Article
Multidisciplinary Sciences
Mark Schmitt, Fatih Ceteci, Jalaj Gupta, Marina Pesic, Tim W. Bottger, Adele M. Nicolas, Kilian B. Kennel, Esther Engel, Matthias Schewe, Asude Callak Kirisozu, Valentina Petrocelli, Yasamin Dabiri, Julia Varga, Mallika Ramakrishnan, Madina Karimova, Andrea Ablasser, Toshiro Sato, Melek C. Arkan, Frederic J. de Sauvage, Florian R. Greten
Summary: In solid tumors, dying cancer cells release ATP and activate paracrine effects on neighboring tumor epithelial cells, triggering an mTOR-dependent pro-survival program and rendering the surviving epithelial cells sensitive to mTOR inhibition. This dependency is due to increased production of reactive oxygen species and DNA damage associated with neighboring cell death.
Review
Cell Biology
Donovan Drouillard, Brian T. Craig, Michael B. Dwinell
Summary: Chemokines play paradoxical roles in cancer, both promoting the migration of metastatic cancer cells and the infiltration of tumor-infiltrating immune cells. Understanding the diversity of chemokine ligands and their receptors is crucial in harnessing the power of immunotherapy in precision oncology. This article reviews the literature on chemokine physiology and discusses its implications in cancer immune phenotypes and current therapies.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Review
Oncology
Baohong Song, Wei Wang, Xuemei Tang, Robby Miguel Wen-Jing Goh, Win Lwin Thuya, Paul Chi Lui Ho, Lu Chen, Lingzhi Wang
Summary: Cancer metastasis is a major challenge in cancer treatment, and resveratrol has shown potential as an anticancer agent to suppress metastasis. However, progress in clinical trials has been limited. Understanding its cellular processes and signaling pathways in tumor metastasis is crucial to develop resveratrol as an effective anticancer agent. This review evaluates the current state and future development strategies of resveratrol against cancer metastasis and discusses novel techniques to accelerate its translation from bench to bedside.
Article
Chemistry, Physical
Ori Maller, Allison P. Drain, Alexander S. Barrett, Signe Borgquist, Brian Ruffell, Igor Zakharevich, Thanh T. Pham, Tina Gruosso, Hellen Kuasne, Johnathon N. Lakins, Irene Acerbi, J. Matthew Barnes, Travis Nemkov, Aastha Chauhan, Jessica Gruenberg, Aqsa Nasir, Olof Bjarnadottir, Zena Werb, Peter Kabos, Yunn-Yi Chen, E. Shelley Hwang, Morag Park, Lisa M. Coussens, Andrew C. Nelson, Kirk C. Hansen, Valerie M. Weaver
Summary: Stromal stiffening in malignant tumours is associated with poor treatment outcomes and increased tumour aggression. Identifying factors that regulate stromal stiffening could lead to biomarkers for patient stratification and interventions to improve outcomes. Experimental studies have shown that therapeutic targeting of tumour-associated macrophages and collagen crosslinking enzymes can reduce metastasis and stromal stiffening in aggressive breast cancer subtypes with stiff stroma. Additionally, the expression of lysyl hydroxylase 2 in the stroma has been linked to disease-specific mortality in breast cancer patients, indicating its potential as a stromal biomarker.
Article
Oncology
Chenwei Wang, Yadi Liao, Wei He, Hong Zhang, Dinglan Zuo, Wenwu Liu, Zhiwen Yang, Jiliang Qiu, Yichuan Yuan, Kai Li, Yuanping Zhang, Yongjin Wang, Yunxing Shi, Yuxiong Qiu, Song Gao, Yunfei Yuan, Binkui Li
Summary: Elafin, upregulated by Sp1, enhances HCC metastasis via the EGFR/AKT pathway and attenuates the anti-metastatic effects of erlotinib. Its high expression in HCC tissues is correlated with aggressive tumor phenotypes and poor prognosis, suggesting Elafin as a valuable prognostic biomarker and therapeutic target for HCC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Xiang Li, Zitao Li, Caijuan Li, Yi Fang, Gaosen Zhang, Yudie Yan, Xiaodi Zhao, Xiaole Song, Zhen Zhang
Summary: The study reveals that miRNA-524-5p/CXCR7 axis regulates angiogenesis in colon cancer cells through AKT and ERK pathways, affecting cell proliferation, migration, and angiogenesis.
