Review
Biochemistry & Molecular Biology
Verena Moosbrugger-Martinz, Corinne Leprince, Marie-Claire Mechin, Michel Simon, Stefan Blunder, Robert Gruber, Sandrine Dubrac
Summary: The discovery of loss-of-function mutations in the filaggrin gene has shed new light on the understanding of skin conditions such as ichthyosis vulgaris and atopic dermatitis. However, there is still much to learn about how filaggrin deficiency contributes to atopic dermatitis and the factors that lead to reduced filaggrin levels. This review re-evaluates the roles of filaggrin in the epidermis and atopic dermatitis, providing insights into its importance for keratinocyte alignment, maintenance of epidermal texture, and cellular abnormalities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chunying Xiao, Zhongbin Sun, Jixin Gao, Yaxing Bai, Chen Zhang, Bingyu Pang, Hongjiang Qiao, Meng Fu, Erle Dang, Gang Wang
Summary: This study demonstrated the critical role of skin barrier protein FLG in the pathogenesis of atopic dermatitis, with CPT-induced dermatitis being more severe in Flg(-/-) mice compared to wild-type mice. Additionally, emollients MPS and ceramide partially restored epidermal function and alleviated skin inflammation in the Flg(-/-) mouse model of AD induced by CPT.
Article
Medicine, General & Internal
Annalisa Astolfi, Francesca Cipriani, Daria Messelodi, Matilde De Luca, Valentina Indio, Costanza Di Chiara, Arianna Giannetti, Lorenza Ricci, Iria Neri, Annalisa Patrizi, Giampaolo Ricci, Andrea Pession
Summary: This study revealed that children with atopic dermatitis carrying FLG mutations are at higher risk of developing severe food allergies, such as anaphylaxis. Peanut and hazelnut were identified as high-risk foods for patients with FLG mutations.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Petra Pavel, Stefan Blunder, Verena Moosbrugger-Martinz, Peter M. Elias, Sandrine Dubrac
Summary: Atopic dermatitis is a chronic inflammatory skin disease influenced by both genetic and environmental factors. Alterations of the epidermal barrier and lipid abnormalities play crucial roles in the development and inflammation of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Allergy
Haengdueng Jeong, Nakyum Lee, Chanyang Uhm, Kyungrae Cho, Heeju Oh, Yeseul Oh, KeLun Zhang, Hye Li Kim, James R. Goldenring, Kyung-Min Lim, Chang Ook Park, Ki Taek Nam
Summary: Rab-25 plays an important role in maintaining skin barrier function and keratinization in atopic dermatitis (AD).
Article
Allergy
Anna Maria Andersson, Julie Solberg, Anders Koch, Lone Skov, Ivone Jakasa, Sanja Kezic, Jacob Pontoppidan Thyssen
Summary: This study analyzed biomarkers in children with atopic dermatitis using tape strips and skin biopsies, finding that cytokine profiles in lesional skin were associated with disease severity, food allergy, and filaggrin gene mutations. Levels of TARC, CTACK, IL-8, and IL-18 in tape strips correlated significantly with AD severity, while skin biopsy data did not show significant correlations. Sampling the stratum corneum with non-invasive tape strips may be useful for identifying biomarkers associated with disease severity, food allergy, and filaggrin mutations.
Article
Chemistry, Multidisciplinary
Beom-Chan Park, Sang-Hyun Ahn, In-Jun Yang, Ki-Bong Kim
Summary: The study found that the Coptis chinensis, Glycyrrhiza uralensis, and fermented Glycine max (3Hb) extract can effectively restore the lipid barrier of the skin and alleviate symptoms of atopic dermatitis. The extract regulates inflammation, Th2 differentiation, and skin defense microenvironment by recovering filaggrin. This suggests the potential of 3Hb extract for proactive therapy in AD.
APPLIED SCIENCES-BASEL
(2021)
Article
Dermatology
Hila Emmert, Hansjoerg Baurecht, Frederieke Thielking, Dora Stoelzl, Elke Rodriguez, Inken Harder, Ehrhardt Proksch, Stephan Weidinger
Summary: This study revealed significant differences in lipid composition between body sites and between AD patients and healthy individuals, as well as correlations between skin microbiome and skin lipid alterations in AD.
EXPERIMENTAL DERMATOLOGY
(2021)
Review
Allergy
Jessica W. Hui-Beckman, Elena Goleva, Evgeny Berdyshev, Donald Y. M. Leung
Summary: Atopic dermatitis (AD) and food allergy (FA) are closely related and one-third of AD children develop concomitant FA. Epithelial barrier dysfunction is important in both diseases. Genetic factors such as filaggrin mutations and IL-4 receptor alpha chain polymorphisms are associated with increased risk. In addition, several environmental exposures lead to reduced filaggrin and contribute to skin barrier dysfunction. Staphylococcus aureus colonization appears to contribute to AD and FA as well as activating the type 2 immune response. Comprehensive multiomic studies have identified distinct atopic endotypes with unique characteristics, providing an opportunity for improved diagnosis and prevention of atopy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Environmental Sciences
Sukhbir Singh, Tapan Behl, Neelam Sharma, Ishrat Zahoor, Sridevi Chigurupati, Shivam Yadav, Mahesh Rachamalla, Aayush Sehgal, Tanveer Naved, Pritima, Sandeep Arora, Saurabh Bhatia, Ahmed Al-Harrasi, Syam Mohan, Lotfi Aleya, Simona Bungau
Summary: Atopic dermatitis is a common chronic skin disease that significantly impacts the lives of patients and their families. Currently, the main pharmacological treatment for atopic dermatitis is topical corticosteroids. However, delivering medications to deeper layers of the skin is challenging due to the skin's anatomy and barrier abnormalities in atopic dermatitis. Therefore, nanotechnology-based topical therapeutics have gained attention as they have the potential to increase drug diffusion and targeting, reducing adverse effects.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Allergy
Tammy Gonzalez, Mariana L. Stevens, Asel Baatyrbek Kyzy, Rosario Alarcon, Hua He, John W. Kroner, Daniel Spagna, Brittany Grashel, Elaine Sidler, Lisa J. Martin, Jocelyn M. Biagini Myers, Gurjit K. Khurana Hershey, Andrew B. Herr
Summary: In the first US early-life cohort of children with atopic dermatitis, the presence of staphylococcal biofilms on skin lesions was found to be associated with increased disease severity, suggesting a pathogenic role forS aureus biofilms in atopic dermatitis development. Additionally, the balance between S epidermidis and S aureus, as well as their biofilm propensity, may have important implications for atopic dermatitis.
Article
Chemistry, Multidisciplinary
Bum Soo Lee, Ye-Ryeong Cho, Minju Jeong, Yoon Seo Jang, Jin-Chul Kim, Sanguine Byun, Ki Hyun Kim
Summary: This study investigated the inhibitory effects of Cornus walteri on atopic dermatitis (AD). The results showed that Cornus walteri reduced the secretion of AD-related chemokines and upregulated filaggrin. Phytochemical analysis led to the identification of six potential bioactive constituents in Cornus walteri, and three of them significantly inhibited the expression of eotaxin-3. These findings suggest that Cornus walteri and its active compounds have potential as therapeutic agents for treating AD.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Nahoko Zeze, Makiko Kido-Nakahara, Gaku Tsuji, Eriko Maehara, Yuki Sato, Sawako Sakai, Kei Fujishima, Akiko Hashimoto-Hachiya, Masutaka Furue, Takeshi Nakahara
Summary: Atopic dermatitis is a skin disorder characterized by inflammation, barrier disruption, and intense itch. This study investigates the involvement of the extracellular signal-regulated kinase (ERK) pathway in the pathogenesis of atopic dermatitis. The results suggest that the ERK pathway plays a role in the development of atopic dermatitis and may be a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Veterinary Sciences
Rosanna Marsella, Kim Ahrens, Rachel Wilkes
Summary: Skin barrier dysfunction is important in atopic dermatitis and may be related to differences in cell growth behavior rather than tight junction protein differences. Atopic keratinocytes have lower TEER than normal keratinocytes, indicating higher epithelial permeability.
