Tumor Derived Extracellular Vesicles Drive T Cell Exhaustion in Tumor Microenvironment through Sphingosine Mediated Signaling and Impacting Immunotherapy Outcomes in Ovarian Cancer

Resistance of melanoma to immune checkpoint inhibitors is overcome by targeting the sphingosine kinase-1

(2020) Caroline Imbert et al.   Nature Communications

Association of PD-L1 expression by immunohistochemistry and gene microarray with molecular subtypes of ovarian tumors

(2020) Curtis David Chin et al.   MODERN PATHOLOGY

SPHK1 is a novel target of metformin in ovarian cancer

(2019) Peter C Hart et al.   MOLECULAR CANCER RESEARCH

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

(2019) Mauro Poggio et al.   CELL

Pro-Survival Lipid Sphingosine-1-Phosphate Metabolically Programs T Cells to Limit Anti-tumor Activity

(2019) Paramita Chakraborty et al.   Cell Reports

Roles of sphingosine-1-phosphate signaling in cancer

(2019) Peng Wang et al.   Cancer Cell International

Inhibiting extracellular vesicles formation and release: a review of EV inhibitors

(2019) Mariadelva Catalano et al.   Journal of Extracellular Vesicles

Targeting the SphK1/S1P/S1PR1 Axis That Links Obesity, Chronic Inflammation, and Breast Cancer Metastasis

(2018) Masayuki Nagahashi et al.   CANCER RESEARCH

S1P promotes migration, differentiation and immune regulatory activity in amniotic-fluid–derived stem cells

(2018) Rita Romani et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Role of sphingolipids in the biogenesis and biological activity of extracellular vesicles

(2018) Claudia Verderio et al.   JOURNAL OF LIPID RESEARCH

Molecular mechanism to recruit galectin-3 into multivesicular bodies for polarized exosomal secretion

(2018) Sebastian Bänfer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphoma

(2018) Tammy Linlin Song et al.   BLOOD

The role of sphingosine-1-phosphate in inflammation and cancer progression

(2018) Masayuki Nagahashi et al.   CANCER SCIENCE

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

Sphingolipid-mediated inflammatory signaling leading to autophagy inhibition converts erythropoiesis to myelopoiesis in human hematopoietic stem/progenitor cells

(2018) Marion Orsini et al.   CELL DEATH AND DIFFERENTIATION

Isolation of High-Purity Extracellular Vesicles by the Combination of Iodixanol Density Gradient Ultracentrifugation and Bind-Elute Chromatography From Blood Plasma

(2018) Zsófia Onódi et al.   Frontiers in Physiology

S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1β

(2017) Benjamin Weichand et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

(2017) Angel Garcia-Diaz et al.   Cell Reports

Potential signaling pathway involved in sphingosine-1-phosphate-induced epithelial-mesenchymal transition in cancer

(2016) YE ZENG et al.   Oncology Letters

Sphingosine-1 Phosphate: A New Modulator of Immune Plasticity in the Tumor Microenvironment

(2016) Yamila I. Rodriguez et al.   Frontiers in Oncology

Cells release subpopulations of exosomes with distinct molecular and biological properties

(2016) Eduard Willms et al.   Scientific Reports

Sphingosine kinase 1 as a potential therapeutic target in epithelial ovarian cancer

(2014) Jeong-Won Lee et al.   INTERNATIONAL JOURNAL OF CANCER

Crystal Structure of Sphingosine Kinase 1 with PF-543

(2014) Jing Wang et al.   ACS Medicinal Chemistry Letters

Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review

(2013) Asfar S. Azmi et al.   CANCER AND METASTASIS REVIEWS

Oncogenic K-Ras Regulates Bioactive Sphingolipids in a Sphingosine Kinase 1-dependent Manner

(2012) Christopher R. Gault et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine-1-phosphate signaling and its role in disease

(2011) Michael Maceyka et al.   TRENDS IN CELL BIOLOGY

Sphingosine-1-phosphate and immune regulation: trafficking and beyond

(2010) Hongbo Chi   TRENDS IN PHARMACOLOGICAL SCIENCES

An Active Form of Sphingosine Kinase-1 Is Released in the Extracellular Medium as Component of Membrane Vesicles Shed by Two Human Tumor Cell Lines

(2010) Salvatrice Rigogliuso et al.   Journal of Oncology