Increased aldehyde reductase expression mediates acquired radioresistance of laryngeal cancer cells via modulating p53

Decreased translation of p21waf1mRNA causes attenuated p53 signaling in some p53 wild-type tumors

(2012) Li-Ju Chang et al.   CELL CYCLE

A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation

(2011) Jane M Valentine et al.   BMC CANCER

DAPK1 mediates the G1 phase arrest in human nasopharyngeal carcinoma cells induced by grifolin, a potential antitumor natural product

(2011) Xiang-jian Luo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Preclinical Development of the Novel Chk1 Inhibitor SCH900776 in Combination with DNA-Damaging Agents and Antimetabolites

(2011) R. Montano et al.   MOLECULAR CANCER THERAPEUTICS

Caspase-2-Mediated Cleavage of Mdm2 Creates a p53-Induced Positive Feedback Loop

(2011) Trudy G. Oliver et al.   MOLECULAR CELL

hSSB1 binds and protects p21 from ubiquitin-mediated degradation and positively correlates with p21 in human hepatocellular carcinomas

(2011) S Xu et al.   ONCOGENE

The G2 DNA damage checkpoint: Could this ancient regulator be the Achilles heel of cancer?

(2010) Karen Kuntz et al.   CANCER BIOLOGY & THERAPY

New plays in the p53 theater

(2010) Yael Aylon et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

MDM2 Promotes Proteasomal Degradation of p21Waf1via a Conformation Change

(2010) Hongxia Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes

(2010) F Al-Ejeh et al.   ONCOGENE

DNA damage response to the Mdm2 inhibitor Nutlin-3

(2009) Rajeev Verma et al.   BIOCHEMICAL PHARMACOLOGY

Ionizing Radiation Induces ATM-independent Degradation of p21Cip1in Transformed Cells

(2009) Scott A. Stuart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small-Molecule Inhibitors of the MDM2-p53 Protein-Protein Interaction to Reactivate p53 Function: A Novel Approach for Cancer Therapy

(2008) Sanjeev Shangary et al.   Annual Review of Pharmacology and Toxicology

Compound C inhibits clonal expansion of preadipocytes by increasing p21 level irrespectively of AMPK inhibition

(2008) Minwoo Nam et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer

(2008) N Bucher et al.   BRITISH JOURNAL OF CANCER

Defective p53 signaling in p53 wild-type tumors attenuates p21waf1 induction and cyclin B repression rendering them sensitive to Chk1 inhibitors that abrogate DNA damage-induced S and G2 arrest

(2008) A. A. Levesque et al.   MOLECULAR CANCER THERAPEUTICS

Transcriptional control of human p53-regulated genes

(2008) Todd Riley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

(2008) S. Shangary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA