Review
Biochemistry & Molecular Biology
Sneha Vivekanandhan, Deborah Bahr, Ashish Kothari, Mohammed Ali Ashary, Mizba Baksh, Emmanuel Gabriel
Summary: Cancer is a major cause of death worldwide and poses a significant burden on healthcare systems and the global economy. Rare cancers, although individually occurring at low frequencies, have a much higher combined frequency of occurrence. Immune-based therapies, such as immune checkpoint inhibitors and CAR T cell therapy, have greatly improved cancer treatment in the past decade.
Review
Oncology
Rita Saude-Conde, Dan Nguyen, Alain Hendlisz
Summary: Immune checkpoint inhibitors have become a cornerstone in the treatment of various metastatic tumors, including gastrointestinal cancers. Promising results from recent studies show potential for immunotherapies in non-metastatic GI cancers.
CURRENT OPINION IN ONCOLOGY
(2023)
Review
Oncology
Khiyam Hussain, Mark S. Cragg, Stephen A. Beers
Summary: Tumors are composed of various cell types, including macrophages, which can either promote or suppress tumor growth. Anti-cancer therapeutics like Rituximab, Herceptin, and Cetuximab work by directly targeting cancer cells and aiding macrophages in eliminating them through the process of antibody-dependent cellular phagocytosis. However, some patients do not respond well to this treatment, prompting the development of new therapies that target macrophages within tumors to improve their ability to eliminate cancer cells.
Review
Oncology
Malcolm Holterhus, Bianca Altvater, Sareetha Kailayangiri, Claudia Rossig
Summary: Cellular immunotherapy has shown limited efficacy in solid cancers of childhood and adolescence due to the presence of immunosuppressive cells in the tumor microenvironment. Strategies to target these cells, such as myeloid cell populations, with pharmacological agents are discussed, as well as novel approaches aiming to harness these cells to enhance antitumor immune responses.
Review
Oncology
Maria Lopez Vazquez, Wanlu Du, Nobuhiko Kanaya, Yohei Kitamura, Khalid Shah
Summary: Patients with extracranial tumors often develop brain metastases, representing the terminal stage of cancer progression. Recent insights in the immune biology of brain metastases and the increasing focus on immunotherapy have led to testing of promising biological immunotherapies for BM, providing future perspectives on the development and implementation of such therapies for patients with brain metastatic cancer.
Article
Biochemistry & Molecular Biology
Fabio Morandi, Irma Airoldi
Summary: HLA-G is an HLA-class Ib molecule involved in tolerance establishment during pregnancy. The expression of HLA-G is restricted in adults but can be observed in tumors, where it contributes to immune escape and tumor progression. It interacts with other immune checkpoint molecules like PD-1, CTLA-4, TIM-3, IDO, and TIGIT. Clinical trials using monoclonal antibodies against HLA-G and other immune checkpoints have shown promising results in cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Vignesh Sivaganesh, Nazifa Promi, Salma Maher, Bela Peethambaran
Summary: Immunotherapy is an emerging form of breast cancer therapy that targets cancer cells with specific receptor profiles. Popular approaches include CAR-T cells and bispecific antibodies, with mention of mRNA vaccine technology. Research on novel molecular targets and human breast cancer markers is advancing the field towards highly targeted immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Yinghan Su, Shota Yamazaki, Ryo Morisue, Jun Suzuki, Toshiaki Yoshikawa, Tetsuya Nakatsura, Masahiro Tsuboi, Atsushi Ochiai, Genichiro Ishii
Summary: The expression level of CD200R differs in T cells between pulmonary artery blood and non-small-cell lung cancer tissue, with higher expression observed in tumor-infiltrating T cells. T cells expressing CD200R also exhibit increased expression of other immune checkpoints, indicating a potential phenotypic change such as T cell exhaustion post-infiltration into the tumor.
Article
Cell & Tissue Engineering
Kai-Hung Wang, Yu-Hsun Chang, Tomor Harnod, Dah-Ching Ding
Summary: Endometrial cancer-derived mesenchymal stem cells (EmCaMSCs) play a role in tumor progression and exhibit immunosuppressive effects. Targeting EmCaMSCs with anti-cytokine and immune checkpoint inhibitors may be a potential treatment strategy for endometrial cancer.
