Evaluation of the effect of food and ketoconazole on the pharmacokinetics of the smoothened inhibitor PF-04449913 in healthy volunteers

Abstract 4504: PF-04449913, a small molecule inhibitor of Hedgehog signaling, is effective in inhibiting tumor growth in preclinical models

(2012) Amy J. Jackson-Fisher et al.   CANCER RESEARCH

Determining the Time Course of CYP3A Inhibition by Potent Reversible and Irreversible CYP3A Inhibitors Using A Limited Sampling Strategy

(2011) S Katzenmaier et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Triazole antifungal agents drug–drug interactions involving hepatic cytochrome P450

(2011) Paul O Gubbins   Expert Opinion on Drug Metabolism & Toxicology

Comparative clinical effectiveness of prophylactic voriconazole/posaconazole to fluconazole/itraconazole in patients with acute myeloid leukemia/myelodysplastic syndrome undergoing cytotoxic chemotherapy over a 12-year period

(2011) M. R. Ananda-Rajah et al.   HAEMATOLOGICA

Clinical effectiveness of posaconazole prophylaxis in patients with acute myelogenous leukaemia (AML): a 6 year experience of the Cologne AML cohort

(2010) J. J. Vehreschild et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Primary antifungal prophylaxis in acute myeloblastic leukemia and myelodysplastic syndrome – still an open question?

(2010) Maria J. G. T. Rüping et al.   LEUKEMIA & LYMPHOMA

Clinical Relevance of the Pharmacokinetic Interactions of Azole Antifungal Drugs with Other Coadministered Agents

(2009) Roger J. M. Brüggemann et al.   CLINICAL INFECTIOUS DISEASES

Effects of oral posaconazole on the pharmacokinetic properties of oral and intravenous midazolam: A phase I, randomized, open-label, crossover study in healthy volunteers

(2009) Gopal Krishna et al.   CLINICAL THERAPEUTICS

Use of posaconazole in the treatment of invasive fungal infections

(2009) Aneesh K Mehta et al.   Expert Review of Hematology

Therapeutic Inhibition of Hedgehog-GLI Signaling in Cancer: Epithelial, Stromal, or Stem Cell Targets?

(2008) Ariel Ruiz i Altaba   CANCER CELL

Patients at High Risk of Invasive Fungal Infections

(2008) Maria J G T Rüping et al.   DRUGS

Sonic hedgehog regulates angiogenesis and myogenesis during post-natal skeletal muscle regeneration

(2008) Giuseppe Straface et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE