Regulation of dimethyl-fumarate toxicity by proteasome inhibitors

Comparison between poor and long-term survivors with glioblastoma: Review of an Australian dataset

(2013) Kathryn Maree Field et al.   Asia-Pacific Journal of Clinical Oncology

HDAC inhibitors enhance the lethality of low dose salinomycin in parental and stem-like GBM cells

(2013) Laurence Booth et al.   CANCER BIOLOGY & THERAPY

Inhibition of the tumour necrosis factor-alpha autocrine loop enhances the sensitivity of multiple myeloma cells to anticancer drugs

(2013) Masanobu Tsubaki et al.   EUROPEAN JOURNAL OF CANCER

Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells

(2013) Roberta Foresti et al.   PHARMACOLOGICAL RESEARCH

Current status of local therapy in malignant gliomas — A clinical review of three selected approaches

(2013) Tareq A Juratli et al.   PHARMACOLOGY & THERAPEUTICS

BG-12 in Multiple Sclerosis

(2013) Robert Fox et al.   SEMINARS IN NEUROLOGY

Targeting mitochondrial dysfunction in lung diseases: emphasis on mitophagy

(2013) Angara Sureshbabu et al.   Frontiers in Physiology

Sorafenib inhibits endogenous and IL-6/S1P induced JAK2-STAT3 signaling in human neuroblastoma, associated with growth suppression and apoptosis

(2012) Fan Yang et al.   CANCER BIOLOGY & THERAPY

OSU-03012 suppresses GRP78/BiP expression that causes PERK-dependent increases in tumor cell killing

(2012) Laurence Booth et al.   CANCER BIOLOGY & THERAPY

Dimethyl Fumarate Inhibits Dendritic Cell Maturation via Nuclear Factor κB (NF-κB) and Extracellular Signal-regulated Kinase 1 and 2 (ERK1/2) and Mitogen Stress-activated Kinase 1 (MSK1) Signaling

(2012) Haiyan Peng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Placebo-Controlled Phase 3 Study of Oral BG-12 for Relapsing Multiple Sclerosis

(2012) Ralf Gold et al.   NEW ENGLAND JOURNAL OF MEDICINE

ER stress sensitizes cells to TRAIL through down-regulation of FLIP and Mcl-1 and PERK-dependent up-regulation of TRAIL-R2

(2011) Rosa Martín-Pérez et al.   APOPTOSIS

The Anti-Inflammatory Effects of Dimethyl Fumarate in Astrocytes Involve Glutathione and Haem Oxygenase-1

(2011) Shao Xia Lin et al.   ASN Neuro

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

(2011) Ralf A. Linker et al.   BRAIN

Alkaline phosphatase variation during carfilzomib treatment is associated with best response in multiple myeloma patients

(2011) Maurizio Zangari et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Valproic acid sensitizes human glioma cells for temozolomide and γ-radiation

(2011) Krista A. Van Nifterik et al.   JOURNAL OF NEURO-ONCOLOGY

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

The pan-HDAC inhibitor vorinostat potentiates the activity of the proteasome inhibitor carfilzomib in human DLBCL cells in vitro and in vivo

(2010) G. Dasmahapatra et al.   BLOOD

Proteasome Inhibitor PS-341 (Bortezomib) Induces Calpain-dependent IκBα Degradation

(2010) Chunyang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets

(2010) Lynn Bedford et al.   NATURE REVIEWS DRUG DISCOVERY

Fumaric acid diesters deprive cultured primary astrocytes rapidly of glutathione

(2010) Maike M. Schmidt et al.   NEUROCHEMISTRY INTERNATIONAL

Fumaric Acid and its Esters: An Emerging Treatment for Multiple Sclerosis

(2009) D. Moharregh-Khiabani et al.   Current Neuropharmacology

Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways

(2009) Can E. Senkal et al.   FASEB JOURNAL

Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study

(2008) Ludwig Kappos et al.   LANCET

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY