Article
Biochemistry & Molecular Biology
Matthew Kellom, Stefano Pagliara, Thomas A. Richards, Alyson E. Santoro
Summary: Transporter proteins play a crucial role in microbial evolution, influencing the strategies of microorganisms to acquire nutrients from the environment. Ammonium transporter proteins in deep ocean environments show an evolutionary trend towards increasing dipoles, potentially to facilitate more effective ammonium acquisition in low nutrient conditions.
Article
Biotechnology & Applied Microbiology
Joao P. C. Pinto, Rutger Brouwer, Araz Zeyniyev, Oscar P. Kuipers, Jan Kok
Summary: This data set is a rich resource for microbiologists interested in common mechanisms of gene expression, regulation, and the physiology of L. lactis. It is also an opportunity for bioinformaticians to develop novel tools for in-depth analysis.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Review
Microbiology
Stephen E. Noell, Ferdi L. Hellweger, Ben Temperton, Stephen J. Giovannoni
Summary: In this review, the regulatory strategies of aquatic oligotrophs, microbial cells adapted to low-nutrient concentrations, are considered. It is observed that oligotrophs use less transcriptional regulation compared to copiotrophic cells adapted to high nutrient concentrations. The retention of alternate mechanisms like riboswitches in oligotrophs allows for faster and more efficient responses with fewer cellular resources. The distinctive regulatory strategies in oligotrophs are discussed in relation to the selective pressures they face and their evolutionary history.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
(2023)
Article
Microbiology
Qun Li, Ailing Guo, Yi Ma, Ling Liu, Wukang Liu, Yuan Zhong, Yawen Zhang
Summary: This study used RNA sequencing and gene deletion strains to reveal the impact mechanism of Ralstonia insidiosa on the formation of suspended aggregates of Listeria monocytogenes, providing a new perspective for analyzing the aggregation mechanisms of food-borne pathogenic bacteria.
Article
Mathematics, Applied
Michael Winkler
Summary: The study investigates a doubly degenerate nutrient taxis model in smoothly bounded convex subdomains of the plane, and establishes conditions for the existence of global weak solutions based on a novel class of functional inequalities.
NONLINEAR ANALYSIS-REAL WORLD APPLICATIONS
(2022)
Article
Microbiology
David Lalaouna, Sylvain Fochesato, Mourad Harir, Philippe Ortet, Philippe Schmitt-Kopplin, Thierry Heulin, Wafa Achouak
Summary: In the beneficial plant root-associated Pseudomonas brassicacearum strain NFM421, the GacS/GacA system positively controls biofilm formation and secondary metabolite production through the synthesis of rsmX, rsmY, and rsmZ. This study reveals genetic amplification of Rsm sRNAs with the discovery of a novel sRNA gene, rsmX-2, and shows that the expression of rsmX-1 and rsmX-2 is GacA-dependent under nutrient-poor conditions. The highest expression levels and longest half-lives of these sRNAs are correlated with nutrient stress, supporting the notion that the Rsm system in P. brassicacearum is likely linked to the stringent response and bacterial adaptation to nutritional stress.
Article
Otorhinolaryngology
Wenkai Zhou, Canbang Peng, Zheqi Liu, Wei Cao
Summary: This study analyzed the risk factors for survival in elderly patients with oral squamous cell carcinoma and developed a novel clinical signature for prognosis. Results indicated that high N stage, low hemoglobin level, low BMI, and high NLR were associated with poor survival outcomes. The constructed nomogram showed a good predictive ability.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Otorhinolaryngology
Cangbang Peng, Ming Tao Chen, Zheqi Liu, Yibo Guo, Yu Zhang, Tong Ji
Summary: Inflammatory myofibroblastic tumors in the head and neck (HNIMTs) sometimes exhibit aggressive clinical features and can undergo malignant transformation. This study found that tumor size, location, and preoperative neutrophil-to-lymphocyte ratio may be associated with the risk of malignant transformation in HNIMTs. Postoperative radiotherapy can benefit HNIMT patients at high risk of malignant transformation.
