The differential susceptibilities of MCF-7 and MDA-MB-231 cells to the cytotoxic effects of curcumin are associated with the PI3K/Akt-SKP2-Cip/Kips pathway

Pharmacological Inactivation of Skp2 SCF Ubiquitin Ligase Restricts Cancer Stem Cell Traits and Cancer Progression

(2013) Chia-Hsin Chan et al.   CELL

Cdks, cyclins and CKIs: roles beyond cell cycle regulation

(2013) S. Lim et al.   DEVELOPMENT

Rapamycin Resistance Is Linked to Defective Regulation of Skp2

(2012) H. Totary-Jain et al.   CANCER RESEARCH

Generation of reactive oxygen species by grape seed extract causes irreparable DNA damage leading to G2/M arrest and apoptosis selectively in head and neck squamous cell carcinoma cells

(2012) S. Shrotriya et al.   CARCINOGENESIS

The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis

(2012) Chia-Hsin Chan et al.   CELL

Skp2 is a Promising Therapeutic Target in Breast Cancer

(2012) Zhiwei Wang et al.   Frontiers in Oncology

Phosphorylation of Ser72 does not regulate the ubiquitin ligase activity and subcellular localization of Skp2

(2011) Christel Boutonnet et al.   CELL CYCLE

Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization

(2011) Tarig Bashir et al.   CELL CYCLE

Curcumin Induces Downregulation of E2F4 Expression and Apoptotic Cell Death in HCT116 Human Colon Cancer Cells; Involvement of Reactive Oxygen Species

(2011) Kyung-Chan Kim et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Subtype and pathway specific responses to anticancer compounds in breast cancer

(2011) L. M. Heiser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FOXO1A Is a Target for HER2-Overexpressing Breast Tumors

(2010) Y. Wu et al.   CANCER RESEARCH

Distinct Biological Roles for the Akt Family in Mammary Tumor Progression: Figure 1.

(2010) Rachelle L. Dillon et al.   CANCER RESEARCH

Honokiol, a phytochemical from the Magnolia plant, inhibits photocarcinogenesis by targeting UVB-induced inflammatory mediators and cell cycle regulators: development of topical formulation

(2010) M. Vaid et al.   CARCINOGENESIS

Phytochemicals in Cancer Prevention and Therapy: Truth or Dare?

(2010) Maria Russo et al.   Toxins

Curcumin―The Paradigm of a Multi-Target Natural Compound with Applications in Cancer Prevention and Treatment

(2010) Marie-Hélène Teiten et al.   Toxins

Skp2: caught in the Akt

(2009) Karin Ecker et al.   NATURE CELL BIOLOGY

Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction

(2009) Daming Gao et al.   NATURE CELL BIOLOGY

Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB

(2009) Hui-Kuan Lin et al.   NATURE CELL BIOLOGY

Oncogenic properties and prognostic implications of the ubiquitin ligase Skp2 in cancer

(2008) Dan D. Hershko   CANCER

EGCG Stabilizes p27kip1in E2-Stimulated MCF-7 Cells through Down-Regulation of the Skp2 Protein

(2008) Hsiu-Chen Huang et al.   ENDOCRINOLOGY

Curcumin as “Curecumin”: From kitchen to clinic

(2007) Ajay Goel et al.   BIOCHEMICAL PHARMACOLOGY