The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism

Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors

(2011) Mithun R. Raje et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Sphingosine Kinase Inhibitors and Cancer: Seeking the Golden Sword of Hercules

(2011) S. Pyne et al.   CANCER RESEARCH

(R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells

(2011) Keng Gat Lim et al.   CELLULAR SIGNALLING

FTY720 Analogues as Sphingosine Kinase 1 Inhibitors

(2011) Keng G. Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ablation of Sphingosine Kinase-2 Inhibits Tumor Cell Proliferation and Migration

(2011) P. Gao et al.   MOLECULAR CANCER RESEARCH

Defining a role for sphingosine kinase 1 in p53-dependent tumors

(2011) L A Heffernan-Stroud et al.   ONCOGENE

The curcumin analog ca27 down-regulates androgen receptor through an oxidative stress mediated mechanism in human prostate cancer cells

(2011) Alexandra M. Fajardo et al.   PROSTATE

High Expression of Sphingosine 1-Phosphate Receptors, S1P1 and S1P3, Sphingosine Kinase 1, and Extracellular Signal-Regulated Kinase-1/2 Is Associated with Development of Tamoxifen Resistance in Estrogen Receptor-Positive Breast Cancer Patients

(2010) Carol Watson et al.   AMERICAN JOURNAL OF PATHOLOGY

Loss of sphingosine kinase-1 in carcinoma cells increases formation of reactive oxygen species and sensitivity to doxorubicin-induced DNA damage

(2010) Andrea Huwiler et al.   BRITISH JOURNAL OF PHARMACOLOGY

FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells

(2010) Francesca Tonelli et al.   CELLULAR SIGNALLING

A critical role for the protein phosphatase 2A B′α regulatory subunit in dephosphorylation of sphingosine kinase 1

(2010) Melissa R. Pitman et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Sphingosine Kinase 1 Inhibitor 2-(p-Hydroxyanilino)-4-(p-chlorophenyl)thiazole Induces Proteasomal Degradation of Sphingosine Kinase 1 in Mammalian Cells

(2010) Carolyn Loveridge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of caspase-2 in stress-induced apoptosis

(2010) Lisa Bouchier-Hayes   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Pharmacology and Antitumor Activity of ABC294640, a Selective Inhibitor of Sphingosine Kinase-2

(2010) K. J. French et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Sphingosine Kinase 1 Induces Tolerance to Human Epidermal Growth Factor Receptor 2 and Prevents Formation of a Migratory Phenotype in Response to Sphingosine 1-Phosphate in Estrogen Receptor-Positive Breast Cancer Cells

(2010) J. S. Long et al.   MOLECULAR AND CELLULAR BIOLOGY

Guanine nucleotides regulate sphingosine kinase 1 activation by eukaryotic elongation factor 1A and provide a mechanism for eEF1A-associated oncogenesis

(2010) T M Leclercq et al.   ONCOGENE

Targeting Sphingosine Kinase 1 Inhibits Akt Signaling, Induces Apoptosis, and Suppresses Growth of Human Glioblastoma Cells and Xenografts

(2009) D. Kapitonov et al.   CANCER RESEARCH

Chiral Vinylphosphonate and Phosphonate Analogues of the Immunosuppressive Agent FTY720

(2009) Xuequan Lu et al.   JOURNAL OF ORGANIC CHEMISTRY

Sphingosine Kinase-1 Is Central to Androgen-Regulated Prostate Cancer Growth and Survival

(2009) Audrey Dayon et al.   PLoS One

A tumor suppressor role for PP2A-B56α through negative regulation of c-Myc and other key oncoproteins

(2008) Hugh K. Arnold et al.   CANCER AND METASTASIS REVIEWS

Clinical Significance of Sphingosine Kinase-1 Expression in Human Astrocytomas Progression and Overall Patient Survival

(2008) J. Li et al.   CLINICAL CANCER RESEARCH

Deactivation of Sphingosine Kinase 1 by Protein Phosphatase 2A

(2008) Renae K. Barr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models

(2008) D. Pchejetski et al.   MOLECULAR CANCER THERAPEUTICS

"Inside-Out" Signaling of Sphingosine-1-Phosphate: Therapeutic Targets

(2008) K. Takabe et al.   PHARMACOLOGICAL REVIEWS