Article
Cell Biology
Dandan Wang, Liangyi Cui, Qing Yang, Jiao Wang
Summary: The up-regulated circZFPM2 in ectopic endometrial tissues can induce EMT through the miR-205-5p /ZEB1 signaling pathway, promoting cell proliferation, migration, and invasion. This may serve as a promising biomarker in the diagnosis and treatment of endometriosis.
CELLULAR SIGNALLING
(2021)
Article
Cell Biology
Zhongjian Yu, Xiongjie Zhu, Ying Li, Min Liang, Meijun Liu, Zhile Liu, Lingyu Qin, Xiaoran Wu, Kunpeng Du, Lu Liu, Yong Wang, Yanfang Zheng
Summary: The study shows that in lung adenocarcinoma, circ-HMGA2 promotes cell metastasis through the miR-1236-3p/EMT axis, indicating that it could be a therapeutic target in LUAD.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Yaoyao Xiong, Xiongbing Zu, Long Wang, Yuan Li, Minfeng Chen, Wei He, Lin Qi
Summary: The study identified lncRNA VIM-AS1 as highly expressed in bladder cancer, especially in metastatic tissues and high-metastatic cell lines. VIM-AS1 acted as a ceRNA for miR-655, competing with ZEB1 for miR-655 binding, promoting EMT in both high- and low-metastatic bladder cancer cells, and enhancing cancer cell metastasis.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Yu-Chuan Yan, Guang-Xiao Meng, Chun-Cheng Yang, Ya-Fei Yang, Si-Yu Tan, Lun-Jie Yan, Zi-Niu Ding, Yun-Long Ma, Zhao-Ru Dong, Tao Li
Summary: In this study, the DAGLA/2-AG axis is found to promote HCC progression by regulating cell proliferation, invasion, and metastasis. Furthermore, DAGLA induces resistance to lenvatinib therapy during HCC treatment. Therefore, inhibiting the DAGLA/2-AG axis could be a novel therapeutic strategy to inhibit HCC progression and enhance the therapeutic effects of TKIs.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Yanhong Wang, Na Li, Yanping Zheng, Anqing Wang, Chunlei Yu, Zhenbo Song, Shuyue Wang, Ying Sun, Lihua Zheng, Guannan Wang, Lei Liu, Jingwen Yi, Yanxin Huang, Muqing Zhang, Yongli Bao, Luguo Sun
Summary: KIAA1217 plays a crucial role in hepatocellular carcinoma (HCC) metastasis by promoting cell migration and invasion through inducing epithelial-mesenchymal transition (EMT), and activating JAK1/2 and STAT3. It interacts with the Notch and Wnt/β-catenin pathways to facilitate HCC metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Medicinal
Jihye Seo, Jain Ha, Eunjeong Kang, Sayeon Cho
Summary: The complex orchestration of gene expression during the transition of epithelial cells into mesenchymal cells is crucial in cancer development and metastasis. EMT-TFs, as primary regulators of this process, play key roles in metastasis and have been implicated in cancer therapy resistance. This review focuses on three main EMT-TFs - Snail, Twist1, and ZEB1 - and their relationship to drug resistance, as well as possible future approaches targeting EMT-TFs.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Xueping Lei, Zhan Li, Yihang Zhong, Songpei Li, Jiacong Chen, Yuanyu Ke, Sha Lv, Lijuan Huang, Qianrong Pan, Lixin Zhao, Xiangyu Yang, Zisheng Chen, Qiudi Deng, Xiyong Yu
Summary: Gli1 promotes the metastasis of non-small cell lung carcinoma and is associated with poor patient survival.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Biochemistry & Molecular Biology
Anda Huna, Beatrice Nawrocki-Raby, Teresita Padilla-Benavides, Julie Gavard, Sylvie Coscoy, David Bernard, Mathieu Boissan
Summary: NME1, not NME2, acts specifically to inhibit EMT and prevent the earliest stages of metastasis. Loss of NME1 leads to a hybrid phenotype associated with higher metastatic potential, while overexpression of NME1 results in a more epithelial phenotype. Additionally, NME1 inhibits key intracellular signaling pathways involved in inducing EMT, such as AKT and MAPK pathways, and affects the distribution and cell-cell adhesion of E-cadherin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Jibin Yao, Yongbin Zhang, Yu Xia, Chenglou Zhu, Xiaoxiong Wen, Tianxiang Liu, Mingxu Da
Summary: Bioinformatics analysis revealed the correlation between PRRX1 gene and lymph node metastasis in gastric cancer. Experimental results showed significantly elevated expression of PRRX1 in gastric cancer tissues, suggesting its role in promoting lymph node metastasis through regulating EMT. Therefore, PRRX1 could potentially serve as a novel biological indicator for predicting or preventing lymph node metastasis in gastric cancer.
