Article
Biochemistry & Molecular Biology
Ji Won Kim, Miso Park, Suntae Kim, Sung Chul Lim, Hyung Shik Kim, Keon Wook Kang
Summary: This study reveals that GV1001 inhibits migration and metastasis of PCa cells by activating the G alpha s/cAMP pathway, phosphorylating AR and YAP1, and decreasing AR-YAP1 binding in the promoter region of the CTGF gene. Additionally, GV1001 upregulated the expression of NKX3.1 and AR-coregulator, indicating its potential as a novel GnRHR ligand to inhibit PCa metastasis.
CELL AND BIOSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Mario Vega, Yu Chen, Yijiang Shi, Joseph Gera, Alan Lichtenstein
Summary: DEPTOR is a protein upregulated in multiple myeloma cells, which inhibits mTOR and promotes AKT activation. This study found that the phosphorylation of DEPTOR at serine 235 regulates its stability, and the association of USP-7 with DEPTOR depends on S235 phosphorylation. In addition, the ERK1 pathway maintains AKT activity through phosphorylation of DEPTOR.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Dhivya Sridaran, Surbhi Chouhan, Kiran Mahajan, Arun Renganathan, Cody Weimholt, Shambhavi Bhagwat, Melissa Reimers, Eric H. Kim, Manish K. Thakur, Muhammad A. Saeed, Russell K. Pachynski, Markus A. Seeliger, W. Todd Miller, Felix Y. Feng, Nupam P. Mahajan
Summary: This study identifies a T-cell pathway that leads to the inactivation of tumor-infiltrating T cells and resistance to immune therapy, thus explaining the limited effectiveness of immune checkpoint blockade (ICB) in solid tumors. Activation of the oncogenic tyrosine kinase ACK1 enhances the function of CSK, a negative regulator of T-cell activation, and constrains the activation of T cells. Inhibition of ACK1 effectively suppresses ICB-resistant tumors, providing new insights into ICB resistance mechanisms and potential targets for expanding ICB therapy.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Zsofia Agnes Bittner, Xiao Liu, Maria Mateo Tortola, Ana Tapia-Abellan, Sangeetha Shankar, Liudmila Andreeva, Matthew Mangan, Marianne Spalinger, Hubert Kalbacher, Peter Duewell, Marta Lovotti, Karlotta Bosch, Sabine Dickhoefer, Ana Marcu, Franziska Herster, Yamel Cardona Gloria, Tzu-Hsuan Chang, Francesca Bork, Carsten L. Greve, Markus W. Loeffler, Olaf-Oliver Wolz, Nadine A. Schilling, Jasmin B. Kuemmerle-Deschner, Samuel Wagner, Anita Delor, Bodo Grimbacher, Oliver Hantschel, Michael Scharl, Hao Wu, Eicke Latz, Alexander N. R. Weber
Summary: The study reveals that Bruton's tyrosine kinase (BTK) affects multiple levels of NLRP3 regulation by interacting with NLRP3 and phosphorylating conserved tyrosine residues upon inflammasome activation, promoting NLRP3 relocalization, oligomerization, ASC polymerization, and inflammasome assembly. This suggests BTK as a multifunctional positive regulator of NLRP3 regulation and its phosphorylation of NLRP3 as a potential therapeutic target for controlling inflammation.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Dermatology
Sijia Wang, Xiuli Yi, Zhenjie Wu, Sen Guo, Wei Dai, Huina Wang, Qiong Shi, Kang Zeng, Weinan Guo, Chunying Li
Summary: CAMKK2 regulates the sensitivity of melanoma cells to ferroptosis by modulating the AMPK.NRF2 pathway, potentially playing a crucial role in melanoma treatment.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Zhiguang Xiao, Stephen R. Hammes
Summary: Neutrophil elastase (NE) plays a role in promoting tumorigenesis by triggering ERK signaling and cell migration in prostate cells. NE stimulates the release of amphiregulin to initiate EGFR-dependent signaling. In prostate cancer cells, NE-mediated migration shifts from EGFR dependence to AXL dependence, suggesting the potential use of combined EGFR and AXL targeted therapy in prostate cancer treatment.
Article
Cell Biology
Athanasios A. Panagiotopoulos, Konstantina Kalyvianaki, Bourcin Serifoglou, Evangelia Konstantinou, George Notas, Elias Castanas, Marilena Kampa
Summary: Calcium homeostasis plays a significant role in the development and progression of prostate cancer, with androgens regulating cell processes through calcium changes. The study found that testosterone can rapidly increase intracellular calcium levels through OXER1 receptor and specific signaling cascade. These findings reveal the receptor involved in rapid calcium changes induced by androgens in prostate cancer cells.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Marta Markiewicz-Potoczny, Anastasia Lobanova, Anisha M. Loeb, Oktay Kirak, Teresa Olbrich, Sergio Ruiz, Eros Lazzerini Denchi
Summary: The loss of TRF2 in mouse embryonic stem cells triggers a compensatory transcriptional program that renders TRF2 dispensable for cell survival and proliferation. The unique DNA damage response in TRF2-null ES cells is controlled by telomere-associated protein POT1B and chromatin remodelling factor BRD2, and is characterized by the upregulation of ZSCAN4.
Article
Biochemistry & Molecular Biology
Hyun-Jung An, Cheol-Jung Lee, Ga-Eun Lee, Youngwon Choi, Dohyun Jeung, Weidong Chen, Hye Suk Lee, Han Chang Kang, Joo Young Lee, Dae Joon Kim, Jin-Sung Choi, Eun Suh Cho, Jong-Soon Choi, Yong-Yeon Cho
Summary: FBXW7 regulates ERK3 stability by promoting its ubiquitination and degradation, thereby suppressing lung cancer cell proliferation.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Cell Biology
Tianhua Zhang, Yuzhen Wang, Hongjiu Yu, Ting Zhang, Lianying Guo, Jie Xu, Xiaoqing Wei, Ning Wang, Yingjie Wu, Xiuli Wang, Lin Huang
Summary: Autophagy plays important roles in cell survival and cell death, particularly in tumorigenesis. This study identified a binding interaction between PRAS40 and PGK1, and revealed how PGK1 regulates autophagy and cell proliferation through phosphorylation of PRAS40 and Beclin1. These findings provide new insights into the role of PGK1/PRAS40 signaling in cancer.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Qiwei Jiang, Xiaomei Zhang, Xiaoming Dai, Shiyao Han, Xueji Wu, Lei Wang, Wenyi Wei, Ning Zhang, Wei Xie, Jianping Guo
Summary: The study demonstrates that S6K1 can directly phosphorylate PDK1, inhibiting the activity of AKT kinase and its role in tumorigenesis. This feedback regulation of AKT signaling through S6K1-mediated PDK1 phosphorylation provides insight into the regulation of the AKT pathway and potential strategies for combating mutant PDK1-driven cancers.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Huiling Zhou, Li Zhou, Qing Guan, Xuyang Hou, Cong Wang, Lijun Liu, Jian Wang, Xinfang Yu, Wei Li, Haidan Liu
Summary: Skp2, an E3 ligase, is overexpressed in NSCLC and is associated with the downregulation of MLKL, a regulator of necroptosis. Inhibition of Skp2 enhances the efficacy of cisplatin, a chemotherapy drug, in NSCLC and inhibits tumor growth. Mechanistically, Skp2 promotes the ubiquitination-mediated degradation of MLKL in cisplatin-resistant NSCLC cells.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mingjun Gao, Yang He, Xin Yin, Xiangbin Zhong, Bingxiao Yan, Yue Wu, Jin Chen, Xiaoyuan Li, Keran Zhai, Yifeng Huang, Xiangyu Gong, Huizhong Chang, Shenghan Xie, Jiyun Liu, Jiaxing Yue, Jianlong Xu, Guiquan Zhang, Yiwen Deng, Ertao Wang, Didier Tharreau, Guo-Liang Wang, Weibing Yang, Zuhua He
Summary: The discovery of a conserved immune suppression network in cereals centered on the Ca2+-sensor ROD1 is significant in understanding how plants fine-tune immune homeostasis. ROD1 promotes reactive oxygen species scavenging and its disruption confers resistance to multiple pathogens. The fungal effector AvrPiz-t structurally mimics ROD1 to suppress host immunity and promote virulence, revealing a molecular framework for breeding disease-resistant, high-yield crops.
Article
Medicine, Research & Experimental
Hao Yu, Xiao Yang, Jinyuan Tang, Shuhui Si, Zijian Zhou, Jiancheng Lu, Jie Han, Baorui Yuan, Qikai Wu, Qiang Lu, Haiwei Yang
Summary: In bladder cancer, downregulation of ALKBH5 is associated with worse prognosis, and knockdown of ALKBH5 promotes cell proliferation, migration, and invasion while decreasing sensitivity to cisplatin chemotherapy. ALKBH5 inhibits bladder cancer progression and sensitizes cells to cisplatin through regulation of the m6A-dependent casein kinase 2 (CK2)α-mediated glycolysis pathway.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Cell Biology
Guowei Wu, Dekang Li, Wei Liang, Weimin Sun, Xingxing Xie, Yilun Tong, Bing Shan, Mengmeng Zhang, Xiaojuan Lu, Junying Yuan, Ying Li
Summary: Activation of TNFR1 by TNF alpha leads to the formation of complex I, which plays a crucial role in determining cell fate. This study identifies PP6 as a component of complex I and shows that it regulates cell death through its phosphatase activity and regulatory subunits. Mechanistic studies reveal that PP6 modulates LUBAC-mediated ubiquitination to promote RIPK1 activation and c-FLIPL degradation. Loss of PP6 due to melanoma-related mutations confers resistance to cell death and promotes cancer progression.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Ameneh Cheshmehkani, Ilya S. Senatorov, Praveen Kandi, Monalisa Singh, April Britt, Renee Hayslett, Nader H. Moniri
INFLAMMATION RESEARCH
(2015)
Article
Pharmacology & Pharmacy
Nader H. Moniri
BIOCHEMICAL PHARMACOLOGY
(2016)
Article
Pharmacology & Pharmacy
Ilya S. Senatorov, Nader H. Moniri
BIOCHEMICAL PHARMACOLOGY
(2018)
Article
Pharmacology & Pharmacy
Gina J. Ryan, Nader H. Moniri, Dawn D. Smiley
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
(2013)
Article
Education, Scientific Disciplines
Brenda L. Gleason, Mark V. Siracuse, Nader H. Moniri, Christine R. Birnie, Curtis T. Okamoto, Michael A. Crouch
AMERICAN JOURNAL OF PHARMACEUTICAL EDUCATION
(2013)
Article
Pharmacology & Pharmacy
Rebecca N. Burns, Monalisa Singh, Ilya S. Senatorov, Nader H. Moniri
BIOCHEMICAL PHARMACOLOGY
(2014)
Article
Oncology
Prabir Kumar Chakraborty, Yushan Zhang, Alexandra S. Coomes, Wan-Ju Kim, Rachel Stupay, Lauren D. Lynch, Tamieka Atkinson, Jae I. Kim, Zhongzhen Nie, Yehia Daaka
Letter
Medicine, General & Internal
Nader H. Moniri, Kathryn M. Momary, Timothy McMahon, Ekta Nayee
MAYO CLINIC PROCEEDINGS
(2018)
Review
Pharmacology & Pharmacy
Kalyn M. Rambacher, Nader H. Moniri
BIOCHEMICAL PHARMACOLOGY
(2020)
Article
Neurosciences
Neha Milind Chitre, Bo Jarrett Wood, Azizi Ray, Nader H. Moniri, Kevin Sean Murnane
Review
Pharmacology & Pharmacy
Nader H. Moniri, Qadan Farah
Summary: The dietary intake of fat, carbohydrates, protein, fiber, and probiotics can influence gut microbiota and GI health, particularly in the colon where fat and fiber can regulate inflammation and carcinogenesis. Short-chained fatty acids (SCFA), such as acetate, propionate, and butyrate, synthesized from dietary fiber by microbiota, play important roles in colorectal health by decreasing inflammation and oxidative stress. The discovery of G protein-coupled free-fatty acid receptors in the early 2000s suggests that many effects of SCFA are cell-surface receptor mediated, with FFA2, FFA3, and GPR109A known to modulate various functions in the GI tract in response to luminal SCFA.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Infectious Diseases
Ashley R. Rizzo, Nader H. Moniri
Summary: This review provides a comprehensive assessment on the role of omadacycline for M.abscessus infections. Omadacycline, a novel antibacterial agent, has been demonstrated to have potent anti-NTM effects and clinical efficacy against M.abscessus. However, due to the low susceptibility of M.abscessus to commonly used antibacterial agents, alternative treatment options need to be explored.
BMC INFECTIOUS DISEASES
(2022)
Article
Pharmacology & Pharmacy
Priyanka F. Karmokar, Nader H. Moniri
Summary: Kidney cancer is a common and deadly cancer, with renal cell carcinoma (RCC) being the most common subtype and having the highest mortality rate. Papillary RCC (pRCC) is the second most frequent subtype and has distinct characteristics compared to other subtypes, including a high degree of metastasis and resistance to treatment. The study shows that the Free-Fatty Acid Receptor-4 (FFA4) is upregulated in pRCC and is associated with the pathological grading of pRCC. FFA4 agonism positively regulates pRCC cell migration and invasion, but reduces cell proliferation and tumor growth.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Kirti Singh, Ilya S. Senatorov, Ameneh Cheshmehkani, Priyanka F. Karmokar, Nader H. Moniri
Summary: Cyclobenzaprine, a muscle relaxant, may cause sedation through the noncompetitive antagonism of histamine H1 receptors. This effect contributes to its adverse reactions.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2022)
Article
Pharmacology & Pharmacy
Ameneh Cheshmehkani, Ilya S. Senatorov, Jyothi Dhuguru, Ola Ghoneim, Nader H. Moniri
BIOCHEMICAL PHARMACOLOGY
(2017)