CELL TRANSPLANTATION
(2022)
Review
Oncology
Markus Bo Schoenberg, Xiaokang Li, Xinyu Li, Yongsheng Han, Jingcheng Hao, Rainer Christoph Miksch, Dominik Koch, Nikolaus Boerner, Nicola Theresa Beger, Julian Nikolaus Bucher, Tobias Simon Schiergens, Markus Otto Guba, Jens Werner, Alexandr V. Bazhin
Summary: This study reviewed the impact of tumor infiltrating leukocyte subsets on survival rates after HCC surgery, finding that high CD3(+), CD8(+), and NK-cell infiltration predicts better survival, while high Treg and neutrophil infiltration predicts lower survival.
Review
Immunology
Ruchi Roy, Sunil Kumar Singh, Sweta Misra
Summary: This article discusses the involvement of the immune system in biological therapies targeting tumor microenvironment. It highlights the significant advancements in utilizing immune cells, particularly T cells, for the treatment of malignant tumors. The article also covers therapeutic approaches and developmental strategies to treat cancer.
Article
Medicine, General & Internal
Chun-Ting Fan, Shih-Tien Hsu, Lou Sun, Sheau-Feng Hwang, Chih-Ku Liu, Yu-Hsiang Shih, Ming-Jer Chen, Hsin-Ni Li, Jun-Sing Wang, Mei-Chin Wen, Chien-Hsing Lu
Summary: Tumor-infiltrating lymphocytes (TILs) have a prognostic role in endometrial cancer (EC), but their role in EC with different histology grades and molecular types is unclear. This study included 237 patients with primary EC and evaluated TILs using a standardized method. The results showed that TILs were not associated with disease progression in EC overall, but were associated with better progression-free survival in high-grade EC patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Raed Sulaiman, Pradip De, Jennifer C. Aske, Xiaoqian Lin, Adam Dale, Nischal Koirala, Kris Gaster, Luis Rojas Espaillat, David Starks, Nandini Dey
Summary: The dual landscape of tumor cells and stromal cells determines the response of a tumor to treatment. However, the mechanistic contribution of PD-L1/L2 and PD-1 signaling in the tumor microenvironment (TME) in endometrial cancers (ECs) is still unclear. This study aims to explore the compartmental pattern of PD-L1/L2 and PD-1 expression in EC tissues and their matched cancer-associated fibroblasts (CAFs).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Obstetrics & Gynecology
Susan M. Lang, Oliver Dorigo
Summary: Advancements in CAR technology have shown promising results in cell-based immunotherapy for gynecologic cancers, offering new hope for patients in clinical trials.
CURRENT OPINION IN OBSTETRICS & GYNECOLOGY
(2022)
Review
Immunology
Rui Rui, Liqun Zhou, Shiming He
Summary: Immunotherapy has revolutionized cancer treatment, with ongoing advancements. The aim of cancer immunotherapy is to activate the host immune system to fight against malignant tumors. Tumor infiltrating leukocytes play a role in tumor microenvironment and their interaction with tumor cells influences tumor progression. Various immunotherapies, such as immune checkpoint inhibitors, cancer vaccines, and adoptive cell transfer, have shown promising efficacy. This review summarizes the recent research progress in tumor immunotherapy, including molecular mechanisms, clinical effects, and limitations.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Nirvana Sadaghianloo, Julie Contenti, Serge Declemy, Damien Ambrosetti, Masa Zdralevic, Mounia Tannour-Louet, Lucilla Fabbri, Gilles Pages, Frederic Bost, Reda Hassen-Khodja, Jacques Pouyssegur, Elixene Jean-Baptiste, Alan Dardik, Nathalie M. Mazure
Summary: Patients with end-stage renal failure need AVFs for dialysis, but these AVFs often fail due to excessive venous thickness. This study found that venous cells adapt their metabolism depending on oxygen concentration, and targeting the hypoxic response pathway with drugs can help decrease excessive venous thickness. In a mouse model, inhibiting HIFs decreased neointimal hyperplasia, suggesting that drugs targeting HIFs could prevent AVF failure.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Biology
Maeva Dufies, Annelies Verbiest, Lindsay S. Cooley, Papa Diogop Ndiaye, Xingkang He, Nicolas Nottet, Wilfried Souleyreau, Anais Hagege, Stephanie Torrino, Julien Parola, Sandy Giuliano, Delphine Borchiellini, Renaud Schiappa, Baharia Mograbi, Jessica Zucman-Rossi, Karim Bensalah, Alain Ravaud, Patrick Auberger, Andreas Bikfalvi, Emmanuel Chamorey, Nathalie Rioux-Leclercq, Nathalie M. Mazure, Benoit Beuselinck, Yihai Cao, Jean Christophe Bernhard, Damien Ambrosetti, Gilles Pages
Summary: Dufies et al. found high Plk1 expression levels in aggressive clear cell renal cell carcinoma and discovered that Plk1 is transcriptionally upregulated in a manner dependent on HIF-2. They also found that high Plk1 expression is correlated to a poor prognosis and resistance to tyrosine kinase inhibitor against VEGF receptor, suggesting a critical role for hypoxia/HIF-2-induced Plk1 in disease progression.
