Review
Neurosciences
Richard Fairless, Hilmar Bading, Ricarda Diem
Summary: Glutamate signalling plays a crucial role in neuroinflammatory diseases, influencing neurodegeneration as well as regulating blood vessels, immune cells, and glial cells. Efforts are being made to utilize the growing understanding of these processes in the development of neuroprotective strategies.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Mateo Rodriguez-Giraldo, Rodrigo E. Gonzalez-Reyes, Sofia Ramirez-Guerrero, Carlos E. Bonilla-Trilleras, Santiago Guardo-Maya, Mauricio O. Nava-Mesa
Summary: Astrocytes play a key role in Alzheimer's disease, with both neuroprotective and neurotoxic effects depending on the disease stage and microenvironmental factors. Therapies targeting astrocytes may be beneficial in preventing or delaying disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ahsas Goyal, Kunal Solanki, Aanchal Verma
Summary: Neurodegenerative disorders are a group of diseases characterized by the slow loss of sensitive neurons. Despite extensive research, no cure exists for these conditions. However, natural substances such as flavonoids, particularly luteolin, have shown promising potential as therapeutic options. Luteolin possesses antioxidant and anti-inflammatory properties, making it a possible treatment for neurodegenerative diseases like Alzheimer's and Parkinson's.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Kamila Kopec, Stanislaw Szleszkowski, Dariusz Koziorowski, Stanislaw Szlufik
Summary: Neurodegenerative diseases are complex and not fully understood. Insufficiency of the glymphatic system and mitochondrial disorders play roles in the development of pathology. These factors interact and drive each other, potentially leading to protein accumulation, impaired glymphatic clearance, and sleep disorders. Clarifying the connection between the glymphatic system and mitochondria in relation to neurodegeneration could lead to new multidirectional therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Danail Minchev, Maria Kazakova, Victoria Sarafian
Summary: Parkinson's disease is a neurodegenerative disorder characterized by neuronal degeneration and the accumulation of alpha-Synuclein aggregates. Neuroinflammation and autophagy are crucial processes implicated in the development of Parkinson's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Priya Durai, Narasimha M. Beeraka, Hemanth Vikram Poola Ramachandrappa, Prakash Krishnan, Pranesh Gudur, Nulgumnalli Manjunathaiah Raghavendra, Prashantha Kumar Bommenahally Ravanappa
Summary: The activity of PPARs is important for the development of therapeutic methods against neurodegenerative diseases. However, more studies are needed to understand the role of PPARs in brain physiology and other neurodegenerative diseases. PPAR signaling can modulate cell signaling mechanisms and have both therapeutic and adverse effects. Natural and synthetic ligands for PPARs have been reported, and PPAR alpha and PPAR gamma agonists have shown neuroprotective effects through modulating mitochondrial dynamics. These agonists may be effective in protecting vulnerable neurons from A beta toxicity in Alzheimer's disease.
CURRENT NEUROPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Juliet Olayinka, Anthony Eduviere, Olusegun Adeoluwa, Adedamola Fafure, Adeshina Adebanjo, Raymond Ozolua
Summary: Quercetin has significant effects against memory impairment induced by scopolamine, attenuating increases in pro-inflammatory mediators and reversing neurodegeneration to restore memory function.
