Chymase inhibition as a pharmacological target: a role in inflammatory and functional gastrointestinal disorders?

Targets of chymase inhibitors

(2011) Shinji Takai et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Pharmacokinetic/pharmacodynamic analyses of chymase inhibitor SUN13834 in NC/Nga mice and prediction of effective dosage for atopic dermatitis patients

(2011) Atsuto Ogata et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Potency variation of small-molecule chymase inhibitors across species

(2010) Jukka Kervinen et al.   BIOCHEMICAL PHARMACOLOGY

Mast cell proteases: multifaceted regulators of inflammatory disease

(2010) G. Pejler et al.   BLOOD

Mast cell chymase inhibition reduces atherosclerotic plaque progression and improves plaque stability in ApoE−/− mice

(2010) Ilze Bot et al.   CARDIOVASCULAR RESEARCH

Subjects with Diarrhea-Predominant IBS Have Increased Rectal Permeability Responsive to Tryptase

(2010) Jae Woong Lee et al.   DIGESTIVE DISEASES AND SCIENCES

Chymase inhibition attenuates tetrachloride-induced liver fibrosis in hamsters

(2010) Koji Komeda et al.   HEPATOLOGY RESEARCH

Mouse Mast Cell Protease-4 Deteriorates Renal Function by Contributing to Inflammation and Fibrosis in Immune Complex-Mediated Glomerulonephritis

(2010) L. Scandiuzzi et al.   JOURNAL OF IMMUNOLOGY

New Approaches to Blockade of the Renin–Angiotensin–Aldosterone System: Chymase as an Important Target to Prevent Organ Damage

(2010) Shinji Takai et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Dual Inhibition of Cathepsin G and Chymase Is Effective in Animal Models of Pulmonary Inflammation

(2009) Bruce E. Maryanoff et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Chymase activity is closely related with plaque vulnerability in a hamster model of atherosclerosis

(2009) Tao Guo et al.   ATHEROSCLEROSIS

TGF-β and fibrosis in different organs — molecular pathway imprints

(2009) Dirk Pohlers et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Emerging drugs for atopic dermatitis

(2009) Peck Y Ong   EXPERT OPINION ON EMERGING DRUGS

A distinct subset of submucosal mast cells undergoes hyperplasia following neonatal maternal separation: a role in visceral hypersensitivity?

(2009) N P Hyland et al.   GUT

 2-Macroglobulin Capture Allows Detection of Mast Cell Chymase in Serum and Creates a Reservoir of Angiotensin II-Generating Activity

(2009) W. W. Raymond et al.   JOURNAL OF IMMUNOLOGY

Mouse Mast Cell Protease 4 Is the Major Chymase in Murine Airways and Has a Protective Role in Allergic Airway Inflammation

(2009) I. Waern et al.   JOURNAL OF IMMUNOLOGY

Chymase Inhibition Provides Pancreatic Islet Protection in Hamsters With Streptozotocin-Induced Diabetes

(2009) Shinji Takai et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Significance of Chymase-Dependent Matrix Metalloproteinase-9 Activation on Indomethacin-Induced Small Intestinal Damages in Rats

(2009) K. Kakimoto et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Inflammatory Bowel Disease

(2009) Clara Abraham et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mast cells regulate homeostatic intestinal epithelial migration and barrier function by a chymase/Mcpt4-dependent mechanism

(2009) Katherine R. Groschwitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cleaved SLPI, a novel biomarker of chymase activity

(2008) Stanley M. Belkowski et al.   BIOLOGICAL CHEMISTRY

Therapeutic potential of non-peptide chymase inhibitors

(2008) Sheila A Doggrell   EXPERT OPINION ON THERAPEUTIC PATENTS

Mast cell chymase contributes to the antibody response and the severity of autoimmune arthritis

(2008) Sofia E. Magnusson et al.   FASEB JOURNAL

Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators

(2008) T Piche et al.   GUT

Long-term alterations of colonic nerve-mast cell interactions induced by neonatal maternal deprivation in rats

(2008) F. Barreau et al.   GUT

The extended substrate specificity of the human mast cell chymase reveals a serine protease with well-defined substrate recognition profile

(2008) M. K. Andersson et al.   INTERNATIONAL IMMUNOLOGY

The extended cleavage specificity of the rodent β-chymases rMCP-1 and mMCP-4 reveal major functional similarities to the human mast cell chymase

(2007) Mattias K. Andersson et al.   MOLECULAR IMMUNOLOGY