Article
Biotechnology & Applied Microbiology
Tamar Leshem, Bat-Shachar Schnall, Maya Azrad, Motti Baum, Assaf Rokney, Avi Peretz
Summary: This study assessed the biofilm-producing capacities of Staphylococcus aureus strains isolated from hospitalized patients in Israel. It found that MRSA strains tend to be greater biofilm-producers than MSSA strains, and there is an association between the presence of the mecA gene and biofilm production.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Microbiology
Jingyi Yu, Lulin Rao, Lingling Zhan, Yan Zhou, Yinjuan Guo, Xiaocui Wu, Zengqiang Song, Fangyou Yu
Summary: The novel small-molecule ZY-214-4 has the potential to prevent or treat Staphylococcus aureus infections by inhibiting biofilm formation and cell aggregation, without cytotoxicity.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Li Shen, Jiao Zhang, Yao Chen, Lulin Rao, Xinyi Wang, Huilin Zhao, Bingjie Wang, Yanghua Xiao, Jingyi Yu, Yanlei Xu, Junhong Shi, Weihua Han, Zengqiang Song, Fangyou Yu
Summary: In this study, a novel small-molecule compound CY-158-11 was synthesized and found to have inhibitory effects on the biofilm formation of Staphylococcus aureus. The subinhibitory concentration of CY-158-11 did not affect bacterial growth and showed no toxicity to cells. The compound effectively prevented initial attachment, repressed PIA production, and suppressed genes involved in biofilm formation. Overall, CY-158-11 inhibits biofilm formation in S. aureus by inhibiting cell adhesion and the expression of icaA gene related to PIA production.
MICROBIOLOGY SPECTRUM
(2023)
Article
Veterinary Sciences
Viviane F. Marques, Huarrisson A. Santos, Thomas H. Santos, Dayanne A. Melo, Shana M. O. Coelho, Irene S. Coelho, Miliane M. S. Souza
Summary: Staphylococcus aureus is the most important species in the etiology of bovine mastitis due to its high prevalence, difficulty in treatment, and biofilm formation. This study found that all 20 isolates of S. aureus from bovine mastitis were able to produce biofilm, with most containing icaA and icaD genes. The prevalence of agr gene type II was 70%, and transcriptional analysis revealed increased expression of ica genes at eight hours of growth, indicating the essential role of polysaccharides production in biofilm formation.
PESQUISA VETERINARIA BRASILEIRA
(2021)
Article
Microbiology
Tiep K. Nguyen, Frederic Peyrusson, Wafi Siala, Nhung H. Pham, Hoang A. Nguyen, Paul M. Tulkens, Francoise Van Bambeke
Summary: Staphylococcus aureus biofilms are resistant to antibiotics due to factors such as drug access blockage and presence of dormant bacteria. Clinical isolates produce more biofilm biomass than the reference strain, especially those with high persister fractions. Moxifloxacin is less effective against biofilms from clinical isolates, attributed to lower drug concentration and presence of moxifloxacin-tolerant subpopulations.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Infectious Diseases
Jie Peng, Xuming Liu, Qiangsheng Lu, Lvfeng Yuan, Wanyou Xu, Hecheng Zhang, Haoyue Zang
Summary: This study investigated the antibacterial effects of five different molecular side chain length lipopeptides on Staphylococcus aureus. Three lipopeptides showed strong antibacterial properties, with C16KGGK having excellent antibacterial action within the safe concentration range and therapeutic influence on Staphylococcus aureus-induced mastitis in mice.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Immunology
Hussain A. Alabdullah, Elise Overgaard, Danielle Scarbrough, Janet E. Williams, Omid Mohammad Mousa, Gary Dunn, Laura Bond, Mark A. McGuire, Juliette K. Tinker
Summary: The study assessed the efficacy of a vaccine against S. aureus infection, showing vaccinated animals did not exhibit clinical symptoms, had enhanced immune responses, and potential protective effects.
Article
Immunology
Eric Brouillette, Coralie Goetz, Daniela Droppa-Almeida, Suzanne Chamberland, Mario Jacques, Francois Malouin
Summary: Non-aureus staphylococci (NAS) colonization in the mammary gland can reduce secondary Staph. aureus colonization, while Streptococcus spp. has less impact on the infection caused by S. aureus.
MICROBES AND INFECTION
(2022)
Article
Microbiology
Silja Avall-Jaaskelainen, Joanna Koort, Heli Simojoki, Suvi Taponen
Summary: Staphylococcus aureus is a common cause of mastitis in dairy herds worldwide, but the presence of virulence genes does not explain the clinical outcomes of mastitis. The variation in virulence gene profiles is mainly between clonal complexes, suggesting allelic variation and regulation differences may play a role in the expression of virulence genes.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Na Geng, Xin Gao, Xiaozhou Wang, Shuai Cui, Jinji Wang, Yongxia Liu, Wei Chen, Jianzhu Liu
Summary: This study demonstrates that hydrogen-rich Vitamin E glycerin has stronger anti-inflammatory effects in mice mastitis induced by Staphylococcus aureus. It reduces the production of inflammatory factors and alleviates tissue damage by inhibiting specific signaling pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Microbiology
Ryota Miyazawa, So Shimoda, Keiichi Matsuda, Ryuta Tobe, Tasuke Ando, Hiroshi Yoneyama
Summary: Staphylococcus aureus is a major pathogen in humans and livestock, causing serious issues such as bovine mastitis. This study monitored cases of intramammary infection caused by S. aureus in the Miyagi Prefecture, Japan, and analyzed the strains obtained from dairy farms. The study found recurrent cases of infection and identified a Methicillin-Sensitive SA (MSSA) ST398 strain isolated from mastitis-containing cows, which is the first confirmed case in Japan. The results highlight the importance of nationwide surveillance to manage the distribution of ST398 strains in dairy farms for human and animal health.
Article
Chemistry, Multidisciplinary
Muhammad Umair Akbar, Asma Haque, Sadia Liaquat, Peter Schierack, Aamir Ali
Summary: This study detected the biofilm formation potential of clinical S. epidermidis isolates and found that the Congo red agar method and tissue culture plate method effectively classified the biofilm formation. Three antibiofilm compounds were assessed against strong biofilm-producing S. epidermidis isolates, and 3-indole acetonitrile showed inhibitory effects on the biofilms. This study highlights the significance of S. epidermidis biofilms and the potential of antibiofilm compounds for treatment and control.
Article
Chemistry, Applied
Jinjin Tong, Xiaolin Hou, Defeng Cui, Wu Chen, Hua Yao, Benhai Xiong, Lirong Cai, Hua Zhang, Linshu Jiang
Summary: This study prepared a novel berberine hydrochloride-carboxymethyl chitosan hydrogel (BH-CMCH) with excellent properties and demonstrated its antibacterial activity against Staphylococcus aureus in a rat mastitis model. Proteomics analysis indicated that BH-CMCH enhanced autolysosome degradation and activated the lysosomal pathway to promote the innate immune response.
CARBOHYDRATE POLYMERS
(2022)
Article
Biotechnology & Applied Microbiology
Jessica Duarte da Silva, Luis D. R. Melo, Silvio B. Santos, Andrew M. Kropinski, Mariana Fonseca Xisto, Roberto Sousa Dias, Isabela da Silva Paes, Marcella Silva Vieira, Jose Junior Ferreira Soares, Davide Porcellato, Vinicius da Silva Duarte, Sergio Oliveira de Paula
Summary: In this study, the biological, genomic, and structural proteomic features of a new jumbo phage vB_SauM-UFV_DC4 (DC4) were reported. DC4 exhibited strong killing activity against Staphylococcus aureus and showed stability at alkaline conditions. The complete genome of DC4 encoded several proteins with unknown functions and had similar lytic proteins and depolymerase activity with closely related jumbo phages.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jie Peng, Qiangsheng Lu, Lvfeng Yuan, Hecheng Zhang
Summary: Mastitis caused by Staphylococcus aureus in dairy cows is difficult to treat due to drug-resistant strains. Novel lipopeptide antibiotics are important for treating bacterial diseases. This study synthesized three cationic lipopeptides and found that C16dKdK exhibited strong antibacterial activity against S. aureus and could safely treat mastitis in mice.
Article
Fisheries
B. Yardimci, B. I. Didinen, E. E. Onuk, S. Metin, A. Ciftci, A. Kubilay, G. Z. Pekmezci, H. Eralp
JOURNAL OF FISH DISEASES
(2016)
Article
Fisheries
A. Ciftci, E. E. Onuk, G. Ciftci, A. Findik, M. U. Sogut, B. I. Didinen, A. Aksoy, K. Ustunakin, T. Gulhan, F. Balta, S. Altun
JOURNAL OF FISH DISEASES
(2016)
Article
Veterinary Sciences
Omer Hakan Muglali, Mustafa Salman, Ayhan Gacar, Filiz Akdag, Mustafa Yavuz Gulbahar, Alper Ciftci, Ertan Emek Onuk, Filiz Karadas, Huseyin Eseceli
TURKISH JOURNAL OF VETERINARY & ANIMAL SCIENCES
(2016)
Article
Veterinary Sciences
Serap Savasan, Sukur Kirkan, Goksel Erbas, Ugur Parin, Alper Ciftci
KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI
(2017)
Article
Agriculture, Dairy & Animal Science
Alper Ciftci, Tuba Ica, Serap Savasan, Baris Sareyyupoglu, Mehmet Akan, Kadir Serdar Diker
TROPICAL ANIMAL HEALTH AND PRODUCTION
(2017)
Article
Veterinary Sciences
Mustafa Salman, Gulay Ciftci, Alper Ciftci
MEDYCYNA WETERYNARYJNA-VETERINARY MEDICINE-SCIENCE AND PRACTICE
(2017)
Article
Agriculture, Dairy & Animal Science
Gulay Ciftci, Ozkan Yigit, Alper Ciftci
TROPICAL ANIMAL HEALTH AND PRODUCTION
(2019)
Article
Veterinary Sciences
Arzu Findik, Alper Ciftci, Taylan Onyay, Merve Gizem Sezener, Yagmur Kocak, Timur Gulhan
TURKISH JOURNAL OF VETERINARY & ANIMAL SCIENCES
(2018)
Article
Dentistry, Oral Surgery & Medicine
Sevda Kurt, Cagla Gul Gurkan, Gonca Cayir Keles Tezal, Alper Ciftci, Pinar Naile Gurgor, Sevki Guler, Burcu Ozkan Cetinkaya
ARCHIVES OF ORAL BIOLOGY
(2019)
Article
Environmental Sciences
Engin Burgaz, Merve Gizem Sezener, Cigdem Dikbas, Ahmet Kemal Ceylan, Muberra Andac, Alper Ciftci
Summary: The study involved synthesizing silver nanoparticles using kale leaf extracts and testing their antibacterial properties when loaded onto cotton fabric. The results showed that cotton fabric containing AgNPs synthesized from kale leaves displayed good antibacterial activity against bacteria.
JOURNAL OF ELEMENTOLOGY
(2021)
Article
Multidisciplinary Sciences
Gokhan Inat, Belgin Siriken, Ceren Baskan, Irfan Erol, Tuba Yildirim, Alper Ciftci
Summary: The study found that the high levels of QS systems and related virulence factors in Pseudomonas aeruginosa isolates are critical for public health. Pyocyanin, protease, and biofilm formation may cause food spoilage and play an essential role in food safety.
SCIENTIFIC REPORTS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Cagla Gul Gurkan, Gonca Cayir Keles, Sevda Kurt, Alper Ciftci, Bulent Ayas, Sevki Guler, Burcu Ozkan Cetinkaya
JOURNAL OF ORAL SCIENCE
(2019)
Article
Fisheries
E. E. Onuk, B. I. Didinen, A. Ciftci, B. Yardimci, G. Z. Pekmezci
BULLETIN OF THE EUROPEAN ASSOCIATION OF FISH PATHOLOGISTS
(2019)
Article
Veterinary Sciences
Mustafa Yavuz Gulbahar, Efe Karaca, Alper Ciftci, Sinem Inal, Ishtiaq Ahmed, Nandhakumar Balakrishnan, Edward Bealmear Breitschwerdt
ANKARA UNIVERSITESI VETERINER FAKULTESI DERGISI
(2019)
Article
Veterinary Sciences
Ertan Emek Onuk, Yeliz Tanriverdi Cayci, Ahmet Yilmaz Coban, Alper Ciftci, Fikri Balta, Behire Isul Didinen, Soner Altun
ANKARA UNIVERSITESI VETERINER FAKULTESI DERGISI
(2017)