Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib

Is TRAIL the holy grail of cancer therapy?

(2009) Thomas Newsom-Davis et al.   APOPTOSIS

Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy

(2009) Pierfausto Seneci et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Small Molecule XIAP Inhibitors Enhance TRAIL-Induced Apoptosis and Antitumor Activity in Preclinical Models of Pancreatic Carcinoma

(2009) M. Vogler et al.   CANCER RESEARCH

Structural Basis for Bivalent Smac-Mimetics Recognition in the IAP Protein Family

(2009) Federica Cossu et al.   JOURNAL OF MOLECULAR BIOLOGY

Engineering a leucine zipper-TRAIL homotrimer with improved cytotoxicity in tumor cells

(2009) D. V. Rozanov et al.   MOLECULAR CANCER THERAPEUTICS

Bid truncation mediated by caspases-3 and -9 in vinorelbine-induced apoptosis

(2008) Akemi Hayakawa et al.   APOPTOSIS

Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2

(2008) Federica Cossu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cytoprotective effects of IAPs revealed by a small molecule antagonist

(2008) Stefanie Galbán et al.   BIOCHEMICAL JOURNAL

SM-164: A Novel, Bivalent Smac Mimetic That Induces Apoptosis and Tumor Regression by Concurrent Removal of the Blockade of cIAP-1/2 and XIAP

(2008) J. Lu et al.   CANCER RESEARCH

Inhibition of Endoplasmic Reticulum Stress-Induced Apoptosis of Melanoma Cells by the ARC Protein

(2008) L. H. Chen et al.   CANCER RESEARCH

Targeting XIAP Bypasses Bcl-2-Mediated Resistance to TRAIL and Cooperates with TRAIL to Suppress Pancreatic Cancer Growth In vitro and In vivo

(2008) M. Vogler et al.   CANCER RESEARCH

TNF-α Induces Two Distinct Caspase-8 Activation Pathways

(2008) Lai Wang et al.   CELL

Apoptosis resistance in epithelial tumors is mediated by tumor-cell-derived interleukin-4

(2008) M Todaro et al.   CELL DEATH AND DIFFERENTIATION

To kill a tumor cell: the potential of proapoptotic receptor agonists

(2008) Avi Ashkenazi et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting the X-Linked Inhibitor of Apoptosis Protein through 4-Substituted Azabicyclo[5.3.0]alkane Smac Mimetics. Structure, Activity, and Recognition Principles

(2008) Eloise Mastrangelo et al.   JOURNAL OF MOLECULAR BIOLOGY

cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination

(2008) Mathieu J.M. Bertrand et al.   MOLECULAR CELL

Design and characterization of bivalent Smac-based peptides as antagonists of XIAP and development and validation of a fluorescence polarization assay for XIAP containing both BIR2 and BIR3 domains

(2007) Zaneta Nikolovska-Coleska et al.   ANALYTICAL BIOCHEMISTRY