Article
Oncology
Allievi Niccolo, Manzo Elena, Paderno Nadiane, Merelli Barbara, Imberti Gianlorenzo, Piazzalunga Dario
Summary: An elderly female patient with long-standing Kaposi's sarcoma underwent palliative electrochemotherapy, which resulted in complete clinical response and resolution of symptoms. This treatment option is valid for managing Kaposi's sarcoma as it offers satisfactory clinical response and symptom control.
Article
Chemistry, Medicinal
Phung Nguyen, Phuong Doan, Tatu Rimpilainen, Saravanan Konda Mani, Akshaya Murugesan, Olli Yli-Harja, Nuno R. Candeias, Meenakshisundaram Kandhavelu
Summary: The discovery of a novel indoline-derived phenolic Mannich base as an activator of GPR17 shows potential for developing chemotherapeutic agents against GBM. The compound inhibits cAMP and Ca2+ to induce cytotoxic effects on GBM cells, presenting a possible innovative treatment for GBM.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Kiarash Eskandari, Mojdeh Fattahi, Hassan Yazdanian, Abbas Haghparast
Summary: Deep brain stimulation (DBS) is a promising treatment for psychostimulant addiction, but further research is needed to fully understand its therapeutic effects and mechanisms. This review summarizes the positive and adverse effects of DBS and highlights the need for controlled studies and research on animals and humans to optimize stimulation parameters and develop less invasive methods.
NEUROCHEMICAL RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Monika Kaurav, Sakina Ruhi, Husni Ahmed Al-Goshae, Ashok Kumar Jeppu, Dhani Ramachandran, Ram Kumar Sahu, Ashish Kumar Sarkar, Jiyauddin Khan, Abu Md Ashif Ikbal
Summary: A brain tumor is an uncontrolled cell proliferation that grows and divides abnormally. Approximately 25,690 primary malignant brain tumors are discovered each year, with 70% originating in glial cells. Nanocarriers have shown significant therapeutic efficacy in various brain diseases.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Nutrition & Dietetics
Hannah Land Lail, Rafaela G. Feresin, Dominique Hicks, Blakely Stone, Emily Price, Desiree Wanders
Summary: Obesity-related inflammation is associated with chronic low-grade inflammation and increased risk of chronic diseases. Berries and their bioactive components have been shown to have beneficial effects on inflammation. Berries may offer a treatment possibility for obesity-induced inflammation and associated comorbidities.
Article
Chemistry, Multidisciplinary
Brice Martin, Tyler Garman, Madeline Laramee, Amy Wang, Xiaohu Zhang, Erin Beck, Kelli Wilson, Carleen Klumpp-Thomas, Crystal McKnight, Xin Xu, Natalie Hagen, David Holland, Nadia Dahmane, Craig J. Thomas, Mark Souweidane
Summary: In this study, a high-throughput screen was conducted on a human patient-derived CPC cell line, identifying 427 potential targets and providing new strategies for CPC treatment. Two combination therapies (topotecan/elimusertib and melphalan/elimusertib) were validated in vitro and in vivo, leading to increased survival in a CPC genetic mouse model. This study identifies multiple promising combinatorial therapeutics for CPC and highlights the potential of intra-arterial delivery in CPC treatment.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Pharmacology & Pharmacy
Erica A. Power, Julian S. Rechberger, Sumit Gupta, Jonathan D. Schwartz, David J. Daniels, Soumen Khatua
Summary: Although there has been a surge in the identification of molecular targets and targeted therapies in pediatric brain tumors in the last decade, the blood brain barrier (BBB) remains a significant challenge for systemic drug delivery. Recent efforts have identified strategies to enhance drug delivery into pediatric brain tumors, including invasive and non-invasive technologies.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Pharmacology & Pharmacy
Stefano Caccavale, Vittorio Tancredi, Paola Vitiello, Antonello Sica, Andrea Ronchi, Renato Franco, Francesco Pastore, Giuseppe Argenziano
Summary: Topical photodynamic therapy (PDT) is a promising treatment option for cutaneous lymphomas, with good tolerability and cosmetic outcomes. However, its mechanism of action and efficacy in treating lymphoproliferative diseases are still not well understood. Further clinical trials are needed to determine the optimal treatment protocol.
Article
Oncology
Lejun Zhang, Zhaoting Ling, Zhengqiang Hu, Guanmin Meng, Xinqiang Zhu, Huifang Tang
Summary: Through network pharmacology analysis, this study found that Huanglianjiedu Decoction may potentially play a therapeutic role in oral squamous cell carcinoma by inhibiting p-ERK1/2 and p-NF-kappa B p65(S468).
CANCER CELL INTERNATIONAL
(2021)
Article
Engineering, Biomedical
Yuan Ding, Sitong Zhang, Zhongquan Sun, Zongrui Tong, Yao Ge, Liuzhi Zhou, Qianhui Xu, Huiping Zhou, Weilin Wang
Summary: This study successfully prepared silibinin and bovine serum albumin nanoparticles and evaluated their therapeutic efficacy against acute liver injury. The nanoparticles showed better biocompatibility and liver distribution compared to silibinin microparticles. They also demonstrated antioxidant and anti-apoptotic effects.
ACTA BIOMATERIALIA
(2022)
Article
Neurosciences
Michael Leon, Cynthia C. Woo
Summary: The loss of olfactory stimulation is closely associated with various neurological disorders, and there may be a causal relationship between them. Enrichment of olfactory stimulation may reduce the risk of these disorders, similar to the cognitive reserve protecting against Alzheimer's disease.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Emma Martinez-Alonso, Alejandro Escobar-Peso, Alicia Aliena-Valero, German Torregrosa, Mourad Chioua, Rocio Fernandez-Serra, Daniel Gonzalez-Nieto, Youness Ouahid, Juan B. Salom, Jaime Masjuan, Jose Marco-Contelles, Alberto Alcazar
Summary: The study found that quinolylnitrone QN23 has neuroprotective effects in the treatment of acute ischemic stroke, reducing neuronal death and apoptosis, decreasing infarct volume, and restoring motor function, making it a promising preclinical candidate for this condition.
Article
Oncology
Gregor Vivod, Nina Kovacevic, Maja Cemazar, Gregor Sersa, Tanja Jesenko, Masa Bosnjak, Simona Kranjc Brezar, Sebastjan Merlo
Summary: This study evaluated the feasibility and suitability of electrochemotherapy as a less radical alternative to pelvic exenteration for treating recurrent vulvar cancer. The results suggest that electrochemotherapy may be a more conservative treatment option, especially for patients with initially higher FIGO stages.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2022)
Article
Chemistry, Multidisciplinary
Naeem Ullah, Javed Ali Khan, Mohammad Sohail Khan, Wahab Khan, Izaz Hassan, Marwa Obayya, Noha Negm, Ahmed S. Salama
Summary: Brain tumors are a serious and life-threatening disease globally. To save lives, researchers have used deep transfer learning approaches and found that the Inceptionresnetv2 algorithm performs best in identifying and classifying glioma, meningioma, and pituitary brain tumors.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Hui Li, Wen Wen, Jia Luo
Summary: This article summarizes the role of endoplasmic reticulum stress in alcoholic pancreatitis and discusses potential therapeutic strategies targeting this stress response.
Article
Cardiac & Cardiovascular Systems
Antonio J. Vallejo-Vaz, Sarah Bray, Guillermo Villa, Julia Brandts, Gaia Kiru, Jennifer Murphy, Maciej Banach, Stefano De Servi, Dan Gaita, Ioanna Gouni-Berthold, G. Kees Hovingh, Jacek J. Jozwiak, J. Wouter Jukema, Robert Gabor Kiss, Serge Kownator, Helle K. Iversen, Vincent Maher, Luis Masana, Alexander Parkhomenko, Andre Peeters, Piers Clifford, Katarina Raslova, Peter Siostrzonek, Stefano Romeo, Dimitrios Tousoulis, Charalambos Vlachopoulos, Michal Vrablik, Alberico L. Catapano, Neil R. Poulter, Kausik K. Ray
Summary: In patients with atherosclerotic cardiovascular disease (ASCVD), achieving European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) LDL-C goals may result in an additional 2% absolute risk reduction (ARR) over 10 years compared to the American College of Cardiology/American Heart Association (ACC/AHA) approach.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Endocrinology & Metabolism
Dennis Zetner, Claus Kamby, Sengul Gulen, Camilla Christophersen, Cecilie B. Paulsen, Emily Piga, Bodil Hoffmeyer, Faisal Mahmood, Jacob Rosenberg
Summary: This study aimed to investigate the impact of topical melatonin during radiation therapy on the quality of life in primary breast cancer patients. A total of 65 patients were included in the study, with 26 in the melatonin group and 22 in the placebo group. The results showed that while there was no difference in breast symptom scores on the last day of radiation, the melatonin group had significantly lower scores over the entire duration of the trial.
JOURNAL OF PINEAL RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sofie Rahbek, Tim Schakel, Faisal Mahmood, Kristoffer H. H. Madsen, Marielle E. P. Philippens, Lars G. G. Hanson
Summary: The study extends a method for controlling the spatial point spread function (PSF) by optimizing the flip angles in the refocusing pulse train of diffusion-weighted SPLICE sequence, resulting in improved image quality with increased signal-to-noise ratio (SNR) and accurate diffusion coefficient estimates.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Health Care Sciences & Services
George F. Mkoma, Soren P. Johnsen, Charles Agyemang, Jakob N. Hedegaard, Helle K. Iversen, Grethe Andersen, Marie Norredam
Summary: This study investigated the differences in acute stroke care between immigrants and Danish-born residents, and found that immigrants were less likely to receive early stroke care and be admitted to stroke unit, as well as received fewer individualized stroke care processes. These disparities were primarily influenced by the socioeconomic status and cohabitation of immigrants.
Article
Engineering, Biomedical
Sofie Rahbek, Faisal Mahmood, Michal R. Tomaszewski, Lars G. Hanson, Kristoffer H. Madsen
Summary: A new prediction framework was proposed in this study to utilize temporal dynamics of tissue features from repeated measurements. The framework was able to classify tumor types and predict the response to radiotherapy using MRI data analysis. The results showed accurate classification of pancreatic tumor types and prediction of tumor volume change. The classification of brain metastases also demonstrated some level of accuracy.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Oncology
Stephanie Tanadini-Lang, Geoff Budgell, Omar Bohoudi, Stefanie Corradini, Davide Cusumano, Gorkem Gungor, Linda G. W. Kerkmeijer, Faisal Mahmood, Simeon Nill, Miguel A. Palacios, Michael Reiner, Daniela Thorwarth, Lotte Wilke, Jochem Wolthaus
Summary: The objective of this study was to define QA tests for oMRgRT systems and to identify important medical physics aspects for installation and commissioning. Twenty-four potentially important QA tests were identified, along with eleven tasks and aspects related to construction, workflow development, and training. A program for QA and commissioning of oMRgRT systems was developed to support safe handling of such systems.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Clinical Neurology
Adam Vittrup Heiberg, Sofie Amalie Simonsen, Henrik Winther Schytz, Helle Klingenberg Iversen
Summary: This study explored the feasibility of fNIRS as a biomarker to assess executive function in AIS patients. The results showed that AIS patients performed worse than the healthy controls in the SCWT. However, both groups exhibited an inverse hemodynamic response in the prefrontal cortex during the test.
NEUROREHABILITATION
(2023)
Article
Public, Environmental & Occupational Health
Hafed Amin Saidane, Thomas Rasmussen, Knud Andersen, Helle Klingenberg Iversen, Anders Sode West
Summary: This study aimed to explore the effect of naturalistic light on agitation in nursing home residents with dementia. The results showed a significant reduction in the frequency of agitation-associated behaviors, suggesting that naturalistic lighting may be a promising nonpharmacological intervention for improving overall agitation in this population.
HERD-HEALTH ENVIRONMENTS RESEARCH & DESIGN JOURNAL
(2023)
Article
Oncology
Mille Vissing, Mascha Pervan, John Ploen, Mazen Schnefeldt, Soren Rafael Rafaelsen, Lars Henrik Jensen, Achim Rody, Julie Gehl
Summary: Calcium electroporation is a local therapy that selectively kills cancer cells in cutaneous metastases. This multicentre study showed that it has a treatment response in various types of cutaneous metastases and can relieve symptoms.
Article
Oncology
Claudia Di Prata, Matteo Mascherini, Alastair MacKenzie Ross, Barbara Silvestri, Erika Kis, Joy Odili, Tommaso Fabrizio, Rowan Pritchard Jones, Christian Kunte, Antonio Orlando, James Clover, Siva Kumar, Francesco Russano, Paolo Matteucci, Tobian Muir, Francesca de Terlizzi, Julie Gehl, Eva-Maria Grischke
Summary: Electrochemotherapy is an effective treatment for cutaneous metastases of various cancers, including breast cancer. This study analyzed breast cancer patients with different receptor statuses (estrogen receptor and HER2 receptor) using the INSPECT database. The study found that ECT treatment was equally effective among different groups, and treating multiple small lesions at the time of occurrence was more effective than treating larger, long-lasting armor-like lesions.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jakob M. Moller, Lars Boesen, Adam Espe Hansen, Karen Kettles, Vibeke Logager
Summary: The purpose of this study was to quantify the variability of ADC and investigate if there were significant differences in ADC between MRI systems and sequences. A phantom model with fixed ADC values was tested in six MRI systems using different sequences. Statistical analysis revealed significant differences in ADC measurements between vendors, while the variation of ADC between MRI systems and sequences was deemed clinically irrelevant.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Uffe Bernchou, Tine Schytte, Anders Bertelsen, Ebbe Laugaard Lorenzen, Carsten Brink, Faisal Mahmood
Summary: This study investigated the impact of abdominal compression on motion and the delivered dose during non-gated, MRI-guided radiation ablation of adrenal gland metastases. The results showed that the use of abdominal compression significantly reduced the target position error and prevented the degradation of target coverage. Most patients maintained acceptable target coverage and dose to intra-luminal organs during motion.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2023)
Article
Oncology
Anne L. H. Bisgaard, Rick Keesman, Astrid L. H. M. W. van Lier, Catherine Coolens, Petra J. van Houdt, Alison Tree, Andreas Wetscherek, Paul B. Romesser, Neelam Tyagi, Monica Lo Russo, Jonas Habrich, Danny Vesprini, Angus Z. Lau, Stella Mook, Peter Chung, Linda G. W. Kerkmeijer, Zeno A. R. Gouw, Ebbe L. Lorenzen, Uulke A. van der Heide, Tine Schytte, Carsten Brink, Faisal Mahmood
Summary: This study aimed to evaluate the variation in ADC measurements and calculations among multiple centers and provide recommendations to minimize it. The results showed that calculation methods had a bigger impact on ADC reproducibility compared to delineation methods. It is suggested to consider these factors when conducting multi-center studies.
RADIOTHERAPY AND ONCOLOGY
(2023)
Correction
Clinical Neurology
G. F. Mkoma, S. P. Johnsen, H. K. Iversen, G. Andersen, M. Norredam
EUROPEAN STROKE JOURNAL
(2023)
Review
Endocrinology & Metabolism
Sarah Seberg Diemar, Stig Sogaard Dahl, Anders Sode West, Sofie Amalie Simonsen, Helle Klingenberg Iversen, Niklas Rye Jorgensen
Summary: This review provides an overview of the circadian variation of bone markers and the factors that influence this rhythmicity. Many bone markers show a marked circadian variation with nighttime or early morning peaks. Factors such as fasting can affect the circadian variation of these markers. Understanding and considering these circadian variations and influencing factors are important for accurate measurement of bone markers.
CALCIFIED TISSUE INTERNATIONAL
(2023)