Review
Biochemistry & Molecular Biology
Aleksandra Hliwa, Bruno Ramos-Molina, Dariusz Laski, Adriana Mika, Tomasz Sledzinski
Summary: Non-alcoholic fatty liver disease (NAFLD) is a major global public health problem characterized by alterations in hepatic lipid metabolism that can lead to serious liver complications. Mass spectrometry-based lipidomics platforms allow for in-depth analysis of lipid changes in NAFLD patients, focusing on alterations in long-chain and short-chain fatty acids levels as well as the expression of genes encoding lipid interconversion enzymes in the liver.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Baodong Yao, Xiaojing Lu, Lai Xu, Yun Jiang
Summary: This study aimed to explore the relationship between serum folate level and non-alcoholic fatty liver disease (NAFLD) among adults. The results showed that serum folate level was inversely associated with the presence of NAFLD. Higher serum folate level may be negatively associated with NAFLD.
FRONTIERS IN NUTRITION
(2023)
Article
Environmental Sciences
Zhengyu Hu, Yan Li, Yuexin Yang, Weidi Yu, Wangcheng Xie, Guodong Song, Yaqin Qian, Zhenshun Song
Summary: This study investigated the levels of PAHs in the US population and their association with the risk of NAFLD. The results showed a positive correlation between multiple PAHs and NAFLD, with HDL and TG mediating the association between PAHs and NAFLD.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Pharmacology & Pharmacy
Siyu Yu, Chunlin Li, Guang Ji, Li Zhang
Summary: Excessive intake of fructose, especially industrial fructose, has been linked to the development of NAFLD by affecting endogenous fructose production, gut barrier, microbiota community, leading to lipid accumulation in the liver and inflammation. Targeting the absorption and metabolism of fructose may be a promising strategy for NAFLD treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Yansu Wang, Yun Shen, Tingting Hu, Yufei Wang, Xiaojing Ma, Haoyong Yu, Yuqian Bao
Summary: This study aimed to investigate the correlation between serum clusterin levels and non-alcoholic fatty liver disease (NAFLD) and explore the mediating role of insulin resistance in this relationship. Participants with NAFLD had significantly higher serum clusterin levels than those without NAFLD. Serum clusterin levels were a positive determinant of fatty liver index (FLI) after adjusting for multiple metabolic risk factors. Insulin resistance partially mediated the relationship between serum clusterin levels and FLI.
ENDOCRINE CONNECTIONS
(2023)
Article
Endocrinology & Metabolism
Yuling Xing, Yunfeng Zhen, Liqun Yang, Lijing Huo, Huijuan Ma
Summary: This study aimed to explore the association between hemoglobin glycation index (HGI) and non-alcoholic fatty liver disease (NAFLD), and to provide new methods for identifying high-risk patients for NAFLD. The results showed a positive correlation between HGI levels and NAFLD occurrence. Body mass index (BMI) partly mediated the impact of HGI on NAFLD. Subgroup analyses indicated that HGI significantly correlated with NAFLD in certain patient populations.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Michael Friden, Fredrik Rosqvist, Hakan Ahlstrom, Heiko G. Niessen, Christian Schultheis, Paul Hockings, Johannes Hulthe, Anders Gummesson, Alkwin Wanders, Fredrik Rorsman, Ulf Riserus, Johan Vessby
Summary: This study investigated the associations between liver fibrosis and fatty acids. Higher levels of TAG 18:1n-9 were associated with lower fibrosis, while higher levels of PL 22:0 were associated with higher fibrosis. These findings may reflect altered fatty acid metabolism.
FRONTIERS IN MEDICINE
(2022)
Letter
Gastroenterology & Hepatology
Alvaro Rivera-Andrade, Jessica L. Petrick, Christian S. Alvarez, Barry I. Graubard, Andrea A. Florio, Maria F. Kroker-Lobos, Dominick Parisi, Neal D. Freedman, Mariana Lazo, Eliseo Guallar, John D. Groopman, Manuel Ramirez-Zea, Katherine A. McGlynn
Summary: This article is linked to Rivera-Andrade et al papers.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Gastroenterology & Hepatology
Mitra Ahadi, Kasra Molooghi, Negin Masoudifar, Ali Beheshti Namdar, Hassan Vossoughinia, Mohammadreza Farzanehfar
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common cause of liver disorders associated with type 2 diabetes mellitus, dyslipidemia, metabolic syndrome, and obesity. The pathogenesis of NAFLD in non-obese patients involves genetic predispositions and dietary factors, particularly high fructose consumption. Treatment typically involves lifestyle changes such as dietary modification, weight loss, and increased physical activity.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Medicine, General & Internal
Marco Castellana, Rossella Donghia, Vito Guerra, Filippo Procino, Luisa Lampignano, Fabio Castellana, Roberta Zupo, Rodolfo Sardone, Giovanni De Pergola, Francesco Romanelli, Pierpaolo Trimboli, Gianluigi Giannelli
Summary: The fatty liver index (FLI) has been shown to perform well in stratifying the risk of non-alcoholic fatty liver disease (NAFLD) but has weak evidence in excluding or diagnosing the disorder. Studies found similar performance in using ultrasound versus other imaging modalities.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Nutrition & Dietetics
Ludovico Abenavoli, Tiziana Larussa, Alessandro Corea, Anna Caterina Procopio, Luigi Boccuto, Marcello Dallio, Alessandro Federico, Francesco Luzza
Summary: NAFLD, characterized by a wide spectrum of liver disorders, is considered a major public health issue globally. Polyphenols, known for their anti-inflammatory and antioxidant properties, are believed to have potential benefits in preventing and treating NAFLD, though limited human clinical trials are available.
Article
Nutrition & Dietetics
Zhongmian Zhang, Lan Wang, Zili Lin, Weitian Yan, Jiaqin Chen, Xiyan Zhang, Wangyu Ye, Jian Li, Zhihong Li
Summary: This study investigates the association between the Dietary Inflammatory Index (DII) and non-alcoholic fatty liver disease (NAFLD) and advanced hepatic fibrosis (AHF) among non-institutionalized adults in the United States. The results show that higher DII levels are associated with increased risk of NAFLD and AHF, particularly in males. Strategies to promote an anti-inflammatory diet should be considered to prevent and ameliorate NAFLD and AHF in adults.
FRONTIERS IN NUTRITION
(2023)
Article
Nutrition & Dietetics
Aowen Tian, Zewen Sun, Miaoran Zhang, Jiuling Li, Xingchen Pan, Peng Chen
Summary: This study aimed to investigate the relationship between dietary fatty acid composition and non-alcoholic fatty liver disease (NAFLD) in populations with typical diets. It found that a PUFA enriched vegetarian dietary pattern was negatively associated with NAFLD risk, while a PUFA enriched carnivore dietary pattern was not associated with NAFLD risk. The mediation analysis indicated that specific fatty acids had a significant indirect effect on the association between dietary patterns and NAFLD.
FRONTIERS IN NUTRITION
(2023)
Article
Integrative & Complementary Medicine
Ammar Salehi-sahlabadi, Farshad Teymoori, Ebrahim Mokhtari, Maryam Taghiyar, Azita Hekmatdoost, Parvin Mirmiran
Summary: A higher dietary phytochemical index (DPI) is associated with a reduced chance of non-alcoholic fatty liver disease (NAFLD) according to a case-control study. Specifically, the highest tertile of vegetable and olives PI is significantly associated with a lower risk of NAFLD.
COMPLEMENTARY THERAPIES IN MEDICINE
(2022)
Article
Nutrition & Dietetics
Shunming Zhang, Yeqing Gu, Shanshan Bian, Magdalena J. Gorska, Qing Zhang, Li Liu, Ge Meng, Zhanxin Yao, Hongmei Wu, Yawen Wang, Tingjing Zhang, Xuena Wang, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Lu Qi, Kaijun Niu
Summary: The study found that dietary patterns rich in animal foods or sugar were associated with a higher risk of NAFLD among Chinese adults, whereas a vegetable-rich dietary pattern was not associated.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Ruixin Zhu, Mikael Fogelholm, Elli Jalo, Sally D. Poppitt, Marta P. Silvestre, Grith Moller, Maija Huttunen-Lenz, Gareth Stratton, Jouko Sundvall, Ian A. Macdonald, Teodora Handjieva-Darlenska, Svetoslav Handjiev, Santiago Navas-Carretero, J. Alfredo Martinez, Roslyn Muirhead, Jennie Brand-Miller, Anne Raben
Summary: The study found that higher intake of processed meat may be associated with greater weight regain and more adverse glycaemic and cardiometabolic risk factors. However, replacing processed meat with other high-protein foods may improve weight maintenance and metabolic health.
CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Ruixin Zhu, Thomas M. Larsen, Sally D. Poppitt, Marta P. Silvestre, Mikael Fogelholm, Elli Jalo, Katja A. Hatonen, Maija Huttunen-Lenz, Moira A. Taylor, Liz Simpson, Kelly A. Mackintosh, Melitta A. McNarry, Santiago Navas-Carretero, J. Alfredo Martinez, Teodora Handjieva-Darlenska, Svetoslav Handjiev, Mathijs Drummen, Margriet S. Westerterp-Plantenga, Tony Lam, Pia S. Vestentoft, Roslyn Muirhead, Jennie Brand-Miller, Anne Raben
Summary: In individuals with overweight or obesity, higher total carbohydrate, glycemic load, and total dietary fiber, but not glycemic index, were associated with increased subjective desire to eat or hunger over 3 years.
CLINICAL NUTRITION
(2022)
Article
Andrology
Jingyuan Xiong, Ye Tian, Aru Ling, Zhenmi Liu, Li Zhao, Guo Cheng
Summary: Genistein directly affects GnRH secretion by modulating the expression of kisspeptin receptors, SIRT1, PKC gamma, and MKRN3 in GT1-7 cells.
SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE
(2022)
Article
Nutrition & Dietetics
Yujie Xu, Jingyuan Xiong, Wanke Gao, Xiaoyu Wang, Shufang Shan, Li Zhao, Guo Cheng
Summary: The association between dietary fat and fat quality and puberty timing is inconsistent. This study found that children with higher intakes of total fat and polyunsaturated fatty acid (PUFA) were more likely to reach puberty at an earlier age, while intakes of saturated fatty acid (SFA) and monounsaturated fatty acid (MUFA) were not independently associated with puberty development.
Article
Medicine, General & Internal
Jingyuan Xiong, Yujie Xu, Xueting Liu, Xiaoyu Wang, Shufang Shan, M. James C. Crabbe, Li Zhao, He Fang, Guo Cheng
Summary: The study showed that higher childhood soy intake is associated with later puberty timing in both Chinese girls and boys, especially among individuals with a higher urinary equol level. This association is independent of prepubertal body fatness and is more pronounced in children with a high cereal fiber intake.
Article
Nutrition & Dietetics
Xue-Ting Liu, Jing-Yuan Xiong, Yu-Jie Xu, Li Zhao, Lars Libuda, Guo Cheng
Summary: The study investigated the association between parental and siblings' sugar-sweetened beverage (SSB) intake and children's SSB consumption, with a focus on potential sex differences in these associations. The results showed that parental SSB consumption was relevant to children's SSB intake, with a stronger influence in boys than girls. Fathers seemed to have a greater impact on children's SSB consumption than mothers. Additionally, children's SSB intake was prospectively associated with their older siblings' SSB consumption.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Jingyuan Xiong, Ye Tian, Guochen Ma, Aru Ling, Shufang Shan, Guo Cheng
Summary: This study investigated the effects of genistein on GT1-7 cells, focusing on its influence on the endocrine and reproductive systems. The researchers performed comparative transcriptomic analyses and constructed ceRNA networks to identify potential targets and pathways related to genistein-induced effects. They discovered that genistein interfered with cell cycle, metabolic processes, GnRH, and mitogen-activated protein kinase signaling pathways. Moreover, they predicted that specific miRNAs and lncRNAs might be involved in regulating genistein-induced GnRH secretion. These findings provide valuable insights into the endocrine-interfering effects of genistein.
MOLECULAR & CELLULAR TOXICOLOGY
(2023)
Article
Nutrition & Dietetics
Marta P. Silvestre, Mikael Fogelholm, Marta Alves, Ana Papoila, Tanja Adam, Amy Liu, Jennie Brand-Miller, Margriet Westerterp-Plantenga, Teodora Handjieva-Darlenska, Ian A. Macdonald, Ruixin Zhu, Elli Jalo, Roslyn Muirhead, Santiago Navas Carretero, Svetoslav Handjiev, Moira A. Taylor, Anne Raben, Sally D. Poppitt
Summary: This study aimed to compare the differences between HbA1c and glucose-related variables in predicting weight loss and glycemic changes in individuals with overweight and hyperglycemia. The results showed that neither HbA1c nor fasting glucose can predict short-term weight loss success, but they may impact the metabolic response to rapid weight loss.
CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Karen Della Corte, Elli Jalo, Niina E. Kaartinen, Liz Simpson, Moira A. Taylor, Roslyn Muirhead, Anne Raben, Ian A. Macdonald, Mikael Fogelholm, Jennie Brand-Miller
Summary: This study found that dietary sugars are linked to overweight and the development of type 2 diabetes. Total sugars were inversely associated with fasting insulin and C-peptide, while free sugars were inversely associated with fasting glucose and HbA1c. Glycaemic index was positively associated with glucose metabolism, and added sugars were positively associated with body fatness and BMI.
Article
Nutrition & Dietetics
Fiona S. S. Atkinson, Marc Cohen, Karen Lau, Jennie C. C. Brand-Miller
Summary: In this study, it was found through a randomised controlled crossover trial that consuming live kombucha can significantly reduce postprandial blood glucose and insulin responses compared to soda water and diet soft drink. This suggests that live kombucha may be beneficial in reducing postprandial hyperglycemia.
FRONTIERS IN NUTRITION
(2023)
Article
Pediatrics
Yan Liu, Hailong Li, Liang Huang, Chaomin Wan, Huiqing Wang, Xuefeng Jiao, Linan Zeng, Zhijun Jia, Guo Cheng, Lei Zhang, Wei Zhang, Lingli Zhang
Summary: This study analyzed drug signals associated with pediatric liver injury and identified 264 disproportionate drug signals. The top 10 drugs with the highest number of reports were paracetamol, methotrexate, vincristine, valproic acid, cyclophosphamide, tacrolimus, prednisone, prednisolone, etoposide, and cytarabine.
Review
Pharmacology & Pharmacy
Miao Zhang, Bingchen Lang, Hailong Li, Liang Huang, Linan Zeng, Zhi-Jun Jia, Guo Cheng, Yu Zhu, Lingli Zhang
Summary: The summary includes 69 studies with 195,894 pediatric patients. The incidence of DIKI in children is 18.2%, with risk factors including ICU admission, surgical intervention, infection, chronic kidney disease, and use of nephrotoxic drugs.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Letter
Medicine, General & Internal
Tianyi He, Xueting Liu, Ruiqi Lv, Guo Cheng
JOURNAL OF EVIDENCE BASED MEDICINE
(2023)
Letter
Medicine, General & Internal
Shufang Shan, Siquan Zhou, Guochen Ma, Xiaoyu Wang, Jingyuan Xiong, Guo Cheng
CHINESE MEDICAL JOURNAL
(2023)
Article
Environmental Sciences
Jingyuan Xiong, Minghui Wang, Ye Tian, Aru Ling, Shufang Shan, Li Zhao, Guo Cheng
Summary: This study found that (+/-)-equol has negative effects on cell viability, increases gonadotropin-releasing hormone secretion, and interferes with the expression of key neuromodulators.
TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY
(2022)