Aurora kinase inhibitors as potential anticancer agents: Recent advances

Synthesis, Anticancer Evaluation, Computer-Aided Docking Studies, and ADMET Prediction of 1,2,3-Triazolyl-Pyridine Hybrids as Human Aurora B Kinase Inhibitors

(2021) Huda R.M. Rashdan et al.   ACS Omega

Synthesis, biological evaluation and molecular modeling study of 2-amino-3,5-disubstituted-pyrazines as Aurora kinases inhibitors

(2020) Yong-Xin Bo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis, biological evaluation of 6-(2-amino-1H-benzo[d]imidazole-6-yl)quinazolin-4(3H)-one derivatives as novel anticancer agents with Aurora kinase inhibition

(2020) Chengcheng Fan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery and optimization of novel phenyldiazepine and pyridodiazepine based Aurora kinase inhibitors

(2020) Natarajan Tamizharasan et al.   BIOORGANIC CHEMISTRY

Synthesis and biological evaluation of nitroxide labeled pyrimidines as Aurora kinase inhibitors

(2019) You-Zhen Ma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis, and biological evaluation of polyphenols with 4,6-diphenylpyrimidin-2-amine derivatives for inhibition of Aurora kinase A

(2019) Young Han Lee et al.   DARU-Journal of Pharmaceutical Sciences

Optimization and biological evaluation of nicotinamide derivatives as Aurora kinase inhibitors

(2019) Baohui Qi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structural basis for the design of allosteric inhibitors of the Aurora kinase A enzyme in the cancer chemotherapy

(2019) Valéria Barbosa de Souza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Synthesis and biological evaluation of 2,4-disubstituted phthalazinones as Aurora kinase inhibitors

(2018) Wei Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery and optimization of novel benzothiophene-3-carboxamides as highly potent inhibitors of Aurora kinases A and B

(2018) Pál Gyulavári et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of aurora kinases inhibitors based on N -trisubstituted pyrimidine scaffold

(2018) Liang Long et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pyrazolo[4,3-b]pyrimido[4,5-e][1,4]diazepine derivatives as new multi-targeted inhibitors of Aurora A/B and KDR

(2018) Qiumeng Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure-based drug design: Synthesis and biological evaluation of quinazolin-4-amine derivatives as selective Aurora A kinase inhibitors

(2018) Liang Long et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Benzimidazole – Schiff bases and their complexes: synthesis, anticancer activity and molecular modeling as Aurora kinase inhibitor

(2018) Asmaa A. Magd-El-Din et al.   ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES

The functional diversity of Aurora kinases: a comprehensive review

(2018) Estelle Willems et al.   Cell Division

Synthesis and identification of 2,4-bisanilinopyrimidines bearing 2,2,6,6-tetramethylpiperidine-N-oxyl as potential Aurora A inhibitors

(2018) Chun-Yan Sang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A comprehensive review on Aurora kinase: Small molecule inhibitors and clinical trial studies

(2017) Ankit C. Borisa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological activity of N4-phenylsubstituted-7H-pyrrolo[2,3-d]pyrimidin-4-amines as dual inhibitors of aurora kinase A and epidermal growth factor receptor kinase

(2017) Sonali Kurup et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthesis and structure elucidation of polyphenols containing the N ′-methyleneformohydrazide scaffold as aurora kinase inhibitors

(2017) Dongsoo Koh et al.   MAGNETIC RESONANCE IN CHEMISTRY

Aurora B Expression as a Prognostic Indicator and Possibile Therapeutic Target in Oral Squamous Cell Carcinoma

(2017) G. Pannone et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Design and synthesis of novel benzoxazole analogs as Aurora B kinase inhibitors

(2016) Ying An et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

3-Cyano-6-(5-methyl-3-pyrazoloamino) pyridines (Part 2): A dual inhibitor of Aurora kinase and tubulin polymerization

(2016) Masahiko Morioka   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of novel inhibitors of Aurora kinases with indazole scaffold: In silico fragment-based and knowledge-based drug design

(2016) Chun-Feng Chang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Aurora kinase inhibitors in cancer research and therapy

(2016) Jonas Cicenas   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Design and synthesis of imidazo[4,5-c]pyridine derivatives as promising Aurora kinase A (AURKA) inhibitors

(2016) D. A. Lomov et al.   RUSSIAN JOURNAL OF ORGANIC CHEMISTRY

Ubiquitin-Mediated Degradation of Aurora Kinases

(2016) Catherine Lindon et al.   Frontiers in Oncology

New Benzimidazoles and Their Antitumor Effects with Aurora A Kinase and KSP Inhibitory Activities

(2015) Amira S. Abd El-All et al.   ARCHIV DER PHARMAZIE

Identification of novel inhibitors of Aurora A with a 3-(pyrrolopyridin-2-yl)indazole scaffold

(2015) Pinrao Song et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Expression Analysis of Aurora-C and Survivin, Two Testis-Specific Genes, in Patients with Colorectal Cancer

(2015) Saba Hosseini et al.   Clinical Laboratory

Synthesis and biological evaluation of 2,4-diaminopyrimidines as selective Aurora A kinase inhibitors

(2015) Wen-Wen Qin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Aurora kinase A gene copy number is associated with the malignant transformation of colorectal adenomas but not with the serrated neoplasia progression

(2015) Laura Casorzo et al.   HUMAN PATHOLOGY

Aurora kinase A in gastrointestinal cancers: time to target

(2015) Ahmed Katsha et al.   Molecular Cancer

Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one derivatives as Aurora A kinase inhibitors: LQTA-QSAR analysis and detailed systematic validation of the developed model

(2015) Ashish M. Kanhed et al.   MOLECULAR DIVERSITY

Regulation of AURKC expression by CpG island methylation in human cancer cells

(2015) Satoshi Fujii et al.   TUMOR BIOLOGY

Aurora kinase A is essential for correct chromosome segregation in mouse zygote

(2015) Veronika Kovarikova et al.   ZYGOTE

MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors

(2015) Todd B. Sells et al.   ACS Medicinal Chemistry Letters

Aurora kinase a suppresses metabolic stress-induced autophagic cell death by activating mTOR signaling in breast cancer cells

(2015) Ling-Zhi Xu et al.   Oncotarget

Discovery of 4-aminoquinazoline—urea derivatives as Aurora kinase inhibitors with antiproliferative activity

(2014) Jin Cai et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cucurbitacin-I inhibits Aurora kinase A, Aurora kinase B and survivin, induces defects in cell cycle progression and promotes ABT-737-induced cell death in a caspase-independent manner in malignant human glioma cells

(2014) Daniel R Premkumar et al.   CANCER BIOLOGY & THERAPY

Design, synthesis and bioevaluation of N-trisubstituted pyrimidine derivatives as potent aurora A kinase inhibitors

(2014) Yu Luo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Aurora Kinase Inhibition Induces PUMA via NF- B to Kill Colon Cancer Cells

(2014) J. Sun et al.   MOLECULAR CANCER THERAPEUTICS

BUB1 mRNA is significantly co-expressed with AURKA and AURKB mRNA in advanced-stage ovarian serous carcinoma

(2014) Ben Davidson et al.   VIRCHOWS ARCHIV

SAR and evaluation of novel 5H-benzo[c][1,8]naphthyridin-6-one analogs as Aurora kinase inhibitors

(2013) Srinivasa Karra et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis, quantum chemical studies and biological activity evaluation of pyrazole–benzimidazole derivatives as potent Aurora A/B kinase inhibitors

(2013) Youguang Zheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Stage I of a phase 2 study assessing the efficacy, safety, and tolerability of barasertib (AZD1152) versus low-dose cytosine arabinoside in elderly patients with acute myeloid leukemia

(2013) Hagop M. Kantarjian et al.   CANCER

Small Molecule Inhibitors of Aurora-A Induce Proteasomal Degradation of N-Myc in Childhood Neuroblastoma

(2013) Markus Brockmann et al.   CANCER CELL

BimEL is phosphorylated at mitosis by Aurora A and targeted for degradation by βTrCP1

(2013) M Moustafa-Kamal et al.   CELL DEATH AND DIFFERENTIATION

Assessment of Aurora a Kinase Expression in Breast Cancer: A Tool for Early Diagnosis?

(2013) Imen Ferchichi et al.   DISEASE MARKERS

Aurora B and Kif2A control microtubule length for assembly of a functional central spindle during anaphase

(2013) Ryota Uehara et al.   JOURNAL OF CELL BIOLOGY

Aurora Isoform Selectivity: Design and Synthesis of Imidazo[4,5-b]pyridine Derivatives as Highly Selective Inhibitors of Aurora-A Kinase in Cells

(2013) Vassilios Bavetsias et al.   JOURNAL OF MEDICINAL CHEMISTRY

Optimization of Ligand and Lipophilic Efficiency To Identify an in Vivo Active Furano-Pyrimidine Aurora Kinase Inhibitor

(2013) Hui-Yi Shiao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Aurora-B overexpression is correlated with aneuploidy and poor prognosis in non-small cell lung cancer

(2013) Masafumi Takeshita et al.   LUNG CANCER

AURKA Governs Self-Renewal Capacity in Glioma-Initiating Cells via Stabilization/Activation of  -catenin/Wnt Signaling

(2013) Z. Xia et al.   MOLECULAR CANCER RESEARCH

Aurora kinase A mediates epithelial ovarian cancer cell migration and adhesion

(2013) T-V Do et al.   ONCOGENE

Gene Amplification and Overexpression of Aurora-C in Breast and Prostate Cancer Cell Lines

(2013) Ali Zekri et al.   ONCOLOGY RESEARCH

Contribution of Aurora-A and -B expression to DNA aneuploidy in gastric cancers

(2013) Kenichi Honma et al.   SURGERY TODAY

New Mitotic Regulators Released from Chromatin

(2013) Hideki Yokoyama et al.   Frontiers in Oncology

Aurora kinase A inhibition-induced autophagy triggers drug resistance in breast cancer cells

(2012) Zhengzhi Zou et al.   Autophagy

Structure-based design of 2,6,7-trisubstituted-7H-pyrrolo[2,3-d]pyrimidines as Aurora kinases inhibitors

(2012) Jean-Yves Le Brazidec et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, biological evaluation, and molecular docking studies of N,1,3-triphenyl-1H-pyrazole-4-carboxamide derivatives as anticancer agents

(2012) Xi Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, SAR and biological evaluation of 1,6-disubstituted-1H-pyrazolo[3,4-d]pyrimidines as dual inhibitors of Aurora kinases and CDK1

(2012) Jean-Yves Le Brazidec et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

3D-QSAR-Assisted Drug Design: Identification of a Potent Quinazoline-Based Aurora Kinase Inhibitor

(2012) Yi-Yu Ke et al.   ChemMedChem

Aurora B is regulated by acetylation/deacetylation during mitosis in prostate cancer cells

(2012) Maria Fadri-Moskwik et al.   FASEB JOURNAL

Phase II study of MLN8237 (alisertib), an investigational Aurora A kinase inhibitor, in patients with platinum-resistant or -refractory epithelial ovarian, fallopian tube, or primary peritoneal carcinoma

(2012) Ursula A. Matulonis et al.   GYNECOLOGIC ONCOLOGY

Phosphorylation of NuMA by Aurora-A kinase in PC-3 prostate cancer cells affects proliferation, survival, and interphase NuMA localization

(2012) Raheleh Toughiri et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Molecular dynamics and free energy studies on Aurora kinase A and its mutant bound with MLN8054: insight into molecular mechanism of subtype selectivity

(2012) Ying Yang et al.   Molecular BioSystems

Nuclear Aurora B and cytoplasmic Survivin expression is involved in lymph node metastasis of colorectal cancer

(2012) HANDAN TUNCEL et al.   Oncology Letters

Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I)

(2011) Lin Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Characterization of Alisertib (MLN8237), an Investigational Small-Molecule Inhibitor of Aurora A Kinase Using Novel In Vivo Pharmacodynamic Assays

(2011) M. G. Manfredi et al.   CLINICAL CANCER RESEARCH

Aurora Kinase A expression is associated with lung cancer histological-subtypes and with tumor de-differentiation

(2011) Marco Lo Iacono et al.   Journal of Translational Medicine

Phase I Assessment of New Mechanism-Based Pharmacodynamic Biomarkers for MLN8054, a Small-Molecule Inhibitor of Aurora A Kinase

(2010) A. Chakravarty et al.   CANCER RESEARCH

Aurora Kinase A Promotes Ovarian Tumorigenesis through Dysregulation of the Cell Cycle and Suppression of BRCA2

(2010) G. Yang et al.   CLINICAL CANCER RESEARCH

MLN8054, an Inhibitor of Aurora A Kinase, Induces Senescence in Human Tumor Cells Both In vitro and In vivo

(2010) J. J. Huck et al.   MOLECULAR CANCER RESEARCH

Phase I Study of the Selective Aurora A Kinase Inhibitor MLN8054 in Patients with Advanced Solid Tumors: Safety, Pharmacokinetics, and Pharmacodynamics

(2010) T. Macarulla et al.   MOLECULAR CANCER THERAPEUTICS

Self-organization of intracellular gradients during mitosis

(2010) Brian G Fuller   Cell Division

The discovery of the potent aurora inhibitor MK-0457 (VX-680)

(2009) David Bebbington et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Stabilization of N-Myc Is a Critical Function of Aurora A in Human Neuroblastoma

(2009) Tobias Otto et al.   CANCER CELL

Aurora A Regulates Prometaphase Progression by Inhibiting the Ability of RASSF1A to Suppress APC-Cdc20 Activity

(2009) S. J. Song et al.   CANCER RESEARCH

Development and Biological Evaluation of a Novel Aurora A Kinase Inhibitor

(2009) Teresa Sardon et al.   CHEMBIOCHEM

The selective Aurora B kinase inhibitor AZD1152 as a novel treatment for hepatocellular carcinoma

(2009) Arihiro Aihara et al.   JOURNAL OF HEPATOLOGY

Aurora-A down-regulates IkappaBα via Akt activation and interacts with insulin-like growth factor-1 induced phosphatidylinositol 3-kinase pathway for cancer cell survival

(2009) Jin-e Yao et al.   Molecular Cancer

ZM447439, a Novel Promising Aurora Kinase Inhibitor, Provokes Antiproliferative and Proapoptotic Effects Alone and in Combination with Bio- and Chemotherapeutic Agents in Gastroenteropancreatic Neuroendocrine Tumor Cell Lines

(2009) I. Georgieva et al.   NEUROENDOCRINOLOGY

Effects of the Aurora kinase inhibitor VX-680 on anaplastic thyroid cancer-derived cell lines

(2008) Y. Arlot-Bonnemains et al.   ENDOCRINE-RELATED CANCER

Expression of Aurora kinase A and B in normal and malignant cervical tissue: High Aurora A kinase expression in squamous cervical cancer

(2008) Nae-Fang Twu et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Effects of the aurora kinase inhibitors AZD1152-HQPA and ZM447439 on growth arrest and polyploidy in acute myeloid leukemia cell lines and primary blasts

(2008) E. Walsby et al.   HAEMATOLOGICA