Article
Biochemistry & Molecular Biology
Indrajeet Ghodke, Michaela Remisova, Audrey Furst, Sinan Kilic, Bernardo Reina-San-Martin, Anna R. Poetsch, Matthias Altmeyer, Evi Soutoglou
Summary: AHNAK functions as a modulator of 53BP1 by controlling its multimerization potential, thereby affecting the activity of the p53 signaling pathway, resulting in different cell responses in cancer cells and non-transformed cells. Loss of AHNAK sensitizes cells to combinatorial cancer treatments by suppressing p53 target gene networks in tumors.
Article
Biology
Marion Rosello, Juliette Vougny, Francois Czarny, Marina C. Mione, Jean-Paul Concordet, Shahad Albadri, Filippo Del Bene
Summary: Researchers have successfully generated precise point mutations in zebrafish models using gene editing technology, mimicking oncogenic mutations in human genes and creating new disease models.
Article
Chemistry, Analytical
Hao-Xiang Liao, Kazuki Bando, Menglu Li, Katsumasa Fujita
Summary: Cell spheroids provide a complex in vitro cell model similar to in vivo tissues. A multifocal Raman spectrophotometer was developed to enable simultaneous analysis of multiple spheroids, allowing for rapid observation of chemical changes in the spheroids.
ANALYTICAL CHEMISTRY
(2023)
Article
Cell Biology
Ziqian Yan, Zhimei Sheng, Yuanhang Zheng, Ruijun Feng, Qinpei Xiao, Lihong Shi, Hongli Li, Chonggao Yin, Hao Luo, Chong Hao, Wenhao Wang, Baogang Zhang
Summary: Studies compared the effects of CAFs-derived exosomes and NFs-derived exosomes on breast cancer cells, finding that CAFs-derived exosomes had a stronger enhancing effect on migration and invasion.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Jiajia Zhang, Zhenzhen Yan, Yukun Wang, Yaguang Wang, Xin Guo, Ju Jing, Xiangnan Dong, Shasha Dong, Xiuhua Liu, Xiaochun Yu, Chen Wu
Summary: The study examined mutations in the TP53 binding protein 1 (53BP1) gene in various human cancers, revealing that these mutations may disrupt the DNA damage repair function of 53BP1 and impact genomic stability.
Article
Cell Biology
Kailing Zhou, Yu Sun, Dan Dong, Chenghai Zhao, Wei Wang
Summary: EMP3 acts as a potential tumor suppressor in breast cancer by inhibiting cell cycle progression, DNA repair, and stem-like properties, leading to enhanced sensitivity of breast cancer cells to DNA-damaging agents.
CELL DEATH & DISEASE
(2021)
Article
Microbiology
Carmen Aurelia Mogoanta, Mircea Sorin Ciolofan, Anca-Maria Istrate-Ofiteru, Stelian-Stefanita Mogoanta, Gabriela-Camelia Rosu, Florin Anghelina, Alina-Nicoleta Capitanescu, Ioana Cristina Opriscan, Nina Ionovici, Mihaela Roxana Mitroi, Oana Badea, Gheorghe Iovanescu
Summary: The development of oropharyngeal squamous cell carcinoma (OPSCC) is strongly associated with risk factors such as smoking, chronic alcohol consumption, and HPV infection. A retrospective study on 406 OPSCC patients revealed that most patients were urban male smokers, while the majority of women in the study were diagnosed with tonsillar OPSCC and had a history of chronic alcoholism. Immunohistochemical analysis showed that the percentage of Ki67-positive nuclei increased with the presence of intratumoral HPV, indicating that active HPV infection leads to an increase in tumor progression rate.
Review
Oncology
Ignacio Campillo-Marcos, Raul Garcia-Gonzalez, Elena Navarro-Carrasco, Pedro A. Lazo
Summary: VRK1 is a nuclear Ser-Thr chromatin kinase that is not mutated in cancer, but is overexpressed in many types of tumors and linked to poor prognosis. It plays crucial roles in regulating cell proliferation and DNA damage response pathways, having both pro-tumorigenic effects and protective anti-tumor roles depending on the cellular context.
Article
Plant Sciences
Kay Zin Kyaw, Woong Sub Byun, Yern-Hyerk Shin, Thanh-Hau Huynh, Ji Yun Lee, Eun Seo Bae, Hyen Joo Park, Dong-Chan Oh, Sang Kook Lee
Summary: Piceamycin (1), a macrocyclic lactam isolated from the silkworm's gut, has been found to possess antibacterial activity. This study investigates the potential anticancer activity of 1 and its underlying mechanisms in colorectal cancer (CRC) cells. The results show that 1 inhibits CRC cell growth by upregulating NDRG1, inducing cell cycle arrest and apoptosis, and inhibiting cell migration. The disruption of the interaction between NDRG1 and c-Myc is also observed. This suggests that 1 may serve as a potential candidate for CRC treatment by regulating NDRG1-mediated functionality.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Environmental Sciences
Xingjie Zhang, Lin Ma, Yue Tang, Jiangyuan Han, Yongmei Qi, Dejun Huang
Summary: The study revealed that Cd-induced promoter hypermethylation of RASSF1A and DAPK1, decreasing their expression and leading to higher level of cell proliferation. Furthermore, Cd at low concentrations could influence DNA methylation, which may serve as the proliferative mechanism of Cd.
ENVIRONMENTAL TOXICOLOGY
(2021)
Editorial Material
Hematology
Ian J. Majewski
Summary: The study investigates how loss of the tumor suppressor gene Cux1 modulates DNA repair activity in the hematopoietic compartment and contributes to the pathogenesis of therapy-related myeloid neoplasms.
Article
Biotechnology & Applied Microbiology
Karim Taouis, Sophie Vacher, Josee Guirouilh-Barbat, Jacques Camonis, Etienne Formstecher, Tatiana Popova, Anne-Sophie Hamy, Ambre Petitalot, Rosette Lidereau, Sandrine M. Caputo, Sophie Zinn-Justin, Ivan Bieche, Keltouma Driouch, Francois Lallemand
Summary: The WWOX tumor suppressor gene is located in an unstable chromosomal region and its expression is decreased or absent in various types of cancer, including breast cancer. Recent studies have shown that WWOX plays a role in maintaining genome stability through its involvement in the DNA damage response. It inhibits homologous recombination in breast cancer cells and promotes DNA repair through non-homologous end joining. Additionally, WWOX has been found to interact with MERIT40, preventing excessive homologous recombination activity and its associated deleterious impact on breast cancer development.
CANCER GENE THERAPY
(2023)
Article
Biology
Madeleine Hart, Sophie D. Adams, Viji M. Draviam
Summary: Nuclear atypia is a hallmark of cancer, and its immediate and long-term impact on cells can be determined through single-cell tracking studies. Multinucleation, a form of nuclear atypia, blocks cell proliferation in p53-compromised cells by increasing DNA damage and causing replication stress, suggesting potential therapeutic approaches for limiting tumor heterogeneity.
COMMUNICATIONS BIOLOGY
(2021)
Article
Neurosciences
Feifei Luo, Yifu Liao, Endong Cao, Yong Yang, Kai Tang, Dexiang Zhou, Dong Zhou, Haiping Cai
Summary: This study found that HIC2 gene is hypermethylated and expressed at low levels in glioma. Hypermethylation and low expression of HIC2 predict poor prognosis. Further experiments showed that HIC2 inhibits glioma proliferation in vitro and in vivo by interacting with RNF44 and PTPRN2.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Cell Biology
Samantha L. Schuster, Sonali Arora, Cynthia L. Wladyka, Pushpa Itagi, Lukas Corey, Dave Young, Bethany L. Stackhouse, Lori Kollath, Qian V. Wu, Eva Corey, Lawrence D. True, Gavin Ha, Patrick J. Paddison, Andrew C. Hsieh
Summary: The study focuses on the significance of 3' untranslated region (3' UTR) somatic mutations in disease, particularly in advanced prostate tumors. The researchers identified thousands of mutations in 3' UTR that are enriched in oncogenic pathways and regulatory elements. They developed two complementary assays to determine the impact of these mutations on mRNA translation and stability and identified functional variants linked to poor prognosis. This work highlights the importance of understanding the role of 3' UTR mutations in cancer progression and suggests potential therapeutic targets.
