Convection-Enhanced Drug Delivery to the Brain: Therapeutic Potential and Neuropathological Considerations

Robot-guided convection-enhanced delivery of carboplatin for advanced brainstem glioma

(2013) N. U. Barua et al.   ACTA NEUROCHIRURGICA

In vitro and in vivo testing of a novel recessed-step catheter for reflux-free convection-enhanced drug delivery to the brain

(2013) T. Gill et al.   JOURNAL OF NEUROSCIENCE METHODS

Intermittent convection-enhanced delivery to the brain through a novel transcutaneous bone-anchored port

(2013) N.U. Barua et al.   JOURNAL OF NEUROSCIENCE METHODS

GDNF, NGF and BDNF as therapeutic options for neurodegeneration

(2013) Shelley J. Allen et al.   PHARMACOLOGY & THERAPEUTICS

Influence of Needle Insertion Speed on Backflow for Convection-Enhanced Delivery

(2012) Fernando Casanova et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Targeted delivery of nerve growth factor via encapsulated cell biodelivery in Alzheimer disease: a technology platform for restorative neurosurgery

(2012) Lars U. Wahlberg et al.   JOURNAL OF NEUROSURGERY

Convection-enhanced delivery of M13 bacteriophage to the brain

(2012) Alexander Ksendzovsky et al.   JOURNAL OF NEUROSURGERY

Gene Transfer Corrects Acute GM2 Gangliosidosis—Potential Therapeutic Contribution of Perivascular Enzyme Flow

(2012) M Begoña Cachón-González et al.   MOLECULAR THERAPY

Atrophy of the Cholinergic Basal Forebrain Over the Adult Age Range and in Early Stages of Alzheimer's Disease

(2011) Michel Grothe et al.   BIOLOGICAL PSYCHIATRY

Widespread suppression of huntingtin with convection-enhanced delivery of siRNA

(2011) David K. Stiles et al.   EXPERIMENTAL NEUROLOGY

Aβ-Degrading Enzymes: Potential for Treatment of Alzheimer Disease

(2011) James Scott Miners et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

An evaluation of the relationships between catheter design and tissue mechanics in achieving high-flow convection-enhanced delivery

(2011) Edward White et al.   JOURNAL OF NEUROSCIENCE METHODS

The development of an implantable catheter system for chronic or intermittent convection-enhanced delivery

(2011) A. Bienemann et al.   JOURNAL OF NEUROSCIENCE METHODS

Tracking accuracy of T2- and diffusion-weighted magnetic resonance imaging for infusate distribution by convection-enhanced delivery

(2011) Rajiv R. Iyer et al.   JOURNAL OF NEUROSURGERY

Intracerebral administration of CpG oligonucleotide for patients with recurrent glioblastoma: a phase II study

(2011) A. Carpentier et al.   NEURO-ONCOLOGY

T2 Imaging in Monitoring of Intraparenchymal Real-Time Convection-Enhanced Delivery

(2011) R Mark Richardson et al.   NEUROSURGERY

Colocalization of Gadolinium-Diethylene Triamine Pentaacetic Acid With High-Molecular-Weight Molecules After Intracerebral Convection-Enhanced Delivery in Humans

(2011) John H Sampson et al.   NEUROSURGERY

Regression of Recurrent Malignant Gliomas With Convection-Enhanced Delivery of Topotecan

(2011) Jeffrey N. Bruce et al.   NEUROSURGERY

Effect of imaging and catheter characteristics on clinical outcome for patients in the PRECISE study

(2010) Sabine Mueller et al.   JOURNAL OF NEURO-ONCOLOGY

Targeted therapy for high-grade glioma with the TGF- 2 inhibitor trabedersen: results of a randomized and controlled phase IIb study

(2010) U. Bogdahn et al.   NEURO-ONCOLOGY

Phase III randomized trial of CED of IL13-PE38QQR vs Gliadel wafers for recurrent glioblastoma

(2010) S. Kunwar et al.   NEURO-ONCOLOGY

Image-guided convection-enhanced delivery of GDNF protein into monkey putamen

(2010) Francisco Gimenez et al.   NEUROIMAGE

Qualitative Imaging of Adeno-Associated Virus Serotype 2–Human Aromatic L-Amino Acid Decarboxylase Gene Therapy in a Phase I Study for the Treatment of Parkinson Disease

(2010) Francisco Valles et al.   NEUROSURGERY

Optimized cannula design and placement for convection-enhanced delivery in rat striatum

(2009) Dali Yin et al.   JOURNAL OF NEUROSCIENCE METHODS

Poor drug distribution as a possible explanation for the results of the PRECISE trial

(2009) John H. Sampson et al.   JOURNAL OF NEUROSURGERY

Optimal region of the putamen for image-guided convection-enhanced delivery of therapeutics in human and non-human primates

(2009) Dali Yin et al.   NEUROIMAGE

Safety and tolerability of putaminal AADC gene therapy for Parkinson disease

(2009) C. W. Christine et al.   NEUROLOGY

ANATOMIC COMPRESSION CAUSED BY HIGH-VOLUME CONVECTION-ENHANCED DELIVERY TO THE BRAIN

(2009) Francisco Valles et al.   NEUROSURGERY

Efficient gene therapy-based method for the delivery of therapeutics to primate cortex

(2009) A. P. Kells et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neprilysin: An Enzyme Candidate to Slow the Progression of Alzheimer's Disease

(2008) Salim S. El-Amouri et al.   AMERICAN JOURNAL OF PATHOLOGY

Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice

(2008) Brian Spencer et al.   BMC NEUROSCIENCE

188Re-loaded lipid nanocapsules as a promising radiopharmaceutical carrier for internal radiotherapy of malignant gliomas

(2008) E. Allard et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Convection-enhanced delivery of polyethylene glycol–coated liposomal doxorubicin: characterization and efficacy in rat intracranial glioma models

(2008) Toshio Kikuchi et al.   JOURNAL OF NEUROSURGERY

HIV TAT Peptide Modifies the Distribution of DNA Nanolipoparticles Following Convection-enhanced Delivery

(2008) J Andrew MacKay et al.   MOLECULAR THERAPY

Convection-enhanced delivery of maghemite nanoparticles: Increased efficacy and MRI monitoring

(2008) Benny Perlstein et al.   NEURO-ONCOLOGY

Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology

(2008) R. O. Carare et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY