Article
Nanoscience & Nanotechnology
Mengjun Zhang, Haodi Yue, Xin Huang, Jialin Wang, Zengbei Li, Xinjie Deng
Summary: This study demonstrates the anti-tumor effects of polyethylenimine-caged platinum nanoclusters on cisplatin-resistant ovarian cancer cells, inhibiting proliferation and migration while promoting apoptosis. The study also validates the role of these nanoclusters in regulating autophagy through the PI3K-AKT-mTOR signaling pathway. These findings suggest the promising potential of platinum nanoclusters as a novel chemotherapeutic agent for cisplatin-resistant ovarian cancer.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Medicine, General & Internal
Shanyu Fang, Ping Zhang, Xinping Chen, Fujun Liu, Fen Wang
Summary: Lanthanum chloride (LaCl3) enhances the anticancer ability of cisplatin (DDP) in ovarian cancer cells by inducing more cell death and apoptosis caused by DDP, along with downregulation of Bcl-2 protein and inactivation of the PI3K/Akt pathway. LaCl3 may be a potential drug to modulate DDP resistance by attenuating DNA repair in ovarian cancer.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jia-Mei Wang, Qi Gao, Qi Zhang, Liang Hao, Jing-Yi Jiang, Ling-Yue Huyan, Bao-Qin Liu, Jing Yan, Chao Li, Hua-Qin Wang
Summary: The study found decreased expression of BAG5 in cisplatin-resistant ovarian cancer cells and tissues. BAG5 knockdown was involved in metabolic reprogramming and maintenance of cancer stem cell-like features by regulating the Rictor-mTORC2 pathway. Upregulation of Bcl6 repressed BAG5 transcription in cisplatin-resistant ovarian cancer. The study identified the Bcl6/BAG5/Rictor-mTORC2 pathway in metabolic reprogramming and maintenance of cancer stem cell-like features in cisplatin-resistant ovarian cancer cells.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Article
Cell Biology
Hefei Li, Yushan Zhang, Xiaomei Lan, Jianhua Yu, Changshuang Yang, Zhijian Sun, Ping Kang, Yi Han, Daping Yu
Summary: Lung cancer is the leading cause of cancer death globally. Cisplatin is a common DNA-damaging drug used in treatment, but resistance often develops. Halofuginone has been identified as a sensitizing agent in lung cancer, inhibiting cell proliferation and inducing apoptosis by affecting PI3K/AKT and MAPK signaling pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xiao Liang, Chunlei Yu, Yunhong Tian, Xiaocong Xiang, Yuexi Luo
Summary: Ovarian cancer is the most common gynecological malignancy, and chemotherapy failure is a major challenge in its treatment. Targeting autophagy is a promising strategy to enhance the cytotoxicity of chemotherapeutic agents. Costunolide inhibits autophagic flux and shows high therapeutic efficacy for ovarian cancer treatment, and it also sensitizes ovarian cancer cells to cisplatin.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Oncology
C. Kong, Z. Zhu, Y. Li, P. Xue, L. Chen
Summary: The study found that HOXA11 is significantly down-regulated in endometrial cancer tissues. Overexpression of HOXA11 promotes apoptosis but inhibits proliferation, migration, and invasion of endometrial cancer cells. Conversely, knockdown of HOXA11 enhances cell proliferation, migration, and invasion through the PTEN/AKT signaling pathway.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ming Sui, Hairong Yang, Mingqi Guo, Wenle Li, Zheng Gong, Jing Jiang, Peiling Li
Summary: The study showed that cajanol significantly restored the sensitivity of A2780/Taxol ovarian cancer cells to paclitaxel by inhibiting P-glycoprotein expression and affecting its transcription and translation through the PI3K/Akt/NF-kappa B pathway. Cajanol may serve as a potential candidate compound for developing paclitaxel sensitizers, presenting a promising approach for overcoming multi-drug resistance in ovarian cancer treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Shanyu Fang, Yuanyuan Luo, Ying Zhang, Houmei Wang, Qianfen Liu, Xinya Li, Tinghe Yu
Summary: In the treatment of epithelial ovarian cancer, a high level of NTNG1 has been found to lead to cisplatin resistance through the GAS6/AXL/Akt pathway, affecting cell apoptosis and survival. NTNG1 may serve as a useful target to overcome drug resistance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Jiangtao Yu, Xiaoli Hu, Xiuxiu Chen, Qiangyong Zhou, Qi Jiang, Zhengzheng Shi, Haiyan Zhu
Summary: CNOT7 plays an important role in biological processes and has potential for treating malignant tumors. This study aimed to investigate the functions and mechanism of CNOT7 in ovarian cancer. Results showed that CNOT7 overexpression in A2780 and SKOV3 cells could be partially or completely eliminated by treatment with the AKT inhibitor LY294002.
Article
Oncology
Lei Lv, Qiyi Yi, Ying Yan, Fengmei Chao, Ming Li
Summary: SPNS2 expression in CRC is regulated by copy number variation and DNA methylation, with high expression associated with colon adenoma and CRC, but low expression correlated with advanced stage and poor prognosis. Ectopic expression of SPNS2 inhibits proliferation, migration, invasion, and metastasis of CRC cells by regulating PTEN and Akt activity.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Li-ying Zhang, Jia-ying Yu, Yan-long Leng, Ran-ran Zhu, Hong-xian Liu, Xin-yu Wang, Ting-ting Yang, Yi-ning Guo, Jing-ling Tang, Xin-chen Zhang
Summary: The study identified miR-181c as downregulated in PTX-resistant ovarian cancer cells and tissues, which induced apoptosis and inhibited the PI3K/Akt pathway by directly targeting GRP78. Overexpression of miR-181c sensitized resistant ovarian cancer to PTX, suggesting a potential therapeutic strategy.
CANCER GENE THERAPY
(2022)
Article
Biology
Yuanyong Feng, Xuedi Cao, Bin Zhao, Chunyan Song, Baoxing Pang, Liang Hu, Chunmei Zhang, Jinsong Wang, Junqi He, Songlin Wang
Summary: While cisplatin is commonly used in OSCC treatment, it has side effects and poor chemosensitivity. Nitrate shows beneficial effects and enhances chemotherapy efficacy. Nitrate can increase cisplatin chemosensitivity, reduce REDD1 expression, and attenuate AKT signaling activation in OSCC cells.
SCIENCE CHINA-LIFE SCIENCES
(2021)
Article
Plant Sciences
Qingfa Tang, Haihong Cao, Ni Tong, Yuanliang Liu, Wanyu Wang, Yuheng Zou, Lanyang Xu, Zhiyun Zeng, Wei Xu, Zhixin Yin, Wenjuan Ma, Qirui Wang
Summary: This study demonstrates that traditional Chinese medicine tubeimoside-I (TBMS1) has a synergistic therapeutic effect against TMZ-resistant glioblastoma multiforme by promoting apoptosis and inhibiting cell proliferation.
Article
Multidisciplinary Sciences
Ruijie Zhang, Xiaozhi Yang, Dana M. Roque, Chenglong Li, Jiayuh Lin
Summary: LLL12B is a novel small molecule that inhibits the STAT3 pathway in ovarian cancer cells, reducing cell viability and proliferation, and enhancing inhibitory effects when used in combination with frontline chemotherapeutic drugs.
Article
Pharmacology & Pharmacy
Amal Al-Shahat, Mohey A. E. Hulail, Nada M. M. Soliman, Tarek Khamis, Liana Mihaela Fericean, Ahmed Hamed Arisha, Rania S. Moawad
Summary: This study aimed to evaluate the ameliorative effects of melatonin as an adjuvant treatment for ovarian damage and fertility impairment induced by cisplatin. The results showed that melatonin could mitigate the cisplatin-induced changes in body weight, ovarian weight, hormone levels, oxidative stress markers, histopathological features, and mRNA expressions of various genes. Overall, melatonin's antioxidant, anti-inflammatory, and anti-apoptotic activities could help preserve fertility in pre-menopausal cancer patients undergoing chemotherapy.
Article
Multidisciplinary Sciences
Kanwal Rehman, Syeda Mehak Munawar, Muhammad Sajid Hamid Akash, Manal Ali Buabeid, Tahir Ali Chohan, Muhammad Tariq, Komal Jabeen, El-Shaimaa A. Arafa
Article
Biochemistry & Molecular Biology
El-Shaimaa A. Arafa, Manal Ali Buabeid, Waseem Hassan, Ghulam Murtaza, Tahir Ali Chohan, Hammad Ahmed
Summary: The study revealed that paraphenylenediamine (PPD) is a highly toxic compound, causing 100% mortality rate and significant effects on the liver, kidneys, and heart. Virgin Coconut Oil (VCO) as a potential antidote, can significantly reduce mortality rate and have a modulatory effect on organ markers.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2021)
Review
Endocrinology & Metabolism
Jingbo Xie, Jian Guo, Zaeema Kanwal, Mingzheng Wu, Xiangyang Lv, Nihal Abdalla Ibrahim, Ping Li, Manal Ali Buabeid, El-Shaimaa A. Arafa, Qingshan Sun
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Waseem Hassan, Manal Ali Buabeid, Umme Kalsoom, Sahar Bakht, Imran Akhtar, Furqan Iqbal, El-Shaimaa A. Arafa
BIOMED RESEARCH INTERNATIONAL
(2020)
Review
Pharmacology & Pharmacy
Zoya Iqbal, El-Shaimaa A. Arafa, Zaeema Kanwal, Ghulam Murtaza
Summary: Nanotechnology, particularly the use of radiolabeled nanocarriers, has shown promising potential in early diagnosis, accurate detection, and treatment of diseases like cancer. The ability to create nanocarriers for targeted drug delivery and molecular imaging has the potential to greatly influence disease management in the near future. The unique advantages of various imaging modalities, such as PET and SPECT, have played a significant role in visualizing biological processes at molecular and cellular levels non-invasively.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Infectious Diseases
Saleh Alghamdi, Bassant Barakat, Ilhem Berrou, Abdulhakim Alzahrani, Abdul Haseeb, Mohamed Anwar Hammad, Sirajudheen Anwar, Abdulmajeed Abdulghani A. Sindi, Hussain A. Almasmoum, Mohammad Albanghali
Summary: A comparative observational study conducted in a hospital in Saudi Arabia found that Hydroxychloroquine treatment did not reduce mortality rates, length of hospital stay, admission to the intensive care unit, time in ICU, and need for mechanical ventilation in patients hospitalized with COVID-19, compared to standard treatment.
Article
Biology
Hany H. Arab, Ahmed M. Ashour, Abdulmalik M. Alqarni, El-Shaimaa A. Arafa, Ahmed M. Kabel
Summary: The immunosuppressant cyclosporine A can cause renal damage, while camel milk, as a natural substance, has the potential to alleviate cyclosporine-induced renal injury. Camel milk can lower levels of nephrotoxicity markers, inhibit renal inflammation, and enhance renal antioxidant capacity.
Article
Immunology
Hany H. Arab, Sarah A. Abd El-Aal, Ahmed H. Eid, El-Shaimaa A. Arafa, Ayman M. Mahmoud, Ahmed M. Ashour
Summary: Troxerutin attenuates MTX-induced renal injury by inhibiting inflammation and apoptosis and activating autophagy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Multidisciplinary Sciences
El-Shaimaa A. Arafa, Mohamed S. Refaey, Omnia A. M. Abd El-Ghafar, Emad H. M. Hassanein, Ahmed M. Sayed
Summary: Research has shown that certain ginsenosides have therapeutic potential in downregulating p38 MAPK signaling, leading to their pharmacological benefits in various ailments. Studies on individual ginsenosides have focused on their specific molecular mechanisms of action, rather than the effects of whole-plant extracts.
Article
Chemistry, Medicinal
Hany H. Arab, Alzahraa A. Elhemiely, Azza A. K. El-Sheikh, Hana J. Al Khabbaz, El-Shaimaa A. Arafa, Ahmed M. Ashour, Ahmed M. Kabel, Ahmed H. Eid
Summary: The study investigated the potential effects of linagliptin on cadmium-induced testicular impairment. Linagliptin showed positive effects by improving histopathological lesions, sperm count/motility, and serum testosterone levels. These effects were mediated by reducing testicular inflammation, suppressing apoptosis, and enhancing autophagy.
Article
Chemistry, Medicinal
Hany H. Arab, Hayat A. Abd El Aal, Shuruq E. Alsufyani, Azza A. K. El-Sheikh, El-Shaimaa A. Arafa, Ahmed M. Ashour, Ahmed M. Kabel, Ahmed H. Eid
Summary: In this study, the effect of topiramate on cadmium-induced testicular impairment was investigated. The results showed that topiramate administration improved serum testosterone levels, sperm count/abnormalities, relative testicular weight, and histopathological changes in cadmium-intoxicated rats. The protective effect of topiramate was achieved by suppressing the NLRP3/caspase-1/IL-1 beta cascade, reducing apoptosis, and activating autophagy in the testes.
Article
Immunology
Emad H. M. Hassanein, Wafaa R. Mohamed, Rasha M. Hussein, El-Shaimaa A. Arafa
Summary: Edaravone (ED) was found to have protective effects against methotrexate (MTX)-induced testicular damage by reducing oxidative stress, inflammation, and apoptosis. It also regulated the Akt/p53 signaling pathway and improved steroidogenesis. These findings highlight the potential of ED as a treatment for MTX-induced testicular damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
El-Shaimaa A. Arafa, Noura T. Shurrab, Manal A. Buabeid
Summary: Chemotherapeutics can cause various toxic effects in the body, but the natural compound tangeretin found in citrus fruits has shown promising antioxidant and anti-inflammatory properties, along with selective toxicity to cancer cells. Tangeretin works through multiple mechanisms to mitigate inflammation and enhance the efficiency of chemotherapy drugs, potentially improving the overall health outcomes for cancer patients.
ADVANCES IN PHARMACOLOGICAL AND PHARMACEUTICAL SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Manal Ali Buabeid, El-Shaimaa A. Arafa, Waseem Hassan, Ghulam Murtaza
BIOMED RESEARCH INTERNATIONAL
(2020)
Article
Endocrinology & Metabolism
El-Shaimaa A. Arafa, Waseem Hassan, Ghulam Murtaza, Manal Ali Buabeid
JOURNAL OF DIABETES RESEARCH
(2020)