Article
Oncology
Chloe E. Barr, Kelechi Njoku, Leo Hotchkies, Neil A. J. Ryan, Y. Louise Wan, David A. Davies, Salman Razvi, Emma J. Crosbie
Summary: Endometrial cancer is the most common gynecological cancer in high-income countries, and thyroid dysfunction may contribute to improved survival outcomes in patients. The study aimed to evaluate the association between thyroid dysfunction and endometrial cancer survival, with findings suggesting potential implications for therapeutic intervention.
Article
Oncology
Matthew R. Kudelka, Yi Lasanajak, David F. Smith, Xuezheng Song, Mohammad S. Hossain, Taofeek K. Owonikoko
Summary: This study assessed the potential utility of altered serum glycosylation in thyroid cancer surveillance. The research found that there were significant differences in three glycans in the serum of patients with thyroid cancer recurrence, and these differences predicted thyroid cancer recurrence. This finding provides a useful biomarker for improving the monitoring and prognosis of thyroid cancer through serum-based testing.
Article
Endocrinology & Metabolism
Zhen Cao, Zejian Zhang, Rui Liu, Mengwei Wu, Zepeng Li, Xiequn Xu, Ziwen Liu
Summary: This study explores novel serum biomarkers for monitoring and predicting recurrence in papillary thyroid cancer (PTC) after thyroidectomy using N-glycomics. The study identifies several candidate serum N-glycan biomarkers, including linkage-specific sialylation, which have potential in predicting recurrence and monitoring the response to initial surgical resection therapy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Hyunju Park, So Young Park, Jun Park, Jun Ho Choe, Man Ki Chung, Sook-Young Woo, Joon Young Choi, Sun Wook Kim, Jae Hoon Chung, Tae Hyuk Kim
Summary: Preoperative serum calcitonin levels are useful in predicting disease recurrence and determining optimal postoperative follow-up strategies for patients with MTC. It is also the best predictive factor for disease-free survival.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Critical Care Medicine
Hongseok Yoo, Jin Young Lee, Junseon Park, Gee Young Suh, Kyeongman Jeon
Summary: The study found that elevated levels of Fas ligand were associated with the severity and mortality of sepsis, but not correlated with RIPK3 levels.
Article
Endocrinology & Metabolism
Hui He, Shan Cong, Yu Wang, Qinghai Ji, Weiyan Liu, Ning Qu
Summary: This study identified the essential role of CADM1-CADM1 in the progression of papillary thyroid cancer (PTC) for the first time. The high expression of CADM1-CADM1 can indicate a good prognosis and increase the sensitivity of targeted drugs.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Hannah R. Nieto, Caitlin E. M. Thornton, Katie Brookes, Albert Nobre de Menezes, Alice Fletcher, Mohammed Alshahrani, Merve Kocbiyik, Neil Sharma, Kristien Boelaert, Jean-Baptiste Cazier, Hisham Mehanna, Vicki E. Smith, Martin L. Read, Christopher J. McCabe
Summary: This study aims to identify potential biomarkers associated with thyroid cancer recurrence by analyzing genetic changes and construct a new prognostic risk model.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cell Biology
Shoji F. Kenji, Keerthi Kurma, Brigitte Collet, Christelle Oblet, Laure Debure, Carmelo Di Primo, Laetitia Minder, Franck Verite, Yannic Danger, Mickael Jean, Aubin Penna, Nicolas Levoin, Patrick Legembre
Summary: CD95 is a death receptor that promotes oncogenesis through various molecular mechanisms. This receptor can undergo cleavage and modification in both cancer cells and normal cells, with the modified N-terminal region potentially regulating receptor aggregation and death signaling.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Eman A. Toraih, Manal S. Fawzy, Bo Ning, Mourad Zerfaoui, Youssef Errami, Emmanuelle M. Ruiz, Mohammad H. Hussein, Muhib Haidari, Melyssa Bratton, Giovane G. Tortelote, Sylvia Hilliard, Naris Nilubol, Jonathon O. Russell, Mohamed A. Shama, Samir S. El-Dahr, Krzysztof Moroz, Tony Hu, Emad Kandil
Summary: The aim of this study was to identify predictive markers for recurrence in papillary thyroid carcinoma (PTC). Using miRNA sequencing, miR-145 was found to be significantly downregulated in PTC tissues and blood, and its deregulation was associated with clinicopathological features of PTC patients. Further mechanistic studies are needed to uncover the role of miR-145 in PTC recurrence.
Review
Biochemistry & Molecular Biology
Yu Zhang, Dong-Dong Jia, Yi-Fei Zhang, Meng-Die Cheng, Wen-Xiu Zhu, Pei-Feng Li, Yin-Feng Zhang
Summary: Thyroid cancer is a common malignant tumor with high morbidity and mortality rates worldwide. Circular RNAs may serve as potential biomarkers and therapeutic targets for both thyroid cancer and autoimmune thyroid disease.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Qianmin Ou, Lingping Tan, Yiting Shao, Fangcao Lei, Weiying Huang, Ning Yang, Yan Qu, Zeyuan Cao, Luhan Niu, Yao Liu, Xiaoxing Kou, Songtao Shi
Summary: Mesenchymal stem cell (MSC)-derived apoptotic vesicles (apoVs) can alleviate organ damage and improve survival in septic mice. ApoVs mainly accumulate in the bone marrow of septic mice via electrostatic charge interactions with positively charged neutrophil extracellular traps (NETs). Additionally, apoVs switch neutrophils NETosis to apoptosis via the apoV-Fas ligand (FasL)-activated Fas pathway. These findings reveal a previously unknown role of apoVs in sepsis treatment and demonstrate an electrostatic charge-directed target therapeutic mechanism, suggesting the involvement of cell death in disease development and therapy.
Article
Oncology
Mariusz Rogucki, Iwona Sidorkiewicz, Magdalena Niemira, Janusz Bogdan Dzieciol, Angelika Buczynska, Agnieszka Adamska, Katarzyna Siewko, Maria Kosciuszko, Katarzyna Maliszewska, Anna Wojcicka, Jakub Supronik, Malgorzata Szelachowska, Joanna Reszec, Adam Jacek Kretowski, Anna Poplawska-Kita
Summary: In this study, the microRNA profile of papillary thyroid cancer (PTC) tissue was investigated to identify important pathways and propose a diagnostic biomarker. Four microRNAs (miR-152-3p, miR-221-3p, miR-551b-3p, and miR-7-5p) were identified as potential diagnostic tools for PTC. This study highlights the potential of microRNAs as diagnostic biomarkers for PTC.
Article
Oncology
Rita A. Busuttil, Joshy George, Colin M. House, Stephen Lade, Catherine Mitchell, Natasha S. Di Costanzo, Sharon Pattison, Yu-Kuan Huang, Patrick Tan, Jae-Ho Cheong, Sun Young Rha, Alex Boussioutas
Summary: The study identified secreted frizzled-related protein 4 (SFRP4) as a biomarker for predicting gastric cancer invasion and recurrence. The functional role of this gene in invasion was confirmed, and changes in serum levels could accurately predict the risk of disease recurrence when combined with AJCC stage.
Article
Multidisciplinary Sciences
MeeYoung Kim, Hyunwoo Shin, Hyong Woo Moon, Yong Hyun Park, Jaesung Park, JiYoul Lee
Summary: This study identified differential expression of urinary exosomal miRNAs in patients with biochemical recurrence of intermediate-risk prostate cancer, with miR-532-5p being an important predictive factor. The upregulation of miR-532-5p suggests its potential as a biomarker for poor prognosis in these patients, warranting further research on its biological functions and mechanisms.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Vipul Bhardwaj, Yan Qin Tan, Ming Ming Wu, Lan Ma, Tao Zhu, Peter E. Lobie, Vijay Pandey
Summary: Nearly 70% of ovarian cancer patients experience recurrence within the first 2 years after initial treatment. Emerging evidence suggests that long non-coding RNAs play a pivotal role in OC progression, therapy resistance and recurrent OC. Studies have reported differential expression patterns of lncRNAs in OC, which are related to increased invasion, metastasis and drug resistance.
Article
Hematology
Deepak Kumar, Chengyu Prince, Carolyn M. Bennett, Michael Briones, Laura Lucas, Athena Russell, Kiran Patel, Satheesh Chonat, Sara Graciaa, Holly Edington, Michael H. White, Lisa Kobrynski, Manar Abdalgani, Suhag Parikh, Sharat Chandra, Jack Bleesing, Rebecca Marsh, Sunita Park, Edmund K. Waller, Sampath Prahalad, Shanmuganathan Chandrakasan
Summary: This study describes the immune characteristics of pediatric Evans syndrome (pES) patients and finds that they have increased T-follicular helper cells, increased T-cell activation, and decreased class-switched memory B cells. The study also reveals that patients with pES without a known gene defect have similar immune abnormalities as those with defined genetic defects. These findings help elucidate the immunobiology of pES.
Article
Oncology
Julie E. Bauman, Zhengjia Chen, Chao Zhang, James P. Ohr, Robert L. Ferris, Gerald M. McGorisk, Stephen Brandt, Sumathi Srivatsa, Amy Y. Chen, Conor E. Steuer, Dong M. Shin, Nabil F. Saba, Fadlo R. Khuri, Taofeek K. Owonikoko
Summary: This randomized trial showed that the combination of everolimus and pasireotide-LAR is more effective in treating thyroid cancer compared to a single agent. Delayed use of this combination strategy appeared to be promising in achieving optimal efficacy.
Article
Oncology
Bassel Nazha, Chao Zhang, Zhengjia Chen, Camille Ragin, Taofeek K. Owonikoko
Summary: The study found that previous androgen deprivation therapy in prostate cancer patients is associated with longer survival when they subsequently develop lung cancer. These findings indicate a potential role of the androgen receptor in lung cancer.
Article
Hematology
Deepak Kumar, Thinh H. Nguyen, Carolyn M. Bennett, Chengyu Prince, Laura Lucas, Sunita Park, Taylor Lawrence, Karin Chappelle, Mariam Ishaq, Edmund K. Waller, Sampath Prahalad, Michael Briones, Shanmuganathan Chandrakasan
Summary: mTOR inhibitors like sirolimus are increasingly used to manage multilineage immune cytopenia (m-IC) in children. However, it is unclear how sirolimus affects the broader immune dysregulation associated with m-IC.
Article
Hematology
Ulrich Jaeger, Nina Worel, Joseph P. McGuirk, Peter A. Riedell, Isabelle Fleury, Yan Du, Xia Han, David Pearson, Santiago Redondo, Edmund K. Waller
Summary: In the PORTIA trial, it was feasible to add pembrolizumab to tisagenlecleucel for adult patients with r/r DLBCL who had& GE;2 prior lines of therapy and had an Eastern Cooperative Oncology Group performance status of& LE;1. The combination showed a manageable safety profile and had potential efficacy benefits when pembrolizumab was given the day before tisagenlecleucel.
Meeting Abstract
Hematology
Caspian Oliai, Rasmus T. Hoeg, Anna Pavlova, Arpita Gandhi, Lori Muffly, Rohtesh S. Mehta, Samer A. Srour, Edmund K. Waller, Robert Lowsky, Sagar S. Patel, Bhagirathbhai Dholaria, Carlos Bachier, Jeremy M. Pantin, Amandeep Salhotra, Joseph P. McGuirk, Nathaniel B. Fernhoff, J. Scott McClellan, Mehrdad Abedi, Robert S. Negrin, Everett H. Meyer
Editorial Material
Hematology
Edmund K. Waller
Summary: In this study, a novel mechanism was identified in which donor NK cells accelerate posttransplant immune reconstitution, shedding light on the importance of this process in allogeneic bone marrow transplantation.
Meeting Abstract
Hematology
Amandeep Salhotra, Samer A. Srour, Rasmus T. Hoeg, Ayman Saad, Everett H. Meyer, Anna Pavlova, Edmund K. Waller, Mwe Mwe Chao, J. Scott McClellan, Nathaniel B. Fernhoff, Robert Lowsky, Mehrdad Abedi
Article
Oncology
David Bernard Miklos, Mohammad Abu Zaid, Julian P. Cooney, Joern C. Albring, Mary Flowers, Alan P. Skarbnik, Ibrahim Yakoub-Agha, Bor-Sheng Ko, Benedetto Bruno, Edmund K. Waller, Jean Yared, Sang Kyun Sohn, Claude-Eric Bulabois, Takanori Teshima, David Jacobsohn, Hildegard Greinix, Ahmad Mokatrin, Yihua Lee, Justin T. Wahlstrom, Lori Styles, Gerard Socie
Summary: In this study, the safety and efficacy of ibrutinib with prednisone in patients with chronic graft-versus-host disease were evaluated. The primary and secondary end points did not show a statistically significant difference between the two treatment groups.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Matthew R. Kudelka, Yi Lasanajak, David F. Smith, Xuezheng Song, Mohammad S. Hossain, Taofeek K. Owonikoko
Summary: This study assessed the potential utility of altered serum glycosylation in thyroid cancer surveillance. The research found that there were significant differences in three glycans in the serum of patients with thyroid cancer recurrence, and these differences predicted thyroid cancer recurrence. This finding provides a useful biomarker for improving the monitoring and prognosis of thyroid cancer through serum-based testing.
Review
Oncology
Asmi Chattaraj, Masood Pasha Syed, Carissa A. A. Low, Taofeek K. K. Owonikoko
Summary: Cisplatin is widely used in the treatment of various cancers, but it poses a risk of hearing impairment. Despite the lack of standardized guidelines for monitoring and treatment of cisplatin-induced ototoxicity, it remains a significant challenge in clinical practice. A review of literature and a survey of practicing oncologists reveal the need for standardization and effective prevention strategies.
JCO ONCOLOGY PRACTICE
(2023)
Article
Oncology
Chloe S. Lalonde, Jeffrey M. Switchenko, Madhusmita Behera, Mehmet A. Bilen, Taofeek K. Owonikoko, Jonathan L. Kaufman, Ajay K. Nooka, Colleen M. Lewis, Elise Hitron, Hannah Collins, Emma C. Judson, Olatunji B. Alese, R. Donald Harvey, Jennifer W. Carlisle
Summary: Racial and ethnic minority populations are consistently under-represented in oncology clinical trials. The sociodemographic characteristics of patients participating in phase I clinical trials were significantly different from those at a comprehensive cancer center. Although phase I patients were more likely to be White, male, and privately insured, the percentage of White patients in phase I trials decreased over time.
Meeting Abstract
Biophysics
L. Gorfinkel, S. Raghunandan, A. Langston, A. Westbrook, S. Gillespie, B. Bratrude, K. Betz, S. W. Choi, J. Davis, C. Duncan, R. Giller, M. Grimley, A. C. Harris, D. Jacobsohn, N. Lalefar, M. Norkin, N. Farhadfar, M. A. Pulsipher, S. Shenoy, A. Petrovic, K. R. Schultz, G. A. Yanik, E. K. Waller, J. T. Horan, B. Watkins, L. S. Kean, M. Qayed
BONE MARROW TRANSPLANTATION
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Anurag Mehta, Qi Meng, Syed F. Ahmad, Annie Ho, Shivang Desai, Devinder Dhindsa, Joshua Zuniga, Shabatun Islam, Zakaria Almuwaqqat, Aditi Nayak, Laurence S. Sperling, Edmund K. Waller, Arshed A. Quyyumi
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Hematology
Christopher Ronald Funk, Shuhua Wang, Kevin Z. Chen, Alexandra Waller, Aditi Sharma, Claudia L. Edgar, Vikas A. Gupta, Shanmuganathan Chandrakasan, Jaquelyn T. Zoine, Andrew Fedanov, Sunil S. Raikar, Jean L. Koff, Christopher R. Flowers, Silvia Coma, Jonathan A. Pachter, Sruthi Ravindranathan, H. Trent Spencer, Mala Shanmugam, Edmund K. Waller
Summary: Manufacturing CART cells with PI3K delta/gamma inhibitor enriches CD8(+) CART cells with stem-like qualities and enhances the efficacy in eliminating CLL in vivo.