Article
Pharmacology & Pharmacy
M. R. Mohammed, S. A. Hamad, A. D. Al-Daeoody, A. A. Shehab, O. S. Ahmed
Summary: This study evaluated the effectiveness of dextrose prolotherapy in treating internal derangement of the temporomandibular joint. 20 patients with internal derangement were treated with injections of 12.5% dextrose. Significant improvements were seen in pain, mouth opening, clicking, and deviation at 2, 4, and 12 weeks post-treatment. Prolotherapy was found to be a safe and effective treatment for alleviating the symptoms of internal derangement of the temporomandibular joint.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Orthopedics
Mengying Jia, Yaoguang Lv, Yingjie Xu, Zhongcheng Gong
Summary: The study revealed the potential involvement of the NLRP3 inflammasome signaling pathway in condylar degeneration of temporomandibular joint osteoarthritis, and demonstrated that sodium hyaluronic acid can reduce certain inflammatory molecules to alleviate inflammation.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Multidisciplinary Sciences
Ayman F. Hegab, Hossam IAbd Al Hameed, Khaled Said Karam
Summary: This study aimed to establish a new classification system for TMJ internal derangement based on MRI and correlate it with clinical findings to develop a nonsurgical treatment protocol. The results showed significant improvement in mouth opening, pain scores, and joint sounds following treatment according to the new staging system.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Laskarin Ana -Marija, Laskarin Gordana, Kehler Tatjana, Grzic Renata, Dulcic Niksa
Summary: Spondyloarthritis (SpA) is a group of autoinflammatory/autoimmune diseases affecting the spine and peripheral joints. Temporomandibular disorders (TMDs) are correlated with cervical spine involvement. Proinflammatory cytokines, such as IL-23, IL-17A, and TNF-alpha, play significant roles in the immunopathogenesis of SpA and inflammation-related TMDs. The concentration of salivary IL-23, IL-17A, or TNF-alpha may serve as potential diagnostic markers for internal derangement of temporomandibular joints (TMJs) in patients with SpA, helping to broaden therapeutic approaches for symptomatic TMJ disorders.
MEDICAL HYPOTHESES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Douglas F. Werkman, Louis G. Mercuri, Jonathan P. Troost, Sharon Aronovich
Summary: Most TMJ surgeons do not prefer to use TMJ discectomy for treating TMJ internal derangements, but in cases of disc perforation or persistent symptomatic disc displacement without reduction, discectomy is considered beneficial.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2021)
Article
Dentistry, Oral Surgery & Medicine
S. Priyadarshini, A. Gnanam, B. Sasikala, P. Elavenil, S. Raja Sethupathy Cheeman, R. Mrunalini, V. B. Krishna Kumar Raja
Summary: The study aimed to compare the efficacy of dextrose prolotherapy with occlusal splints in treating internal derangement of the temporomandibular joint. Results showed that prolotherapy was superior in providing long-term clinical relief, with reduction in pain and clicking along with improved mouth opening. Patients who received prolotherapy demonstrated improvement in pain, mouth opening, and clicking, with no significant difference in deviation observed after 1 year.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ting Xu, Jing Shuai, Zhiyuan Gu, Mengjie Wu
Summary: This study investigated the beneficial effects of intra-articular injection of Salubrinal on temporomandibular joint osteoarthritis (TMJOA) using a rabbit model of anterior disc displacement (ADD). The results showed that Salubrinal alleviated cartilage degradation following ADD, suggesting that it could be a potential therapeutic approach for preventing TMJOA.
Article
Dentistry, Oral Surgery & Medicine
Ahmed Abd El-Latif Mosleh, Ibrahim Mohamed Nowair, Khalid Abd El-Hamid Saad, Abd El-Fatah Abd El-Mongy Sadakah
Summary: This study aimed to compare the effectiveness of arthroscopic-assisted lateral pterygoid muscle release and scarification of retrodiscal tissues in treating temporomandibular joint internal derangement. Data collected through functional examination and MRI assessment showed that both treatments were beneficial for anteriorly displaced discs that don't respond to conservative treatments.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Joao L. G. C. Monteiro, Toru Takusagawa, Belmiro C. E. Vasconcelos, Sara I. Pai, Joseph P. McCain, Fernando P. S. Guastaldi
Summary: This study aimed to describe rabbit temporomandibular joint (TMJ) anatomy and provide a minimally invasive approach for creating TMJ defects in order to investigate the regenerative potential of biomaterials. The surgical procedure had an average duration of 35.5 minutes with no major complications, demonstrating the feasibility of the model.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
D. Torul, B. Cezairli, K. Kahveci
Summary: The study compared the efficacy of HA and i-PRF in treating Wilkes stage III internal derangement, with i-PRF showing better improvements in pain intensity and maximum mouth opening. Additionally, the use of i-PRF after arthrocentesis was more effective in the short term.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2021)
Article
Primary Health Care
Khalid Arab, Faisal A. Alfaqeeh, Michel Alain Danino
Summary: The study retrospectively analyzed the use of Umbrella-shaped Perforated Screws (UPS) for treating Temporomandibular Joint Internal Derangement (ID). Among 105 patients included, 77% experienced no or minimal pain post-surgery, 101 patients regained good eating habits, and only 34 patients had persistent clicking despite the surgery.
JOURNAL OF FAMILY MEDICINE AND PRIMARY CARE
(2021)
Article
Cell & Tissue Engineering
W. Liao, J. Sun, Y. Wang, Y. He, K. Su, Y. Lu, G. Liao, Y. Sun
Summary: This study confirms that histone deacetylase (HDAC) inhibitors can improve the inhibition of chondrogenesis caused by arthritis, and it identifies the inhibition of the IL-6/MMP13 pathway as a contributing factor to this process.
BONE & JOINT RESEARCH
(2022)
Review
Dentistry, Oral Surgery & Medicine
Roque Miguel Rodhen, Thiago Azario de Holanda, Fabiola Jardim Barbon, Wellington Luiz de Oliveira da Rosa, Noeli Boscato
Summary: This systematic review compares minimally invasive and invasive surgical procedures for managing arthrogenous temporomandibular joint disorders. The results show significantly lower VAS scores and higher MIO values after discectomy. However, the currently available scientific evidence is unclear, and further research is needed on the use of invasive surgical procedures for arthrogenous TMD management.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Szonja Vingender, Ferenc Dori, Peter Schmidt, Peter Hermann, Mihaly Tamas Vaszilko
Summary: This study aimed to evaluate the clinical effects of hyaluronic acid (HA), platelet-rich plasma (PRP), and platelet-rich fibrin (I-PRF) injections in the internal derangement of the temporomandibular joint. The results showed that HA administration significantly improved maximal mouth opening (MMO), while all treatment groups showed a significant decrease in pain level (VAS). Comparing low and high molecular weight forms of hyaluronic acid (HAL, HAH), no significant difference was found in the evaluation of MMO and VAS values. Platelet concentrates should be preferred in intra-articular treatment to reduce the risk of adverse effects.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Najwa Jamil AbdulRazzak, Jafar Abdulhadi Sadiq, Atheer Talib Jiboon
Summary: Temporomandibular joint disorders (TMDs) are often misdiagnosed and mistreated conditions in medical practice. This study compared the effectiveness of two minimally invasive procedures, arthrocentesis and glucocorticosteroid injection, in managing internal derangement of the TMJ. Results after 4 months showed that arthrocentesis had more promising outcomes compared to glucocorticosteroid injection in the treatment of TMJ internal derangement.
ORAL AND MAXILLOFACIAL SURGERY-HEIDELBERG
(2021)
Article
Oncology
Chengzhong Lin, Zhenhu Ren, Xi Yang, Rong Yang, Yiming Chen, Zheqi Liu, Zhenlin Dai, Yu Zhang, Youya He, Chunye Zhang, Xu Wang, Wei Cao, Tong Ji
Article
Dentistry, Oral Surgery & Medicine
Zhonglong Liu, Fengshuo Zhu, Wei Cao, Jian Sun, Chenping Zhang, Yue He
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2020)
Article
Dentistry, Oral Surgery & Medicine
Zhen-Hu Ren, Kun Wu, Rong Yang, Zhe-Qi Liu, Wei Cao
Article
Medicine, Research & Experimental
Xueqin Zhu, Xing Qin, Xiaoning Wang, Yingnan Wang, Wei Cao, Jianjun Zhang, Wantao Chen
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2020)
Article
Multidisciplinary Sciences
Chengyao Zhang, Wei Cao, Jiawu Wang, Jiannan Liu, Jialiang Liu, Hao Wu, Siyi Li, Chenping Zhang
Article
Otorhinolaryngology
Wenkai Zhou, Canbang Peng, Zheqi Liu, Wei Cao
Summary: This study analyzed the risk factors for survival in elderly patients with oral squamous cell carcinoma and developed a novel clinical signature for prognosis. Results indicated that high N stage, low hemoglobin level, low BMI, and high NLR were associated with poor survival outcomes. The constructed nomogram showed a good predictive ability.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Oncology
Xuejie Li, Zheqi Liu, Wenkai Zhou, Xiaofang Liu, Wei Cao
Summary: The study revealed that high expression of CCL22 in T/MF SCC may promote the recruitment of Th2 cells and help predict a better survival. Additionally, mutations in NOTCH1 inhibit the differentiation of Th2 cells, facilitating tumor progression.
