期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 74, 期 8, 页码 3192-3195出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo900023u
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资金
- NCI NIH HHS [CA92160, R01 CA092160, R01 CA092160-08] Funding Source: Medline
- NHLBI NIH HHS [R24 HL083187, HL083187, R24 HL083187-04] Funding Source: Medline
The first enantioselective synthesis of chiral isosteric phosphonate analogues of FTY720 is described. One of these analogues, FTY720-(E)-vinylphosphonate (S)-5, but not its R enantiomer, elicited a potent antiapoptotic effect in intestinal epithelial cells, suggesting that it exerts its action via the enantioselective activation of a receptor. (S)-5 failed to activate the sphingosine 1-phosphate type 1 (S1P(1)) receptor.
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