The endoplasmic reticulum protein folding factory and its chaperones: new targets for drug discovery?

Chaperone-Targeting Cytotoxin and Endoplasmic Reticulum Stress-Inducing Drug Synergize to Kill Cancer Cells

(2015) Joseph M. Backer et al.   NEOPLASIA

Bacitracin is not a specific inhibitor of protein disulfide isomerase

(2010) Anna-Riikka Karala et al.   FEBS Journal

Inhibition of Secretion of Interleukin (IL)-12/IL-23 Family Cytokines by 4-Trifluoromethyl-celecoxib Is Coupled to Degradation via the Endoplasmic Reticulum Stress Protein HERP

(2010) Martin McLaughlin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Small Molecule Inhibitor of Endoplasmic Reticulum Oxidation 1 (ERO1) with Selectively Reversible Thiol Reactivity

(2010) Jaime D. Blais et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Flavonol Activation Defines an Unanticipated Ligand-Binding Site in the Kinase-RNase Domain of IRE1

(2010) R. Luke Wiseman et al.   MOLECULAR CELL

Insulin-Like Growth Factor-I Regulation of Immune Function: A Potential Therapeutic Target in Autoimmune Diseases?

(2010) T. J. Smith   PHARMACOLOGICAL REVIEWS

Physiology and pathology of proteostasis in the early secretory compartment

(2010) Tiziana Anelli et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Glucose regulated protein 94 is required for muscle differentiation through its control of the autocrine production of insulin-like growth factors

(2009) Olga Ostrovsky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Activation and clinical significance of the unfolded protein response in breast cancer

(2009) P Scriven et al.   BRITISH JOURNAL OF CANCER

Targeting of Bone-Derived Insulin-Like Growth Factor-II by a Human Neutralizing Antibody Suppresses the Growth of Prostate Cancer Cells in a Human Bone Environment

(2009) T. Kimura et al.   CLINICAL CANCER RESEARCH

α1-Antitrypsin deficiency, chronic obstructive pulmonary disease and the serpinopathies

(2009) Ugo I. Ekeowa et al.   CLINICAL SCIENCE

Cell-surface Processing of the Metalloprotease Pro-ADAMTS9 Is Influenced by the Chaperone GRP94/gp96

(2009) Bon-Hun Koo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes

(2009) Chih-Chi Andrew Hu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Chaperone Activity of GRP94 Toward Insulin-like Growth Factor II Is Necessary for the Stress Response to Serum Deprivation

(2009) Olga Ostrovsky et al.   MOLECULAR BIOLOGY OF THE CELL

ERp29 Restricts Connexin43 Oligomerization in the Endoplasmic Reticulum

(2009) Shamie Das et al.   MOLECULAR BIOLOGY OF THE CELL

Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions

(2009) A Gualberto et al.   ONCOGENE

Valproate, a Mood Stabilizer, Induces WFS1 Expression and Modulates Its Interaction with ER Stress Protein GRP94

(2009) Chihiro Kakiuchi et al.   PLoS One

The protein disulfide isomerase AGR2 is essential for production of intestinal mucus

(2009) S.-W. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Life and death of a BiP substrate

(2009) Joel H. Otero et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

N-Butyldeoxynojirimycin is a broadly effective anti-HIV therapy significantly enhanced by targeted liposome delivery

(2008) Stephanie Pollock et al.   AIDS

Iminosugars in Combination with Interferon and Ribavirin Permanently Eradicate Noncytopathic Bovine Viral Diarrhea Virus from Persistently Infected Cells

(2008) S. D. Woodhouse et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Herp enhances ER-associated protein degradation by recruiting ubiquilins

(2008) Tae-Yeon Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endoplasmic reticulum HSP90b1 (gp96, grp94) optimizes B-cell function via chaperoning integrin and TLR but not immunoglobulin

(2008) B. Liu et al.   BLOOD

Increasing Melanoma Cell Death Using Inhibitors of Protein Disulfide Isomerases to Abrogate Survival Responses to Endoplasmic Reticulum Stress

(2008) P. E. Lovat et al.   CANCER RESEARCH

Aggravated Endoplasmic Reticulum Stress as a Basis for Enhanced Glioblastoma Cell Killing by Bortezomib in Combination with Celecoxib or Its Non-Coxib Analogue, 2,5-Dimethyl-Celecoxib

(2008) A. Kardosh et al.   CANCER RESEARCH

NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis

(2008) S. A. Eccles et al.   CANCER RESEARCH

Protein quality control in the early secretory pathway

(2008) Tiziana Anelli et al.   EMBO JOURNAL

Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3

(2008) Kseniya Petrova et al.   EMBO JOURNAL

Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas

(2008) Hua-chuan Zheng et al.   HUMAN PATHOLOGY

The unfolded protein response in hereditary haemochromatosis

(2008) S.F. de Almeida et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Triplex Profiling of Functionally Distinct Chaperones (ERp29/PDI/BiP) Reveals Marked Heterogeneity of the Endoplasmic Reticulum Proteome in Cancer

(2008) Steven D. Shnyder et al.   JOURNAL OF PROTEOME RESEARCH

ERp29 is a Radiation-Responsive Gene in IEC-6 Cell

(2008) Bo ZHANG et al.   JOURNAL OF RADIATION RESEARCH

ERdj4 and ERdj5 Are Required for Endoplasmic Reticulum-associated Protein Degradation of Misfolded Surfactant Protein C

(2008) Mei Dong et al.   MOLECULAR BIOLOGY OF THE CELL

ERp29, an endoplasmic reticulum secretion factor is involved in the growth of breast tumor xenografts

(2008) Souren Mkrtchian et al.   MOLECULAR CARCINOGENESIS

Stable complexes formed by Grp94 with human IgG promoting angiogenic differentiation of HUVECs by a cytokine-like mechanism

(2008) Elisa Tramentozzi et al.   MOLECULAR IMMUNOLOGY

Identification of proteins that modify cataract of mouse eye lens

(2008) Wolfgang Hoehenwarter et al.   PROTEOMICS

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE

Influenza vaccine strain selection and recent studies on the global migration of seasonal influenza viruses

(2008) Colin A. Russell et al.   VACCINE

Celecoxib transiently inhibits cellular protein synthesis

(2007) Peter Pyrko et al.   BIOCHEMICAL PHARMACOLOGY

The human PDI family: Versatility packed into a single fold

(2007) Christian Appenzeller-Herzog et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH