Article
Medicine, Research & Experimental
Yu Liu, Lili Zou, Peng Wang, Jingxuan Zhou, Chunling Yuan, Jun Wang
Summary: The study investigated the role of nerve growth factor (NGF) in neurogenesis of breast cancer cells, revealing its potential importance in regulating cancer-associated neurogenesis and affecting the migration, invasion, and metastasis abilities of tumor cells.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Cell Biology
Terri Kagan, Gloria Stoyanova, Richard A. Lockshin, Zahra Zakeri
Summary: This study investigates the different functions of ceramide in cellular differentiation and dedifferentiation. The results suggest that the function of ceramide heavily depends on its intracellular location, and further understanding of its function requires resolving its location during cellular status changes.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Multidisciplinary Sciences
PinFen Chua, William K. Lim
Summary: This study investigated the applications of different PC12 variants in neuroprotection research, identifying optimal culture conditions for PC12 Riken and NS-1 cells, and determining collagen IV as the preferred adhesive substrate for both cell lines. In the in vitro stroke model, NS-1 cells achieved a maximal differentiation of 72.7% after optimization, and the 5-HT1A agonist 8-OH-DPAT was found to be neuroprotective in PC12 cells.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Luke Erber, Shirelle Liu, Yao Gong, Phu Tran, Yue Chen
Summary: Iron and oxygen deficiencies are common in pathophysiological conditions. Adaptive responses to these deficiencies include repression of mitochondrial respiration, promotion of angiogenesis, and cell cycle control. This study used a proteomics analysis to identify global proteomic changes caused by hypoxia and iron deficiency in neuronal cells.
Article
Cell Biology
Nessma Sultan, Laila E. Amin, Ahmed R. Zaher, Mohammed E. Grawish, Ben A. Scheven
Summary: Dental pulp stem cells secrete neurotrophic factors that significantly promote cell survival and neurite outgrowth in PC12 cells, with NGF, BDNF, and GDNF playing important roles. These factors may have potential therapeutic applications for peripheral nerve repair.
NEURAL REGENERATION RESEARCH
(2021)
Article
Neurosciences
Vito Antonio Baldassarro, Maura Cescatti, Maria Luisa Rocco, Luigi Aloe, Luca Lorenzini, Luciana Giardino, Laura Calza
Summary: This study revealed the impact of nerve growth factor (NGF) on the survival, differentiation, and maturation of astrocytes and the cells responsible for myelin formation, turnover, and repair in the central nervous system (CNS), as well as its protective role in OPCs under pathological conditions.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Yi-jun Liu, Xiao-feng Chen, Li-ping Zhou, Feng Rao, Dian-ying Zhang, Yan-hua Wang
Summary: This study aimed to analyze the effect and mechanism of Wnt5a-loaded fibrin hydrogel on a 10-mm rat sciatic nerve defect. Results showed that Wnt5a could promote Schwann cell proliferation and the expression of various neurotrophic factors, and the Wnt5a/Fn group outperformed the control groups in terms of nerve regeneration and functional recovery 12 weeks after the operation. The Wnt5a/Fn nerve conduit may promote peripheral nerve defect regeneration by facilitating multiple neurotrophin secretion, combining vascularization and neurotrophic growth cues.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Polymer Science
Qiuxia Li, Litao Sun, Xiaobei Huang, Shuai Liu, Haiyang Yong, Chenfei Wang, Jianzhong Li, Dezhong Zhou
Summary: Biodegradable and lipid-like highly branched poly(beta-amino ester)s (HPAESA) were developed to enhance the biological functions of adipose-derived stem cells by gene transfection. HPAESA showed significantly higher efficiency and cell viability, as well as the ability to promote neurite outgrowth.
Review
Biochemistry & Molecular Biology
Brian M. Ortmann, James A. Nathan
Summary: Organisms have evolved oxygen-sensing mechanisms to adapt to oxygen availability; HIFs play a crucial role in oxygen-sensing in metazoans; Genetic studies have contributed significantly to our understanding of oxygen-sensing pathways.
Article
Multidisciplinary Sciences
Ibtesam Rajpar, Gaurav Kumar, Paolo Fortina, Ryan E. Tomlinson
Summary: In mature bone, NGF produced by osteoblasts following mechanical loading signals through TrkA receptor on sensory nerves to support bone formation. TLR4, a key receptor in NF-KB signaling pathway, is required for initiating NGF-TrkA signaling for load-induced bone formation. Loss of TLR4 signaling reduces lamellar bone formation and dysregulates inflammatory signaling after mechanical loading, revealing the important role of osteoblastic TLR4 in skeletal adaptation to mechanical forces.
Review
Biochemistry & Molecular Biology
Guzel Kudoyarova, Dmitriy Veselov, Vladislav Yemelyanov, Maria Shishova
Summary: In this review, we summarize the mechanisms that compensate for the decline in aquaporin activity under hypoxic conditions, providing increased water entry into cells and accelerated shoot elongation. These mechanisms include changes in gene expression and post-transcriptional processes, and the involvement of hormones in the control of aquaporin activity is also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Ana Garcia-del Rio, Endika Prieto-Fernandez, Leire Egia-Mendikute, Asier Antonana-Vildosola, Borja Jimenez-Lasheras, So Young Lee, Adrian Barreira-Manrique, Samanta Romina Zanetti, Ander de Blas, Paloma Velasco-Beltran, Alexandre Bosch, Ana M. Aransay, Asis Palazon
Summary: Factor-inhibiting HIF (FIH) is an asparagine hydroxylase expressed in tumors, and its deletion may lead to increased metabolism, decreased proliferation, and increased immune infiltration in cancer cells.
Article
Fisheries
Liulan Zhao, Xiaohong Tang, Rui Huang, Qiao Liu, Lei Liao, Yifan Hu, Kuo He, Xin Zhang, Jiazhong Guo, Shiyi Chen, Song Yang
Summary: This study investigated the effect of acute hypoxia on liver angiogenesis in largemouth bass. The results showed that hypoxia exposure promoted angiogenesis occurrence and increased the concentration of vasodilation factors. Hypoxia exposure also up-regulated the expression of certain genes and proteins related to angiogenesis. The findings suggest that acute hypoxia can stimulate liver angiogenesis in largemouth bass through the HIF-dependent pathway.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Agronomy
Noreen Zahra, Muhammad Bilal Hafeez, Kanval Shaukat, Abdul Wahid, Sadam Hussain, Rubina Naseer, Ali Raza, Shahid Iqbal, Muhammad Farooq
Summary: Oxygen is a limiting factor for plant growth under submerged conditions, and plants have evolved various adaptations to cope with oxygen deprivation. However, metabolic reactions and molecular regulation under oxygen deprivation are not well understood. Understanding how plants respond to oxygen deficiency is crucial for developing anoxia and hypoxia tolerant varieties for flood-prone areas.
JOURNAL OF AGRONOMY AND CROP SCIENCE
(2021)
Article
Neurosciences
Yulia V. Dobryakova, Yulia S. Spivak, Maria I. Zaichenko, Alena A. Koryagina, Vladimir A. Markevich, Mikhail Yu. Stepanichev, Alexey P. Bolshakov
Summary: The study explored the beneficial effects of adeno-associated virus (AAV)-mediated overexpression of nerve growth factor (NGF) in hippocampus of rats with cholinergic deficit caused by immunotoxin 192IgG-saporin. While NGF overexpression did not prevent loss of ChAT-positive neurons, it restored normal animal behavior and reversed negative changes in hippocampal synaptic characteristics induced by cholinergic deficit. The beneficial effects of NGF were not related to maintenance of cholinergic function.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.