The CCL2-CCR2 astrocyte-cancer cell axis in tumor extravasation at the brain

The cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic dissemination

(2021) Giovanni S. Offeddu et al.   Communications Biology

Proteomic Profiling of the ECM of Xenograft Breast Cancer Metastases in Different Organs Reveals Distinct Metastatic Niches

(2020) Jess D. Hebert et al.   CANCER RESEARCH

The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood–brain barrier

(2020) Tetyana P. Buzhdygan et al.   NEUROBIOLOGY OF DISEASE

Brain metastases

(2019) Achal Singh Achrol et al.   Nature Reviews Disease Primers

Vessel co-option in cancer

(2019) Elizabeth A. Kuczynski et al.   Nature Reviews Clinical Oncology

Development and Cell Biology of the Blood-Brain Barrier

(2019) Urs H. Langen et al.   Annual Review of Cell and Developmental Biology

Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies

(2019) Tae-Eun Park et al.   Nature Communications

An on-chip model of protein paracellular and transcellular permeability in the microcirculation

(2019) Giovanni S. Offeddu et al.   BIOMATERIALS

Blood–Brain Barrier Dysfunction in a 3D In Vitro Model of Alzheimer's Disease

(2019) Yoojin Shin et al.   Advanced Science

3D brain angiogenesis model to reconstitute functional human blood–brain barrier in vitro

(2019) Somin Lee et al.   BIOTECHNOLOGY AND BIOENGINEERING

3D self-organized microvascular model of the human blood-brain barrier with endothelial cells, pericytes and astrocytes

(2018) Marco Campisi et al.   BIOMATERIALS

In vitro models of molecular and nano-particle transport across the blood-brain barrier

(2018) Cynthia Hajal et al.   Biomicrofluidics

Hemodynamic Forces Tune the Arrest, Adhesion, and Extravasation of Circulating Tumor Cells

(2018) Gautier Follain et al.   DEVELOPMENTAL CELL

Inflamed neutrophils sequestered at entrapped tumor cells via chemotactic confinement promote tumor cell extravasation

(2018) Michelle B. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metastatic Brain Tumors Disrupt the Blood-Brain Barrier and Alter Lipid Metabolism by Inhibiting Expression of the Endothelial Cell Fatty Acid Transporter Mfsd2a

(2018) Shweta Tiwary et al.   Scientific Reports

The Role of Astrocytes in Multiple Sclerosis

(2018) Gerald Ponath et al.   Frontiers in Immunology

Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension

(2018) Humberto Mestre et al.   Nature Communications

On-chip human microvasculature assay for visualization and quantification of tumor cell extravasation dynamics

(2017) Michelle B Chen et al.   Nature Protocols

Brain Metastases: Surgical Treatment and Overall Survival

(2017) Giancarlo D'Andrea et al.   World Neurosurgery

CCL2/Monocyte Chemoattractant Protein 1 and Parathyroid Hormone Action on Bone

(2017) Jawed Akhtar Siddiqui et al.   Frontiers in Endocrinology

A Low Permeability Microfluidic Blood-Brain Barrier Platform with Direct Contact between Perfusable Vascular Network and Astrocytes

(2017) Seokyoung Bang et al.   Scientific Reports

Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer

(2016) Qing Chen et al.   NATURE

Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus

(2016) Nicholas H. Varvel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury

(2016) Yejie Shi et al.   Nature Communications

Targeting the CCL2-CCR2 signaling axis in cancer metastasis

(2016) Su Yin Lim et al.   Oncotarget

Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip

(2016) Anna Herland et al.   PLoS One

Imaging of Angiotropism/Vascular Co-Option in a Murine Model of Brain Melanoma: Implications for Melanoma Progression along Extravascular Pathways

(2016) Laurent A. Bentolila et al.   Scientific Reports

A dynamic in vivo-like organotypic blood-brain barrier model to probe metastatic brain tumors

(2016) Hui Xu et al.   Scientific Reports

Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor

(2015) Jacquelyn A. Brown et al.   Biomicrofluidics

Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth

(2015) Lin Zhang et al.   NATURE

Serpins Promote Cancer Cell Survival and Vascular Co-Option in Brain Metastasis

(2014) Manuel Valiente et al.   CELL

Astrocyte CCL2 sustains immune cell infiltration in chronic experimental autoimmune encephalomyelitis

(2014) Roy Y. Kim et al.   JOURNAL OF NEUROIMMUNOLOGY

Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S

(2014) Lisa Sevenich et al.   NATURE CELL BIOLOGY

Endothelial CCR2 Signaling Induced by Colon Carcinoma Cells Enables Extravasation via the JAK2-Stat5 and p38MAPK Pathway

(2012) Monika Julia Wolf et al.   CANCER CELL

Autocrine CCL2 promotes cell migration and invasion via PKC activation and tyrosine phosphorylation of paxillin in bladder cancer cells

(2012) Hsiao-Ying Chiu et al.   CYTOKINE

Brain Metastases from Prostate Cancer: An 11-Year Analysis in the MRI Era with Emphasis on Imaging Characteristics, Incidence, and Prognosis

(2012) Vaios Hatzoglou et al.   JOURNAL OF NEUROIMAGING

CCL2 disrupts the adherens junction: implications for neuroinflammation

(2012) Toni K Roberts et al.   LABORATORY INVESTIGATION

Microfluidic assay for simultaneous culture of multiple cell types on surfaces or within hydrogels

(2012) Yoojin Shin et al.   Nature Protocols

CCL2-Expressing Astrocytes Mediate the Extravasation of T Lymphocytes in the Brain. Evidence from Patients with Glioma and Experimental Models In Vivo

(2012) Maria Angeles Carrillo-de Sauvage et al.   PLoS One

CCL2 increases MMP-9 expression and cell motility in human chondrosarcoma cells via the Ras/Raf/MEK/ERK/NF-κB signaling pathway

(2011) Chih-Hsin Tang et al.   BIOCHEMICAL PHARMACOLOGY

Interstitial flow influences direction of tumor cell migration through competing mechanisms

(2011) W. J. Polacheck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epidemiology of Brain Metastases

(2011) Lakshmi Nayak et al.   Current Oncology Reports

Fluorescent whole-mount method for visualizing three-dimensional relationships in intact and regenerating adult newt spinal cords

(2010) Katherine A. Zukor et al.   DEVELOPMENTAL DYNAMICS

Metastatic colonization: Settlement, adaptation and propagation of tumor cells in a foreign tissue environment

(2010) Tsukasa Shibue et al.   SEMINARS IN CANCER BIOLOGY

Monocyte Chemoattractant Protein-1 (MCP-1): An Overview

(2009) Satish L. Deshmane et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Genes that mediate breast cancer metastasis to the brain

(2009) Paula D. Bos et al.   NATURE

Real-time imaging reveals the single steps of brain metastasis formation

(2009) Yvonne Kienast et al.   NATURE MEDICINE

Non-invasive measurement of solute permeability in cerebral microvessels of the rat

(2008) Wei Yuan et al.   MICROVASCULAR RESEARCH

Transcellular transport of CCL2 across brain microvascular endothelial cells

(2007) Shujun Ge et al.   JOURNAL OF NEUROCHEMISTRY