Article
Medicine, Research & Experimental
Yuliu Zhang, Jianping Du, Xiaofan Duan, Wei Peng, Lei Lv, Zhiyu Chen, Yumei Zhang
Summary: In this study, RIPK1 expression was found to significantly contribute to cisplatin-induced apoptosis in human ESCC cells. Reduced RIPK1 expression promoted cell proliferation, while overexpressed RIPK1 facilitated apoptosis. Mechanistic investigations revealed that inhibition of RIPK1 proliferation in ESCC cells was regulated through activation of the c-Jun NH2-terminal kinase signaling pathway, leading to mitochondrial damage, ATP depletion, and increased reactive oxygen species generation.
Article
Biochemistry & Molecular Biology
Yuko Oda, Christian T. Wong, Dennis H. Oh, Mark B. Meyer, J. Wesley Pike, Daniel D. Bikle
Summary: The vitamin D receptor (VDR) and its ligand play a crucial role in regulating the fate of epidermal stem cells. Deletion of VDR in specific stem cells results in impaired migration and regeneration of the interfollicular epidermis, but not the sebaceous gland. Genomic analysis revealed a functional association between VDR and p63, a transcription factor essential for epidermal keratinocyte proliferation and differentiation. This study highlights the importance of VDR and its interaction with p63 in orchestrating epidermal stem cell fate.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Jiao Luo, Xiujun Tan, Ling Ye, Chenglin Wang
Summary: The study reveals that the JNK signaling pathway plays a positive role in the formation of dental papilla cell polarity, as indicated by the up-regulation of polarity-related genes and rescue effects of RhoA Q63L mutant. JNK activation is linked to polarization, migration, and differentiation of dental papilla cells, highlighting its importance in tooth development.
Article
Fisheries
Ping Zhong, Zhongneng Xu, Wei Chen, Kai Peng, Yuping Sun, Xiaopeng Wu, Huiming Sun, Xiaoying Chen, Peng Luo, Chaozheng Li, Huo Li, Wen Huang
Summary: 9C-Jun NH2-terminal kinase (JNK)-interacting protein 4 (JIP4) is identified and characterized in Litopenaeus vannamei, serving as an essential component in organizing and linking the MAPK pathway. Lv-JIP4 is widely expressed in various tissues, with high levels in muscle, and plays a potential role in activating and phosphorylating Lv-p38(MAPK) in response to low-temperature stress.
AQUACULTURE REPORTS
(2021)
Article
Nutrition & Dietetics
Wusun Li, Yingying Lin, Yujia Luo, Yuqi Wang, Yao Lu, Yixuan Li, Huiyuan Guo
Summary: Vitamin D mediated through VDR protects against IR-induced intestinal injury by inhibiting apoptosis of crypt stem/progenitor cells. VDR deficiency may lead to more severe DNA damage and apoptosis, impairing intestinal regeneration and survival time. Targeting VDR could be an effective strategy for treatment of gastrointestinal syndrome in clinical radiation therapy.
Review
Biochemistry & Molecular Biology
Hyunwook Cho, Jung-Mi Hah
Summary: JNK3 plays a crucial role in neurodegenerative diseases, and this study summarizes the research on JNK3 inhibitors, focusing on structural and docking insights.
Article
Cell Biology
Khatoun Al Moussawi, Kathryn Chung, Thomas M. Carroll, Christian Osterburg, Artem Smirnov, Rebecca Lotz, Paul Miller, Zinaida Dedeic, Shan Zhong, Martin Oti, Evelyn N. Kouwenhoven, Ruth Asher, Robert Goldin, Michael Tellier, Shona Murphy, Huiqing Zhou, Volker Dotsch, Xin Lu
Summary: Concurrent mutation of RAS oncogene and tumor suppressor p53 is common in tumorigenesis. Loss of p53 inhibitor iASPP promotes tumorigenesis by regulating the expression of genes involved in skin differentiation and inflammation. The JNK-iASPP-AP1 regulatory axis is crucial for tissue homeostasis.
Article
Oncology
Keiko Tanimura, Tadaaki Yamada, Mano Horinaka, Yuki Katayama, Sarina Fukui, Kenji Morimoto, Takayuki Nakano, Shinsaku Tokuda, Yoshie Morimoto, Masahiro Iwasaku, Yoshiko Kaneko, Junji Uchino, Kazue Yoneda, Seiji Yano, Toshiyuki Sakai, Koichi Takayama
Summary: Through activation of the JNK/c-Jun signaling, novel adaptive resistance has been identified as a key factor leading to failure of ALK-TKIs treatment, suggesting that combination therapy targeting JNK and ALK-TKIs may significantly delay regrowth of lung cancer cells and potentially improve patient outcomes.
Article
Biochemistry & Molecular Biology
Anna A. Zhdankina, Dmitry I. Tikhonov, Sergey V. Logvinov, Mark B. Plotnikov, Andrei I. Khlebnikov, Nataliya G. Kolosova
Summary: Age-related macular degeneration (AMD) is the leading cause of irreversible visual impairment worldwide. JNK inhibitor IQ-1S shows potential in preventing and treating AMD, as it improves histological abnormalities associated with retinopathy in the OXYS rat model, including improved blood circulation, increased functional activity of the retinal pigment epithelium, reduced VEGF expression, and increased PEDF expression.
Article
Biochemistry & Molecular Biology
Igor A. Schepetkin, Oleksander S. Karpenko, Anastasia R. Kovrizhina, Liliya N. Kirpotina, Andrei I. Khlebnikov, Stepan I. Chekal, Alevtyna V. Radudik, Maryna O. Shybinska, Mark T. Quinn
Summary: The JNK family, including JNK1-3 proteins, regulates various physiological processes. The study aimed to find JNK inhibitors with high selectivity for JNK3. 26 new tryptanthrin-6-oxime analogs were synthesized and evaluated, and compounds 4d and 4e showed high selectivity for JNK3 and inhibited inflammatory responses. The results suggest the potential for developing anti-inflammatory drugs with selectivity for JNK3.
Article
Biochemistry & Molecular Biology
Masashi Okada, Yurika Nakagawa-Saito, Yuta Mitobe, Asuka Sugai, Keita Togashi, Shuhei Suzuki, Chifumi Kitanaka
Summary: Glioma stem cells (GSCs) play a critical role in the malignancy of glioblastoma multiforme (GBM) by resisting therapy and promoting tumor initiation. This study reveals that phospholipase C (PLC) epsilon is highly expressed in GSCs and maintains their stemness and survival capacity through the activation of JNK pathway. PLC epsilon may serve as a promising therapeutic target for GSCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Xuejun Ge, Hanting Xie, Lu Wang, Ran Li, Fang Zhang, Jing Xu, Bin Zhao, Jie Du
Summary: miR-122 expression is increased in the epithelial layer of oral lichen planus (OLP), promoting apoptosis of oral keratinocytes by decreasing VDR expression.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Review
Oncology
Isaacson B. Adelani, Oluwakemi A. Rotimi, Emmanuel N. Maduagwu, Solomon O. Rotimi
Summary: Vitamin D deficiency may aid HCC progression and play vital roles in skeletal mineralization and cell cycle regulation. Studies have shown that Vitamin D plays crucial roles in the anticancer effects in HCC and can serve as therapeutic targets. Research advancements have revealed the multifaceted mechanisms of Vitamin D in HCC development.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Junghoon Lee, Soo Woong Kim, Min Chul Cho
Summary: The combined treatment with JNK-inhibitors and HGF can effectively restore erectile function in a rat model of CNCI by anti-apoptosis and preservation of endothelium or smooth muscle, showing superior therapeutic effects compared to using each agent alone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Siamak Shahidi, Khadijeh Ramezani-Aliakbari, Alireza Komaki, Iraj Salehi, Sayedpayam Hashemi, Sara Soleimani Asl, Parisa Habibi, Fatemeh Ramezani-Aliakbari
Summary: This study found that vitamin D can improve cardiac hypertrophy in aged rats by increasing cardiac mitophagy and decreasing apoptosis.
MOLECULAR BIOLOGY REPORTS
(2023)