JOURNAL OF ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Pedro Bule, Sandra Isabel Aguiar, Frederico Aires-Da-Silva, Joana Nunes Ribeiro Dias
Summary: Chemokines play a crucial role in cancer development by influencing various processes such as angiogenesis, metastasis, and stemness. The chemokine network has emerged as a potential target for immunotherapy and may have therapeutic effects when used alone or in combination with other treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yewen Feng, Lu Deng, Hengrui Guo, Yumin Zhao, Fu Peng, Gang Wang, Chenghao Yu
Summary: Curcumae rhizoma essential oil (OCR) inhibits the proliferation of colon cancer cells and endothelial cells, reduces tumor angiogenesis, and improves tumor vessel structures in both in vitro and in vivo models of colon cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Yuki Ohta, Masayuki Fujii, Sirirat Takahashi, Ai Takano, Kosaku Nanki, Mami Matano, Hikaru Hanyu, Megumu Saito, Mariko Shimokawa, Shingo Nishikori, Yoshiko Hatano, Ryota Ishii, Kazuaki Sawada, Akihito Machinaga, Wataru Ikeda, Takeshi Imamura, Toshiro Sato
Summary: This study develops an experimental platform for tracking cancer stem cells in colorectal cancer and identifies dormant LGR5(+) cancer stem cells. Transcriptome analysis reveals an upregulation of cell-adhesion molecule COL17A1 in dormant cancer stem cells, and chemotherapy disrupts this dormancy through FAK-YAP activation. Inhibition of YAP signaling prevents chemoresistant cells from exiting dormancy and delays tumor regrowth.
Review
Biochemistry & Molecular Biology
Marina Ibragimova, Matvey Tsyganov, Nikolai Litviakov
Summary: This review discusses the main mechanisms of CSCs in breast cancer, including markers and signaling pathways, heterogeneity, plasticity, and ecological behavior. The study also considers the significance of dynamic heterogeneity of CSCs and dynamic transitions between CSCs and non-CSCs for metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Hina Mir, Neeraj Kapur, Dominique N. Gales, Praveen K. Sharma, Gabriela Oprea-Ilies, Anita T. Johnson, Rajesh Singh, Shailesh Singh
Summary: Breast cancer (BrCa) is the second leading cause of cancer-related deaths in American women, and its incidence is increasing. This study highlights the importance of the chemokine axis CXCR6/CXCL16 in promoting BrCa and suggests it as a potential therapeutic target for advanced-stage BrCa.
Article
Medicine, Research & Experimental
Eun Ji Lee, Soo Jin Park, Aeran Seol, Hyunji Lim, Sumin Park, Ji Yeon Ahn, Jeong Mook Lim, Hee Seung Kim
Summary: This study confirms that piglets can serve as a model for peritoneal metastasis by inoculating ovarian cancer cell lines from humans. Using two cell lines, the rate of peritoneal metastasis is 75%.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Mengjie Liu, Xiao Fu, Lili Jiang, Jiequn Ma, Xiaoqiang Zheng, Shuhong Wang, Hui Guo, Tao Tian, Kejun Nan, Wenjuan Wang
Summary: RBP-J kappa is overexpressed in colon cancer tissues and associated with advanced colon cancer phenotypes, macrophage infiltration, and shorter survival. Colon cancer cells with high RBP-J kappa expression induce the expression of TGF-beta 1 in tumor-associated macrophages by secreting CXCL11, promoting metastasis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Oncology
Yihe Yan, Leting Zheng, Qiang Du, Hamza Yazdani, Kun Dong, Yarong Guo, David A. Geller
Summary: IRF-1 regulates anti-tumor immunity in HCC by modulating CXCL10 and CXCR3, inhibiting proliferation and promoting apoptosis. It overcomes proliferation partly through activating the CXCL10/CXCR3 autocrine axis.
Article
Medicine, Research & Experimental
Weibo Feng, Wenjie Huang, Jie Chen, Chenyang Qiao, Danfei Liu, Xiaoyu Ji, Meng Xie, Tongyue Zhang, Yijun Wang, Mengyu Sung, Dean Tian, Daiming Fan, Yongzhan Nie, Kaichun Wu, Limin Xia
Summary: HOXB5 gene plays a crucial role in promoting colorectal cancer metastasis by transactivating metastatic related genes CXCR4 and ITGB3. Additionally, a positive feedback loop of CXCL12-HOXB5-CXCR4 has been identified to have an important role in colorectal cancer metastasis.
Article
Oncology
Julie Antomarchi, Damien Ambrosetti, Charlotte Cohen, Jerome Delotte, Anne Chevallier, Babou Karimdjee-Soilihi, Melanie Ngo-Mai, Annie Schmid-Alliana, Heidy Schmid-Antomarchi
CANCER MICROENVIRONMENT
(2019)
Article
Nanoscience & Nanotechnology
Marine Le Goas, Marie Paquet, Aurelie Paquirissamy, Julien Guglielmi, Cathy Compin, Juliette Thariat, Georges Vassaux, Valerie Geertsen, Olivier Humbert, Jean-Philippe Renault, Geraldine Carrot, Thierry Pourcher, Beatrice Cambien
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2019)
Article
Nanoscience & Nanotechnology
Maha Hafsi, Sandra Preveral, Christopher Hoog, Joel Herault, Geraldine Adryanczyk Perrier, Christopher T. Lefevre, Herve Michel, David Pignol, Jerome Doyen, Thierry Pourcher, Olivier Humbert, Juliette Thariat, Beatrice Cambien
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2020)
Article
Medicine, General & Internal
Maha Hichri, Georges Vassaux, Jean-Marie Guigonis, Thierry Juhel, Fanny Graslin, Julien Guglielmi, Thierry Pourcher, Beatrice Cambien
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Chemistry, Multidisciplinary
Marine Le Goas, Fabienne Testard, Olivier Tache, Nabila Debou, Beatrice Cambien, Geraldine Carrot, Jean-Philippe Renault
Article
Microbiology
Beatrice Cambien, Kevin Lebrigand, Alberto Baeri, Nicolas Nottet, Catherine Compin, Audrey Lamit, Olivier Ferraris, Christophe N. Peyrefitte, Virginie Magnone, Jerome Henriques, Laure-Emmanuelle Zaragosi, Sophie Giorgetti-Peraldi, Frederic Bost, Marine Gautier-Isola, Roger Rezzonico, Pascal Barbry, Robert Barthel, Bernard Mari, Georges Vassaux
Article
Oncology
Fabio Castillo-Rivera, Alejandro Ondo-Mendez, Julien Guglielmi, Jean-Marie Guigonis, Lun Jing, Sabine Lindenthal, Andrea Gonzalez, Diana Lopez, Beatrice Cambien, Thierry Pourcher
Summary: The uptake of iodide mediated by NIS plays a crucial role in the treatment of thyroid cancer and other malignant solid tumors. However, the expression of NIS is impacted by hypoxia and quiescence, leading to impaired treatment outcomes.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Philippe Collery, Patricia Lagadec, Imene Krossa, Charlotte Cohen, Julie Antomarchi, Didier Varlet, Marianna Lucio, Jean-Marie Guigonis, Jean-Claude Scimeca, Heidy Schmid-Antomarchi, Annie Schmid-Alliana
Summary: The study aimed to investigate the anti-tumor effects of Re-diSe on mice bearing 4T1 breast tumors and correlate them with several biomarkers. The results showed that Re-diSe did not have anti-tumor activity in this experiment. However, the choice of the experimental model is crucial for further evaluation of the compound's effects.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2022)
Article
Oncology
Maria Magdalena Canali, Melanie Guyot, Thomas Simon, Douglas Daoudlarian, Joelle Chabry, Clara Panzolini, Agnes Petit-Paitel, Nicolas Hypolite, Sarah Nicolas, Pierre Bourdely, Heidy Schmid-Antomarchi, Annie Schmid-Alliana, Javier Soria, Babou Karimdjee Soilihi, Paul Hofman, Armelle Prevost-Blondel, Masashi Kato, Evelyne Mougneau, Nicolas Glaichenhaus, Philippe Blancou
Summary: An enriched environment reduces lung metastasis in mice, potentially through the reprogramming of inflammatory monocytes and modulation of adrenergic receptors and glucocorticoid receptors signaling. This study highlights the complex role of inflammatory monocytes in cancer progression and suggests a novel anti-tumor mechanism associated with environmental factors.
CANCER CELL INTERNATIONAL
(2023)
Article
Oncology
P. H. I. L. I. P. P. E. Collery, B. E. R. N. H. A. R. D. Michalke, M. A. R. I. A. N. N. A. Lucio, D. I. D. I. E. R. Varlet, Jean -marie Guigonis, Jean-claude Scimeca, H. E. I. D. Y. Schmid-antomarchi, A. N. N. I. E. Schmid-alliana
Summary: This study aimed to investigate the tumor effects of a lower dose (0.1 mg/kg) of Re-diSe and assay the concentrations of Re and Se in plasma. The results showed that the 0.1 mg/kg dose of Re-diSe significantly increased the plasma Se concentrations, while the weight of tumors remained unchanged.
ANTICANCER RESEARCH
(2023)
Article
Infectious Diseases
Gaurav Kumar, Heidy Schmid-Antomarchi, Annie Schmid-Alliana, Michel Ticchioni, Pierre-Marie Roger
Summary: In patients with Idiopathic CD4 T cell lymphocytopenia (ICL), there is higher expression of inhibitory molecules PD-1/PDL-1 and CTLA-4 on CD4 T cells, along with an increase in regulatory T cells and high activation but low proliferation of CD4 T cells. The alteration in the expression of both the costimulatory pathway and the apoptotic pathway may contribute to the observed down-regulation of CD4 T cell functions and numbers in ICL.
INFECTIOUS DISEASE REPORTS
(2021)
Article
Nanoscience & Nanotechnology
Marine Le Goas, Aurelie Paquirissamy, Dorra Gargouri, Giulia Fadda, Fabienne Testard, Caroline Aymes-Chodur, Emile Jubeli, Thierry Pourcher, Beatrice Cambien, Serge Palacin, Jean-Philippe Renault, Geraldine Carrot
ACS APPLIED BIO MATERIALS
(2019)