Article
Immunology
Kerstin Muelling, Alexa Josephine Fischer, Elena Siakaeva, Mathis Richter, Sharareh Bordbari, Ilona Spyra, Christian Koester, Dirk M. Hermann, Matthias Gunzer, Ursula Felderhoff-Mueser, Ivo Bendix, Jadwiga Jablonska, Josephine Herz
Summary: This study found that neutrophils in the neonatal brain are rapidly activated after experimental hypoxia-ischemia, producing reactive oxygen species and showing an increased proportion of hyperactivated/aged cells compared to peripheral neutrophils. Delayed neutrophil depletion led to reduced cellular neurodegeneration and decreased microglial and astroglial activation, offering new possibilities for therapeutic approaches in post-hypoxic brain injury.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Pharmacology & Pharmacy
Jose Martinez-Orgado, Maria Villa, Aaron del Pozo
Summary: CBD shows neuroprotective effects in newborn pigs and rodents with HIBI, modulating the major components of HIBI pathophysiology. It has the potential to be an effective treatment for neonatal HIBI.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Nutrition & Dietetics
Helene Roumes, Pierre Goudeneche, Luc Pellerin, Anne-Karine Bouzier-Sore
Summary: Polyphenols, including resveratrol, have potential neuroprotective effects against neonatal hypoxia-ischemia-induced damage due to their anti-apoptotic, anti-inflammatory, and anti-oxidative properties, and may enhance brain energy metabolism. Maternal supplementation at nutritional doses shows promising results and could be a novel prophylactic treatment for neonatal hypoxia-ischemia.
Review
Pharmacology & Pharmacy
Ferenc Domoki
Summary: Hypoxic-ischemic encephalopathy (HIE) is a major cause of morbidity and mortality in term neonates. Recent studies have shown that molecular hydrogen may have neuroprotective effects in combating the deleterious consequences of hypoxic-ischemic insults. However, further research is needed to explore the potential synergistic effect of hydrogen with therapeutic hypothermia for the treatment of HIE.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Nutrition & Dietetics
Eduardo Sanches, Yohan van de Looij, Sadou Sow, Audrey Toulotte, Analina da Silva, Laura Modernell, Stephane Sizonenko
Summary: This study demonstrates that lactoferrin (Lf) supplementation attenuates acute and long-term cerebral injuries caused by hypoxia-ischemia in a dose-dependent manner. The optimal dose of 1 g/kg of Lf showed the best effects, reducing brain volume decreases and other detrimental effects. The research emphasizes the need for better understanding of Lf's effects and potential harmful effects on immature brains.
Article
Pharmacology & Pharmacy
Gorane Beldarrain, Enrique Hilario, Idoia Lara-Celador, Marc Chillida, Ana Catalan, Antonia Angeles Alvarez-Diaz, Daniel Alonso-Alconada
Summary: Neonatal hypoxia-ischemia (HI) can lead to a neurological condition called hypoxic-ischemic encephalopathy (HIE) in newborns, resulting in overall disability. The current treatment for affected neonates is therapeutic hypothermia, but it is not always effective in preventing the harmful effects of HI. Therefore, cannabinoids are being researched as potential new therapies. Modulating the endocannabinoid system (ECS) may reduce brain damage and stimulate cell proliferation. This study examined the middle- and long-term effects of 2-AG, the most abundant endocannabinoid, after neonatal HI in rats, and found that it reduced brain injury and promoted cell proliferation, suggesting long-lasting neuroprotective effects.
Article
Chemistry, Medicinal
Tingting Li, Jiangbing Li, Tong Li, Yijing Zhao, Hongfei Ke, Shuanglian Wang, Dexiang Liu, Zhen Wang
Summary: The study found that L-Cysteine treatment prevented acute brain damage and long-term memory impairment in neonatal mice exposed to hypoxia-ischemia. This protective effect was associated with the phosphorylation of Akt and PTEN. The neuroprotective effects of L-Cysteine were attenuated when the PI3K inhibitor, LY294002, was used.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Review
Neurosciences
Qianting Deng, Chongyun Wu, Timon Cheng-Yi Liu, Rui Duan, Luodan Yang
Summary: Neonatal hypoxic-ischemic encephalopathy (HIE) is the leading cause of neonatal mortality and disability. Currently, hypothermia is the only approved treatment, but its therapeutic efficacy is limited. Therefore, there is a need to understand the molecular pathogenesis of HIE and develop novel therapies.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Chemistry, Applied
Han Gao, Lin Guo, Chengcheng Shi, Yining Zhu, Chao Yang, Wujiong Xia
Summary: A transition-metal-free photoinduced radical-mediated alpha-oxy C-H cyclobutylation reaction was developed, which enables the synthesis of 1,3-disubstituted cyclobutanes in high yields. The reaction proceeds via photo-induced hydrogen atom transfer to generate alpha-oxy carbon-centered radical intermediates.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Organic
Yufei Li, Xin Liang, Kaikai Niu, Jun Gu, Fang Liu, Qing Xia, Qingmin Wang, Weihua Zhang
Summary: An attractive, versatile, and operationally simple visible-light-induced trifluoromethylation method has been demonstrated, which is transition-metal-free, photocatalyst-free, and oxidant-free. Inexpensive and readily available triflic anhydride (Tf2O) was chosen as the radical trifluoromethyl source, and thianthrene was used as a recyclable Tf2O-activating reagent, achieving a high-yielding and scalable trifluoromethylation reaction. Density functional theory and mechanistic studies revealed that the reaction involves a free radical homolytic process excited by visible light, generating a key trifluoromethyl radical intermediate.
Review
Biology
Sarah Kolnik, Thomas R. Wood
Summary: Vitamin E has potential as a neuroprotectant in newborn infants with brain injury, but its effectiveness in clinical settings is still uncertain. Recent studies have shown that fat emulsions containing higher levels of Vitamin E can improve outcomes in neonatal co-morbidities, leading to a reconsideration of Vitamin E administration as a potential therapeutic modality. This review discusses the structure, mechanism(s) of action, evidence in animal models, and association with health outcomes in neonates, highlighting the need for further research and assessment of safety profiles before large clinical trials.
Article
Biochemistry & Molecular Biology
Eduardo Sanches, Yohan van de Looij, Dini Ho, Laura Modernell, Analina da Silva, Stephane Sizonenko
Summary: Combining early oral administration of lactoferrin with whole body hypothermia can enhance neuroprotection in neonatal hypoxic-ischemic encephalopathy, preventing lactate accumulation, reducing inflammation, and mitigating brain damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Organic
Yingming Ren, Yaxin Ge, Qinqin Yan, Shiliu Chen, Yang Li, Lijun Li, Zhong-Quan Liu, Zejiang Li
Summary: The study explores a free radical-initiated cascade cyclization of unactivated alkenes with chloralkanes, providing a protocol for the synthesis of chlorinated heterocycles or polycyclic compounds through selective activation of the alpha-C(sp(3))-H bond of chloralkanes. Various radical inhibition experiments, radical capture operations, and radical clock tests were conducted in this system.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Neurosciences
Aminah Sheikh, Xiangying Meng, Joseph P. Y. Kao, Patrick O. Kanold
Summary: The study reveals that neonatal hypoxia-ischemia injuries lead to persistent changes in intracortical connections, which may interfere with brain development and impact the subsequent development of disorders.
Article
Clinical Neurology
Lucia Beckmann, Stefanie Obst, Nicole Labusek, Hanna Abberger, Christian Koester, Ludger Klein-Hitpass, Sven Schumann, Christoph Kleinschnitz, Dirk M. Hermann, Ursula Felderhoff-Mueser, Ivo Bendix, Wiebke Hansen, Josephine Herz
Summary: Clinical and experimental studies suggest sexual dimorphism in neonatal brain injury and therapy responses caused by hypoxia-ischemia (HI). This study found that regulatory T cells (Tregs) from neonatal female mice provide neuroprotection, while Tregs from male mice increase secondary neurodegeneration, which may be associated with intrinsic transcriptional differences between sexes. There is an urgent need for sex-stratified clinical and preclinical analyses.
Article
Cell Biology
Shufeng Yu, Desislava Met Doycheva, Marcin Gamdzyk, Yuanyuan Gao, Yong Guo, Zackary D. Travis, Jiping Tang, Wen-Xiong Chen, John H. Zhang
Summary: The activation of MC1R with BMS-470539 attenuates oxidative stress and neuronal apoptosis in a neonatal HI rat model, improving neurological deficits. This effect is partially mediated by the MC1R/cAMP/PKA/Nurr1 signaling pathway.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Letter
Critical Care Medicine
Gerald Matchett, Irina Gasanova, Christina A. Riccio, Mary C. Sunna, Babatunde O. Ogunnaike
INTENSIVE CARE MEDICINE
(2022)
Review
Nanoscience & Nanotechnology
Vikram Jadhav, Arun Bhagare, Ismat H. Ali, Akshay Dhayagude, Dnyaneshwar Lokhande, Jayraj Aher, Mohammed Jameel, Mycal Dutta
Summary: Biosynthesis of nanomaterials, as an environmentally friendly method, has many advantages and serves as a bridge for interdisciplinary research. Using extracts from the Moringa oleifera plant, metal and metal oxide nanomaterials can be synthesized with potential applications.
JOURNAL OF NANOMATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Caiyou Zeng, Xuejun Sun, Bojin Qi, Yipeng Wang, Haibo Wang, Zhejun Tan, Yong Peng, Baoqiang Cong
Summary: This study demonstrates a novel strategy to enhance the strength and ductility of AA2219 Al-6.3Cu alloy arc-welded joints by introducing TiC particles and using a distinctive ultrasonic frequency double-pulsed arc. The fabricated TiCp/Al6.3Cu joint shows a fine-grained structure and a hierarchical alpha-Al grain structure embedded with dense nano-precipitation. The joint exhibits an unprecedented joint coefficient and excellent mechanical performance.
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
(2022)
Article
Cell Biology
Xuan Shi, Lina Zhu, Sheng Wang, Wanli Zhu, Quanfu Li, Juan Wei, Di Feng, Meiyun Liu, Yuanli Chen, Xuejun Sun, Hongtao Lu, Xin Lv
Summary: This study explored the protective effects of magnesium hydride (MgH2) on two types of ARDS models and its underlying mechanism in a lipopolysaccharide (LPS)-induced ARDS model of the A549 cell line. Results showed that MgH2 exerted anti-inflammatory, antioxidant, anti-apoptotic, and barrier-protective effects by regulating molecular signaling pathways. The in vivo study also demonstrated that MgH2-treated mice had a better survival rate and less pathological damage.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Pharmacology & Pharmacy
Xiaoya Li, Xueqi Ma, Xintong Chen, Tingfang Wang, Qing Liu, Yongfang Wang, Zhezhe Li, Juan Hofer, Fangbing Li, Liang Xiao, Xuejun Sun, Jinggang Mo
Summary: This study analyzed the molecular composition of the medusa and polyp of Aurelia coerulea and compared its toxicity with another scyphozoan jellyfish, Stomolophus meleagris. The results showed that A. coerulea medusae and polyps have similar molecular compositions, but their gene expressions are significantly different. A. coerulea medusa displayed weaker toxicity compared to S. meleagris medusa, and the variation in toxin expressions may be an important factor contributing to the difference in toxicity.
Article
Nanoscience & Nanotechnology
Vikram Jadhav, Arun Bhagare, Shadma Wahab, Dnyaneshwar Lokhande, Chandraprabha Vaidya, Akshay Dhayagude, Mohammad Khalid, Jayraj Aher, Amine Mezni, Mycal Dutta
Summary: Calcium oxide nanoparticles (CaO NPs) have unique catalytic and biological properties, making them highly applicable in material science, environmental science, and medicinal science. Using a biological method to synthesize CaO NPs can reduce the use of hazardous chemicals and be cost-effective and ecologically profitable. This study investigated the production of CaO NPs using Moringa oleifera plant leaves aqueous extract and demonstrated their antimicrobial activities.
JOURNAL OF NANOMATERIALS
(2022)
Article
Cell Biology
Jinwei Pang, Nathanael Matei, Jianhua Peng, Wen Zheng, Jing Yu, Xu Luo, Richard Camara, Ligang Chen, Jiping Tang, John H. Zhang, Yong Jiang
Summary: Delayed recanalization at day 3 postinfarct can significantly improve neurological outcomes after ischemic stroke. Macrophages play a critical role in this process by promoting angiogenesis and reducing neurodegeneration.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Engineering, Manufacturing
Xuejun Sun, Bojin Qi, Zihao Jiang, Caiyou Zeng, Baoqiang Cong
Summary: In this study, different current modes were used to butt-weld 1460 Al-Li alloy plates. The effects of these current modes on the weld microstructure and mechanical properties were compared. The results showed that modulating pulsed current can refine the grains in the weld zone and fusion zone, and significantly increase the quantity and width of a fine strip-like equiaxed grain zone. Both P-VPTIG and DP-VPTIG processes effectively enhanced the strength and elongation of the joints.
JOURNAL OF MANUFACTURING PROCESSES
(2022)
Article
Economics
Jingpei Ma, Xuejun Sun
Summary: The development of green technology allows manufacturers in traditional industries to reduce carbon emissions, but the adoption of this technology varies among manufacturers. By implementing an effective green technology licensing strategy, highly efficient manufacturers can share their technology with less efficient manufacturers. The government has introduced subsidies to promote the use of green technology among manufacturers. However, the effectiveness of these subsidies, especially in the face of intense market competition, is still uncertain. This study develops a game theory model to analyze the optimal subsidy policy for the government.
MANAGERIAL AND DECISION ECONOMICS
(2023)
Editorial Material
Medicine, Research & Experimental
Xuejun Sun, Shigeo Ohta, John H. Zhang
MEDICAL GAS RESEARCH
(2023)
Article
Endocrinology & Metabolism
Chensheng Le, Xin Hu, Lusha Tong, Xianghua Ye, Junyi Zhang, Jun Yan, Prativa Sherchan, John H. Zhang, Feng Gao, Jiping Tang
Summary: This study investigated the role of LAR in neuroinflammation after intracerebral hemorrhage (ICH) using a mouse model. The results showed that LAR contributed to neuroinflammation after ICH via the RhoA/IRS-1 pathway, and the inhibitor ELP may be a potential therapeutic strategy to attenuate LAR-mediated neuroinflammation after ICH.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Review
Clinical Neurology
Ben Gaastra, John Zhang, Will Tapper, Diederik Bulters, Ian Galea
Summary: Sphingosine-1-phosphate (S1P) plays a role in the pathophysiology of neurological injury after aneurysmal subarachnoid haemorrhage (aSAH). The literature agrees that S1P increases in cerebrospinal fluid following aSAH and contributes to cerebral artery vasospasm. However, the role of S1P in the parenchyma is less clear, with conflicting studies suggesting both beneficial and harmful effects. This review provides a concise interpretation of the conflicting data and discusses the potential repurposing of S1P receptor modulators for aSAH.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Payal Walunj, Arpita Roy, Vikram Jadhav, Pragati Athare, Akshay Dhaygude, Jayraj Aher, Jari S. S. Algethami, Dnyaneshwar Lokhande, Mohammed S. S. Alqahtani, Arun Bhagare, Saad Alghamdi, Lienda Bashier Eltayeb, Issa Saad Al-Moraya, Krishna Kumar Yadav, Yongtae Ahn, Byong-Hun Jeon
Summary: This study investigates the applications of zinc oxide nanoparticles in medicinal and photocatalytic degradation of dyes. Polyol-mediated ZnO NPs were successfully synthesized using the non-aqueous-based reflux method and characterized using various techniques. The results reveal that these nanoparticles have good crystallinity and exhibit photocatalytic and antimicrobial properties.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Physical
Yogeshwar Baste, Vikram Jadhav, Arpita Roy, Saad Alghamdi, Mohamed Abbas, Jari S. Algethami, Mazen Almehmadi, Mamdouh Allahyani, Devvret Verma, Krishna Kumar Yadav, Byong-Hun Jeon, Hyun-Kyung Park
Summary: The synthesis of silver-incorporated copper oxide nanomaterials (Ag@CuO NMs) using a polyol-mediated refluxing method is discussed in this study. The photocatalytic activity of these nanomaterials, specifically their ability to degrade methylene blue (MB) dye, is investigated. Results show that the NMs with 5% weight of silver exhibited the highest degradation activity against MB dye, indicating their potential for wastewater purification.
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.
