Article
Endocrinology & Metabolism
Heesun Lee, Hyo Eun Park, Ji Won Yoon, Su-Yeon Choi
Summary: This study found an association between visceral adipose tissue (VAT) measurement and coronary artery calcification (CAC) progression in Korean population, with VAT area on CT being the strongest predictor of CAC progression. The evaluation of body fat distribution may help identify high-risk subjects in apparently healthy individuals.
DIABETES & METABOLISM JOURNAL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Binit Sureka, Thomas George, Mahendra Kumar Garg, Mithu Banerjee, Surender Deora, Ravinder Sukhla, Akhil Goel, Pawan Kumar Garg, Taruna Yadav, Pushpinder Singh Khera
Summary: This study aimed to investigate the feasibility of using VFV, SFV, and VSR to detect metabolically obese normal weight individuals in the Asian Indian population. The results showed that patients with metabolic risk factors had significantly higher VFV, SFV, and VSR compared to those without risk factors. The volume of subcutaneous fat was significantly higher in females than males. The cutoff values for predicting at least one metabolic syndrome differed between males and females.
EUROPEAN RADIOLOGY
(2023)
Article
Endocrinology & Metabolism
Sun Ok Song, Seung Jin Han, Steven E. Kahn, Donna L. Leonetti, Wilfred Y. Fujimoto, Edward J. Boyko
Summary: In this study of non-diabetic Japanese Americans, higher leptin concentration was associated with greater accumulation of intra-abdominal fat, while higher adiponectin concentration was associated with lesser accumulation of intra-abdominal fat over 5 years. This suggests that leptin and adiponectin may independently influence regional body fat distribution.
Article
Endocrinology & Metabolism
Fiorella Palmas, Andreea Ciudin, Raul Guerra, Daniel Eiroa, Carina Espinet, Nuria Roson, Rosa Burgos, Rafael Simo
Summary: This study aims to evaluate the accuracy of a new method that combines CT imaging data with automatic software and artificial intelligence to estimate body composition in patients with obesity. The results show that this new method has high accuracy in estimating body composition in obese patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Han-Joon Lee, Jae Hyoung Cho, Woo-Jae Cho, Seong-Ho Gang, Seung-Hwan Park, Bong-Jun Jung, Hyeun Bum Kim, Kun Ho Song
Summary: This study evaluated the effectiveness of a synbiotic preparation containing L. gasseri BNR17 in reducing body fat in obese dogs. The results showed significant reductions in body weight, body condition score, and subcutaneous fat mass after supplementation with the synbiotic preparation. Additionally, the microbiome analysis revealed increased microbial diversity and an increase in carbohydrate and lipid metabolism.
Article
Oncology
Toshiaki Iwase, Aaroh Parikh, Seyedeh S. Dibaj, Yu Shen, Tushaar Vishal Shrimanker, Sudpreeda Chainitikun, Kumiko Kida, Maryanne E. Sapon, Onur Sahin, Anjali James, Andrea Yizel Delgado Medrano, Ann H. Klopp, Naoto T. Ueno
Summary: The study found that a low ratio of total visceral adipose tissue to subcutaneous adipose tissue (V/S ratio <= 34) in breast cancer patients was associated with shorter overall survival. The prognostic effect of body composition measurements in patients with locally advanced breast cancer was more significant compared to those with early breast cancer. Further research is needed to clarify the biological mechanisms underlying this association.
Article
Multidisciplinary Sciences
Rui Zheng, Karl Michaelsson, Tove Fall, Solve Elmstahl, Lars Lind
Summary: This study identified metabolites associated with total fat (%) and fat distribution, and observed an association between sex and fat distribution. These findings provide clues for further research on the metabolic pathways through which obesity affects health.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Uli Fehrenbach, Tilo Wuensch, Pia Gabriel, Laura Segger, Takeru Yamaguchi, Timo Alexander Auer, Nick Lasse Beetz, Christian Denecke, Dino Kroll, Jonas Raakow, Sebastian Knitter, Sascha Chopra, Peter Thuss-Patience, Johann Pratschke, Bernd Hamm, Matthias Biebl, Dominik Geisel
Summary: This study used CT scans to assess body composition imaging biomarkers in esophageal cancer patients, finding that sarcopenic patients have a higher risk of complications post-surgery, while those with sarcopenic obesity are more prone to postoperative pneumonia, leading to prolonged hospitalization. Additionally, low preoperative muscle mass and its decrease during follow-up are associated with lower disease-free survival and overall survival.
Article
Oncology
Aman Wadhwa, Shawn Lim, Chen Dai, Gabriel Daniels, Kandice Adams, Joshua S. S. Richman, Andrew McDonald, Grant R. R. Williams, Smita Bhatia
Summary: This study found that children, adolescents, and young adults with lymphoma and rhabdomyosarcoma experience a decline in skeletal muscle density early during treatment, which is associated with the risk of chemotherapy toxicity. Future research should focus on preventing the loss of muscle during treatment.
Article
Oncology
Aman Wadhwa, Kandice M. Adams, Chen Dai, Joshua S. Richman, Andrew M. McDonald, Grant R. Williams, Smita Bhatia
Summary: The study found that low skeletal muscle density in children with lymphoma or rhabdomyosarcoma may be associated with hematologic toxicities, while skeletal muscle index and height-adjusted total adipose tissue are not correlated with hematologic toxicities.
Article
Endocrinology & Metabolism
Haishan Huang, Xiaobin Zheng, Xiaoming Wen, Jingyi Zhong, Yanting Zhou, Lingling Xu
Summary: This study found that visceral fat affects insulin secretion and sensitivity in Chinese patients with T2DM, and the impact is more significant in overweight/obese individuals. This suggests that visceral fat plays a crucial role in diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Yuanhuan Wei, Jingjing Liang, Yixiang Su, Jue Wang, William Kwame Amakye, Jianliang Pan, Xinwei Chu, Bingjie Ma, Yanyan Song, Yan Li, Limei Mao, Zheqing Zhang
Summary: The study found that the gut microbiome and short-chain fatty acids are significantly associated with obesity and body fat distribution in the pediatric population, playing an important role in children's bodies.
CLINICAL NUTRITION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jung Hee Hong, Hyunsook Hong, Ye Ra Choi, Dong Hyun Kim, Jin Young Kim, Jeong-Hwa Yoon, Soon Ho Yoon
Summary: This study aimed to evaluate the correlation between single- and multi-slice cross-sectional thoracolumbar and whole-body compositions. Retrospective analysis of patients who underwent whole-body PET-CT scans was conducted. The results showed that single-slice L2-3 (abdominal CT range) and L1 (chest CT range) analysis had the best correlation of around 0.90 with whole-body composition. Multi-slice waist averaging provided a slightly higher correlation of 0.92.
INSIGHTS INTO IMAGING
(2023)
Article
Urology & Nephrology
Thomas Dienemann, Susan L. Ziolkowski, Shaun Bender, Simin Goral, Jin Long, Joshua F. Baker, Justine Shults, Babette S. Zemel, Peter P. Reese, F. Perry Wilson, Mary B. Leonard
Summary: After kidney transplantation, recipients experienced gains in muscle mass and strength, but the increase in fat mass outpaced muscle mass, resulting in persistent relative sarcopenia. Physical activity increased in the early months post-transplantation, but remained lower than controls.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2021)
Article
Nutrition & Dietetics
Massimo Pellegrini, Giulia Besutti, Marta Ottone, Simone Canovi, Efrem Bonelli, Francesco Venturelli, Roberto Fari, Angela Damato, Candida Bonelli, Carmine Pinto, Guido Ligabue, Pierpaolo Pattacini, Paolo Giorgi Rossi, Marwan El Ghoch
Summary: The aim of this study was to evaluate the association of adipose tissue characteristics with survival in rectal cancer patients. The results showed that increasing adipose tissue area may have a protective effect on survival, while increasing density was associated with poorer survival. Adipose tissue density influenced survival in rectal cancer patients, indicating the importance of further research in this area.
Article
Biochemistry & Molecular Biology
David Val-Laillet, Sylvie Guerin, Nicolas Coquery, Isabelle Nogret, Michele Formal, Veronique Rome, Laurence Le Normand, Paul Meurice, Gwenaelle Randuineau, Paul Guilloteau, Charles-Henri Malbert, Patricia Parnet, Jean-Paul Lalles, Jean-Pierre Segain
Article
Medicine, Research & Experimental
Charles-Henri Malbert, Mickael Genissel, Jean-Louis Divoux, Christine Henry
JOURNAL OF TRANSLATIONAL MEDICINE
(2019)
Review
Agriculture, Dairy & Animal Science
D. Val-Laillet
Article
Radiology, Nuclear Medicine & Medical Imaging
Charles-Henri Malbert, Michael Horowitz, Richard L. Young
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2019)
Article
Nutrition & Dietetics
Ryan Jalleh, Hung Pham, Chinmay S. Marathe, Tongzhi Wu, Madeline D. Buttfield, Seva Hatzinikolas, Charles H. Malbert, Rachael S. Rigda, Kylie Lange, Laurence G. Trahair, Christine Feinle-Bisset, Christopher K. Rayner, Michael Horowitz, Karen L. Jones
Article
Endocrinology & Metabolism
Charles-Henri Malbert, Alain Chauvin, Michael Horowitz, Karen L. Jones
Summary: In insulin-resistant animals, reduced GLP-1 receptor density leads to impaired inhibitory signaling in the portal sensor, resulting in a desensitization of vagal sensitivity to portal glucose.
Article
Neurosciences
Charles-Henri Malbert, David Val-Laillet, Paul Meurice, Jean-Paul Lalles, Jacques Delarue
Summary: The study evaluated the central effects of replacing saturated fatty acids with different types of PUFA in obesogenic diets. The results showed significant differences in BBB permeability and heart rate variability between the fish oil and lard groups, indicating detrimental effects of saturated fatty acid changes on heart rate variability.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Biochemical Research Methods
Charles-Henri Malbert
Summary: An open-source solution using 3D-printable mechanical pieces and software tools was successfully applied for frameless stereotaxic targeting in pigs of varying weights. Localization was achieved using an IR camera and CT imaging, with positive targeting confirmed in the first trial for all subjects by radiopaque CT enhancement or actual recording of the STN electrophysiological signature.
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Review
Integrative & Complementary Medicine
Xuwen Zhang, David Val-Laillet
Summary: Obesity and related diseases are a global threat to health, prompting increased interest in acupuncture, electroacupuncture, and related therapies due to their relatively low side effects. This study reviews various animal models used in obesity research over the past decade, assessing their advantages, disadvantages, and suitability for acupuncture and related therapies studies.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Endocrinology & Metabolism
Ambre Godet, Alexandra Fortier, Elise Bannier, Nicolas Coquery, David Val-Laillet
Summary: Emotional eating refers to the tendency to (over)eat in response to emotions. It involves the consumption of high-calorie palatable foods and can lead to eating disorders, metabolic disorders, and obesity. Although abnormal emotion processing is associated with emotional eating, the neural pathways involved are still not well-known.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Article
Nutrition & Dietetics
Laurence Lacaze, Sarah Rochdi, Annaelle Couvert, Steve Touboulic, Sylvie Guerin, Gwenaelle Randuineau, David Martin, Veronique Rome, Charles-Henri Malbert, Frederic Derbre, David Val-Laillet, Ronan Thibault
Summary: This study successfully replicated the pathophysiology of marasmus malnutrition in Yucatan minipigs through a low-calorie/low-protein diet. It comprehensively examined body composition, gut microbiota, blood parameters, and muscle tissue. The findings indicate that this experimental model is valid for mimicking severe malnutrition and muscle atrophy associated with malnutrition in humans.
CLINICAL NUTRITION
(2022)
Article
Integrative & Complementary Medicine
Xuwen Zhang, Sylvie Guerin, Youenn Launay, Yann Serrand, Nicolas Coquery, David Val-Laillet
Summary: This study aimed to compare the gut-brain axis responses to acute electroacupuncture (EA) at different acupoint combinations in the minipig model. The results showed that acute EA can significantly modulate several physiological and metabolic parameters and induce different brain activity responses. The head-abdomen combination appears to be the most promising combination, with potential regulation on ghrelin levels and appetite.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Multidisciplinary Sciences
Ambre Godet, Yann Serrand, Alexandra Fortier, Brieuc Leger, Elise Bannier, David Val-Laillet, Nicolas Coquery
Summary: Neurofeedback training has the potential to prevent and treat brain and behavioral impairments, with the dorsolateral prefrontal cortex being an important region of interest. However, the use of functional near-infrared spectroscopy in neurofeedback training is sensitive to extracerebral vascularization, which can affect the accuracy of cortical activity measurements.
Article
Neurosciences
David Val-Laillet, Ameni Kanzari, Sylvie Guerin, Gwenaelle Randuineau, Nicolas Coquery
NEUROSCIENCE LETTERS
(2020)
Article
Endocrinology & Metabolism
Charles-Henri Malbert, Alain Chauvin, Michael Horowitz, Karen L. Jones
BMJ OPEN DIABETES RESEARCH & CARE
(2020)