Article
Oncology
Bojie Chen, Shuwen Lei, Xinlu Yin, Mengjia Fei, Yixin Hu, Yuan Shi, Yanan Xu, Lei Fu
Summary: By studying the metabolic phenotypes of papillary thyroid carcinoma (PTC) and the effects of mitochondrial activity on tumor progression, it was found that reversible mitochondrial inhibition has a durable suppressive effect on PTC growth. The results provide new insights into the use of mitochondrial inhibitors in anticancer therapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Haijun Kang, Dongmei Huang, Heng Li, Xuejun Deng, Siyuan Liu, Wenjun Gou, Linglin Liu, Yuyan Qiu, Xu Yang
Summary: This study found that the long non-coding RNA lncNALT plays an important role in the pathogenesis of hypertensive retinopathy. Knockdown of lncNALT enhances the viability, proliferation, migration, and invasion of human retinal microvascular endothelial cells (RMECs) via the PTEN/PI3K/AKT pathway.
Article
Multidisciplinary Sciences
Feng Zhi, Bowen Li, Chuanxia Zhang, Fan Xia, Rong Wang, Weihong Xie, Sihui Cai, Dawei Zhang, Ren Kong, Yiqiao Hu, Yilin Yang, Ya Peng, Jun Cui
Summary: NLRP6 enhances the PI3K/AKT pathway by binding and degrading p85 alpha, promoting tumorigenesis. The interaction between NLRP6 and p85 alpha offers a potential therapeutic target for tumor treatment.
NATURE COMMUNICATIONS
(2023)
Article
Plant Sciences
Xin Han, Guoyong Zhang, Guanghong Chen, Yuting Wu, Tong Xu, Honglin Xu, Bin Liu, Yingchun Zhou
Summary: This study found that Buyang Huanwu Decoction (BYHWD) can improve myocardial infarction (MI) by promoting angiogenesis. The underlying mechanism involves the suppression of PTEN and activation of the PI3K/Akt/GSK38 signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Soo-Hyeon Kim, Byung-Joon Seung, Seung-Hee Cho, Ha-Young Lim, Min-Kyung Bae, Jung-Hyang Sur
Summary: The frequency of PIK3CA H1047R mutation in canine mammary tumors is 14.3%, leading to dysregulation of downstream molecules Akt2, p-Akt, and PTEN, with the exception of a higher level of PTEN in mutated tumors. No significant correlation was found between PIK3CA H1047R mutation and expression of downstream molecules, suggesting the dysregulation of components in the PI3K/Akt/PTEN pathway is a feature in canine mammary tumors distinct from the mutation.
Review
Biochemistry & Molecular Biology
Sushmaa Chandralekha Selvakumar, K. Auxzilia Preethi, Durairaj Sekar
Summary: Cancer is a global threat and current therapeutics lack specificity and have side effects. Researchers have been studying the PTEN/PI3K/AKT pathway and microRNAs as potential targets for novel cancer therapeutics. This review focuses on the role of miRNAs in regulating the PTEN/PI3K/AKT axis in various cancers.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Biotechnology & Applied Microbiology
Siou-Min Luo, Wen-Chivan Tsai, Chia-Kuang Tsai, Ying Chen, Dueng-Yuan Hueng
Summary: The study showed higher expression of ARID4B in WHO grade IV tumors, and knocking down ARID4B suppressed glioma cell proliferation and induced apoptosis, indicating that ARID4B may act as an oncogene in human gliomas.
