Article
Oncology
Toshiya Kamiyama, Tatsuya Orimo, Kenji Wakayama, Tatsuhiko Kakisaka, Shingo Shimada, Akihisa Nagatsu, Yoh Asahi, Takeshi Aiyama, Hirofumi Kamachi, Akinobu Taketomi
Summary: AHCC may be a safe and effective adjuvant therapy for preventing HCC recurrence after curative hepatectomy.
INTEGRATIVE CANCER THERAPIES
(2022)
Article
Surgery
YiFeng Wu, ChaoYong Tu, ChuXiao Shao
Summary: This study found that monocyte to lymphocyte ratio (MLR), tumor size, tumor differentiation, and BCLC stage are all risk factors for early recurrence and recurrence-free survival of hepatocellular carcinoma. Combining these factors can better predict the occurrence of early recurrence.
Article
Oncology
Hilda Samimi, Rezvan Tavakoli, Parviz Fallah, Alireza Naderi Sohi, Maryam Amini Shirkouhi, Mahmood Naderi, Vahid Haghpanah
Summary: This study suggests that BI-847325 may be an effective multi-targeted anticancer drug for the treatment of ATC. It inhibits the functions of MEK1/2 and AURKB, induces thyroid differentiation markers and apoptosis, and decreases multidrug resistance, cell cycle progression, proliferation, angiogenesis, and invasion.
CANCER CELL INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Junyi Shen, Weili Qi, Junlong Dai, Shusheng Leng, Kangyi Jiang, Yu Zhang, Shun Ran, Chuan Li, Tianfu Wen
Summary: This study compared the effects of tenofovir (TDF) and entecavir (ETV) on the recurrence of hepatocellular carcinoma (HCC) beyond the Milan criteria. The results showed that TDF treatment significantly reduced the risk of HCC recurrence compared to ETV therapy.
CHINESE MEDICAL JOURNAL
(2022)
Article
Medicine, General & Internal
Wencui Li, Lizhu Han, Bohan Xiao, Xubin Li, Zhaoxiang Ye
Summary: This study aimed to identify the independent risk factors for AFP-NHCC and construct an individual prediction nomogram of early recurrence. The researchers found several independent predictors for early recurrence of AFP-NHCC and developed an effective nomogram. This nomogram could assist physicians in making more accurate personalized treatment decisions for AFP-NHCC patients.
Article
Gastroenterology & Hepatology
Xiaoyun Zhang, Chuan Li, Tianfu Wen, Lunan Yan, Jiayin Yang, Hong Tang, Changli Lu
Summary: Postoperative oral antiviral treatment with nucleoside or nucleotide analogues can suppress viral replication and reduce tumor recurrence in HBV-related HCC patients. Nucleotide analogues significantly decreased HCC recurrence and HCC-related death, especially in patients with cirrhosis, HBeAg-negative status, and positive HBV-DNA.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Surgery
Linye He, Zijing Xia, Xiaoyun Zhang, Zhihui Li, Tianfu Wen, Chuan Li
Summary: This study found that HBV-related HCC patients treated with consistent TDF therapy had a significantly lower risk of tumor recurrence than those treated with ETV after curative treatment.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Integrative & Complementary Medicine
ZHENG Dong-hai, YANG Jia-mei, WU Jian-xiong, CHENG Shu-qun, ZHANG Shao-geng, WU Dong, LI Ai-jun, FU Xiao-hui, LI Xun, QI Fu-chen, DUAN Wei-hong, CHEN Jun-hui, YANG Zhi-ying, LIANG Lu, ZENG Jin-xiong, ZHENG Wei-da, WU Meng-chao
Summary: Cidan Capsule combined with adjuvant TACE can reduce early recurrence in HCC patients with a high risk of recurrence after curative resection, making it a suitable option for postoperative anti-recurrence treatment.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Review
Chemistry, Physical
Priya, Shalini Jaswal, Ghanshyam Das Gupta, Sant Kumar Verma
Summary: Aurora kinase family plays a critical role in cell division and the cell cycle, and overexpression of AURKA and AURKB has been linked to the development of various carcinomas. The synthesis and development of Aurora Kinase inhibitors offer new opportunities for anticancer therapy.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Review
Chemistry, Medicinal
Tathagata Pradhan, Ojasvi Gupta, Gurpreet Singh, Vikramdeep Monga
Summary: Aurora kinases, a family of regulatory proteins playing a crucial role in cell proliferation, have emerged as validated drug targets for anticancer drug discovery. The design and development of Aurora kinase inhibitors have been widely explored as potential anticancer agents, showing promising results in growth inhibition and apoptosis in tumor cells.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Oncology
Nikolaos Machairas, Dimitrios Papaconstantinou, Panagiotis Dorovinis, Diamantis I. Tsilimigras, Myrto D. Keramida, Stylianos Kykalos, Dimitrios Schizas, Timothy M. Pawlik
Summary: In patients with recurrent hepatocellular carcinoma (HCC), both repeat hepatectomy (RH) and radiofrequency ablation (RFA) are viable treatment options. This systematic review and meta-analysis aimed to compare the outcomes of patients undergoing RH versus RFA for recurrent HCC. The results showed that both treatments had comparable overall and disease-free survival rates, but patients undergoing RH were less likely to develop a second recurrence. However, RH was associated with higher overall and major morbidity rates. Despite this, repeat resection remains the preferred option due to its better disease control.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hui Huang, Mei-Qing Cheng, Dan-Ni He, Meng-Fei Xian, Dan Zeng, Shao-Hong Wu, Chao-Qun Li, Si-Min Ruan, Ming-De Li, Man-Xia Lin, Ming-De Lu, Ming Kuang, Wei Wang, Li-Da Chen
Summary: This study investigated the performance of US LI-RADS in surveillance for recurrent hepatocellular carcinoma (RHCC) after curative treatment. Four criteria using US LI-RADS or Alpha-fetoprotein (AFP) as the surveillance algorithm were evaluated. The criterion of US-2/3 or AFP ≥ 20μg/L had higher sensitivity and negative predictive value, but lower specificity.
EUROPEAN RADIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Vijay H. Masand, Sami A. Al-Hussain, Mithilesh M. Rathore, Sumer D. Thakur, Siddhartha Akasapu, Abdul Samad, Aamal A. Al-Mutairi, Magdi E. A. Zaki
Summary: In this study, a comprehensive quantitative structure-activity relationship (QSAR) analysis was conducted using 561 structurally diverse aurora kinase B inhibitors. The resulting QSAR model showed high statistical performance and successfully identified key pharmacophoric features for inhibiting AKB.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Antal H. Kovacs, Dong Zhao, Jinqiang Hou
Summary: This paper presents a comprehensive review of the preclinical and clinical candidates of Aurora B inhibitors as potential anticancer drugs. The recent advances in the field of Aurora B inhibitor development will be highlighted, and the binding interactions between Aurora B and inhibitors based on crystal structures will be presented and discussed to provide insights for the future design of more selective Aurora B inhibitors.
Article
Multidisciplinary Sciences
Rajdeep Das, Martin Sjostrom, Raunak Shrestha, Christopher Yogodzinski, Emily A. Egusa, Lisa N. Chesner, William S. Chen, Jonathan Chou, Donna K. Dang, Jason T. Swinderman, Alex Ge, Junjie T. Hua, Shaheen Kabir, David A. Quigley, Eric J. Small, Alan Ashworth, Felix Y. Feng, Luke A. Gilbert
Summary: The study integrates clinical and functional genomics data, identifying potential driver genes KIF4A and WDR62 for metastatic prostate cancer. These genes are shown to drive aggressive prostate cancer phenotypes in multiple models, regardless of AR status, and are associated with poor patient outcomes.
NATURE COMMUNICATIONS
(2021)
Letter
Dermatology
Toshiyuki Yamamoto, Akiko Nishibu, Yoshinobu Eishi
JOURNAL OF DERMATOLOGY
(2017)
Article
Cell Biology
Shohei Tomii, Takumi Akashi, Noboru Ando, Tomoki Tamura, Akira Sakurai, Asami Terada, Asuka Furukawa, Yoshimi Suzuki, Kou Kayamori, Kei Sakamoto, Hironori Ishibashi, Yoshinobu Eishi
Article
Oncology
Yoshiteru Ohata, Shu Shimada, Yoshimitsu Akiyama, Kaoru Mogushi, Keisuke Nakao, Satoshi Matsumura, Arihiro Aihara, Yusuke Mitsunori, Daisuke Ban, Takanori Ochiai, Atsushi Kudo, Shigeki Arii, Minoru Tanabe, Shinji Tanaka
MOLECULAR CANCER THERAPEUTICS
(2017)
Article
Oncology
Toshitaka Uomori, Yoshiya Horimoto, Kaoru Mogushi, Joe Matsuoka, Mitsue Saito
Article
Multidisciplinary Sciences
Emiko Yoshida, Yasuhisa Terao, Noriko Hayashi, Kaoru Mogushi, Atsushi Arakawa, Yuji Tanaka, Yosuke Ito, Hiroko Ohmiya, Yoshihide Hayashizaki, Satoru Takeda, Masayoshi Itoh, Hideya Kawaji
SCIENTIFIC REPORTS
(2017)
Article
Pathology
Norimichi Chiyonobu, Shu Shimada, Yoshimitsu Akiyama, Kaoru Mogushi, Michiko Itoh, Keiichi Akahoshi, Satoshi Matsumura, Kosuke Ogawa, Hiroaki Ono, Yusuke Mitsunori, Daisuke Ban, Atsushi Kudo, Shigeki Arii, Takayoshi Suganami, Shoji Yamaoka, Yoshihiro Ogawa, Minoru Tanabe, Shinji Tanaka
AMERICAN JOURNAL OF PATHOLOGY
(2018)
Article
Multidisciplinary Sciences
Yoshiya Horimoto, Masahiko Tanabe, Saiko Kazuno, Yoshiki Miura, Kaoru Mogushi, Hiroshi Sonoue, Atsushi Arakawa, Kazunori Kajino, Toshiyuki Kobayashi, Mitsue Saito
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
Kazuya Takamochi, Kaoru Mogushi, Hideya Kawaji, Kota Imashimizu, Mariko Fukui, Shiaki Oh, Masayoshi Itoh, Yoshihide Hayashizaki, Weijey Ko, Masao Akeboshi, Kenji Suzuki
Article
Multidisciplinary Sciences
Kenta Mukaihara, Yu Tanabe, Daisuke Kubota, Keisuke Akaike, Takuo Hayashi, Kaoru Mogushi, Masaki Hosoya, Shingo Sato, Eisuke Kobayashi, Taketo Okubo, Youngji Kim, Shinji Kohsaka, Tsuyoshi Saito, Kazuo Kaneko, Yoshiyuki Suehara
Article
Cell Biology
Katsumi Oishi, Takashi Ito, Daisuke Sakonishi, Keisuke Uchida, Masaki Sekine, Mariko Negi, Daisuke Kobayashi, Keiko Miura, Takumi Akashi, Yoshinobu Eishi
Review
Medicine, General & Internal
Tetsuo Yamaguchi, Ulrich Costabel, Andrew McDowell, Josune Guzman, Keisuke Uchida, Kenichi Ohashi, Yoshinobu Eishi
Summary: Sarcoidosis may have multiple causative agents, including infectious and non-infectious factors. Research suggests that Mycobacterium tuberculosis and Propionibacterium acnes are the most common microorganisms involved in the development of sarcoidosis. Differential diagnosis and treatment of sarcoidosis may involve immunohistochemistry with specific antibodies to distinguish cases caused by different etiologies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Microbiology
Takuma Isshiki, Sakae Homma, Yoshinobu Eishi, Matsuko Yabe, Kazuya Koyama, Yasuhiko Nishioka, Tetsuo Yamaguchi, Keisuke Uchida, Kurara Yamamoto, Kenichi Ohashi, Atsushi Arakawa, Kazutoshi Shibuya, Susumu Sakamoto, Kazuma Kishi
Summary: Propionibacterium acnes is associated with the pathogenesis of sarcoidosis. Immunohistochemistry with a PAB antibody can differentiate sarcoidosis from other granulomatous diseases by detecting P. acnes in granulomas. The automated Leica system has the best detection sensitivity for P. acnes in sarcoid granulomas.
Editorial Material
Gastroenterology & Hepatology
Takashi Ito, Yoshinobu Eishi, Daisuke Kobayashi, Takumi Akashi, Morio Koike, Kenichi Ohashi
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Agriculture, Dairy & Animal Science
Luciana Mandrioli, Victorio Codotto, Giulia D'Annunzio, Enrico Volpe, Francesca Errani, Yoshinobu Eishi, Keisuke Uchida, Maria Morini, Giuseppe Sarli, Sara Ciulli
Summary: Pathological and microbiological investigations were conducted on ornamental cichlids, revealing the potential presence of Cutibacterium acnes and Mycobacterium spp. in the fish, posing potential health risks to humans.
Article
Respiratory System
Els Beijer, Kees Seldenrijk, Yoshinobu Eishi, Keisuke Uchida, Jan Damen, Jan C. Grutters, Marcel Veltkamp
Summary: The study demonstrates the presence of Propionibacterium acnes in granulomas of Dutch sarcoidosis patients, with its frequency higher in patients with chronic disease requiring treatment. This suggests a potential benefit of antibiotic therapy for a subgroup of sarcoidosis patients.