation schemes for radiotherapy now becoming standard practice.
Article
Biochemistry & Molecular Biology
Zikou Liu, Laura F. Dagley, Kristy Shield-Artin, Samuel N. Young, Aleksandra Bankovacki, Xiangyi Wang, Michelle Tang, Jason Howitt, Che A. Stafford, Ueli Nachbur, Cheree Fitzgibbon, Sarah E. Garnish, Andrew Webb, David Komander, James M. Murphy, Joanne M. Hildebrand, John Silke
Summary: MLKL undergoes multi-mono-ubiquitylation during necroptosis, accumulating in a digitonin-insoluble cell fraction. This ubiquitylated MLKL form can be reduced by expression of a deubiquitylating enzyme located on the plasma membrane, correlating with turnover. Removal of ubiquitin from MLKL induces its activation independent of necroptosis signaling, controlling basal levels to prevent unwanted cell death.
Article
Biochemistry & Molecular Biology
Marine Beck, Mathilde Baranger, Ahlam Moufok-Sadoun, Emilie Bersuder, Isabelle Hinkel, Georg Mellitzer, Elisabeth Martin, Laetitia Marisa, Isabelle Duluc, Aurelien de Reynies, Christian Gaiddon, Jean-Noel Freund, Isabelle Gross
Summary: This study focused on the atypical cadherin MUCDHL, which is down-regulated in colorectal tumors, especially in tumors with worse prognosis. Loss of MUCDHL enhanced tumor incidence and burden in intestinal tumor-prone mice, and targeted key oncogenic signaling pathways through its extracellular domain. The study illustrates how the loss of a gene critical for the morphological and functional features of mature cells contributes to tumorigenesis by dysregulating oncogenic pathways.
Article
Pathology
Yanqin Yu, Jinqi Hao, Lu Wang, Xiaojiao Zheng, Caixia Xie, Hailiang Liu, Jiao Wu, Shu Qiao, Jihai Shi
Summary: This study revealed a new mechanism of AS-IV in inhibiting M2 macrophage polarization-induced breast cancer progression by suppressing the TGF-beta and Akt/Foxo1 signaling pathways.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Cell Biology
Huahua Zhang, Jiming Han, Jing Zhang, Jiyu Miao, Fang Li, Kaijie Tang, Kai Zhou, Baojun Duan, Wen Li, Jing Cheng, Ying Sun, Ni Hou, Chen Huang
Summary: Epidemiological studies have shown that antidepressants may reduce the risk of colorectal cancer, but the underlying mechanisms are unknown. This study found that the antidepressant venlafaxine can counteract the promotion of colon cancer by norepinephrine. The norepinephrine transporter was also found to be associated with the prognosis of patients with colorectal cancer.
CELL DEATH DISCOVERY
(2023)
Article
Integrative & Complementary Medicine
Ming-hui Wu, Kun Wu, Yuan-bing Zhu, Da-chuan Li, Huan Yang, Hong Zeng
Summary: The study aimed to investigate the molecular mechanisms underlying the effect of baicalin on prostate cancer progression. The results showed that baicalin exhibited a potential therapeutic effect on PCa via inhibiting the Notch1/NF-kappa B signaling pathway and its mediated cancer stemness.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Article
Oncology
Angela N. Giaquinto, Hyuna Sung, Kimberly D. Miller, Joan L. Kramer, Lisa A. Newman, Adair Minihan, Ahmedin Jemal, Rebecca L. Siegel
Summary: This article provides an update on female breast cancer statistics in the United States, including data on incidence, mortality, survival, and mammography screening. It shows that breast cancer incidence rates have increased over the past few decades, driven by localized-stage and hormone receptor-positive disease. However, breast cancer mortality rates have been steadily declining since 1989, although at a slower pace in recent years. Despite lower incidence rates, there remains a racial disparity in breast cancer mortality, with higher rates among Black women compared to White women.
CA-A CANCER JOURNAL FOR CLINICIANS
(2022)
Article
Multidisciplinary Sciences
Keiji Itoh, Olga Ossipova, Sergei Y. Sokol
Summary: Pnhd binds and inactivates Admp to promote notochord development by reducing Smad1 phosphorylation. Additionally, Pnhd cooperates with Chordin and a truncated BMP4 receptor in inducing notochord markers in ectoderm cells, leading to notochord defects in Pnhd-depleted embryos.
Article
Cell Biology
Tanja Niedermair, Meet Bhatt, Maximilian Babel, Moritz Feustel, Andreas Mamilos, Helmut Schweikl, Gerlinde Ferstl, Paul Hofman, Christoph Brochhausen
Summary: One major goal of biobanks is to provide optimal biospecimen quality, achieved through standardized procedures for collection, processing, and storage. Temporary storage of biosamples is necessary for maintaining sample quality, with considerations for dewar size, maximum storage time, and cryotube material.
BIOPRESERVATION AND BIOBANKING
(2023)
Article
Oncology
David Jeremie Birnbaum, Maelle Picard, Quentin Da Costa, Thomas Delayre, Pascal Finetti, Olivier Cabaud, Emilie Agavnian, Bernadette De Rauglaudre, Emilie Denicolai, Francois Bertucci, Emilie Mamessier
Summary: Hepatocellular carcinoma (HCC) is a common and deadly cancer, and new treatments are needed. Immune checkpoint inhibitors (ICIs) have shown promise for HCC. By analyzing a large transcriptomic database, we found that the TIGIT/DNAM-1 axis, particularly the PVRIG molecule, could be a potential therapeutic option for HCC.
Review
Cell Biology
Paul Hofman, Marc G. Denis
Summary: The assessment of minimal residual disease (MRD) from blood samples has potential in optimizing patient care for resected non-small cell lung carcinoma (NSCLC). Evaluating MRD status can improve overall survival for early stage NSCLC patients and reduce the toxic effects and financial burden of treatment. Clinical trials have examined MRD in early stage NSCLC, highlighting the need to bridge the gap between research and routine practice. Further action is necessary to assess the relevance of MRD detection in interventional clinical studies, comparing different techniques, time points, and cutoffs. This article investigates and provides recommendations for optimizing MRD evaluation in NSCLC.
Review
Biochemistry & Molecular Biology
Serena Janho Dit Hreich, Paul Hofman, Valerie Vouret-Craviari
Summary: This article focuses on the role of the purinergic receptor P2RX7 in controlling tumor growth by releasing IL-18 and modulating anti-tumor immunity. It summarizes the receptor activities of P2RX7 and how IL-18 controls tumor growth. Furthermore, the potential of targeting the P2RX7/IL-18 pathway in combination with classical immunotherapies to fight cancer is discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Marius Ilie, Jonathan Benzaquen, Veronique Hofman, Elodie Long-Mira, Sandra Lassalle, Jacques Boutros, Christophe Bontoux, Virginie Lespinet-Fabre, Olivier Bordone, Virginie Tanga, Maryline Allegra, Myriam Salah, Julien Fayada, Sylvie Leroy, Matteo Vassallo, Irit Touitou, Johan Courjon, Julie Contenti, Michel Carles, Charles-Hugo Marquette, Paul Hofman
Summary: As new SARS-CoV-2 variants emerge, it is important to improve the efficiency and availability of viral genome sequencing, especially in samples with low viral load. In this study, retrospective SARS-CoV-2 genome sequencing was performed on 175 positive samples, and the analysis successfully detected Delta and Omicron variants in low viral load samples. The results showed that there was no significant difference in viral load between patients infected with the Omicron variant and those infected with the Delta variant.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
Veronique Hofman, Samantha Goffinet, Christophe Bontoux, Elodie Long-Mira, Sandra Lassalle, Marius Ilie, Paul Hofman
Summary: The detection of ROS1 rearrangements in metastatic non-squamous non-small cell lung carcinoma permits efficient targeted therapy. However, the rarity of ROS1 rearrangements, suboptimal specificity of ROS1 IHC, and limited availability of ROS1 FISH make the current testing algorithm challenging and time-consuming. RNA NGS can be a viable alternative to replace ROS1 IHC as a screening method.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cell Biology
Sandy Giuliano, Christopher Montemagno, Marie-Angela Domdom, Manon Teisseire, Patrick Brest, Daniel J. Klionsky, Paul Hofman, Gilles Pages, Baharia Mograbi
Summary: Nearly fifty million older people suffer from neurodegenerative diseases, and this number is expected to triple by 2050. Defective lysosomal acidification and impairment of the autophagy pathway have been identified as modifiable risk factors for dementia. The long-term prescribing of lysosomotropic drugs to the elderly, such as proton pump inhibitors, chloroquine, and hydroxychloroquine, may be connected to the incidence of neurodegenerative diseases.
Review
Oncology
Edwin Roger Parra, Marius Ilie, Ignacio I. Wistuba, Paul Hofman
Summary: Over the past decade, there has been a revolution in cancer treatment with the shift towards targeted molecular therapies and immune-based therapies, particularly immune-checkpoint inhibitors (ICIs). However, not all patients with advanced non-small cell lung cancer (aNSCLC) benefit equally from immunotherapy, and there is a need for additional predictive markers for ICIs efficacy. Multiplex immunostaining, which evaluates multiple molecules in the tumor at the same time, shows promise in optimizing patient selection for ICIs. This review aims to explore the role of multiplex immunostaining in immuno-thoracic oncology and its current advantages and limitations in clinical practice.
BRITISH JOURNAL OF CANCER
(2023)
Review
Oncology
Patrick Brest, Baharia Mograbi, Gilles Pages, Paul Hofman, Gerard Milano
Summary: The combination of immune checkpoint inhibitors and anti-angiogenic agents shows promise in cancer treatment by enhancing response rates and prolonging progression-free survival. However, it also comes with increased side effects and requires careful monitoring.
BRITISH JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Nicola Normanno, Jose Carlos Machado, Edoardo Pescarmona, Simonetta Buglioni, Lara Navarro, Riziero Esposito Abate, Anabela Ferro, Rob Mensink, Matilde Lambiase, Virginie Lespinet-Fabre, Byron Calgua, Philip M. Jermann, Marius Ilie, Paul Hofman
Summary: This multicenter study evaluated the performance of the Oncomine Dx Express Test on the Ion Torrent Genexus System for detecting DNA and RNA variants in solid tumors. The test showed high accuracy and sensitivity, providing results in a short turnaround time, which can support timely decision-making for targeted therapeutic interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Durgesh Wankhede, Christophe Bontoux, Sandeep Grover, Paul Hofman
Summary: mKRAS G12C mutation has been proven to be a promising prognostic factor for patients with non-small cell lung cancer (NSCLC), negatively impacting survival. Additionally, high PD-L1 expression in these tumors opens doors for potential therapeutic opportunities.
Article
Health Care Sciences & Services
Christophe Bontoux, Aubiege Marcovich, Samantha Goffinet, Florian Pesce, Virginie Tanga, Doriane Bohly, Myriam Salah, Kevin Washetine, Zeineb Messaoudi, Jean-Marc Felix, Christelle Bonnetaud, Lihui Wang, Geetha Menon, Jean-Philippe Berthet, Charlotte Cohen, Jonathan Benzaquen, Charles-Hugo Marquette, Sandra Lassalle, Elodie Long-Mira, Veronique Hofman, Luc Xerri, Marius Ilie, Paul Hofman
Summary: We established a lymphoma biobank in Nice, France, which contains high-quality biological materials and clinical data for lymphoma patients. The biobank is ISO 9001 and ISO 20387 certified and aims to support translational research projects into lymphoma.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Arnaud Martel, Baharia Mograbi, Barnabe Romeo, Lauris Gastaud, Salome Lalvee, Katia Zahaf, Julien Fayada, Sacha Nahon-Esteve, Christelle Bonnetaud, Myriam Salah, Virginie Tanga, Stephanie Baillif, Corine Bertolotto, Sandra Lassalle, Paul Hofman
Summary: Liquid biopsy and circulating tumor cell (CTC) screening have gained attention in the past two decades for detecting various solid malignancies. However, the lack of reproducibility due to different CTC platforms using different technologies is a major limitation for daily clinical use. This study compares the efficiency of four commercially available CTC platforms for detecting and identifying uveal melanoma cells. The results show significant differences in recovery rates among the platforms, highlighting the importance of considering other factors before using a CTC platform in clinical practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)