Article
Biochemistry & Molecular Biology
Consuelo Pasten, Mauricio Lozano, Jocelyn Rocco, Flavio Carrion, Cristobal Alvarado, Jessica Liberona, Luis Michea, Carlos E. Irarrazabal
Summary: The study found that aminoguanidine (AG) acts as an antioxidant compound and plays a renal protective role during renal ischemia-reperfusion injury (IRI) by inhibiting oxidative stress and inflammation, thus restoring kidney function.
Review
Biochemistry & Molecular Biology
Tamara Merz, Oscar McCook, Cosima Brucker, Christiane Waller, Enrico Calzia, Peter Radermacher, Thomas Datzmann
Summary: The discovery of endogenous H2S with cytoprotective properties has led to efforts in developing H2S as a therapeutic agent. H2S's ability to regulate various processes makes it potentially useful in managing critical illnesses. However, current methods of delivering H2S are not feasible for clinical use. Na2S2O3, a clinically approved compound, shows promise in pre-clinical studies for managing critical illnesses. Clinical trials are investigating its potential in myocardial infarction, and it may also be relevant for pre-eclampsia and COVID-19 pneumonia.
Article
Biochemistry & Molecular Biology
Changjiang Gu, Fanqi Kong, Junkai Zeng, Xiangwu Geng, Yanqing Sun, Xiongsheng Chen
Summary: Delayed remote ischemic preconditioning (RIPC) has protective effects against spinal cord ischemia-reperfusion injury (SCIRI) in mice, and SIRT3 is involved in this protection through the NMDAR-AMPK-PGC-1 alpha signaling pathway.
CELL AND BIOSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Boyu Xia, Qi Li, Jingjing Wu, Xiaomei Yuan, Fei Wang, Xu Lu, Chao Huang, Koulong Zheng, Rongrong Yang, Le Yin, Kun Liu, Qingsheng You
Summary: Sinomenine has cardioprotective effects in a mouse model of myocardial ischemia-reperfusion injury by attenuating oxidative stress, inflammation, and apoptosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Wen An, Ju-Seop Kang
Summary: Metformin can alleviate hepatic and myocardial injury induced by hepatic ischemia-reperfusion by inhibiting oxidative stress.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
I-Chieh Wang, Jian-Hong Lin, Wen-Sen Lee, Chin-Hung Liu, Ting-Yuan Lin, Kun-Ta Yang
Summary: This study found that baicalein and luteolin can protect cardiomyocytes from ischemia/reperfusion-induced ferroptosis by reducing the accumulation of ROS and MDA.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Carmine Rocca, Anna De Bartolo, Maria Concetta Granieri, Vittoria Rago, Daniela Amelio, Flavia Falbo, Rocco Malivindi, Rosa Mazza, Maria Carmela Cerra, Loubna Boukhzar, Benjamin Lefranc, Jerome Leprince, Youssef Anouar, Tommaso Angelone
Summary: The cell-permeable PSELT provides pharmacological preconditioning cardioprotection by mitigating ERS and oxidative stress, and by regulating endogenous SELENOT.
Article
Biochemistry & Molecular Biology
Hyun Seok Hwang, Aida Rahimi Kahmini, Julia Prascak, Alexis Cejas-Carbonell, Isela C. Valera, Samantha Champion, Mikayla Corrigan, Florence Mumbi, Michelle S. Parvatiyar
Summary: This study investigated the role of sarcospan (SSPN) in the cardiac response to acute ischemia-reperfusion (IR) injury. The findings suggested that SSPN deficiency in mice leads to increased infarct size and arrhythmia susceptibility post-IR injury. Additionally, SSPN depletion resulted in decreased Ca2+ handling capacity and increased oxidative stress pathways in cardiomyocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Lile Dong, Lianhong Yin, Ruomiao Li, Lina Xu, Youwei Xu, Xu Han, Yan Qi
Summary: Dioscin has shown protective effects against lung ischemia/reperfusion injury by regulating the FXR/LKB1 signaling pathway to reduce oxidative stress, apoptosis, and inflammation levels, making it a potential candidate for treating LI/RI.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Mao Yang, Ningning Xi, Meng Gao, Yanwei Yu
Summary: Sitagliptin has a protective effect against I/R injury in cardiomyocytes, potentially by regulating SIRT3 and autophagy.
