Article
Multidisciplinary Sciences
Wiebke Winkler, Carlota Farre Diaz, Eric Blanc, Hanna Napieczynska, Patrick Langner, Marvin Werner, Barbara Walter, Brigitte Wollert-Wulf, Tomoharu Yasuda, Arnd Heuser, Dieter Beule, Stephan Mathas, Ioannis Anagnostopoulos, Andreas Rosenwald, Klaus Rajewsky, Martin Janz
Summary: By targeting the expression of genes involved in MM subgroup-specific chromosomal translocations into mouse GC B cells, we have generated distinct MM-like disease models that recapitulate key features of human tumors, which provides insights into the pathogenesis and therapeutic vulnerabilities of different MM subgroups.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Hematology
Manjun Li, Melissa K. Bennett, John Toubia, Victoria S. Pope, Melinda N. Tea, Sarah Tamang, Michael S. Samuel, Paul H. Anderson, Briony L. Gliddon, Jason A. Powell, Stuart M. Pitson
Summary: This article describes the development of a mouse model of bortezomib-resistant multiple myeloma for the evaluation of new therapeutic approaches.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mari I. Suominen, Jenni Maki-Jouppila, Anna Huhtinen, Birgitta Sjoholm, Jukka P. Rissanen, Anniina Luostarinen, Katja M. Fagerlund, Esa Alhoniemi, Gerhard Siemeister, Dominik Mumberg, Sanna-Maria Kakonen, Arne Scholz
Summary: The combination therapy of bortezomib and radium-223 shows synergistic effects in inhibiting MM cell proliferation and improving bone health, making it a potential novel therapy for multiple myeloma and myeloma bone disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Nor Hayati Ismail, Ali Mussa, Mutaz Jamal Al-Khreisat, Shafini Mohamed Yusoff, Azlan Husin, Muhammad Farid Johan
Summary: Multiple myeloma is an incurable hematologic malignancy characterized by abnormal proliferation of monoclonal plasma cells. It is often diagnosed at a late stage due to uncertain and nonspecific symptoms. The disease involves massive genomic alterations and complicated protein modifications, making the discovery of effective treatments challenging. Proteomics research using mass spectrometry and bioinformatics can provide valuable insights into protein changes and potential treatment targets.
Review
Biochemistry & Molecular Biology
Giuseppe Murdaca, Alessandro Allegra, Francesca Paladin, Fabrizio Calapai, Caterina Musolino, Sebastiano Gangemi
Summary: This study examines the role of molecules such as high-mobility group box-1, heat shock proteins, and S100 proteins in the induction of neoangiogenesis in multiple myeloma, highlighting their significance in disease progression. The modulation of the host immune system and inhibition of neoangiogenesis may serve as potential therapeutic targets for MM treatment, aiming to improve survival outcomes and reduce the risk of relapsed/refractory disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Nor Hayati Ismail, Ali Mussa, Nur Atikah Zakaria, Mutaz Jamal Al-Khreisat, Muhamad Aidil Zahidin, Noor Nabila Ramli, Siti Nur Nabeela A'ifah Mohammad, Rosline Hassan, Noor Haslina Mohd Noor, Salfarina Iberahim, Zefarina Zulkafli, Shafini Mohamed Yusoff, Azlan Husin, Muhammad Farid Johan
Summary: Multiple myeloma (MM) is a complex and heterogeneous disease caused by the abnormal proliferation of malignant monoclonal plasma cells in the bone marrow. Despite recent improvements in treatment outcomes, MM is still considered incurable and requires new medications or therapeutic strategies to overcome resistance. Genetic abnormalities and epigenetic changes play important roles in the pathogenesis and development of the disease, making epigenetic pathways potential targets for novel treatments.
Article
Biotechnology & Applied Microbiology
Yu Yang Ng, Zhicheng Du, Xi Zhang, Wee Joo Chng, Shu Wang
Summary: The study demonstrates that the co-expression of CXCR4 and anti-BCMA CAR on NK cells is an effective way to control MM progression by enhancing NK cell infiltration into the bone marrow and reducing tumor burden, leading to prolonged survival of patients.
CANCER GENE THERAPY
(2022)
Review
Oncology
Almudena Garcia-Ortiz, Yaiza Rodriguez-Garcia, Jessica Encinas, Elena Maroto-Martin, Eva Castellano, Joaquin Teixido, Joaquin Martinez-Lopez
Summary: Multiple myeloma is a hematologic cancer characterized by clonal proliferation of plasma cells in the bone marrow, with disease progression influenced by the tumor microenvironment created by various cells and soluble factors. Understanding the elements that control the microenvironment could lead to better-targeted therapies for this incurable disease.
Review
Immunology
Liuyun Zhang, Yunhui Xiang, Yanying Li, Juan Zhang
Summary: This review summarizes the impact of gut microbiota on the progression and treatment of multiple myeloma (MM), as well as the effects of alterations in gut microbiota on treatment response and complications in MM patients undergoing hematopoietic stem cell transplantation (HSCT). The study highlights the role of gut microbiota-immune system interactions in tumor immunotherapy, particularly in the context of tumor vaccine immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Syed Hassan Mehdi, Austin C. Gentry, Jue-Yeon Lee, Chong-Pyoung Chung, Donghoon Yoon
Summary: Multiple myeloma (MM) is a clonal B-cell disorder characterized by the proliferation of malignant plasma cells in the bone marrow, and interactions between MM cells and the bone microenvironment play a significant role. NIPEP-OSS, a peptide with targeted osteogenic activity, delays the progression of mouse myeloma through bone formation in animal models of MM bone disease. In both NSG and C57BL/KaLwRij models, the survival rates and median survival times were significantly different between the control and treated groups, indicating the potential anti-myeloma activity of NIPEP-OSS.
Article
Hematology
Connor M. D. Williams, Jacqueline E. Noll, Alanah L. Bradey, Jvaughn Duggan, Vicki J. Wilczek, Makutiro G. Masavuli, Branka Grubor-Bauk, Romana A. Panagopoulos, Duncan R. Hewett, Krzysztof M. Mrozik, Andrew C. W. Zannettino, Kate Vandyke, Vasilios Panagopoulos
Summary: Expression of myeloperoxidase (MPO), a key inflammatory enzyme, is negatively associated with solid tumor development. In a mouse model of myeloma, MPO was found to enhance tumor cell homing and promote tumor growth by inducing the expression of MM growth factors. By inhibiting MPO, researchers were able to significantly reduce overall tumor burden, suggesting that MPO-specific inhibitors may be an effective therapeutic strategy for limiting MM progression.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Xiangjun Shi, Yanzhe Wei, Xingchen Yao, Boran Du, Xiaoguang Wu, Xiangyu Kong, Xinru Du
Summary: Multiple myeloma is a tumor characterized by abnormal proliferation of plasma cells, causing severe bone diseases. Research has shown that drug-loaded PMMA bone cement can effectively inhibit tumor growth and dissemination, as well as promote apoptosis of tumor cells.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Oncology
Michael J. Vanwyngarden, Zachary J. Walker, Yang Su, Olivia Perez de Acha, Brett M. Stevens, Peter A. Forsberg, Tomer M. Mark, William Matsui, Bin Liu, Daniel W. Sherbenou
Summary: In this study, a novel antibody-drug conjugate (ADC) targeting cell surface complement inhibitor CD46 was developed. The curative potential of CD46-ADC was demonstrated by its ability to abrogate the engraftment of primary multiple myeloma (MM) cell xenografts.
Article
Medicine, General & Internal
Noa Gross Even-Zohar, Marjorie Pick, Liron Hofstetter, Adir Shaulov, Boaz Nachmias, Eyal Lebel, Moshe E. Gatt
Summary: Elevated CD24 expression is strongly correlated with survival in patients with multiple myeloma, and can be used as a prognostic factor for predicting clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Jin Wang, Yi Hu, Habib Hamidi, Cedric Dos Santos, Jingyu Zhang, Elizabeth Punnoose, Wenjin Li
Summary: Multiple myeloma (MM) is a disease characterized by clonal expansion of malignant plasma cells in the bone marrow. This study analyzed transcriptome data from MM patients and found that highly expressed cancer testis antigens and immune suppressive cell infiltration are associated with MM progression. The TGF-beta signature is also linked to worse outcomes in relapsed/refractory MM patients. Furthermore, patients with newly diagnosed MM can be classified into immune-low and immune-high phenotypes. The baseline tumor microenvironment status could potentially inform treatment choices for patients ineligible for stem cell transplantation and predict response to CAR-T therapy in relapsed/refractory MM patients.
FRONTIERS IN ONCOLOGY
(2022)
Meeting Abstract
Rheumatology
J. Ablin, I. Eshed, M. Berman, V. Aloush, I. Wigler, D. Caspi, M. Likhter, A. Sharabi, A. Rom-Broyde, S. Borok, D. Levartovsky, Y. Wolman, D. Paran, M. Anouk, O. Elkayam
ANNALS OF THE RHEUMATIC DISEASES
(2015)
Meeting Abstract
Rheumatology
G. Gibor, N. Ilan, S. Journo, A. Sharabi, O. Elkayam, I. Vlodavsky, U. Arad
ANNALS OF THE RHEUMATIC DISEASES
(2016)
Article
Rheumatology
Shay Brikman, Victoria Furer, Jonathan Wollman, Sara Borok, Hagit Matz, Arik Polachek, Ofir Elalouf, Amir Sharabi, Ilana Kaufman, Daphna Paran, Ori Elkayam
JOURNAL OF RHEUMATOLOGY
(2016)
Article
Critical Care Medicine
Irena Litinsky, Elizabeth Fireman, Daphna Paran, Ari Polachek, Adi Broide, Amir Sharabi, Marina Anouk, Ori Elkayam
Review
Biochemistry & Molecular Biology
Isaac R. Kasper, Sokratis A. Apostolidis, Amir Sharabi, George C. Tsokos
TRENDS IN MOLECULAR MEDICINE
(2016)
Editorial Material
Oncology
Amir Sharabi
FRONTIERS IN ONCOLOGY
(2016)
Article
Immunology
Amir Sharabi, Isaac R. Kasper, George C. Tsokos
CLINICAL IMMUNOLOGY
(2018)
Article
Immunology
Zev Sthoeger, Amir Sharabi, Ilan Asher, Heidy Zinger, Rafael Segal, Gene Shearer, Ori Elkayam, Edna Mozes
CLINICAL IMMUNOLOGY
(2018)
Article
Orthopedics
G. Gibor, N. Ilan, S. Journo, A. Sharabi, J. Dreyer, S. Gertel, P. Singh, A. Menachem, N. Snir, O. Elkayam, I. Vlodavsky, U. Arad
OSTEOARTHRITIS AND CARTILAGE
(2018)
Review
Biotechnology & Applied Microbiology
Amir Sharabi, Maria G. Tsokos, Ying Ding, Thomas R. Malek, David Klatzmann, George C. Tsokos
NATURE REVIEWS DRUG DISCOVERY
(2018)
Article
Medicine, Research & Experimental
Amir Sharabi, Hao Li, Isaac R. Kasper, Wenliang Pan, Esra Meidan, Maria G. Tsokos, Vaishali R. Moulton, George C. Tsokos
Article
Medicine, Research & Experimental
Hao Li, Maria G. Tsokos, Sean Bickerton, Amir Sharabi, Yi Li, Vaishali R. Moulton, Philip Kong, Tarek M. Fahmy, George C. Tsokos
Article
Medicine, General & Internal
Saar Anis, Amir Sharabi, Yair Mina, Ainat Klein, Emanuela Cagnano, Ori Elkayam, Tanya Gurevich
ISRAEL MEDICAL ASSOCIATION JOURNAL
(2016)
Meeting Abstract
Rheumatology
Irena Litinsky, Elizabeth Fireman, Ari Polachek, Adi Broyde, Amir Sharabi, Marina Anouk, Daphna Paran, Ori Elkayam
ARTHRITIS & RHEUMATOLOGY
(2015)
Meeting Abstract
Rheumatology
G. Gibor, U. Arad, J. Wallman, J. Ablin, V. Aloush, I. Kaufman, S. Jacky, D. Caspi, O. Elkayam, D. Paran, A. Sharabi
ANNALS OF THE RHEUMATIC DISEASES
(2017)