Article
Physiology
Yan Pan, Shuo Sun, Xingxing Wang, Aidong Chen, Xuejie Fei, Wei Wang, Ying Han
Summary: Silencing salusin-beta in SHR rats was shown to improve endothelium-dependent relaxation and vascular remodeling, reduce arterial blood pressure and vasoconstriction, possibly by increasing eNOS activity and NO release.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Environmental Sciences
Hui Chen, Yongxiang Qin, Jiawei Pu, Jinxing Hu, Yuezhong Wen
Summary: This study investigated the toxicity of the chiral synthetic auxin herbicide DCPP to Arabidopsis, as well as the mutual regulation of NO, H2O2, O-2, and phytohormones at the enantiomeric level. The results revealed the important role of ROS in the enantioselective effect of DCPP and the potential redistribution of phytohormones between leaves and roots.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Chemistry, Multidisciplinary
Yuxuan Ma, Zhangwei Lu, Bin Jia, Ye Shi, Jun Dong, Shuoxing Jiang, Zhe Li
Summary: This study introduces a targeted treatment for rheumatoid arthritis (RA) using folic acid-modified triangular DNA origami nanostructures (FA-tDONs). The FA-tDONs can efficiently scavenge reactive oxygen species (ROS) and nitric oxide (NO), leading to the transition of pro-inflammatory macrophages to an anti-inflammatory phenotype. In an RA mouse model, FA-tDONs treatment effectively alleviates synovial inflammation and cartilage damage, attenuating disease progression.
Article
Plant Sciences
Yu-Ying Sun, Jia-Qi Wang, Ru-Hua Xiang, Zhong-Guang Li
Summary: This study found that nitric oxide (NO) can enhance thermotolerance in maize seedlings by triggering the LCD/H2S signaling pathway. Additionally, NO also improves the adaptability of maize seedlings to heat stress by regulating the activity of the ROS scavenging system.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Chemistry, Medicinal
Xuanxuan Liu, Xingxing Wang, Yan Pan, Li Zhao, Shuo Sun, Ang Luo, Changlei Bao, Haiyang Tang, Ying Han
Summary: Artemisinin treatment has beneficial effects on endothelium-dependent vascular relaxation in SHRs, improving hypertension by regulating eNOS activity and NO release. It can also decrease heart rate and basal vascular tension.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Kangmin Yang, Srividya Velagapudi, Alexander Akhmedov, Simon Kraler, Tetiana Lapikova-Bryhinska, Martin O. Schmiady, Xiaoping Wu, Leiluo Geng, Giovanni G. Camici, Aimin Xu, Thomas F. Luscher
Summary: This study aimed to investigate the therapeutic potential of chronic recombinant murine SIRT1 (rmSIRT1) supplementation to alleviate endothelial and vascular dysfunction in diabetic mice. The results showed that arterial SIRT1 levels were significantly reduced in diabetic conditions, while rmSIRT1 supplementation restored SIRT1 levels and improved endothelial function and vascular compliance. The study suggests that SIRT1 supplementation may represent a novel therapeutic strategy to prevent and treat diabetic vascular disease by enhancing eNOS activity and suppressing NOX-related oxidative stress.
CARDIOVASCULAR RESEARCH
(2023)
Article
Plant Sciences
Indrani Manna, Saikat Sahoo, Maumita Bandyopadhyay
Summary: Researchers have found that nickel oxide nanoparticles affect the exposed roots of Allium cepa by disrupting cell membranes and being internalized within cell organelles, leading to disturbances in cellular homeostasis and survival. This external intervention causes changes in the cellular environment, reflected in crucial biochemical profiles.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Wenrui Dai, Shao Zhang, Huan Shang, Shuning Xiao, Zhangliu Tian, Wenbo Fan, Xiaolang Chen, Shike Wang, Wei Chen, Dieqing Zhang
Summary: Semiconductor photocatalytic technology has the potential to efficiently reduce low concentrations of gaseous nitric oxide (NO), but the suboptimal selectivity in NO removal is a challenge. In this study, a defective CdS/Na2Ti3O7 heterostructure is designed to promote charge transfer kinetics and refine reactive oxygen species (ROS) generation, leading to high selectivity and catalytic activity in NO removal.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Plant Sciences
Cheng Zhang, Zhiqiang Song, Pinyuan Jin, Xiuhong Zhou, Huajian Zhang
Summary: Xylooligosaccharides (XOS), major byproducts of biofuel production, can trigger stomatal closure in Arabidopsis by inducing the production of ROS and NO, mediated by salicylic acid signaling and independent of ABA signaling.
PHYSIOLOGIA PLANTARUM
(2021)
Article
Chemistry, Multidisciplinary
Dongzhi Xue, Yue Cao, Yinghui Wang, Zhijia Lv, Longhai Jin, Songtao Zhang, Wanying Li, Junduo Wu, Jianhua Liu, Shuyan Song, Xiaogang Liu, Hongjie Zhang
Summary: A novel theranostic nanoagent GLIF based on Gd2(WO4)3:Nd3+ nanoparticles loaded with ploy-L-arginine (PLA), indocyanine green (ICG), and lactoferrin (LF) has been developed for efficient low-dose drug therapy and imaging diagnosis of glioblastoma. GLIF showed significant therapeutic effect and diagnostic performance in vitro and in vivo.
Review
Plant Sciences
Dandan Huang, Guangqin Jing, Lili Zhang, Changbao Chen, Shuhua Zhu
Summary: NO, H2S, and ROS play essential signaling roles in cells through oxidative post-translational modification within suitable ranges of concentration to maintain redox balance and regulate DNA repair pathways, including mtDNA. The interactions among them are intricate, influencing their generation, elimination, and signaling actions. Additionally, NO and H2S may be involved in epigenetic variations in DNA damage repair of plants.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Ji-Hye Lee, Hiroshi Uyama, Oh-Kyoung Kwon, Young-Jin Kim
Summary: The study explores the integration of multi-modal therapies using a PLIN monolith to enhance PTT efficacy in treating osteosarcomas and regenerating bone defects. The PLIN monolith exhibits enhanced photothermal activity on osteosarcomas without causing phototoxicity in normal osteoblasts, and induces significant apoptotic cell death in cancer cells.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Martina Janku, Tereza Jedelska, Lucie Cincalova, Antonin Sedlar, Jaromir Mikulik, Lenka Luhova, Jan Lochman, Marek Petrivalsky
Summary: Elicitins are proteinaceous elicitors that enhance plant defense by inducing hypersensitive response and resistance to phytopathogens. They trigger a variety of responses through recognition by membrane receptors or high-affinity sites, including production of reactive oxygen species and nitric oxide. Different types of elicitins have varying abilities to induce cell death, ROS and phytohormones. Specific lysine and valine residues play key roles in their biological activity and enhancement of necrotic effects.
Article
Environmental Sciences
Ravi Gautam, JiHun Jo, Manju Acharya, Anju Maharjan, DaEun Lee, K. C. Pramod Bahadur, ChangYul Kim, KilSoo Kim, HyoungAh Kim, Yong Heo
Summary: Polyethylene microplastics (PE-MPs) have different effects on human cells, depending on the size of the microplastics, cell type, and tissue. PE-MPs can induce intracellular oxidative stress and inflammatory response, but the effects vary among different cell lines.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Cell Biology
Hang Xing, Zhiqi Zhang, Guangbin Shi, Yixin He, Yi Song, Yuhong Liu, Elizabeth O. Harrington, Frank W. Sellke, Jun Feng
Summary: Diabetes is associated with coronary endothelial dysfunction, which can be partly attributed to persistent oxidative stress and mitochondrial generation of reactive oxygen species. Inhibition of small-conductance Ca2+-activated K+ channels in diabetes contributes to the downregulation of endothelial function. Chronic administration of the mitochondria-targeted antioxidant mito-Tempo shows promising results in improving coronary endothelial function and SK channel activity in diabetic mice, suggesting that targeting mROS may be a novel strategy for treating vascular complications in diabetes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Mingyu Huo, Xiaoyun Cao, Hongsong Zhang, Chi Wai Lau, Huiling Hong, Francis M. Chen, Yu Huang, Ajay Chawla, Xiao Yu Tian
Summary: This study aims to investigate the contribution of BMAL1 to the pro-fibrotic macrophage phenotype in the vasculature during hypertension.
CARDIOVASCULAR RESEARCH
(2022)
Article
Multidisciplinary Sciences
Chak Kwong Cheng, Xiao Lin, Yujie Pu, Joyce Ka Yu Tse, Yu Wang, Cheng-Lin Zhang, Xiaoyun Cao, Chi Wai Lau, Juan Huang, Lei He, Jiang-Yun Luo, Yu-Tsung Shih, Song Wan, Chi Fai Ng, Li Wang, Ronald Ching Wan, Jeng-Jiann Chiu, Ting Fung Chan, Xiao Yu Tian, Yu Huang
Summary: This study utilized single-cell RNA sequencing to explore the transcriptional landscape and heterogeneity of dysfunctional endothelial cells in atherosclerotic aortae. SOX4 was identified as a novel marker for atherosclerosis and was shown to promote atherogenesis and endothelial-to-mesenchymal transition. Hyperlipidemia-associated cytokines and oscillatory blood flow were found to upregulate SOX4 expression, while the anti-diabetic drug metformin suppressed SOX4 levels in endothelial cells.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Li Wang, Chak Kwong Cheng, Min Yi, Kathy O. Lui, Yu Huang
Summary: Vascular endothelium plays a crucial role in maintaining vascular homeostasis and regulating vascular function through the release of vasoactive molecules. Imbalance between relaxing and contracting factors derived from the endothelium leads to endothelial dysfunction, which is a critical contributor in aging and chronic cardiometabolic disorders. Oxidative stress and inflammation are key players in endothelial dysfunction and are considered as potential targets for intervention in patients with cardiovascular and metabolic diseases.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qiangqiang Li, Rongliang Wang, Zhe Zhang, Haixing Wang, Xiaomin Lu, Jiajun Zhang, Alice Pik-Shan Kong, Xiao Yu Tian, Hon-Fai Chan, Arthur Chi-Kong Chung, Jack Chun-Yiu Cheng, Qing Jiang, Wayne Yuk-Wai Lee
Summary: Exercise in later life is important for bone health, but the effectiveness may be impaired due to the degeneration of osteocyte activity and lacunocanalicular networks. In this study, it was found that the deletion of Sirt3 in osteocytes could impair the formation of dendritic processes and inhibit bone gain in response to exercise. Mechanistic studies revealed that Sirt3 regulates E11/gp38 through the PKA/CREB signaling pathway. Additionally, the Sirt3 activator honokiol enhanced osteocyte sensitivity and reduced bone loss in aged mice.
CELL DEATH AND DIFFERENTIATION
(2023)
Review
Pharmacology & Pharmacy
Pooi-Fong Wong, Murugan Dharmani, Thamil Selvee Ramasamy
Summary: This review discusses the role of senotherapeutics in MSC senescence, rejuvenation, and transplantation, with examples of some tested compounds in vitro. Senotherapeutics target cellular senescence through senolytic and senomorphic functions to induce apoptosis and suppress chronic inflammation caused by the senescence-associated secreted phenotype (SASP). They could delay aging-associated degeneration and be used to eliminate senescent MSCs during in vitro expansion or bioprocessing for transplantation. The prospects, challenges, and the way forward in clinical applications of senotherapeutics in cell-based therapeutics are also discussed.