ONCOTARGETS AND THERAPY
(2021)
Review
Medicine, Research & Experimental
Chun-Lin Xiao, Wen-Chao Yin, Yan-Chun Zhong, Jia-Quan Luo, Lu-Lin Liu, Wu-Yang Liu, Kai Zhao
Summary: Spinal cord injury is a severe central nervous system injury that leads to sensory and motor dysfunction. The PI3K/Akt signaling pathway plays a key role in the pathological processes and neuronal recovery of spinal cord injury, and its activation can promote neurological function recovery by reducing cell apoptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Anatomy & Morphology
Yongbo Hu, Yiming He, Wei Liu, Shun Yu, Yabing Wei, Shaohua Bai, Yu Su, Bin Xiao
Summary: SIAH2 acts as an oncogene in colorectal cancer, promoting tumor proliferation, migration, and invasion. It activates the PI3K/AKT signaling pathway and is regulated by PTEN loss.
Article
Gastroenterology & Hepatology
Gao Liu, Bao-Ye Sun, Jian Sun, Pei-Yun Zhou, Ruo-Yu Guan, Cheng Zhou, Zhang-Fu Yang, Zhu-Tao Wang, Jian Zhou, Jia Fan, Yong Yi, Shuang-Jian Qiu
Summary: This study revealed that BRG1 regulates lipid metabolism in HCC cells by controlling GLMP and the PI3K/AKT pathway. Both BRG1 and GLMP may serve as therapeutic targets for disorders associated with dysregulated lipid metabolism.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Biotechnology & Applied Microbiology
Qin Zhu, Xian Zhang, Hong-Yan Zai, Wei Jiang, Ke-Jing Zhang, Yu-Qiong He, Yu Hu
Summary: The study suggests that circSLC8A1 plays a role in breast cancer by regulating the miR-671 and PTEN/PI3k/Akt signaling pathways, leading to inhibition of tumor growth and metastasis.
Article
Biochemistry & Molecular Biology
Mydhili Govindarasu, Pari Abirami, Govindasamy Rajakumar, Mohammad Azam Ansari, Mohammad N. Alomary, Faris F. Aba Alkhayl, Abdulaziz A. Aloliqi, Muthu Thiruvengadam, Manju Vaiyapuri
Summary: Kaempferitrin shows promise as a potential therapeutic agent for colorectal cancer, as it inhibits cancer cell proliferation and induces apoptosis through the PI3K/AKT signaling pathway.
PROCESS BIOCHEMISTRY
(2022)
Review
Cell Biology
Santiago Vidal, Yanis Hichem Bouzaher, Ahmed El Motiam, Rocio Seoane, Carmen Rivas
Summary: The PI3K/AKT pathway, regulated by SUMOylation, plays a crucial role in various physiological processes and may be involved in human diseases.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Zuping Wu, Chenchen Zhou, Quan Yuan, Demao Zhang, Jing Xie, Shujuan Zou
Summary: CTGF promotes intercellular communication in chondrocytes through upregulating Cx43 expression and activating the PI3K/Akt signaling pathway.
CELL PROLIFERATION
(2021)
Article
Plant Sciences
Tao Wang, Zhiyuan Chen, Hui Chen, Xi Yu, Lei Wang, Xiuheng Liu
Summary: The study aimed to investigate the mechanism by which brusatol regulates the growth of renal cancer cells through the PTEN/PI3K/AKT signaling pathway. The results showed that brusatol significantly inhibited the proliferation, migration, and invasion of A498, ACHN, and OSRC-2 renal cancer cell lines, and increased apoptosis rates.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Takayuki Kodama, Yu-ichiro Koma, Noriaki Arai, Aya Kido, Naoki Urakawa, Mari Nishio, Manabu Shigeoka, Hiroshi Yokozaki
LABORATORY INVESTIGATION
(2020)
Article
Medicine, General & Internal
Manabu Shigeoka, Yu-ichiro Koma, Maki Kanzawa, Masaya Akashi, Hiroshi Yokozaki
Article
Pathology
Masataka Fujikawa, Yu-ichiro Koma, Masayoshi Hosono, Naoki Urakawa, Kohei Tanigawa, Masaki Shimizu, Takayuki Kodama, Hiroki Sakamoto, Mari Nishio, Manabu Shigeoka, Yoshihiro Kakeji, Hiroshi Yokozaki
Summary: The overexpression of CCL1 in TAM-like macrophages promotes ESCC progression by enhancing cell motility, while the expression of CCR8 receptor on ESCC cell surface also plays a significant role. These interactions suggest novel therapeutic targets for treating ESCC.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Medicine, Research & Experimental
Hiroki Sakamoto, Yu-ichiro Koma, Nobuhide Higashino, Takayuki Kodama, Kohei Tanigawa, Masaki Shimizu, Masataka Fujikawa, Mari Nishio, Manabu Shigeoka, Yoshihiro Kakeji, Hiroshi Yokozaki
Summary: The study reveals that PAI-1 derived from cancer-associated fibroblasts promotes invasion of esophageal squamous cell carcinoma cells and migration of macrophages through LRP1. High expression of PAI-1 and/or LRP1 is associated with poor prognosis in ESCC patients, suggesting PAI-1/LRP1 axis could be a potential target for cancer therapy.
LABORATORY INVESTIGATION
(2021)
Article
Oncology
Shihori Tanabe, Sabina Quader, Ryuichi Ono, Horacio Cabral, Kazuhiko Aoyagi, Akihiko Hirose, Hiroshi Yokozaki, Hiroki Sasaki
Review
Cell Biology
Manabu Shigeoka, Yu-ichiro Koma, Mari Nishio, Masaya Akashi, Hiroshi Yokozaki
Summary: This review highlights the significance of macrophages in oral carcinogenesis and proposes studying the alteration of macrophage infiltrating compartments as a novel approach for gaining insights into cancer prevention and early detection.
Article
Oncology
Masaki Shimizu, Yu-ichiro Koma, Hiroki Sakamoto, Shuichi Tsukamoto, Yu Kitamura, Satoshi Urakami, Kohei Tanigawa, Takayuki Kodama, Nobuhide Higashino, Mari Nishio, Manabu Shigeoka, Yoshihiro Kakeji, Hiroshi Yokozaki
Summary: In this study, we found that MT2A plays a crucial role in the progression of ESCC, affecting the migration and invasiveness of tumor cells in CAF-like cells and cancer cells. MT2A and IGFBP2 may serve as potential novel therapeutic targets in ESCC.
Article
Oncology
Manabu Shigeoka, Yu-ichiro Koma, Takayuki Kodama, Mari Nishio, Masaya Akashi, Hiroshi Yokozaki
Summary: This study revealed that tongue cancer cell-derived CCL20 induced by interaction with macrophages promotes CD163 expression on macrophages.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pathology
Kohei Tanigawa, Shuichi Tsukamoto, Yu-ichiro Koma, Yu Kitamura, Satoshi Urakami, Masaki Shimizu, Masataka Fujikawa, Takayuki Kodama, Mari Nishio, Manabu Shigeoka, Yoshihiro Kakeji, Hiroshi Yokozaki
Summary: Direct co-culture of esophageal squamous cell carcinoma (ESCC) cells and macrophages enhances the migration and invasion abilities of ESCC cells and promotes ESCC progression through the Akt and p38 MAPK signaling pathways. The expression and release of S100A8/A9 are significantly increased in co-cultured ESCC cells and play a crucial role in this process.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Oncology
Shihori Tanabe, Sabina Quader, Ryuichi Ono, Horacio Cabral, Kazuhiko Aoyagi, Akihiko Hirose, Hiroshi Yokozaki, Hiroki Sasaki
Summary: The study identifies alterations in gene expression and network regulation in diffuse- and intestinal-type gastric cancer (GC) related to cell cycle regulation and DNA damage response, highlighting the significance of cell cycle regulation in epithelial-mesenchymal transition (EMT). The findings may provide broader insights into cancer stem cells (CSCs) and suggest new possibilities for the involvement of the cell cycle in EMT.