Article
Multidisciplinary Sciences
Deepika Kandilya, Sukanya Shyamasundar, Dhiraj Kumar Singh, Avijit Banik, Manoor Prakash Hande, Walter Stunkel, Yap Seng Chong, S. Thameem Dheen
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Yongqiang Luo, Ramya Viswanathan, Manoor Prakash Hande, Amos Hong Pheng Loh, Lih Feng Cheow
Article
Biotechnology & Applied Microbiology
Varsha Hande, Keith Teo, Prarthana Srikanth, Jane See Mei Wong, Swaminathan Sethu, Wilner Martinez-Lopez, Manoor Prakash Hande
Summary: Acetaldehyde (AA) has been classified as a probable human carcinogen due to its ability to cause tumors following inhalation or alcohol consumption. Individuals with deficiencies in the enzymes that are involved in the metabolism of AA are more susceptible to its toxicity. Studies have shown that AA induces DNA damage and cytogenetic abnormalities.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2021)
Article
Biology
Eric Gregoire, Joan Francesc Barquinero, Gaetan Gruel, Mohamedamine Benadjaoud, Juan S. Martinez, Christina Beinke, Adayabalam Balajee, Philip Beukes, William F. Blakely, Inmaculada Dominguez, Pham Ngoc Duy, Octavia Monteiro Gil, Inci Guclu, Kamile Guogyte, Savina Petrova Hadjidekova, Valeria Hadjidekova, Prakash Hande, Seongjae Jang, Katalin Lumniczky, Roberta Meschini, Mirta Milic, Alegria Montoro, Jayne Moquet, Mercedes Moreno, Farrah N. Norton, Ursula Oestreicher, Jelena Pajic, Laure Sabatier, Sylwester Sommer, Antonella Testa, Georgia Terzoudi, Marco Valente, Perumal Venkatachalam, Anne Vral, Ruth C. Wilkins, Andrzej Wojcik, Demetre Zafiropoulos, Ulrike Kulka
Summary: In the event of a mass-casualty radiological incident, networking and inter-laboratory comparisons are crucial for ensuring consistent results in biological dosimetry laboratories. While significant harmonization efforts have been made at the European level, challenges remain with the statistical tools and diversity in dose-effect curves highlighted by this study.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Article
Biology
Varsha Hande, Karthik Prathaban, M. Prakash Hande
Summary: The seminar-style educational module on Radiation and Society at Tembusu College, NUS aimed to equip students with analytical tools to assess evidence on nuclear energy and societal perceptions of radiation, with interactive sessions covering topics like historical dimensions, radiation science, and societal impacts. The post-course survey revealed students perceived nuclear energy as safe and reliable but preferred renewable energy, indicating the effectiveness of the sessions in raising awareness.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2022)
Editorial Material
Biology
Veena Kumari Hande, Manoor Prakash Hande
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Shivam Rai, A. R. S. Badarinath, Alex George, Sneha Sitaraman, Sudha Anandt, Anand Moses, Radha Saraswathy, Stephen Charles Bronson, K. Thirumal Babu, M. Prakash Hande
Summary: This study aimed to investigate the relationship between telomere shortening and age-related diseases (such as type 2 diabetes and idiopathic dilated cardiomyopathy) in a south Indian population. The results showed a negative correlation between telomere length and age, diabetes, and idiopathic dilated cardiomyopathy. The study supports the usefulness of telomere length measurements as a marker for age-related diseases.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2022)
Article
Biotechnology & Applied Microbiology
Grace Kah Mun Low, Aloysius Poh Leong Ting, Edwin Dan Zhihao Fok, Kalpana Gopalakrishnan, Dimphy Zeegers, Aik Kia Khaw, Manikandan Jayapal, Wilner Martinez-Lopez, M. Prakash Hande
Summary: The Xeroderma Pigmentosum D (XPD) protein plays a crucial role in the repair of oxidative DNA damage and telomere maintenance. Primary fibroblasts derived from patients with Xeroderma Pigmentosum D showed increased susceptibility, reduced repair capacity, and telomeric loss when exposed to oxidative stress. Gene expression profiling revealed alterations in genes involved in transcription, nucleotide metabolism, and cellular processes.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2022)
Article
Biotechnology & Applied Microbiology
Gavin Yong-Quan Ng, Varsha Hande, Min Hui Ong, Beverly Wen-Xin Wong, Zachary Wai-Loon Loh, Wei D. Ho, Lionel B. Handison, Ian Ming-Sheng P. Tan, David Y. Fann, Thiruma Arumugam, M. Prakash Hande
Summary: Telomeres play a critical role in maintaining cellular fate and are closely related to ageing and age-associated diseases. Dietary habits and interventions may promote healthy ageing, but further research is needed to establish the link between dietary intervention and telomere maintenance.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2022)
Article
Geriatrics & Gerontology
Gavin Yong-Quan Ng, Dominic Paul Lee Kok Sheng, Han-Gyu Bae, Sung Wook Kang, David Yang-Wei Fann, Jinsu Park, Joonki Kim, Asfa Alli-Shaik, Jeongmi Lee, Eunae Kim, Sunyoung Park, Jeung-Whan Han, Vardan Karamyan, Eitan Okun, Thameem Dheen, Manoor Prakash Hande, Raghu Vemuganti, Karthik Mallilankaraman, Lina H. K. Lim, Brian K. Kennedy, Grant R. Drummond, Christopher G. Sobey, Jayantha Gunaratne, Mark P. Mattson, Roger Sik-Yin Foo, Dong-Gyu Jo, Thiruma V. Arumugam
Summary: Intermittent fasting can modulate H3K9 trimethylation in the cerebellum and trigger transcriptomic changes associated with metabolic processes. Part of the epigenomic and transcriptomic modulations induced by IF can be preserved for at least 3 months post-IF, but termination of IF results in a loss of H3K9 trimethylation regulation of the transcriptome.
Biographical-Item
Biotechnology & Applied Microbiology
Manoor Prakash Hande
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2022)
Article
Biotechnology & Applied Microbiology
Abhik Chakraborty, Souvick Roy, Manoor Prakash Hande, Birendranath Banerjee
Summary: The study aimed to elucidate the genomic instability among couples experiencing unexplained recurrent pregnancy loss. It was found that individuals with unexplained recurrent pregnancy loss exhibited higher levels of intracellular oxidative stress and basal genomic instability compared to fertile controls. This study highlights the role of genomic instability in cases of unexplained recurrent pregnancy loss.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2023)
Biographical-Item
Biology
M. Prakash Hande, Hiroo Nakajima
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)
Meeting Abstract
Environmental Sciences
N. G. Gavin, Thiruma Arumugam, Prakash Hande
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2022)
Article
Oncology
Sok Lin Foo, Karishma Sachaphibulkij, Corinne L. Y. Lee, Gracemary L. R. Yap, Jianzhou Cui, Thiruma Arumugam, Lina H. K. Lim
Summary: This study reveals a signaling network involving ANXA1 between metastatic breast cancer cells and microglia, which promotes the recruitment and activation of microglia. Inhibition of ANXA1 and its receptor may be therapeutically beneficial in the treatment of breast cancer and secondary metastasis to the brain.
BREAST CANCER RESEARCH
(2022)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
