Chk1-induced CCNB1 overexpression promotes cell proliferation and tumor growth in human colorectal cancer

Chk1 as a new therapeutic target in triple-negative breast cancer

(2014) Laurence Albiges et al.   BREAST

RBM3-Regulated Genes Promote DNA Integrity and Affect Clinical Outcome in Epithelial Ovarian Cancer

(2014) Õsa Ehlén et al.   Translational Oncology

Sticky siRNAs targeting survivin and cyclin B1 exert an antitumoral effect on melanoma subcutaneous xenografts and lung metastases

(2013) Valerie Kedinger et al.   BMC CANCER

The cancer therapeutic potential of Chk1 inhibitors: how mechanistic studies impact on clinical trial design

(2013) Ruth Thompson et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Regulatory motifs in Chk1

(2013) Michael L. Caparelli et al.   CELL CYCLE

Sensitization of Pancreatic Cancer to Chemoradiation by the Chk1 Inhibitor MK8776

(2013) C. G. Engelke et al.   CLINICAL CANCER RESEARCH

Roles of Chk1 in cell biology and cancer therapy

(2013) Youwei Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

Chk1/2 Inhibition Overcomes the Cisplatin Resistance of Head and Neck Cancer Cells Secondary to the Loss of Functional p53

(2013) M. A. Gadhikar et al.   MOLECULAR CANCER THERAPEUTICS

CHEK again: Revisiting the development of CHK1 inhibitors for cancer therapy

(2013) S. McNeely et al.   PHARMACOLOGY & THERAPEUTICS

Identification of cyclin B1 and Sec62 as biomarkers for recurrence in patients with HBV-related hepatocellular carcinoma after surgical resection

(2012) Li Weng et al.   Molecular Cancer

Suppressed miR-424 expression via upregulation of target gene Chk1 contributes to the progression of cervical cancer

(2012) J Xu et al.   ONCOGENE

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Genetics, Cytogenetics, and Epigenetics of Colorectal Cancer

(2011) Lucia Migliore et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma

(2011) K. A. Cole et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restoration of the tumor suppressor p53 by downregulating cyclin B1 in human papillomavirus 16/18-infected cancer cells

(2010) N N Kreis et al.   ONCOGENE

Targeting cyclin B1 inhibits proliferation and sensitizes breast cancer cells to taxol

(2009) Ilija Androic et al.   BMC CANCER

Cyclin B1 is an efficacy-predicting biomarker for Chk1 inhibitors

(2008) Zhan Xiao et al.   BIOMARKERS

CDK inhibitors in cancer therapy: what is next?

(2007) Marcos Malumbres et al.   TRENDS IN PHARMACOLOGICAL SCIENCES