期刊
TRENDS IN MOLECULAR MEDICINE
卷 22, 期 9, 页码 784-797出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2016.07.003
关键词
-
资金
- NIH [RO1 A1068787, T32AI074549]
Regulatory T cells (Tregs) are capable of dampening immune-mediated inflammation and avert the destructive effects of uncontrolled inflammation. Distinct molecules and pathways, including various transcription factors, phosphatases, and kinases, impact the ability of Tregs to function as negative regulators of the immune response, and are presumably amenable to therapeutic manipulation. Here, we discuss recently identified molecular networks and the therapeutic potential for treating autoimmune diseases.
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