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
(2022)
Article
Oncology
Yibo Guo, Yiting Sun, Mingtao Chen, Yisheng Feng, Xu Zhang, Tong Ji, Zheqi Liu, Yu Zhang
Summary: The study reveals noncanonical autophagy-independent functions of autophagy-related genes ATG9B and ATG7 in HNSCC. ATG9B protects HNSCC patients by downregulating cancer cell EMT, while ATG7 is correlated with the immunosuppressive environment in HNSCC. These findings contribute to a better understanding of the intricacies of autophagy and may have implications for precision treatment using autophagy-targeted therapies.
JOURNAL OF ONCOLOGY
(2022)
Article
Oncology
Wenkai Zhou, Xu Zhang, Yisheng Feng, Yu Zhang, Zheqi Liu
Summary: This study investigated the predictive value and function of CCL17/CCL22 in HNSCC. The results showed that high expression of CCL17/CCL22 was marginally associated with overall survival in HNSCC patients and positively correlated with CD4+ T cell infiltration levels. The findings suggested that high expression of CCL17/CCL22 might predict favorable responses to immune checkpoint blockade therapy in HNSCC patients.
CURRENT PROBLEMS IN CANCER
(2022)
Article
Biochemistry & Molecular Biology
Zhenlin Dai, Zheqi Liu, Rong Yang, Wei Cao, Tong Ji
Summary: Osteosarcoma (OS), the most common malignant bone tumor, lacks updated treatment strategies. This study identified EVI2B as a significantly upregulated gene in OS tumor samples and demonstrated its association with chemokine signaling, cytokine-cytokine receptor interaction, and Human T-cell leukemia virus 1 infection. The prognostic prediction model including EVI2B, DOCK2, and CD33 indicated EVI2B as an independent protective prognostic marker in OS. The study also revealed the close relationship between EVI2B expression, monocyte and macrophage infiltration in OS, providing clear evidence for its prognostic value.
Article
Chemistry, Multidisciplinary
Wenkai Zhou, Yisheng Feng, Chengzhong Lin, Chi Kuan Chao, Ziqi He, Shiyao Zhao, Jieyuan Xue, Xu-Yun Zhao, Wei Cao
Summary: A highly expressed lncRNA DUXAP9, found in oral squamous cell carcinoma (OSCC), is positively associated with poor prognosis. DUXAP9 promotes OSCC cell proliferation, migration, invasion, and tumor growth through the upregulation of N-cadherin, Vimentin, Ki67, PCNA, and EZH2 and downregulation of E-cadherin. Yin Yang 1 (YY1) activates the transcription of DUXAP9 in OSCC. Moreover, DUXAP9 interacts with EZH2 and inhibits its degradation, thereby blocking its translocation from the nucleus to the cytoplasm. DUXAP9 may serve as a promising therapeutic target for OSCC.
Article
Engineering, Biomedical
Yiting Sun, Hongjian Zhang, Yu Zhang, Zheqi Liu, Dongming He, Wanlin Xu, Siyi Li, Chenping Zhang, Zhen Zhang
Summary: Biomaterials can enhance peripheral nerve regeneration by modulating the immune microenvironment and promoting SCs remyelination. In this study, inorganic Li-Mg-Si bioceramics were used to fabricate scaffolds that showed no cytotoxicity to SCs but promoted their migration and differentiation towards a remyelination state. The LMS-containing scaffolds also promoted macrophage polarization towards pro-regenerative M2-like cells, which facilitated SCs migration and differentiation. Implantation with LMS-containing nerve guidance conduits increased M2-like macrophage infiltration and enhanced nerve regeneration and motor functional recovery in a rat model of sciatic nerve injury.
BIOACTIVE MATERIALS
(2023)