A Perspective on the Development of c-Jun N-terminal Kinase Inhibitors as Therapeutics for Alzheimer’s Disease: Investigating Structure through Docking Studies

Properties of FDA-approved small molecule protein kinase inhibitors: a 2021 update

(2021) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Thiophene-Pyrazolourea Derivatives as Potent, Orally Bioavailable, and Isoform-Selective JNK3 Inhibitors

(2020) Yangbo Feng et al.   ACS Medicinal Chemistry Letters

Multistage Screening Reveals 3-Substituted Indolin-2-one Derivatives as Novel and Isoform-Selective c-Jun N-terminal Kinase 3 (JNK3) Inhibitors: Implications to Drug Discovery for Potential Treatment of Neurodegenerative Diseases

(2019) Xiaodong Dou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) Emma Nichols et al.   LANCET NEUROLOGY

c-Jun NH 2 -terminal kinase inhibitor bentamapimod reduces induced endometriosis in baboons: an assessor-blind placebo-controlled randomized study

(2016) Mostafa Hussein et al.   FERTILITY AND STERILITY

Inhibition of c-Jun N-terminal kinase activation reverses Alzheimer disease phenotypes in APPswe/PS1dE9 mice

(2015) Qiong Zhou et al.   ANNALS OF NEUROLOGY

The ins and outs of selective kinase inhibitor development

(2015) Susanne Müller et al.   Nature Chemical Biology

Bentamapimod (JNK Inhibitor AS602801) Induces Regression of Endometriotic Lesions in Animal Models

(2015) Stephen S. Palmer et al.   Reproductive Sciences

Structural Basis and Biological Consequences for JNK2/3 Isoform Selective Aminopyrazoles

(2015) HaJeung Park et al.   Scientific Reports

Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives

(2014) Ke Zheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics

(2014) Apirat Chaikuad et al.   Nature Chemical Biology

Kinase Drug Discovery – What’s Next in the Field?

(2013) Philip Cohen et al.   ACS Chemical Biology

Hit-to-lead optimization and kinase selectivity of imidazo[1,2-a]quinoxalin-4-amine derived JNK1 inhibitors

(2013) Bei Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

4-Phenyl-7-azaindoles as potent, selective and bioavailable IKK2 inhibitors demonstrating good in vivo efficacy

(2012) John Liddle et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of Checkpoint Kinase Inhibitor (S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by Structure-Based Design and Optimization of Thiophenecarboxamide Ureas

(2012) Vibha Oza et al.   JOURNAL OF MEDICINAL CHEMISTRY

JNK3 Perpetuates Metabolic Stress Induced by Aβ Peptides

(2012) Sung Ok Yoon et al.   NEURON

Specificity of Linear Motifs That Bind to a Common Mitogen-Activated Protein Kinase Docking Groove

(2012) A. Garai et al.   Science Signaling

Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor

(2011) Véronique Plantevin Krenitsky et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

X-ray crystal structure of JNK2 complexed with the p38α inhibitor BIRB796: Insights into the rational design of DFG-out binding MAP kinase inhibitors

(2010) Andreas Kuglstatter et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration

(2010) Gary D. Probst et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

1-Aryl-3,4-dihydroisoquinoline inhibitors of JNK3

(2009) John A. Christopher et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity

(2008) Stanley D. Chamberlain et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Crystal Structure of JNK2 Reveals Conformational Flexibility in the MAP Kinase Insert and Indicates Its Involvement in the Regulation of Catalytic Activity

(2008) David Shaw et al.   JOURNAL OF MOLECULAR BIOLOGY

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL