Review
Chemistry, Multidisciplinary
Caiyan Zhao, Xiaoyu Pang, Zuo Yang, Sheng Wang, Hongzhang Deng, Xiaoyuan Chen
Summary: TAMs are key players in tumor progression and can be modulated using nanotechnology-based strategies, such as inhibiting their recruitment, depleting M2-polarized macrophages, and reprogramming them into M1-polarized macrophages. Nanoparticles can also be used to image TAMs for novel treatment options and therapy monitoring.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Oncology
Xiaobo Li, Minfeng Chen, Weijin Lu, Jun Tang, Lijuan Deng, Qing Wen, Maohua Huang, Rong Deng, Geni Ye, Wencai Ye, Dongmei Zhang
Summary: This study reveals that FAP alpha is overexpressed in TA-MSCs, leading to secretion of multiple C-C motif chemokine ligands, which promote recruitment of CCR2(+) TAMs and polarization of TAMs into the M2 phenotype, thus facilitating TNBC pulmonary metastasis. The FAP alpha-activated prodrug induces apoptosis in FAP alpha(+) TA-MSCs, suppressing TAM recruitment and polarization, ultimately inhibiting TNBC metastasis. Targeting TA-MSCs with an FAP alpha-activated prodrug emerges as a promising strategy for inhibiting TNBC metastasis.
Review
Oncology
Shunyao Zhu, Ziyi Luo, Xixi Li, Xi Han, Senlin Shi, Ting Zhang
Summary: Tumor-associated macrophages (TAMs) play a crucial role in the tumor microenvironment by secreting various factors that influence tumor growth and development. Different phenotypes of TAMs have distinct effects on tumors, making them an important target in tumor immunotherapy.
Review
Immunology
Guoqing Wang, Kunhong Zhong, Zeng Wang, Zongliang Zhang, Xin Tang, Aiping Tong, Liangxue Zhou
Summary: This review discusses the characteristics and functions of TAMs in GBM, and evaluates the current state of TAMs-targeting strategies. TAMs are logical therapeutic targets for GBM, and understanding how TAMs promote GBM progression is of great significance for new immune therapeutic approaches for GBM patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Xinqun Huang, Jingsong Cao, Xuyu Zu
Summary: In breast cancer, tumor-associated macrophages (TAMs) play a crucial role in promoting tumor growth through various mechanisms, but can promote tumor regression by repolarizing into M1 macrophages. TAMs are established as effective targets for breast cancer treatment.
Article
Cell Biology
Xiangzhou Chen, Mingqiang Yang, Jiang Yin, Pan Li, Shanshan Zeng, Guopei Zheng, Zhimin He, Hao Liu, Qian Wang, Fan Zhang, Danyang Chen
Summary: This study reveals a novel mechanism by which TAMs promote EMT and enhance CSC properties in TNBC via activation of CCL2/AKT/beta-catenin signaling, providing new strategies for the diagnosis and treatment of TNBC.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Oncology
Shuo Wang, Haiyang Jiang, Caiwei Zheng, Ming Gu, Xinyu Zheng
Summary: In this study, the role of tumor-associated macrophages (TAMs) in promoting breast cancer microcalcifications by secreting bone morphogenetic protein 2 (BMP-2) was elucidated. It was found that the presence of microcalcifications was significantly associated with the increased expression of CD168 and BMP-2, as well as poor prognosis. These findings suggest that TAMs contribute to the formation of microcalcifications in breast cancer cells through multiple pathways involving BMP-2 and its downstream factors.
Article
Medicine, Research & Experimental
Ruoyu Mu, Zhe Zhang, Congwei Han, Yiming Niu, Zhen Xing, Zhencheng Liao, Jinzhi Xu, Ningyi Shao, Guokai Chen, Junfeng Zhang, Lei Dong, Chunming Wang
Summary: Nonhealing diabetic wounds can be effectively healed by training macrophages to mimic the reparative functions of tumor-associated macrophages (TAMs), which produce immunosuppressive and proliferative factors. These TAM-educated macrophages (TAMEMs) outperform other macrophage phenotypes in reducing inflammation, promoting angiogenesis, and activating fibroblasts. A nine-factor cocktail has also been developed to train human primary monocytes into TAMEMs, enabling the preparation of safer and autologous cells. This study demonstrates the potential of recapitulating TAMs' reparative activities in non-tumor cells for regenerative medicine.