DRUG DISCOVERY TODAY
(2023)
Article
Pharmacology & Pharmacy
Huanyu Ding, Minchun Jiang, Chi Wai Lau, Jianfang Luo, Andrew M. M. Chan, Li Wang, Yu Huang
Summary: YAP inhibition by CBL0137 is a promising therapeutic approach for atherosclerotic vascular disease.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Sport Sciences
Xiaoyuan Zhang, Xiao Yu Tian, Masashi Miyashita, Fenghua Sun, Wendy Y. J. Huang, Chen Zheng, Man Kuk Sum, Stephen H. S. Wong
Summary: The study aimed to investigate the effects of individualized accumulated or continuous exercise on postprandial glucose (PPG) control in young adults with obesity. The results showed that both continuous and accumulated exercise reduced PPG, insulin, and C-peptide concentrations, and improved glucose fluctuations. Accumulated exercise maintained lower PPG concentrations for a longer time than continuous exercise in young adults with obesity.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Siti Sarah M. Sofiullah, Dharmani Devi Murugan, Suhaila Abd Muid, Wu Yuan Seng, Sharifah Zamiah Syed Abdul Kadir, Razif Abas, Nurul Raudzah Adib Ridzuan, Nor Hisam Zamakshshari, Choy Ker Woon
Summary: Cardiovascular disease (CVD) is the leading cause of death worldwide. NADPH oxidase (NOX)-derived reactive oxygen species (ROS) production contributes to the development of CVD. Treatment options mainly rely on drugs, but alternatives with lesser adverse effects are needed. Natural products, due to their medicinal properties including antioxidants, have gained interest as complementary therapy for CVD. This review focuses on the potential of natural products targeting NOX-derived ROS generation in treating CVD.
Article
Genetics & Heredity
Qian He, Kevin Chun Hei Wu, Adam N. Bennett, Beifang Fan, Jundong Liu, Ruixuan Huang, Alice P. S. Kong, Xiaoyu Tian, Man Ki Maggie Kwok, Kei Hang Katie Chan
Summary: This study used a two-sample Mendelian randomisation approach to investigate the relationship between genetic variants and expression or DNA methylation of NSAID target genes. The results revealed that lower expression and DNA methylation of NEU1 in blood were associated with lower CRP levels and decreased risk of MDD. The findings suggest the potential role of NEU1 inhibitors or supplements in the treatment of MDD.
PHARMACOGENOMICS JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Chak Kwong Cheng, Huanyu Ding, Minchun Jiang, Huiyong Yin, Maik Gollasch, Yu Huang
Summary: Perivascular adipose tissue (PVAT) refers to the aggregate of adipose tissue surrounding the vasculature, exhibiting the phenotypes of white, beige and brown adipocytes. PVAT is actively involved in the regulation of reactive oxygen species (ROS) homeostasis and inflammation in the vascular system. The phenotype-genotype of PVAT varies in different regions of the vasculature and plays a role in cardiovascular pathogenesis. Treatments targeting PVAT may provide new therapeutic insights for cardiovascular diseases.
Article
Multidisciplinary Sciences
Chenguang Wang, Yalan Wu, Yangxian Li, Yang Zhang, Yee Lok Fung, Ka Kui Tong, Chi Wai Lau, Li Xiang, Kin Ming Kwan, Li-Ru You, Yu Huang, Xiao Yu
Summary: The study reveals that endothelial Smad4 plays a role in the beiging of white adipose tissue through angiogenesis and the expansion of adipose precursors. Knocking out Smad4 leads to attenuated angiogenesis and proliferation of adipogenic precursors. Furthermore, Smad4 is found to be involved in angiogenesis-related pathways in human endothelial cells.
Article
Cell Biology
Huixian Li, Chufeng He, Ruiwen Zhu, Francis M. Chen, Lin Wang, Fung Ping Leung, Xiao Yu Tian, Gary Tse, Wing Tak Wong
Summary: This study reveals that interleukin-4 (IL-4) and interleukin-13 (IL-13) play a critical role in post-ischemic angiogenesis. Deficiency of IL-4/IL-13 leads to impaired reperfusion and muscle repair in ischemic muscles. Mechanistically, IL-4/IL-13 promote endothelial cell proliferation, migration, and tube formation through the IL-4Ra/STAT6 signaling pathway. Additionally, decreased expression of IL-4/IL-13 is associated with angiogenesis deficit in diabetic peripheral arterial disease (PAD), while IL-4/IL-13 treatment can rescue this defective regeneration.
Article
Tropical Medicine
Yucinda Y. Y. Khor, Siew-Keah Lee, M. Dharmani Devi, Wei Chih Ling
Summary: The effect of EGCG on endothelial dysfunction in SHR was investigated. SHR were divided into four groups: WKY control, SHR control, SHR treated with EGCG, and SHR treated with losartan. The blood pressure was monitored every 3 days and endothelium-dependent relaxation was assessed at the end of treatment. The levels of reactive oxygen species, nitric oxide, tetrahydrobiopterin, cyclic guanosine monophosphate, and AT1 receptor protein were measured.
ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE
(2023)
Article
Sport Sciences
Chen Zheng, Jason M. R. Gill, Feng Hua Sun, Wendy Yajun Huang, Sinead Sheridan, Xiang-Ke Chen, Yalan Wu, Chun-Kwok Wong, Xiao Yu Tian, Stephen Heung-Sang Wong
Summary: Increasing daily physical activity is an effective way to reduce the risk of cardiometabolic diseases. This study compared the effects of increasing light physical activity (LPA) and moderate-to-vigorous physical activity (MVPA) on cardiometabolic markers in Chinese adults with obesity. The results showed that MVPA had more positive effects on body composition and cardiometabolic biomarkers compared to LPA.
JOURNAL OF SPORTS SCIENCES
(2023)
Meeting Abstract
Pharmacology & Pharmacy
Satirah Zainalabidin, Nurellya Faqhiraah Aziz, Dharmani Devi Murugan, Mohd Kaisan Mahadi
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Paola Orlandi, Marta Banchi, Francesca Vaglini, Marco Carli, Stefano Aringhieri, Arianna Bandini, Carla Pardini, Cristina Viaggi, Michele Lai, Greta Ali, Alessandra Ottani, Eleonora Vandini, Patrizia Guidi, Margherita Bernardeschi, Veronica La Rocca, Giulio Francia, Gabriella Fontanini, Mauro Pistello, Giada Frenzilli, Daniela Giuliani, Marco Scarselli, Guido Bocci
Summary: This study investigates the role of MC4R in melanoma and the use of the selective antagonist ML in combination with vemurafenib. The results show that ML can inhibit melanoma cell proliferation and induce apoptosis through the inhibition of ERK1/2 phosphorylation and reduction of BCL-XL expression. The combination of vemurafenib and ML exhibits a synergistic effect in vitro and inhibits tumor growth in vivo without causing adverse effects.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Conor J. Bloxham, Katina D. Hulme, Fabrizio Fierro, Christian Fercher, Cassandra L. Pegg, Shannon L. O'Brien, Simon R. Foster, Kirsty R. Short, Sebastian G. B. Furness, Melissa E. Reichelt, Masha Y. Niv, Walter G. Thomas
Summary: Bitter taste receptors (T2Rs) are a type of G protein-coupled receptors that allow humans to detect aversive and toxic substances. This study characterized the functional properties of previously identified T2Rs in human cardiac tissues and their naturally occurring polymorphisms. The results showed differences in signaling among different T2R variants, and revealed a potential association between the T2R50 Tyr203 variant and cardiovascular disease.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Lu Chen, Huanying Shi, Wenxin Zhang, Yongjun Zhu, Haifei Chen, Zimei Wu, Huijie Qi, Jiafeng Liu, Mingkang Zhong, Xiaojin Shi, Tianxiao Wang, Qunyi Li
Summary: This study demonstrates that Carfilzomib exhibits potent anti-tumor activity against esophageal squamous cell carcinoma (ESCC) by triggering mitochondrial apoptosis and reprogramming cellular metabolism. It has been identified that activating transcription factor 3 (ATF3) plays a crucial role as a cellular target in ESCC cells treated with Carfilzomib. Overexpression of ATF3 effectively counteracts the effects of Carfilzomib on ESCC cell proliferation, apoptosis, and metabolic reprogramming. Furthermore, ATF3 mediates the anti-tumor activity of Carfilzomib, suggesting its potential as a therapeutic agent for ESCC.
BIOCHEMICAL PHARMACOLOGY
(2024)
Review
Pharmacology & Pharmacy
Xing Zhang, Xiang Li, Ran Xia, Hong-Sheng Zhang
Summary: This review summarizes recent progress on the mechanisms of ferroptosis resistance in cancer and highlights the role of redox status and metabolism. Combination therapy for ferroptosis has great potential in treating resistant malignant tumors.
BIOCHEMICAL PHARMACOLOGY
(2024)