Article
Cell Biology
Kazuyoshi Yanagihara, Yuki Iino, Hiroshi Yokozaki, Takanori Kubo, Tatsuya Oda, Takashi Kubo, Masayuki Komatsu, Hiroki Sasaki, Hitoshi Ichikawa, Takeshi Kuwata, Toshio Seyama, Atsushi Ochiai
Summary: This study successfully established 13 matched patient-derived tumor models of PDA, including PDX, PDCL, and CDX. By comparing the histological and molecular alterations in these model systems, researchers found that PDX tumors had similar molecular alterations to PDCL and CDX tumors, while OI tumors showed specific immunohistochemical profiles. These patient-derived tumor models provide useful tools for monitoring responses to antineoplastic agents and studying the biology of PDA.
Article
Oncology
Yu Kitamura, Yu-ichiro Koma, Kohei Tanigawa, Shuichi Tsukamoto, Yuki Azumi, Shoji Miyako, Satoshi Urakami, Takayuki Kodama, Mari Nishio, Manabu Shigeoka, Yoshihiro Kakeji, Hiroshi Yokozaki
Summary: High infiltration of tumor-associated macrophages (TAMs) is correlated with poor prognosis of esophageal squamous cell carcinoma (ESCC). In this study, direct co-culture of ESCC cells with macrophages induced interleukin 7 receptor (IL-7R) expression. Overexpression of IL-7R promoted ESCC cell survival and growth via the activation of the Akt and Erk1/2 signaling pathways. The IL-7/IL-7R axis also contributed to ESCC cell migration via the Akt and Erk1/2 signaling pathways. ESCC patients with high IL-7R expression in cancer nests exhibited poor disease-free survival.
Article
Oncology
Shuichi Tsukamoto, Yu-ichiro Koma, Yu Kitamura, Kohei Tanigawa, Yuki Azumi, Shoji Miyako, Satoshi Urakami, Masayoshi Hosono, Takayuki Kodama, Mari Nishio, Manabu Shigeoka, Hiroshi Yokozaki
Summary: Tumor-associated macrophages (TAMs) play a role in the progression of esophageal squamous cell carcinoma (ESCC). A direct co-culture system was used to study the interaction between ESCC cells and TAMs, revealing that matrix metalloproteinase 9 (MMP9) expression in ESCC cells was induced by direct co-culture with TAMs. MMP9 was associated with ESCC cell migration and invasion, and its expression was controlled by the Stat3 signaling pathway. Immunohistochemical analyses showed that MMP9 expression in cancer cells at the invasive front was related to high infiltration of M2-like TAMs and worse survival of patients. However, MMP9 expression in cancer stroma was not associated with any clinicopathological factors or patient prognoses.
Article
Oncology
Satoshi Urakami, Yu-ichiro Koma, Shuichi Tsukamoto, Yuki Azumi, Shoji Miyako, Yu Kitamura, Takayuki Kodama, Mari Nishio, Manabu Shigeoka, Hirofumi Abe, Yu Usami, Yuzo Kodama, Hiroshi Yokozaki
Summary: M2 macrophages contribute to the progression of oesophageal squamous cell carcinoma (ESCC) by promoting the proliferation and migration of Het-1A cells. This phenomenon is mediated by the mTOR-p70S6K signaling pathway activated by hypersecreted YKL-40 and OPN. YKL-40 and OPN also promote M2 polarization, proliferation, and migration of macrophages.
JOURNAL OF PATHOLOGY
(2023)
Article
Genetics & Heredity
Shihori Tanabe, Eger Boonstra, Taehun Hong, Sabina Quader, Ryuichi Ono, Horacio Cabral, Kazuhiko Aoyagi, Hiroshi Yokozaki, Edward J. Perkins, Hiroki Sasaki
Summary: This study analyzed the molecular networks of anti-cancer drugs such as cisplatin, carboplatin, oxaliplatin, and arsenic trioxide in various types of cancer to reveal the mechanism of drug resistance. The study also highlighted the significance of tumor microenvironment in the treatment of drug-resistant cancer.