Article
Immunology
Huaying Wang, Shanshan Guo, Bingdian Wang, Xueqi Liu, Li Gao, Chaoyi Chen, Yonggui Wu
Summary: The study found that carnosine can alleviate acute kidney injury, inflammation and ferroptosis. Treatment with carnosine reduced lipid peroxidation and iron accumulation, suppressed oxidative stress, and inhibited ferroptosis. Furthermore, carnosine was shown to bind with GPX4, which is a potential target for its protective effects on kidney cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hyeonbin Shin, Seungwon Jeong, Yeongjong Lee, Chanhee Jeon, Gayoung Kwon, Sooyeon Kim, Dongwon Lee
Summary: Renal ischemia-reperfusion (IR) injury is a common complication in clinical settings and currently lacks effective treatment. This study developed a novel nanoparticle drug that can protect the kidneys from IR injury by eliminating hydrogen peroxide (H2O2), exerting anti-inflammatory and anti-apoptotic effects. These nanoparticles have potential therapeutic value not only for renal IR injury but also for other inflammatory diseases associated with reactive oxygen species (ROS).
Article
Plant Sciences
Xiaoqi Zhao, Yutong Liu, Lei Wang, Chaolong Yan, Han Liu, Wenxin Zhang, Hongting Zhao, Chen Cheng, Zhipeng Chen, Tianze Xu, Kuanyu Li, Jing Cai, Tong Qiao
Summary: Oridonin exhibits a protective effect on hindlimb ischemia-reperfusion injury, possibly through Nrf2-mediated oxidative stress and NLRP3-mediated inflammasome activation.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yu Zheng, Yingying Tao, Xiaobo Zhan, Qi Wu
Summary: The NR4A1/LKB1/AMPK axis is a new protective pathway involved in hepatocyte ischemia-reperfusion injury (IRI). It can improve cell viability, reduce oxidative stress and inflammation through negative regulation on the LKB1/AMPK pathway, while inducing apoptosis and autophagy.
Article
Medicine, Research & Experimental
Shengyang Ding, Xinyu Duanmu, Lingshan Xu, Liang Zhu, Zhouquan Wu
Summary: Myocardial ischemia-reperfusion injury (MIRI) refers to the additional damage that occurs during the restoration of blood flow to the heart tissue after ischemic damage. Ozone therapy has been shown to reduce myocardial injury and protect against oxidative stress. In this study, ozone pretreatment was used in in vitro and in vivo models of ischemia-reperfusion injury, and it was found that ozone regulates the expression levels of ferroptosis-related proteins and transcription factors, leading to the protection of the myocardium. The Nrf2/Slc7a11/Gpx4 signaling pathway was identified as the mechanism responsible for the protective effects of ozone.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Monika Bartekova, Adriana Adameova, Aniko Gorbe, Kristina Ferenczyova, Olga Pechanova, Antigone Lazou, Naranjan S. Dhalla, Peter Ferdinandy, Zoltan Giricz
Summary: This review discusses the impact of CMDs on cardiac redox homeostasis, the role of OxS in cardiac pathologies, and the potential therapeutic effects of natural and synthetic antioxidants in CMDs. Despite numerous preclinical and clinical studies, no antioxidant therapy for the prevention and treatment of CMDs has been successfully translated, highlighting a significant translational gap in this field.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Arpad Kovacs, Melissa Herwig, Heidi Budde, Simin Delalat, Detmar Kolijn, Beata Bodi, Roua Hassoun, Melina Tangos, Saltanat Zhazykbayeva, Agnes Balogh, Daniel Czuriga, Sophie Van Linthout, Carsten Tschoepe, Naranjan S. Dhalla, Andreas Muegge, Attila Toth, Zoltan Papp, Judit Barta, Nazha Hamdani
Summary: The study revealed different molecular mechanisms between right ventricular dysfunction and left ventricular failure in heart failure patients. Interventricular differences were observed in oxidative stress and inflammation markers in heart tissue, as well as in CaMKII activity and cardiomyocyte passive stiffness. These findings suggest distinct signaling pathways in sarcomeric proteins for the right ventricle versus the left ventricle.
Review
Biochemistry & Molecular Biology
Anureet K. Shah, Sukhwinder K. Bhullar, Vijayan Elimban, Naranjan S. Dhalla
Summary: The transition from cardiac hypertrophy to heart failure is not well defined, but it is suggested that elevated levels of vasoactive hormones under pathological conditions play a critical role in the development of both cardiac hypertrophy and heart failure. These hormones induce an increase in ventricular wall tension through their respective receptor-mediated signal transduction systems at initial stages, leading to the development of cardiac hypertrophy.
Review
Physiology
Mohamad Nusier, Anureet K. Shah, Naranjan S. Dhalla
Summary: The sarcoplasmic reticulum (SR) in the heart plays a crucial role in regulating intracellular calcium levels and influencing cardiac contraction and relaxation. Composed of various proteins and phospholipids, the SR function is closely linked to cardiac performance and can be targeted for drug development in heart disease treatment.
PHYSIOLOGICAL RESEARCH
(2021)
Review
Physiology
Anureet K. Shah, Naranjan S. Dhalla
Summary: Vitamins play a role in maintaining cardiovascular function, with deficiency of certain vitamins linked to cardiovascular abnormalities and supplementation potentially reducing cardiovascular disease risk. However, research on the role of vitamins in cardiovascular disease and their therapeutic effects is currently inconclusive and conflicting.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Naranjan S. Dhalla, Vijayan Elimban, Monika Bartekova, Adriana Adameova
Summary: Oxidative stress plays an important role in heart disease by promoting cellular damage, cardiomyocyte loss, and abnormal calcium handling.
Article
Biochemistry & Molecular Biology
Adriana Adameova, Csaba Horvath, Safa Abdul-Ghani, Zoltan V. Varga, M. Saadeh Suleiman, Naranjan S. Dhalla
Summary: This review highlights the importance of regulated necrosis-like cell death program in cardiac ischemic injury. Key molecules of the necroptosis signaling pathway have been found to protect the heart by reducing infarct size and improving myocardial dysfunction. The non-canonical pathway is also associated with ischemic heart injury. Oxidative stress may be involved in the mechanisms of this cell death program.
Article
Biochemistry & Molecular Biology
Paramjit S. Tappia, Anureet K. Shah, Bram Ramjiawan, Naranjan S. Dhalla
Summary: Ischemia/reperfusion injury can compromise cardiac function recovery, but ischemic preconditioning (IP) can reduce oxidative stress and intracellular Ca2+ overload, improving cardiac function and providing cardioprotective effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Physiology
Vladimir Lj. Jakovljevic, Dragan M. Djuric, Naranjan S. Dhalla
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Paramjit S. Tappia, Bram Ramjiawan, Naranjan S. Dhalla
Summary: This article discusses the role of the alpha 1-AR-Gq alpha-PLC mediated hypertrophic signaling pathway in different stages of cardiac hypertrophy development. The results suggest that specific PLC isozymes may serve as important therapeutic targets for attenuating cardiac hypertrophy in vulnerable patient populations.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Naranjan S. Dhalla, Sukhwinder K. Bhullar, Anureet K. Shah
Summary: This article discusses the impact of changes in both cardiomyocytes and nonmyocyte extracellular matrix (ECM) on heart failure, with an emphasis on oxidative stress, inflammatory cytokines, metabolic alterations, and calcium-handling defects. It also highlights the importance of protein kinase alterations, mitochondrial calcium overload, activation of proteases and phospholipases, and changes in gene expression for subcellular remodeling in the occurrence of heart dysfunction.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2022)
Review
Cell Biology
Paramjit S. Tappia, Naranjan S. Dhalla
Summary: The activation of phospholipase C (PLC) plays a key role in the response of cardiomyocytes to hypertrophic agents. PLC activity leads to the generation of downstream signal transducers, which in turn promote the expression of fetal genes and cardiomyocyte growth. This study focuses on the regulation of PLC gene expression, particularly in the norepinephrine-alpha(1)-adrenoceptor signaling pathway. It suggests that targeting specific PLC isozymes could potentially mitigate cardiac hypertrophy.
Review
Biochemistry & Molecular Biology
Naranjan S. Dhalla, Anureet K. Shah, Adriana Adameova, Monika Bartekova
Summary: Ischemia-reperfusion injury is associated with impaired cardiac function, oxidative stress, intracellular Ca2+-overload, and protease activation.
Review
Cell Biology
Sukhwinder K. Bhullar, Naranjan S. Dhalla
Summary: Exposure of the heart to angiotensin has different effects on cardiac hypertrophy depending on the duration of exposure. The activation of Ang type 1 receptors (AT(1)R) mediates hypertrophic response, while the activation of Ang type 2 receptors (AT(2)R) and Mas receptors exert antihypertrophic effects. The understanding of these signaling mechanisms may lead to new therapeutic approaches for preventing or reversing angiotensin-induced cardiac hypertrophy.
Review
Pharmacology & Pharmacy
Paramjit S. Tappia, Bram Ramjiawan, Naranjan S. Dhalla
Summary: This article discusses the role of α(1)-AR-Gqα-PLC-mediated hypertrophic signaling pathway, which may complement other signal transduction mechanisms in the early stages of cardiac hypertrophy and become more relevant in the late stage. Certain specific PLC isozymes may serve as important targets for attenuating cardiac hypertrophy in vulnerable patients.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2022)