VETERINARY SCIENCES
(2022)
Review
Dermatology
Thomas Luger, Masayuki Amagai, Brigitte Dreno, Marie-Ange Dagnelie, Wilson Liao, Kenji Kabashima, Tamara Schikowski, Ehrhardt Proksch, Peter M. Elias, Michel Simon, Eric Simpson, Erin Grinich, Matthias Schmuth
Summary: AD is a chronic inflammatory skin disorder characterized by eczematous and pruritic skin lesions, with increasing prevalence worldwide in recent decades. Studies have shown that genetic defects affecting structural proteins of the skin barrier, as well as exposure to environmental allergens and pollutants, contribute to the development of AD. Research on epidermal barrier function, inflammation, lipid metabolism, and bacterial communities is crucial for understanding the complex etiology of AD and developing new therapies.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Article
Allergy
Vivian Wang, Matthew Keefer, Peck Y. Ong
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2019)
Article
Dermatology
Zelma C. Chiesa Fuxench, Julie K. Block, Mark Boguniewicz, John Boyle, Luz Fonacier, Joel M. Gelfand, Mitchell H. Grayson, David J. Margolis, Lynda Mitchell, Jonathan Silverberg, Lawrence Schwartz, Eric L. Simpson, Peck Y. Ong
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2019)
Meeting Abstract
Allergy
Vivian Wang, Matthew Keefer, Peck Y. Ong
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2019)
Meeting Abstract
Allergy
Jonathan I. Silverberg, Joel Gelfand, David Margolis, Mark Boguniewicz, Luz S. Fonacier, Mitchell H. Grayson, Peck Y. Ong, Zelma Chiesa Fuxench, Eric L. Simpson
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2019)
Article
Dermatology
J. Silverberg, D. J. Margolis, M. Boguniewicz, L. Fonacier, M. H. Grayson, P. Y. Ong, Z. C. Chiesa Fuxench, E. L. Simpson, J. M. Gelfand
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2019)
Article
Dermatology
J. I. Silverberg, J. M. Gelfand, D. J. Margolis, M. Boguniewicz, L. Fonacier, M. H. Grayson, P. Y. Ong, Z. C. Chiesa Fuxench, E. L. Simpson
BRITISH JOURNAL OF DERMATOLOGY
(2019)
Article
Dermatology
J. I. Silverberg, D. J. Margolis, M. Boguniewicz, L. Fonacier, M. H. Grayson, P. Y. Ong, Z. C. Fuxench, E. L. Simpson
BRITISH JOURNAL OF DERMATOLOGY
(2020)
Article
Allergy
Philippe A. Eigenmann, Kirsten Beyer, Gideon Lack, Antonella Muraro, Peck Y. Ong, Scott H. Sicherer, Hugh A. Sampson
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2020)
Article
Allergy
Anna B. Fishbein, Jonathan I. Silverberg, Eve J. Wilson, Peck Y. Ong
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2020)
Meeting Abstract
Dermatology
J. I. Silverberg, D. J. Margolis, M. Boguniewicz, L. Fonacier, M. H. Grayson, P. Y. Ong, Z. C. Fuxench, E. L. Simpson
BRITISH JOURNAL OF DERMATOLOGY
(2020)
Review
Allergy
Ioana Agache, Yang Song, Margarita Posso, Pablo Alonso-Coello, Claudio Rocha, Ivan Sola, Jessica Beltran, Cezmi Akdis, Mubeccel Akdis, Knut Brockow, Tomas Chivato, Stefano del Giacco, Thomas Eiwegger, Kilian Eyerich, Ana Gimenez-Arnau, Jan Gutermuth, Emma Guttman-Yassky, Marcus Maurer, Graham Ogg, Peck Y. Ong, Liam O'Mahony, Jurgen Schwarze, Thomas Werfel, Carlos Canelo-Aybar, Oscar Palomares, Marek Jutel
Summary: This review evaluated the efficacy, safety, and economic impact of dupilumab compared to standard care for uncontrolled moderate-to-severe atopic dermatitis. Dupilumab showed significant improvements in symptoms and quality of life for both adult and adolescent patients. Long-term safety data is needed for both children and adults, along with more efficacy data for the pediatric population.
Review
Allergy
Ioana Agache, Claudio Rocha, Ana Pereira, Yang Song, Pablo Alonso-Coello, Ivan Sola, Jessica Beltran, Margarita Posso, Cezmi Akdis, Mubeccel Akdis, Knut Brockow, Tomas Chivato, Stefano del Giacco, Thomas Eiwegger, Kilian Eyerich, Ana Gimenez-Arnau, Jan Gutermuth, Emma Guttman-Yassky, Marcus Maurer, Graham Ogg, Peck Ong, Liam O'Mahony, Jurgen Schwarze, Thomas Werfel, Carlos Canelo-Aybar, Oscar Palomares, Marek Jutel
Summary: This review found that 150mg of omalizumab does not provide clinically meaningful improvement for CSU, while 300mg leads to significant improvements in symptoms, quality of life, reduction in medication use, and drug-related serious adverse events.
Review
Allergy
Vivian Wang, Juri Boguniewicz, Mark Boguniewicz, Peck Y. Ong
Summary: Atopic dermatitis is a chronic inflammatory skin disease that increases the risk of skin and systemic infections. Preventive therapy focuses on improving skin barrier and anti-inflammatory treatments, with controversy surrounding the use of antibiotics during exacerbation. Further studies are needed to determine the role of antibiotics in treating AD exacerbation.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2021)
Article
Allergy
Ioana Agache, Cezmi Akdis, Mubeccel Akdis, Knut Brockow, Tomas Chivato, Stefano del Giacco, Thomas Eiwegger, Kilian Eyerich, Ana Gimenez-Arnau, Jan Gutermuth, Emma Guttman-Yassky, Marcus Maurer, Graham Ogg, Peck Y. Ong, Liam O'Mahony, Juergen Schwarze, Amena Warner, Thomas Werfel, Oscar Palomares, Marek Jutel
Summary: Atopic dermatitis imposes a significant burden on patients, families and healthcare systems. Management is difficult and there are still many issues that require further clarification.
Meeting Abstract
Allergy
G. Chan, P. Ong
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2020)