EMBO MOLECULAR MEDICINE
(2023)
Review
Immunology
Zhen Li, Qijun Yu, Qingyuan Zhu, Xiaojing Yang, Zhaobin Li, Jie Fu
Summary: The evaluation of tumor-host interaction and intratumoral heterogeneity in the tumor microenvironment (TME) is gaining attention in cancer therapies. Machine learning algorithms are increasingly being used to analyze TAMs, leading to a better understanding of their role in tumor biology and potential applications in tumor diagnosis, treatment stratification, and survival predictions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fan Zhang, Pan Li, Shuang Liu, Mingqiang Yang, Shanshan Zeng, Junjian Deng, Danyang Chen, Yanmei Yi, Hao Liu
Summary: Breast cancer is the most common cancer among women worldwide, and while advancements have improved survival rates, metastasis remains a major obstacle. Breast cancer stem cells play a key role in metastasis and recurrence. Targeting the beta-Catenin/CCL2 signaling pathway may be an effective strategy for breast cancer therapy, as shown in this study's findings.
Review
Biochemistry & Molecular Biology
Sarah E. Blitz, Ari D. Kappel, Florian A. Gessler, Neil V. Klinger, Omar Arnaout, Yi Lu, Pier Paolo Peruzzi, Timothy R. Smith, Ennio A. Chiocca, Gregory K. Friedman, Joshua D. Bernstock
Summary: Oncolytic virotherapy uses viruses to selectively infect malignant cells and stimulate antitumor response. The involvement of tumor-associated macrophage/microglia appears to play a crucial role in the failure of oncolytic virotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Veterinary Sciences
Ilaria Porcellato, Monica Sforna, Adriana Lo Giudice, Ilaria Bossi, Alice Musi, Alessia Tognoloni, Elisabetta Chiaradia, Luca Mechelli, Chiara Brachelente
Summary: The tumor microenvironment is a complex system where neoplastic cells interact with immune and stromal cells. Tumor-associated macrophages (TAMs) are considered to be one of the most important cellular components in tumors, and their characterization and association with tumor features were studied in this research.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Oncology
Tetiana Hourani, James A. Holden, Wenyi Li, Jason C. Lenzo, Sara Hadjigol, Neil M. O'Brien-Simpson
Summary: The tumor microenvironment plays a crucial role in tumorigenesis, with TAMs being closely associated with tumor progression, therapy resistance, and poor survival rates. Targeting TAMs has become an increasingly explored strategy in cancer treatment, with efforts focused on methods like blocking recruitment, stimulating repolarization, and depletion. Additionally, nanomaterials are being investigated for their potential in precise delivery of chemotherapeutic cargo to TAMs.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Elham Sajjadi, Gabriella Gaudioso, Andrea Terrasi, Francesca Boggio, Konstantinos Venetis, Mariia Ivanova, Letizia Bertolasi, Gianluca Lopez, Letterio Runza, Alice Premoli, Daniele Lorenzini, Elena Guerini-Rocco, Stefano Ferrero, Valentina Vaira, Nicola Fusco
Summary: Breast cancers with osteoclast-like stromal giant cells (OSGC) have an activated tumor immune microenvironment (TIME). Shared epigenetic events occur between breast cancer cells and OSGC, but the immunophenotype and miRNA profiles of different cellular compartments suggest that OSGC likely belong to the spectrum of M2 tumor-associated macrophages (TAMs).
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hoda T. Amer, Reda A. Eissa, Hend M. El Tayebi
Summary: This study investigates the epigenetic regulation of CD80 and mesothelin (MSLN) in tumor-associated macrophages (TAMs) of triple-negative breast cancer (TNBC) and HER2-positive breast cancer. The results show that the manipulation of MALAT1 and HOTAIR expression can influence the expression of CD80 and MSLN in TAMs. Additionally, HOTAIR has an upstream regulatory effect on MALAT1.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Medical Laboratory Technology
Chih-Yi Liu, Andrey Bychkov, Shipra Agarwal, Yun Zhu, Jen-Fan Hang, Chiung-Ru Lai, Hee Young Na, Weiwei Li, Zhiyan Liu, Deepali Jain, Ayana Suzuki, Mitsuyoshi Hirokawa, Noel Chia, Min En Nga, Tikamporn Jitpasutham, Somboon Keelawat, So Yeon Park, Shinya Satoh, Chien-Chin Chen, Dilini Gunawardena, Priyanthi Kumarasinghe, Chan Kwon Jung, Kennichi Kakudo
Summary: This study summarizes the handling of MTC in contemporary Asian thyroid FNA practice. Although the detection rate of MTC by cytology alone is less satisfactory, integration with ancillary tests could achieve an excellent performance. Recognition of constitutive cytomorphologic features is necessary for each cytopreparatory method, which may lead to a lower threshold for further MTC workup.
DIAGNOSTIC CYTOPATHOLOGY
(2021)
Article
Pathology
Huy Gia Vuong, Ayana Suzuki, Hee Young Na, Pham Van Tuyen, Doan Minh Khuy, Hiep Canh Nguyen, Tikamporn Jitpasutham, Agustina Abelardo, Takashi Amano, So Yeon Park, Chan Kwon Jung, Mitsuyoshi Hirokawa, Ryohei Katoh, Kennichi Kakudo, Andrey Bychkov
Summary: In this study, the Asian pediatric thyroid nodules had a higher resection rate and risk of malignancy compared to adults, suggesting the need for adjustments to TBSRTC in the pediatric population.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2021)
Article
Oncology
Anne Trinh, Carlos R. Gil Del Alcazar, Sachet A. Shukla, Koei Chin, Young Hwan Chang, Guillaume Thibault, Jennifer Eng, Bojana Jovanovic, C. Marcelo Aldaz, So Yeon Park, Joon Jeong, Catherine Wu, Joe Gray, Kornelia Polyak
Summary: The transition from DCIS to IDC involves genetic correlations despite long latency periods and therapeutic interventions. Immune hot and cold tumors can arise early in DCIS, with different degrees of immune cell mixing between DCIS and IDC. Tumor-specific copy-number aberrations and mutations are associated with differences in immune signaling in IDC, potentially modulating immune function and driving the transition to IDC.
MOLECULAR CANCER RESEARCH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Youngjune Kim, Jiwon Rim, Sun Mi Kim, Bo La Yun, So Yeon Park, Hye Shin Ahn, Bohyoung Kim, Mijung Jang
Summary: The study found that CAD software has a high detection rate for breast cancer, but it has a low positive predictive value and a high false positive rate. False-negative results are common in asymptomatic patients and are associated with specific ultrasound findings.
Article
Oncology
Jung Sun Kim, Koung Jin Suh, Dae-Won Lee, Go-Un Woo, Miso Kim, Se Hyun Kim, Han Suk Ryu, Kyung-Hun Lee, Tae-Yong Kim, Sae-Won Han, So Yeon Park, In Ae Park, Jee Hyun Kim, Seock-Ah Im
Summary: This study aimed to assess the real-world efficacy of nab-paclitaxel in metastatic breast cancer patients. The results showed that nab-paclitaxel is a reasonable treatment option for heavily pre-treated and/or taxane-exposed patients with metastatic breast cancer.
CANCER RESEARCH AND TREATMENT
(2022)
Article
Endocrinology & Metabolism
Chang Ho Ahn, Hee Young Na, So Yeon Park, Hyeong Won Yu, Su-Jin Kim, June Young Choi, Kyu Eun Lee, Sang Wan Kim, Kyeong Cheon Jung, Jung Hee Kim
Summary: Variable expression of steroidogenic enzymes in adrenal adenoma underlies the clinical heterogeneity of PA and is associated with treatment outcomes. CYP11B1 expression was positively correlated with the severity of hypercortisolemia, and CYP11B2 was positively correlated with that of hyperaldosteronism. Patients with absent clinical improvement after adrenalectomy had lower CYP11B2 expression than those with complete success.
CLINICAL ENDOCRINOLOGY
(2022)
Article
Pathology
Hye Ju Kang, Sun Young Kwon, Ahrong Kim, Woo Gyeong Kim, Eun Kyung Kim, Ae Ree Kim, Chungyeul Kim, Soo Kee Min, So Young Park, Sun Hee Sung, Hye Kyoung Yoon, Ahwon Lee, Ji Shin Lee, Hyang Im Lee, Ho Chang Lee, Sung Chul Lim, Sun Young Jun, Min Jung Jung, Chang Won Jung, Soo Youn Cho, Eun Yoon Cho, Hye Jeong Choi, So Yeon Park, Jee Yeon Kim, In Ae Park, Youngmee Kwon
Summary: The study investigated diagnostic reproducibility of papillary breast lesions (PBLs) in core needle biopsy (CNB) specimens using World Health Organization (WHO) classification. Results showed discrepancies in diagnostic agreement with WHO classification, despite improvements with simplifying classifications and immunohistochemical staining for CK5 and p63. Further intensive consensus studies are needed to enhance the diagnostic reproducibility of PBLs with WHO classification.
JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Hee Young Na, Hyeong Won Yu, Woochul Kim, Jae Hoon Moon, Chang Ho Ahn, Sang Il Choi, Yeo Koon Kim, June Young Choi, So Yeon Park
Summary: This study reveals a relatively low frequency of TERT promoter mutations in Korean patients with PTC. Certain clinicopathological features including old age, tall cell variant, increased mitoses, tumour necrosis, and gross extrathyroidal extension were found to be indicative of TERT promoter mutations in PTCs.
CLINICAL ENDOCRINOLOGY
(2022)
Article
Oncology
Ji Won Woo, Hye Yeon Choi, Milim Kim, Yul Ri Chung, So Yeon Park
Summary: This study identified miR-145, miR-205, and miR-451 as down-regulated miRNAs in invasive breast cancer (IBC) compared to ductal carcinoma in situ (DCIS). Furthermore, their expression levels were lower in high-risk DCIS cases and correlated with various clinicopathological features. These miRNAs may play a role as tumor suppressors in the progression of DCIS to invasive carcinoma.
Correction
Oncology
Ji Won Woo, Hye Yeon Choi, Milim Kim, Yul Ri Chung, So Yeon Park
Review
Pathology
Hee Young Na, So Yeon Park
Summary: NIFTP, reclassified as a non-cancerous thyroid neoplasm, has impacted the evaluation of malignancy risk in thyroid diseases through changes in diagnostic criteria, incidence, and preoperative cytologic diagnoses.
JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Ji-Jung Jung, Eun-Kyu Kim, Eunyoung Kang, Jee Hyun Kim, Se Hyun Kim, Koung Jin Suh, Sun Mi Kim, Mijung Jang, Bo La Yun, So Yeon Park, Changjin Lim, Wonshik Han, Hee-Chul Shin
Summary: A machine learning model was developed and externally validated to predict pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) in breast cancer patients using routinely collected clinical and demographic variables. The model was trained and internally validated using patient data from Seoul National University Bundang Hospital, and five machine learning techniques were used to compare the predictive performance. The model was then externally validated using an independent cohort from Seoul National University Hospital.
JOURNAL OF BREAST CANCER
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Younjung Choi, Sun Mi Kim, Mijung Jang, Bo La Yun, Eunyoung Kang, Eun-Kyu Kim, So Yeon Park, Bohyoung Kim, Nariya Cho, Woo Kyung Moon
Summary: Combining ductography and ultrasound (US) has a high sensitivity for detecting malignancy in patients with pathological nipple discharge and negative mammography, and it enables lesion localization for optimal treatment plans.
KOREAN JOURNAL OF RADIOLOGY
(2022)
Article
Oncology
Ji Won Woo, Yul Ri Chung, Milim Kim, Hye Yeon Choi, Soomin Ahn, So Yeon Park
Summary: MDSCs play a crucial role in tumor progression through immunologic and non-immunologic mechanisms, with the marker S100A8 showing significant expression in pre-invasive and invasive breast cancers. The infiltration of S100A8+ immune cells was associated with a poorer prognosis in both early and invasive carcinomas, especially in hormone receptor-positive subgroups. Additionally, the infiltration of other immune cell subsets was higher in S100A8+ immune cell (+) group, indicating a complex interaction between different immune cell populations in breast cancer progression.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Review
Oncology
Soo Youn Cho, So Yeon Park, Young Kyung Bae, Jee Yeon Kim, Eun Kyung Kim, Woo Gyeong Kim, Youngmee Kwon, Ahwon Lee, Hee Jin Lee, Ji Shin Lee, Jee Young Park, Gyungyub Gong, Hye Kyoung Yoon
Summary: The Breast Pathology Study Group of the Korean Society of Pathologists has developed a standardized pathology reporting format for breast cancer, comprising 'standard data elements,' 'conditional data elements,' and a biomarker report form. It is expected that this standardized pathology report will improve diagnostic concordance and communication between pathologists and clinicians, as well as between pathologists inter-institutionally.
JOURNAL OF BREAST CANCER
(2021)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.