Uncoupling protein-2 mediates the protective action of berberine against oxidative stress in rat insulinoma INS-1E cells and in diabetic mouse islets

Uncoupling Protein-2 Mediates DPP-4 Inhibitor-Induced Restoration of Endothelial Function in Hypertension Through Reducing Oxidative Stress

(2013) Limei Liu et al.   ANTIOXIDANTS & REDOX SIGNALING

Novel insights into pancreatic β-cell glucolipotoxicity from real-time functional analysis of mitochondrial energy metabolism in INS-1E insulinoma cells

(2013) Jonathan Barlow et al.   BIOCHEMICAL JOURNAL

NADPH oxidase inhibition prevents beta cell dysfunction induced by prolonged elevation of oleate in rodents

(2013) K. Koulajian et al.   DIABETOLOGIA

Berberine exerts nephroprotective effect against cisplatin-induced kidney damage through inhibition of oxidative/nitrosative stress, inflammation, autophagy and apoptosis

(2013) Robert Domitrović et al.   FOOD AND CHEMICAL TOXICOLOGY

AMPK modulates glucose-sensing in insulin-secreting cells by altered phosphotransfer to KATP channels

(2013) Craig Beall et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Glucose-Stimulated Oxidative Stress in Mononuclear Cells Is Related to Pancreatic β-Cell Dysfunction in Polycystic Ovary Syndrome

(2013) Steven K. Malin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Alteration of the intestinal barrier and GLP2 secretion in Berberine-treated type 2 diabetic rats

(2013) C Y Shan et al.   JOURNAL OF ENDOCRINOLOGY

Effect of Berberine Administration on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion

(2013) Karina G. Pérez-Rubio et al.   Metabolic Syndrome and Related Disorders

Berberine improves insulin resistance in cardiomyocytes via activation of 5′-adenosine monophosphate-activated protein kinase

(2013) Wenguang Chang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Bmal1 and  -Cell Clock Are Required for Adaptation to Circadian Disruption, and Their Loss of Function Leads to Oxidative Stress-Induced  -Cell Failure in Mice

(2013) J. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

Uric acid induces oxidative stress and growth inhibition by activating adenosine monophosphate-activated protein kinase and extracellular signal-regulated kinase signal pathways in pancreatic β cells

(2013) Yongneng Zhang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Berberine Ameliorate Oxidative Stress and Astrogliosis in the Hippocampus of STZ-Induced Diabetic Rats

(2013) Hamid Kalalian Moghaddam et al.   MOLECULAR NEUROBIOLOGY

Resveratrol Protects DAergic PC12 Cells from High Glucose-Induced Oxidative Stress and Apoptosis: Effect on p53 and GRP75 Localization

(2013) Justine Renaud et al.   NEUROTOXICITY RESEARCH

Boldine protects endothelial function in hyperglycemia-induced oxidative stress through an antioxidant mechanism

(2012) Yeh Siang Lau et al.   BIOCHEMICAL PHARMACOLOGY

Metabolomic analysis of pancreatic beta cells following exposure to high glucose

(2012) Martina Wallace et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The use of animal models in diabetes research

(2012) Aileen JF King   BRITISH JOURNAL OF PHARMACOLOGY

Uncoupling Protein-2 Protects Endothelial Function in Diet-Induced Obese Mice

(2012) Xiao Yu Tian et al.   CIRCULATION RESEARCH

NADPH Oxidase NOX2 Defines a New Antagonistic Role for Reactive Oxygen Species and cAMP/PKA in the Regulation of Insulin Secretion

(2012) N. Li et al.   DIABETES

Berberine inhibits mouse insulin gene promoter through activation of AMP activated protein kinase and may exert beneficial effect on pancreatic β-cell

(2012) Ning Shen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Impaired Expression of Uncoupling Protein 2 Causes Defective Postischemic Angiogenesis in Mice Deficient in AMP-Activated Protein Kinase α Subunits

(2011) Ming-Jiang Xu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

β-Cell Uncoupling Protein 2 Regulates Reactive Oxygen Species Production, Which Influences Both Insulin and Glucagon Secretion

(2011) Christine A. Robson-Doucette et al.   DIABETES

Activation of AMP-Activated Protein Kinase Is Required for Berberine-Induced Reduction of Atherosclerosis in Mice: The Role of Uncoupling Protein 2

(2011) Qilong Wang et al.   PLoS One

Effects and Action Mechanisms of Berberine and Rhizoma coptidis on Gut Microbes and Obesity in High-Fat Diet-Fed C57BL/6J Mice

(2011) Weidong Xie et al.   PLoS One

8,8-Dimethyldihydroberberine with improved bioavailability and oral efficacy on obese and diabetic mouse models

(2010) Zhe Cheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Guidelines for reporting experiments involving animals: the ARRIVE guidelines

(2010) JC McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

Reactive oxygen species and uncoupling protein 2 in pancreatic β-cell function

(2010) J. Pi et al.   DIABETES OBESITY & METABOLISM

Uncoupling protein-2 attenuates glucose-stimulated insulin secretion in INS-1E insulinoma cells by lowering mitochondrial reactive oxygen species

(2010) Charles Affourtit et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oral Intake of Rosiglitazone Promotes a Central Antihypertensive Effect Via Upregulation of Peroxisome Proliferator-Activated Receptor-γ and Alleviation of Oxidative Stress in Rostral Ventrolateral Medulla of Spontaneously Hypertensive Rats

(2010) Samuel H.H. Chan et al.   HYPERTENSION

Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity

(2009) Woo Sik Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Berberine suppresses proinflammatory responses through AMPK activation in macrophages

(2009) Hyun Woo Jeong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Modulation of glucagon-like peptide-1 release by berberine: In vivo and in vitro studies

(2009) Yunli Yu et al.   BIOCHEMICAL PHARMACOLOGY

Persistent Oxidative Stress Due to Absence of Uncoupling Protein 2 Associated with Impaired Pancreatic β-Cell Function

(2009) Jingbo Pi et al.   ENDOCRINOLOGY

Uncoupling protein 2 regulates reactive oxygen species formation in islets and influences susceptibility to diabetogenic action of streptozotocin

(2009) Simon C Lee et al.   JOURNAL OF ENDOCRINOLOGY

On the role of uncoupling protein-2 in pancreatic beta cells

(2008) Charles Affourtit et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Berberine Acutely Inhibits Insulin Secretion from β-Cells through 3′,5′-Cyclic Adenosine 5′-Monophosphate Signaling Pathway

(2008) Libin Zhou et al.   ENDOCRINOLOGY

Berberine promotes glucagon-like peptide-1 (7–36) amide secretion in streptozotocin-induced diabetic rats

(2008) Shou-Si Lu et al.   JOURNAL OF ENDOCRINOLOGY

The selective detection of mitochondrial superoxide by live cell imaging

(2008) Kristine M Robinson et al.   Nature Protocols

Uncoupling protein-2 contributes significantly to high mitochondrial proton leak in INS-1E insulinoma cells and attenuates glucose-stimulated insulin secretion

(2007) Charles Affourtit et al.   BIOCHEMICAL JOURNAL