Review
Cardiac & Cardiovascular Systems
Marios K. Georgakis, Juergen Bernhagen, Laura H. Heitman, Christian Weber, Martin Dichgans
Summary: Decades of research have established atherosclerosis as an inflammatory disease. Clinical trials have shown the efficacy of anti-inflammatory strategies in reducing cardiovascular events, but there is a need for new anti-inflammatory agents that target atherosclerosis-specific immune mechanisms. The CCL2-CCR2 axis has therapeutic potential in human atherosclerosis. However, there are challenges and opportunities related to pharmacological targeting of this pathway that need further investigation and discussion.
EUROPEAN HEART JOURNAL
(2022)
Review
Immunology
Haixia Zhang, Ke Yang, Feng Chen, Qianqian Liu, Jingyu Ni, Weilong Cao, Yunqing Hua, Feng He, Zhihao Liu, Lan Li, Guanwei Fan
Summary: This article describes the mechanisms of action of the CCL2-CCR2 axis in cardiovascular diseases and explores its potential as a targeted therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Gaile Gudauskiene, Alvita Vilkeviciute, Greta Gedvilaite, Rasa Liutkeviciene, Dalia Zaliuniene
Summary: This study found the associations between minor alleles at CCL2 rs1024611 and rs2857656, elevated CCL2 serum levels, and the development of early AMD.
Article
Hematology
Luka Zivkovic, Yaw Asare, Jurgen Bernhagen, Martin Dichgans, Marios K. Georgakis
Summary: This study systematically reviewed and meta-analyzed studies on the use of CCL2/CCR2 blockade in atheroprone mice. The results showed that CCL2/CCR2 blockade can attenuate atherosclerotic lesion size and improve lesion morphology. However, the majority of existing studies have major quality issues, highlighting the need for additional high-quality research.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Integrative & Complementary Medicine
Yanling Sheng, Xiaowei Gong, Jing Zhao, Yan Liu, Yadong Yuan
Summary: Pulmonary arterial hypertension (PAH) is a cardiopulmonary disease, and crocin may be a potential treatment by its anti-inflammatory properties.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Immunology
Ping Xu, Feng Zhang, Min-min Chang, Cheng Zhong, Cheng-Hong Sun, Hao-Ran Zhu, Jing-Chun Yao, Zhi-Zhong Li, Si-Tao Li, Wen-Cai Zhang, Guo-Dong Sun
Summary: This study demonstrates that γδ T cells are recruited to the site of spinal cord injury through CCL2/CCR2 signaling, exacerbating inflammatory response and worsening neurological impairment. This mechanism could be a potential therapeutic target for future SCI treatment.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Biochemistry & Molecular Biology
Suguru Kadomoto, Kouji Izumi, Atsushi Mizokami
Summary: Chemokines are a family of cytokines that play important roles in cancer progression. The CCL2-CCR2 axis is a major chemokine signaling pathway that impacts tumor progression significantly.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Wei Bin Fang, Diana Sofia Acevedo, Curtis Smart, Brandon Zinda, Nadia Alissa, Kyle Warren, Garth Fraga, Li-Ching Huang, Yu Shyr, Wei Li, Lu Xie, Vincent Staggs, Yan Hong, Fariba Behbod, Nikki Cheng
Summary: DCIS is the most common type of pre-invasive breast cancer in women, with most cases unlikely to progress to invasive breast cancer. Increased CCL2/CCR2 signaling in breast tissue is associated with DCIS progression, potentially serving as a signature to predict the likelihood of DCIS progressing to IDC.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Sun Ryu, Xuemei Liu, Tingting Guo, Zhaohua Guo, Jintao Zhang, Yu-Qing Cao
Summary: Migraine, especially chronic migraine, lacks effective treatment. This study suggests that the chemokine CCL2 and its receptor CCR2 play a crucial role in the development of chronic pain in migraine. Inhibiting the CCL2-CCR2 pathway can alleviate chronic headache-related behaviors.
Article
Multidisciplinary Sciences
Emanuela Colombo, Daniela Triolo, Claudia Bassani, Francesco Bedogni, Marco Di Dario, Giorgia Dina, Evelien Fredrickx, Isabella Fermo, Vittorio Martinelli, Jia Newcombe, Carla Taveggia, Angelo Quattrini, Giancarlo Comi, Cinthia Farina
Summary: The study revealed that TrkB signaling in astrocytes plays a crucial role in demyelination, fostering oligodendrocyte damage and contributing to chronic demyelination in multiple sclerosis. Additionally, the neurotrophin receptor TrkB was found associated with the expression and release of copper ions during neuroinflammation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Gustavo Ignacio Diaz-Rubio, Fernanda-Isadora Corona-Meraz, Perla-Monserrat Madrigal-Ruiz, Jesus-Aureliano Robles-De Anda, Eduardo Gomez-Banuelos, Jorge Castro-Albarran, Luis-Javier Flores-Alvarado, Monica Vazquez-Del Mercado, Felipe De Jesus Perez-Vazquez, Oscar-Enrique Pizano-Martinez, Rosa-Elena Navarro-Hernandez
Summary: In rheumatoid arthritis patients with insulin resistance, the expression pattern of chemokine receptors showed a parallel increase with their respective ligands, potentially exacerbating chronic inflammation.