Editorial Material
Oncology
Wei Cao, Qiang Shen, Ming Yann Lim
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Lei Wang, Wenjing Pang, Kun Zhou, Lei Li, Feng Wang, Wei Cao, Xiangjun Meng
Summary: This study provides further insights into the risk factors for esophageal squamous cell carcinoma (ESCC) in patients with a history of head and neck squamous cell carcinoma (HNSCC). The study found that HNSCC patients, especially drinkers with an alcohol flushing response and those with high Ki67 labeling index (Ki67 LI) in HNSCC tissue, were more likely to develop ESCC.
JOURNAL OF ONCOLOGY
(2022)
Article
Cell Biology
Yu Zhang, Chengzhong Lin, Zheqi Liu, Yiting Sun, Mingtao Chen, Yibo Guo, Wei Liu, Chenping Zhang, Wantao Chen, Jian Sun, Ronghui Xia, Yuhua Hu, Xi Yang, Jiang Li, Zhiyuan Zhang, Wei Cao, Shuyang Sun, Xu Wang, Tong Ji
Summary: This study reveals that cancer cells can utilize nociceptive nerves to survive in nutrient-poor environments. Cancer cells secrete NGF through ROS-triggered activation of c-Jun, which stimulates nerves to produce CGRP. The neurogenic CGRP induces cytoprotective autophagy in cancer cells through Rap1-mediated disruption of the mTOR-Raptor interaction. Blocking CGRP can inhibit the vicious cycle between cancer cells and nerves and therapeutically benefit nutrient-starvation therapies.
Article
Biochemistry & Molecular Biology
Zhenlin Dai, Zheqi Liu, Rong Yang, Wei Cao, Tong Ji
Summary: Osteosarcoma (OS), the most common malignant bone tumor, lacks updated treatment strategies. This study identified EVI2B as a significantly upregulated gene in OS tumor samples and demonstrated its association with chemokine signaling, cytokine-cytokine receptor interaction, and Human T-cell leukemia virus 1 infection. The prognostic prediction model including EVI2B, DOCK2, and CD33 indicated EVI2B as an independent protective prognostic marker in OS. The study also revealed the close relationship between EVI2B expression, monocyte and macrophage infiltration in OS, providing clear evidence for its prognostic value.
Article
Chemistry, Multidisciplinary
Wenkai Zhou, Yisheng Feng, Chengzhong Lin, Chi Kuan Chao, Ziqi He, Shiyao Zhao, Jieyuan Xue, Xu-Yun Zhao, Wei Cao
Summary: A highly expressed lncRNA DUXAP9, found in oral squamous cell carcinoma (OSCC), is positively associated with poor prognosis. DUXAP9 promotes OSCC cell proliferation, migration, invasion, and tumor growth through the upregulation of N-cadherin, Vimentin, Ki67, PCNA, and EZH2 and downregulation of E-cadherin. Yin Yang 1 (YY1) activates the transcription of DUXAP9 in OSCC. Moreover, DUXAP9 interacts with EZH2 and inhibits its degradation, thereby blocking its translocation from the nucleus to the cytoplasm. DUXAP9 may serve as a promising therapeutic target for OSCC.
Article
Cell Biology
Zheqi Liu, Wenkai Zhou, Chengzhong Lin, Xiaoning Wang, Xu Zhang, Yu Zhang, Rong Yang, Wantao Chen, Wei Cao
Summary: FOXD2-AS1 is closely associated with clinical characteristics in oral squamous cell carcinoma, and its high expression predicts poor prognosis in patients. It functions by promoting cell proliferation and migration, suppressing adaptive immunity, and participating in the development of oral squamous cell carcinoma.
Article
Medicine, Research & Experimental
Xiaohao Liu, Dongsheng Mao, Guoli Deng, Yuchen Song, Fan Zhang, Shiqi Yang, Genxi Li, Feng Liu, Wei Cao, Xiaoli Zhu
Article
Oncology
Lei Wang, Wenjing Pang, Kun Zhou, Lei Li, Feng Wang, Wei Cao, Xiangjun Meng
Summary: This study investigated the clinicopathological features of esophageal cancer in patients with a history of head and neck squamous cell carcinoma (HNSCC). Most cases were male patients aged 50-69 years, with higher proportion of early esophageal cancer and successful surgical treatment in the synchronous carcinoma group compared to the metachronous carcinoma group. Detection of esophageal cancer should be prioritized in HNSCC patients.
TRANSLATIONAL CANCER RESEARCH
(2021)