Article
Gastroenterology & Hepatology
Cindy Lobe, Marie Vallette, Ander Arbelaiz, Ester Gonzalez-Sanchez, Laura Izquierdo, Anna Pellat, Nathalie Guedj, Corentin Louis, Valerie Paradis, Jesus M. Banales, Cedric Coulouarn, Chantal Housset, Javier Vaquero, Laura Fouassier
Summary: The transcription factor ZEB1 plays a crucial role in the progression of cholangiocarcinoma by regulating the crosstalk between tumor cells and cancer-associated fibroblasts (CAFs), leading to tumor dedifferentiation and CAF activation. In vitro and in vivo experiments demonstrated that ZEB1 promotes epithelial-mesenchymal transition and stemness in tumor cells, as well as inducing myofibroblast proliferation through the upregulation of connective tissue growth factor (CTGF). The study also found that ZEB1 controls the expression of paracrine signals such as HGF and IL6 in both tumor cells and myofibroblasts.
Article
Nutrition & Dietetics
Homa Hajimehdipoor, Zahra Tahmasvand, Fatemeh Ghorban Nejad, Marc Maresca, Sadegh Rajabi
Summary: This study investigated the effects of rutin on the proliferation, metastasis, and angiogenesis of breast cancer cells. Rutin was found to stimulate the proliferation and migration of MDA-MB-231 and MCF-7 cells. It also modulated the expression of genes involved in cell adhesion and angiogenesis.
Article
Multidisciplinary Sciences
Yan Guo, Xiaoqin Lu, Yao Chen, Beatriz Rendon, Robert A. Mitchell, Miriam Cuatrecasas, Marlies Cortes, Antonio Postigo, Yongqing Liu, Douglas C. Dean
Summary: The expression of proteins such as PDL1 and CD47 by cancer cells affects resistance to immunotherapy. Studies have also found that tumor-associated macrophages may influence the activation and migration of T cells through M2 polarization.
Article
Biochemistry & Molecular Biology
Qing-Xiang Meng, Ke-Nie Wang, Jun-Hui Li, Hui Zhang, Zhao-Hui Chen, Xue-Jie Zhou, Xu-Chen Cao, Ping Wang, Yue Yu
Summary: The study found that ZNF384 is significantly overexpressed in breast cancer and promotes breast cancer metastasis by regulating ZEB1 expression and inducing an epithelial and mesenchymal-like phenotype. Additionally, ZNF384 may be a target of miR-485-5p, and ZEB1 can up-regulate ZNF384 expression by repressing miR-485-5p expression. These findings provide evidence for the prognostic and therapeutic potential of ZNF384 in breast cancer patients.
MOLECULAR MEDICINE
(2022)
Article
Cell Biology
Taiyuan Li, Cheng Tan, Zhixiang Huang, Lingling Yang, Hua Dai, Bo Tang, Benping Xiao, Jianfeng Li, Xiong Lei
Summary: miR-144-3p is down-regulated in colorectal adenocarcinoma, and its low expression is associated with adverse clinicopathologic characteristics and poor prognosis. By targeting ZEB1/2, miR-144-3p can inhibit cell proliferation, invasion, and EMT in CRA.
Article
Biotechnology & Applied Microbiology
Xiaoxu Liu, Jing Wu, Bo Yang, Yuanyuan Zhao, Yafan Wang, Shuhong Pan, Suibing Miao, Xiaohua Wu
Summary: This study found that the hsa_circ_0005991/miR-30b-3p/Cdc42EP1 axis promotes the epithelial-mesenchymal transition process in endometriosis, providing a theoretical basis for the mechanism exploration and therapy of this disease.
Article
Immunology
Dafa Ding, Huijuan Yong, Na You, Wei Lu, Xu Yang, Xiaolong Ye, Yayun Wang, Tingting Cai, Xiaoling Zheng, Hui Chen, Bota Cui, Faming Zhang, Xingyin Liu, Jian-Hua Mao, Yibing Lu, Hang Chang
Summary: This study found that fecal microbiota transplantation (FMT) therapy can improve symptoms and metabolic parameters in patients with type 2 diabetes mellitus (T2DM). Out of 17 patients, 11 showed significant improvement. Additionally, the presence of certain microbial species can predict the clinical response to FMT treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Cell Biology
Binbin Yuan, Chengfei Jiang, Lingyan Chen, Lihui Wen, Jinlong Cui, Min Chen, Shu Zhang, Lin Zhou, Yimeng Cai, Jian-Hua Mao, Xiaoping Zou, Bo Hang, Pin Wang
Summary: Through evaluating the DNA repair gene signature in gastric cancer patients, this study found that patients with high scores had better therapeutic outcomes with immune checkpoint blockade therapy. These high DRGS score patients exhibited higher levels of anti-tumor lymphocyte infiltration, tumor mutation burden, PD-L1 expression, and longer overall survival.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Medicine, Research & Experimental
Sundus F. Shalabi, Mark A. LaBarge
Summary: There are numerous risk factors for breast cancer, some of which have poorly understood biological mechanisms. The lack of prevention options highlights the importance of understanding the mechanistic basis of cancer susceptibility and finding new targets for breast cancer prevention.
Article
Engineering, Environmental
Xiaochen Tang, Neal Benowitz, Lara Gundel, Bo Hang, Christopher M. Havel, Eunha Hoh, Peyton Jacob, Jian-Hua Mao, Manuela Martins-Green, Georg E. Matt, Penelope J. E. Quintana, Marion L. Russell, Altaf Sarker, Suzaynn F. Schick, Antoine M. Snijders, Hugo Destaillats
Summary: Tobacco-specific nitrosamines (TSNAs) may pose long-term health risks to nonsmokers, especially in homes contaminated with thirdhand smoke.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Oncology
Xiao-Ping Liu, Xiaoqing Jin, Saman Seyed Ahmadian, Xu Yang, Su-Fang Tian, Yu-Xiang Cai, Kuldeep Chawla, Antoine M. Snijders, Yankai Xia, Paul J. van Diest, William A. Weiss, Jian-Hua Mao, Zhi-Qiang Li, Hannes Vogel, Hang Chang
Summary: By developing and validating cellular morphometric subtypes (CMS), personalized diagnosis and therapy for LGG patients can be achieved. These subtypes can predict patient prognosis and treatment response based on molecular alterations and immune microenvironment, and also have translational impact on glioblastoma.
Article
Biology
Polly Y. Chang, James Bakke, Chris J. Rosen, Kathleen A. Bjornstad, Jian-Hua Mao, Eleanor A. Blakely
Summary: This study aimed to investigate the dose-response relationship of lung tumorigenesis after exposure to different ion beams in mice. Results showed a non-linear relationship between lung tumor prevalence and dose, suggesting potential threshold doses depending on the LET of the beams.
Article
Oncology
Xuan-Yu Mao, Jesus Perez-Losada, Mar Abad, Marta Rodriguez-Gonzalez, Cesar A. Rodriguez, Jian-Hua Mao, Hang Chang
Summary: This study utilizes artificial intelligence to analyze cellular morphometric, gene, and microbiome data of breast cancer patients and establishes a scoring system for risk stratification. The scoring system can predict the overall survival and progress-free survival of patients more accurately than clinical factors and biomarkers alone.
WORLD JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Veterinary Sciences
Libette J. Roman, Antoine M. Snijders, Hang Chang, Jian-Hua Mao, Kristina J. A. Jones, Gregory W. Lawson
Summary: This study examines the effect of different barrier practices on the fecal microbiome of breeding C57Bl/6J mice. The results show that differences in barrier husbandry practices can affect fecal microbiome divergence in both the parental and filial generations of different breeding colonies.
JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE
(2023)
Article
Environmental Sciences
Hui Yang, Xinzhi Wang, Pin Wang, Li He, Suzyann F. Schick, Peyton Jacob, Neal Benowitz, Lara A. Gundel, Chi Zhu, Yankai Xia, Jamie L. Inman, Hang Chang, Antoine M. Snijders, Jian-Hua Mao, Bo Hang
Summary: Increasing evidence suggests that thirdhand smoke (THS) exposure has adverse health effects and may increase cancer risk. This study used the Collaborative Cross (CC) mouse population-based model system to assess the effects of THS exposure on cancer risk and found an increased incidence and burden of tumors in THS-treated mice. Lung and liver tissues were particularly susceptible to tumorigenesis after THS exposure. The study also highlighted the importance of host genetic background in individual susceptibility to THS-induced tumorigenesis and emphasized the need to consider genetic factors when determining cancer risk in humans exposed to THS.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Substance Abuse
Georg E. Matt, Lydia Greiner, Rachael A. Record, Heather Wipfli, Jamie Long, Nathan G. Dodder, Eunha Hoh, Nicolas Lopez Galvez, Thomas E. Novotny, Penelope J. E. Quintana, Hugo Destaillats, Xiaochen Tang, Antoine M. Snijders, Jian-Hua Mao, Bo Hang, Suzaynn Schick, Peyton Jacob, Prue Talbot, E. Melinda Mahabee-Gittens, Ashley L. Merianos, Thomas F. Northrup, Lara Gundel, Neal L. Benowitz
Summary: Since the 1970s, policies prohibiting smoking indoors have saved numerous lives and reduced healthcare expenditure. However, these policies do not fully protect the public from the long-lasting toxic residues of tobacco smoke, known as thirdhand smoke. This article discusses the differences between secondhand and thirdhand smoke exposure and proposes four policy considerations to better protect the public and remediate thirdhand smoke.
Article
Endocrinology & Metabolism
Lijuan Chen, Lin Guo, Susu Feng, Congcong Wang, Zhicheng Cui, Sijing Wang, Qingmiao Lu, Hang Chang, Bo Hang, Antoine M. Snijders, Jian-Hua Mao, Yibing Lu, Dafa Ding
Summary: This study confirms the effectiveness of FMT in treating patients with T2DM and demonstrates its positive impact on gut microbiome, serum metabolites, intestinal epithelial barrier, inflammation, and circulating immune cells.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
Article
Biochemistry & Molecular Biology
Parijat Senapati, Masaru Miyano, Rosalyn W. Sayaman, Mudaser Basam, Amy Leung, Mark A. Labarge, Dustin E. Schones
Summary: DNA methylation plays a primary role in repressing transposable elements (TEs) in mammalian genomes, and the loss of methylation commonly observed in cancer cells and during aging leads to the loss of epigenetic repression of TEs. This study profiles DNA methylation in human mammary luminal epithelial cells (LEps) from younger and older women and reveals that specific TE subfamilies act as regulatory elements in normal cells and display consistent methylation changes with age. These methylation changes at TEs impact the regulation of genes associated with luminal breast cancers and may increase susceptibility to breast cancer.
Article
Cell Biology
Aurora Gomez-Vecino, Roberto Corchado-Cobos, Adrian Blanco-Gomez, Natalia Garcia-Sancha, Sonia Castillo-Lluva, Ana Martin-Garcia, Marina Mendiburu-Elicabe, Carlos Prieto, Sara Ruiz-Pinto, Guillermo Pita, Alejandro Velasco-Ruiz, Carmen Patino-Alonso, Purificacion Galindo-Villardon, Maria Linarejos Vera-Pedrosa, Jose Jalife, Jian-Hua Mao, Guillermo Macias de Plasencia, Andres Castellanos-Martin, Maria del Mar Saez-Freire, Susana Fraile-Martin, Telmo Rodrigues-Teixeira, Carmen Garcia-Macias, Julie Milena Galvis-Jimenez, Asuncion Garcia-Sanchez, Maria Isidoro-Garcia, Manuel Fuentes, Maria Begona Garcia-Cenador, Francisco Javier Garcia-Criado, Juan Luis Garcia-Hernandez, Maria Angeles Hernandez-Garcia, Juan Jesus Cruz-Hernandez, Cesar Augusto Rodriguez-Sanchez, Alejandro Martin Garcia-Sancho, Estefania Perez-Lopez, Antonio Perez-Martinez, Federico Gutierrez-Larraya, Antonio J. Carton, Jose Angel Garcia-Saenz, Ana Patino-Garcia, Miguel Martin, Teresa Alonso-Gordoa, Christof Vulsteke, Lieselot Croes, Sigrid Hatse, Thomas Van Brussel, Diether Lambrechts, Hans Wildiers, Hang Chang, Marina Holgado-Madruga, Anna Gonzalez-Neira, Pedro L. Sanchez, Jesu Perez Losada
Summary: Cardiotoxicity due to anthracyclines (CDA) affects cancer patients, and identifying individuals at risk is challenging. In this study, the authors investigated intermediate molecular phenotypes (IMPs) associated with myocardial damage to determine CDA susceptibility. By analyzing a mouse cohort treated with doxorubicin and docetaxel, they identified genetic markers linked to IMPs and CDA. These markers were also found to be associated with CDA in cancer patients, highlighting their potential as predictive factors. Additionally, genetic risk scores were generated using machine-learning regression to personalize patient management.
Article
Oncology
Xuanyu Mao, Yimeng Cai, Sarah Long, Jesus Perez-Losada, Jian-Hua Mao, Hang Chang
Summary: Increased mitotic activity is associated with the genesis and aggressiveness of many cancers. The mitotic network activity index (MNAI) constructed based on a 54-gene mitotic apparatus network has been evaluated as a potential prognostic biomarker in a pan-cancer study. The study confirmed the significant association of MNAI with overall survival, progression-free survival, and other prognostic endpoints in multiple cancer types, and also revealed its association with genetic instability and treatment response.
FRONTIERS IN ONCOLOGY
(2023)
Article
Microbiology
Kenneth H. H. Wan, Soo Park, Benjamin W. W. Booth, Ella C. C. Brydon, Joanne Eichenberger, Jamie L. L. Inman, Jian-Hua Mao, Antoine M. M. Snijders, Susan E. E. Celniker
Summary: Microbacterium sp. BDGP8 is a facultative anaerobic gram-positive bacterium belonging to the family Microbacteriaceae. Its complete genome consists of a single circular chromosome of 3,293,567 bp with a G + C content of 69.84% and two plasmids of 49,365 bp and 32,884 bp.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2023)