Review
Immunology
Liyang Fei, Xiaochen Ren, Haijia Yu, Yifan Zhan
Summary: CCR2 is predominantly expressed by monocytes/macrophages with proinflammatory functions, and targeting CCR2 has been investigated as a strategy to modify the tumor microenvironment and enhance anti-tumor immunity. In addition to blocking chemotaxis of suppressive myeloid cells, CCR2 signaling has underappreciated effects on myeloid cell survival and function polarization. T cells also express CCR2, and targeting CCR2 is shown to favor the anti-tumor arm of immune responses by affecting tissue homing of Treg cells and enhancing Treg functional potency.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Dermatology
Rintaro Shibuya, Yoshihiro Ishida, Sho Hanakawa, Tatsuki R. Kataoka, Yasuhide Takeuchi, Teruasa Murata, Arisa Akagi, Zachary Chow, Toshiaki Kogame, Satoshi Nakamizo, Saeko Nakajima, Gyohei Egawa, Takashi Nomura, Naotomo Kambe, Akihiko Kitoh, Kenji Kabashima
Summary: The CCL2-CCR2 signaling pathway plays a critical role in the development of SDS-induced cumulative irritant contact dermatitis (ICD). Treatment with SDS upregulates CCL2, and mice deficient in CCR2 show reduced neutrophil accumulation and alleviated ICD. Neutrophil depletion can alleviate SDS-induced ICD, and intradermal administration of IL-1 beta restores neutrophil accumulation and the development of ICD in CCR2-deficient mice.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Cynthia Hajal, Yoojin Shin, Leanne Li, Jean Carlos Serrano, Tyler Jacks, Roger D. Kamm
Summary: The study demonstrates that astrocytes promote cancer cell extravasation across the blood-brain barrier by secreting CCL2 and the CCL2-CCR2 astrocyte-cancer cell axis plays a fundamental role in this process.
Article
Cell & Tissue Engineering
L. Tao, Y. Zhou, B. Zeng, X. Yang, M. Su
Summary: miR-183 was downregulated in tissue samples from patients and mice with OA. In DMM mice, overexpression of miR-183 inhibited the expression of proinflammatory cytokines (IL-6, IL-1 beta, TNF-alpha) and pain-related factors (TRPV1, Nav1.3, Nav1.7, Nav1.8) in DRG. OA pain was relieved by miR-183-mediated inhibition of macrophage infiltration, and dual luciferase reporter assay demonstrated that miR-183 directly targeted TGF alpha.
BONE & JOINT RESEARCH
(2021)
Article
Hematology
Miguel Alejandro Lopez-Ramirez, Angela Pham, Romuald Girard, Tine Wyseure, Preston Hale, Atsuki Yamashita, Janne Koskimaki, Sean Polster, Laleh Saadat, Ignacio A. Romero, Charles T. Esmon, Frederic Lagarrigue, Issam A. Awad, Laurent O. Mosnier, Mark H. Ginsberg
Article
Medicine, Research & Experimental
Juan Aparicio-Blanco, Ignacio A. Romero, David K. Male, Karla Slowing, Luis Garcia-Garcia, Ana I. Torres-Suarez
MOLECULAR PHARMACEUTICS
(2019)
Article
Biochemistry & Molecular Biology
Emily F. Goodall, Vicki Leach, Chunfang Wang, Johnathan Cooper-Knock, Paul R. Heath, David Baker, David R. Drew, M. Jill Saffrey, Julie E. Simpson, Ignacio A. Romero, Stephen B. Wharton
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Neurosciences
Zerin Alimajstorovic, Ester Pascual-Baixauli, Cheryl A. Hawkes, Basil Sharrack, A. Jane Loughlin, Ignacio A. Romero, Jane E. Preston
FLUIDS AND BARRIERS OF THE CNS
(2020)
Article
Genetics & Heredity
Perla Pucci, Erik Venalainen, Ilaria Alborelli, Luca Quagliata, Cheryl Hawkes, Rebecca Mather, Ignacio Romero, Sushilaben H. Rigas, Yuzhuo Wang, Francesco Crea
Review
Neurosciences
David M. F. Francisco, Luca Marchetti, Sabela Rodriguez-Lorenzo, Eduardo Frias-Anaya, Ricardo M. Figueiredo, Peter Winter, Ignacio Andres Romero, Helga E. de Vries, Britta Engelhardt, Remy Bruggmann
FLUIDS AND BARRIERS OF THE CNS
(2020)
Article
Biochemistry & Molecular Biology
Petros Pousinis, Ines R. Ramos, M. Nicola Woodroofe, Laura M. Cole
Article
Geriatrics & Gerontology
Eduardo Frias-Anaya, Radka Gromnicova, Igor Kraev, Vadim Rogachevsky, David K. Male, Francesco Crea, Cheryl A. Hawkes, Ignacio A. Romero
Summary: Aging female blood-brain barrier (BBB) exhibits regionally specific ultrastructural alterations, which may lead to oxidative stress, abnormal capillary blood flow, and decreased barrier stability.
NEUROBIOLOGY OF AGING
(2021)
Article
Neurosciences
Shereen Nizari, Jack A. Wells, Roxana O. Carare, Ignacio A. Romero, Cheryl A. Hawkes
Summary: The interplay between cholinergic innervation and vascular function is crucial in the development and progression of CAA, suggesting that combined eNOS/cholinergic therapies may enhance Aβ clearance from the brain and reduce its deposition as CAA.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Miriam Sartages, Ebel Floridia, Mar Garcia-Colomer, Cristina Iglesias, Manuel Macia, Patricia Penas, Pierre-Olivier Couraud, Ignacio A. Romero, Babette Weksler, Celia M. Pombo, Juan Zalvide
Article
Oncology
Rebecca L. Mather, Abhijit Parolia, Sandra E. Carson, Erik Venalainen, David Roig-Carles, Mustapha Jaber, Shih-Chun Chu, Ilaria Alborelli, Rebecca Wu, Dong Lin, Noushin Nabavi, Elena Jachetti, Mario P. Colombo, Hui Xue, Perla Pucci, Xinpei Ci, Cheryl Hawkes, Yinglei Li, Hardev Pandha, Igor Ulitsky, Crystal Marconett, Luca Quagliata, Wei Jiang, Ignacio Romero, Yuzhuo Wang, Francesco Crea
Summary: Metastatic neuroendocrine prostate cancer (NEPC) is a highly aggressive disease with increasing incidence. The study identified LINC00261 as significantly upregulated in NEPC, driving proliferation and metastasis through effects on CBX2 and FOXA2. This indicates that LINC00261 may be utilized as a therapeutic target and a biomarker for NEPC.
MOLECULAR ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Conor McQuaid, Andrea Halsey, Maeva Dubois, Ignacio Romero, David Male
Summary: Targeting therapeutic agents to specific tissues is crucial for new disease treatments, with the transferrin receptor being a potential target due to its presence on dividing cells and brain endothelium. This study compared different polypeptides for their ability to bind to brain endothelium and target therapeutic agents to the CNS. The findings showed that attaching a TfR-targeting polypeptide significantly increased endocytosis rates by brain endothelium and enhanced nanoparticle movement across cells.
Article
Education & Educational Research
Katherine E. Rawlinson, Catherine J. Duckett, Hollie Shaw, M. Nicola Woodroofe, Melissa M. Lacey
Summary: Through analyzing data from a large-scale family-focused public engagement event hosted within a university campus setting, the study found that the event attracted new visitors annually, with a significant increase in perceived knowledge among participants from low education progression areas. Participants reported both immediate and long-term positive impacts, including increases in components of science capital and positive perceptions of the university and its students.
INTERNATIONAL JOURNAL OF SCIENCE EDUCATION PART B-COMMUNICATION AND PUBLIC ENGAGEMENT
(2021)
Article
Neurosciences
Chiara Barberio, Aimee Withers, Yash Mishra, Pierre-Olivier Couraud, Ignacio A. A. Romero, Babette Weksler, Roisin M. Owens
Summary: The blood-brain barrier (BBB) is a crucial component of the neurovascular unit (NVU) that regulates brain homeostasis and microenvironment. Researchers have developed an in vitro tri-culture NVU model using human-derived cell lines, which allows for better understanding of BBB mechanisms and improved testing and delivery of therapeutics.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Meeting Abstract
Oncology
P. Pucci, E. Venalainen, I. Alborelli, L. Quagliata, R. Mather, S. Rigas, I. Romero, Y. Wang, F. Crea
ANNALS OF ONCOLOGY
(2019)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.