Article
Biochemistry & Molecular Biology
Frederic Brosseron, Kilian Kleemann, Carl-Christian Kolbe, Francesco Santarelli, Sergio Castro-Gomez, Pawel Tacik, Eicke Latz, Frank Jessen, Michael T. Heneka
Summary: Studies have shown a close correlation between a set of inflammatory markers and levels of tau or neurofilament, suggesting an inflammatory response to neuronal damage. These markers could be important in diagnosing AD.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Food Science & Technology
Yen-Chun Koh, Dickson Chok, Chun-Han Chang, Chia-Cheng Wei, Chia-Tung Wu, Ko-Chun Cheng, Kalyanam Nagabhushanam, Chi-Tang Ho, Min-Hsiung Pan
Summary: This study aims to evaluate the preventive effect of piceatannol on glutamate-induced neurodegeneration via mitochondrial rescue. The results show that piceatannol can prevent glutamate-induced apoptosis, reduce mitochondrial reactive oxygen species accumulation, promote mitochondrial biogenesis, and preserve mitochondrial functionality. Piceatannol effectively protects dopaminergic neurons from degradation and preserves their controlled responses.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Review
Cell Biology
Jaclyn Iannucci, Paula Grammas
Summary: Neurodegenerative diseases, including Alzheimer's disease, are major causes of death and disability worldwide. Neuroinflammation is a critical factor in these diseases, and exploring the role of thrombin in neuroinflammation can provide insights into other neurodegenerative diseases. Elevated levels of thrombin are found in conditions that increase Alzheimer's disease risk, and it drives neuroinflammation through activation of microglia, astrocytes, and endothelial cells. Inhibiting thrombin could be an effective therapeutic strategy for interrupting the inflammatory cascade and treating neurodegenerative diseases.
Review
Neurosciences
Rosalia Fernandez-Calle, Sabine C. Konings, Javier Frontinan-Rubio, Juan Garcia-Revilla, Lluis Camprubi-Ferrer, Martina Svensson, Isak Martinson, Antonio Boza-Serrano, Jose Luis Venero, Henrietta M. Nielsen, Gunnar K. Gouras, Tomas Deierborg
Summary: This article reviews the impact of the APOE genotype on late-onset Alzheimer's disease and central nervous system pathology, covering various factors influencing disease development, such as neuroinflammation, cell function, synaptic function, etc.
MOLECULAR NEURODEGENERATION
(2022)
Review
Biochemistry & Molecular Biology
Madiha Rasheed, Junhan Liang, Chaolei Wang, Yulin Deng, Zixuan Chen
Summary: Neuroinflammation plays a significant role in the initiation and progression of Parkinson's disease, activating the neuronal immune system and triggering a vicious cycle of inflammation-induced dopaminergic neuron damage. Epigenetic mechanisms are at the forefront of regulating neuroinflammatory factors, offering potential for breaking this cycle. These mechanisms do not work independently but cooperatively, impacting various neuroinflammatory pathways and potentially influencing PD development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Anna Hau-Yee Kong, Aston Jiaxi Wu, Olivia Ka-Yi Ho, Maggie Ming-Ki Leung, Alexis Shiying Huang, Yuanyuan Yu, Ge Zhang, Aiping Lyu, Min Li, King-Ho Cheung
Summary: Neuroinflammation is a precursor to neurodegenerative diseases, and targeting it with aptamers offers potential diagnostic and therapeutic applications. This review summarizes the use of aptamers for diagnosing and treating inflammatory biomolecules and cells associated with neurodegenerative diseases. It also discusses the potential of short nucleotides for targeted brain delivery and the challenges of using aptamers as therapeutic agents. Overall, this review assesses the potential of aptamers as a pioneering approach for CNS target delivery and the treatment of neuroinflammation and neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Arash Heidari, Niloufar Yazdanpanah, Nima Rezaei
Summary: Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the loss of dopaminergic neurons and aggregation of alpha-synuclein. Recent studies suggest that neuroinflammation may contribute to the loss of dopaminergic neurons in PD.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Clinical Neurology
Kevin Connolly, Mikael Lehoux, Ryan O'Rourke, Benedetta Assetta, Guzide Ayse Erdemir, Jack A. Elias, Chun Geun Lee, Yu-Wen Alvin Huang
Summary: CHI3L1 is a biomarker for early detection of neuroinflammation and disease diagnosis of AD. It is primarily provided by astrocytes in the brain and may play a crucial role in neuroinflammation and neurodegenerative diseases. In peripheral tissues, it is also a master regulator for injury and repair events.
ALZHEIMERS & DEMENTIA
(2023)