COMMUNICATIONS BIOLOGY
(2021)
Article
Urology & Nephrology
Damien Ambrosetti, Michael Coutts, Charlotte Paoli, Matthieu Durand, Delphine Borchiellini, Christopher Montemagno, Olivia Rastoin, Arnaud Borderie, Renaud Grepin, Nathalie Rioux-Leclercq, Jean-Christophe Bernhard, Gilles Pages, Maeva Dufies
Summary: The study found that VEGFR-TKI significantly increased the number of CAFs in tumors, which were associated with shorter disease-free and overall survival in patients. The presence of CAFs was also correlated with lymphangiogenesis and lymph node metastasis, and CAFs promoted cell migration while reducing the cytotoxic effect of VEGFR-TKI on tumor cells.
Article
Dermatology
Christophe Perrin, Damien Ambrosetti
Summary: This study characterizes the features and diagnostic criteria of pleomorphic onychomatricoma, a rare condition that mimics malignant neoplasms.
ACTA DERMATO-VENEREOLOGICA
(2022)
Article
Cell Biology
Solene-Florence Kammerer-Jacquet, Camille Gandon, Frederic Dugay, Brigitte Laguerre, Benoit Peyronnet, Romain Mathieu, Gregory Verhoest, Karim Bensalah, Xavier Leroy, Sebastien Aubert, Catherine Vermaut, Fabienne Escande, Virginie Verkarre, Eva Comperat, Damien Ambrosetti, Florence Pedeutour, Marc-Antoine Belaud-Rotureau, Nathalie Rioux-Leclercq
Summary: This study reports the clinical, histological, immunohistochemical, and genetic features of nine cases of renal cell carcinoma with TFEB amplification. The diagnosis of this rare molecular subgroup is confirmed by FISH analysis, and CGH analysis reveals complex genomic alterations. The prognosis is poor, and combination therapy might be beneficial for these aggressive tumors.
Article
Biochemistry & Molecular Biology
Philippe Collery, Patricia Lagadec, Imene Krossa, Charlotte Cohen, Julie Antomarchi, Didier Varlet, Marianna Lucio, Jean-Marie Guigonis, Jean-Claude Scimeca, Heidy Schmid-Antomarchi, Annie Schmid-Alliana
Summary: The study aimed to investigate the anti-tumor effects of Re-diSe on mice bearing 4T1 breast tumors and correlate them with several biomarkers. The results showed that Re-diSe did not have anti-tumor activity in this experiment. However, the choice of the experimental model is crucial for further evaluation of the compound's effects.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2022)
Letter
Cell Biology
Christophe Perrin, Giorgio Toni, Michael Coutts, Damien Ambrosetti
Review
Biochemistry & Molecular Biology
Audrey Simonaggio, Damien Ambrosetti, Virginie Verkarre, Marie Auvray, Stephane Oudard, Yann-Alexandre Vano
Summary: MiTF/TFE translocation renal cell carcinoma (tRCC) is a rare and aggressive subtype of RCC, which is more prevalent in the pediatric population and represents 4% of all RCCs in adults. The diagnosis of tRCC involves translocations of genes such as TFE3, TFEB or MITF. TFE break-apart fluorescent in situ hybridization (FISH) is considered the gold standard for diagnosis. tRCC exhibits heterogeneous clinical behaviors and is more aggressive in adults. Effective treatment options for metastatic tRCC are limited, highlighting the need for better therapeutic approaches. Comprehensive genetic sequencing analyses have provided insights into the biological heterogeneity of tRCC, aiding in the development of more effective treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Urology & Nephrology
Astrid Boulenger de Hauteclocque, Loic Ferrer, Damien Ambrosetti, Solene Ricard, Pierre Bigot, Karim Bensalah, Francois Henon, Nicolas Doumerc, Arnaud Mejean, Virginie Verkarre, Charles Dariane, Stephane Larre, Cecile Champy, Alexandre de La Taille, Franck Bruyere, Morgan Roupret, Philippe Paparel, Stephane Droupy, Alexis Fontenil, Jean-Jacques Patard, Xavier Durand, Thibaut Waeckel, Herve Lang, Cedric Lebacle, Laurent Guy, Geraldine Pignot, Matthieu Durand, Jean-Alexandre Long, Thomas Charles, Evanguelos Xylinas, Romain Boissier, Mokrane Yacoub, Thierry Colin, Jean-Christophe Bernhard
Summary: This study assessed the impact of pathological upstaging in renal cell carcinoma patients and evaluated the oncological safety of different surgical approaches. A machine-learning model was developed to predict upstaging. The findings showed that machine-learning technology can be useful in evaluating and predicting upstaging in renal cell carcinoma. Partial nephrectomy did not compromise oncological outcomes in incidental upstaging, even for large tumors.
Article
Oncology
Maria Magdalena Canali, Melanie Guyot, Thomas Simon, Douglas Daoudlarian, Joelle Chabry, Clara Panzolini, Agnes Petit-Paitel, Nicolas Hypolite, Sarah Nicolas, Pierre Bourdely, Heidy Schmid-Antomarchi, Annie Schmid-Alliana, Javier Soria, Babou Karimdjee Soilihi, Paul Hofman, Armelle Prevost-Blondel, Masashi Kato, Evelyne Mougneau, Nicolas Glaichenhaus, Philippe Blancou
Summary: An enriched environment reduces lung metastasis in mice, potentially through the reprogramming of inflammatory monocytes and modulation of adrenergic receptors and glucocorticoid receptors signaling. This study highlights the complex role of inflammatory monocytes in cancer progression and suggests a novel anti-tumor mechanism associated with environmental factors.
CANCER CELL INTERNATIONAL
(2023)
Article
Oncology
P. H. I. L. I. P. P. E. Collery, B. E. R. N. H. A. R. D. Michalke, M. A. R. I. A. N. N. A. Lucio, D. I. D. I. E. R. Varlet, Jean -marie Guigonis, Jean-claude Scimeca, H. E. I. D. Y. Schmid-antomarchi, A. N. N. I. E. Schmid-alliana
Summary: This study aimed to investigate the tumor effects of a lower dose (0.1 mg/kg) of Re-diSe and assay the concentrations of Re and Se in plasma. The results showed that the 0.1 mg/kg dose of Re-diSe significantly increased the plasma Se concentrations, while the weight of tumors remained unchanged.
ANTICANCER RESEARCH
(2023)
Review
Urology & Nephrology
Michael Baboudjian, Daniel Moser, Takafumi Yanagisawa, Bastien Gondran-Tellier, Eva M. Comperat, Damien Ambrosetti, Laurent Daniel, Cyrille Bastide, Shahrokh F. Shariat, Eric Lechevallier, Pietro Diana, Alberto Breda, Benjamin Pradere, Romain Boissier
Summary: Active surveillance of biopsy-proven renal oncocytomas shows a low tumor growth rate, with oncological safety and good patient compliance. AS may represent a promising alternative to immediate treatment. Further studies on the long-term outcomes of AS are needed.
EUROPEAN UROLOGY OPEN SCIENCE
(2022)
Proceedings Paper
Cardiac & Cardiovascular Systems
Rudan Xiao, Eric Debreuve, Damien Ambrosetti, Xavier Descombes
Summary: This study investigates the importance of vascular network structure in RCC diagnosis, and builds a dataset and features to demonstrate the role of vascular networks in RCC histopathological images.
MEDICAL IMAGE COMPUTING AND COMPUTER ASSISTED INTERVENTION - MICCAI 2021, PT VI
(2021)
Article
Medicine, Research & Experimental
Anais Hagege, Damien Ambrosetti, Julien Boyer, Alexandre Bozec, Jerome Doyen, Emmanuel Chamorey, Xingkang He, Isabelle Bourget, Julie Rousset, Esma Saada, Olivia Rastoin, Julien Parola, Frederic Luciano, Yihai Cao, Gilles Pages, Maeva Dufies
Summary: High expression of Plk1 is associated with poor prognosis in HNSCC, while onvansertib shows potential therapeutic effects by inducing apoptosis. Combination of onvansertib with cisplatin and/or radiotherapy synergistically induces tumor cell death.
Article
Infectious Diseases
Gaurav Kumar, Heidy Schmid-Antomarchi, Annie Schmid-Alliana, Michel Ticchioni, Pierre-Marie Roger
Summary: In patients with Idiopathic CD4 T cell lymphocytopenia (ICL), there is higher expression of inhibitory molecules PD-1/PDL-1 and CTLA-4 on CD4 T cells, along with an increase in regulatory T cells and high activation but low proliferation of CD4 T cells. The alteration in the expression of both the costimulatory pathway and the apoptotic pathway may contribute to the observed down-regulation of CD4 T cell functions and numbers in ICL.
INFECTIOUS DISEASE REPORTS
(2021)