Review
Oncology
Randy S. D'Amico, Manish K. Aghi, Michael A. Vogelbaum, Jeffrey N. Bruce
Summary: Convection-enhanced delivery (CED) is a method of targeted, local drug delivery to the central nervous system that shows promise for treating glioblastoma (GBM), although the long-term efficacy of the agents studied remains difficult to assess at present.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Oncology
John H. Sampson, Achal Singh Achrol, Manish K. Aghi, Krystof Bankiewicz, Martin Bexon, Steven Brem, Andrew Brenner, Chandtip Chandhasin, Sajeel Chowdhary, Melissa Coello, Benjamin M. Ellingson, John R. Floyd, Seunggu Han, Santosh Kesari, Yael Mardor, Fahar Merchant, Nina Merchant, Dina Randazzo, Michael Vogelbaum, Frank Vrionis, Eva Wembacher-Schroeder, Miroslaw Zabek, Nicholas Butowski
Summary: This article introduces the application of MDNA55 in the treatment of recurrent GBM. Through clinical trials, it has been verified that MDNA55 can effectively control tumors and improve the survival rate of patients, showing the best efficacy at high doses.
Article
Biotechnology & Applied Microbiology
Ye Wu, Weili Jin, Qixue Wang, Junhu Zhou, Yunfei Wang, Yanli Tan, Xiaoteng Cui, Fei Tong, Eryan Yang, Jian Wang, Chunsheng Kang
Summary: FGFR3-TACC3 (F3-T3) gene fusions are considered a potential target for precision therapy in human glioblastoma. Using the CRISPR-Cas13a system to target the F3-T3 fusion genes in cancer cells induces collateral damage, reduces tumor cell proliferation, and suppresses tumor growth.
Review
Chemistry, Physical
Tao Tang, Baisong Chang, Mingxi Zhang, Taolei Sun
Summary: Gliomas are the most common primary brain tumors in adults, and the difficulty in accurately imaging and determining the malignancy grade of gliomas has significant impact on diagnostic accuracy and subsequent surgery or therapy. The rapid development of emerging nanoprobes provides a promising opportunity for the precise imaging and therapy of gliomas, enabling efficient crossing of the blood-brain barrier and targeted treatment. Challenges and future directions in nanoprobe-based diagnosis and treatment of gliomas are also discussed.
NANOSCALE HORIZONS
(2021)
Article
Medicine, Research & Experimental
Shixue Yang, Jixing Zhao, Xiaoteng Cui, Qi Zhan, Kaikai Yi, Qixue Wang, Menglin Xiao, Yanli Tan, Biao Hong, Chuan Fang, Chunsheng Kang
Summary: The study demonstrates that targeted inhibitors can effectively disrupt energy metabolism in GBM and inhibit tumor proliferation.
Article
Medicine, Research & Experimental
Constantine J. Georgiou, Zhongli Cai, Noor Alsaden, Hyungjun Cho, Minou Behboudi, Mitchell A. Winnik, James T. Rutka, Raymond M. Reilly
Summary: In this study, convection-enhanced delivery (CED) of 23 +/- 3 nm gold nanoparticles (AuNPs) labeled with the beta-particle-emitting radionuclide 177Lu (177Lu-AuNPs) was found to be highly effective for treating orthotopic U251-Luc human glioblastoma multiforme (GBM) tumors in NRG mice. The cytotoxicity of 177Lu-AuNPs on U251-Luc cells was confirmed through in vitro experiments, while in vivo studies showed that the tumors treated with 177Lu-AuNPs exhibited growth arrest and improved long-term survival compared to control mice. Overall, this study highlights the potential of CED using 177Lu-AuNPs as a promising treatment for GBM patients. Rating: 8/10
MOLECULAR PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Pavan S. Upadhyayula, Eleonora F. Spinazzi, Michael G. Argenziano, Peter Canoll, Jeffrey N. Bruce
Summary: Convection enhanced delivery (CED) is a technique used for treating glioma by infusing treatments directly into the brain parenchyma. The manuscript describes the physical principles behind CED, common pitfalls, and optimization methods. The institutional experience using topotecan CED for malignant glioma treatment is highlighted.
Article
Oncology
Jasleen Kaur, Guangliang Ding, Li Zhang, Yong Lu, Hao Luo, Lian Li, Edward Boyd, Qingjiang Li, Min Wei, Zhenggang Zhang, Michael Chopp, Quan Jiang
Summary: The study demonstrated the impact of GBM on the glymphatic response in the rat brain. Reduced glymphatic waste clearance may lead to the accumulation of toxic waste solutes.
Article
Chemistry, Analytical
Mingzhu Fan, Huakui Huang, Yang Xu, Shulong Wang, Shengyu Chen, Zhihui Luo, Jiayao Xu
Summary: A novel Au-nucleic acid nanoprobe, catalyzed by mRNA, has been developed for live cell imaging and precise treatment of tumor cells. This nanoprobe exhibits the remarkable ability to differentiate between tumor cells and normal cells through live cell mRNA imaging, while selectively inducing apoptosis in tumor cells.
ANALYTICAL METHODS
(2023)
Article
Engineering, Biomedical
Jason N. Mehta, Manuel K. Rausch, Christopher G. Rylander
Summary: Convection-enhanced delivery (CED) is an investigational method for treating glioblastoma, but it has not been widely used in clinical practice due to its inability to fully saturate the target region. However, a recent study has shown that controlled catheter movement and constant pressure infusions can increase the dispersion volume in brain tissue, allowing for more even distribution of therapeutics.
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
(2022)
Review
Pharmacology & Pharmacy
Sumel Ashique, Krishnan Anand
Summary: Extracellular vesicles (ECVs) have been abandoned as bio-inspired drug delivery systems (DDS) in the biomedical field. ECVs have a natural ability to cross over extracellular and intracellular barriers, making them superior to manufactured nanoparticles. Additionally, they have the ability to move beneficial biomolecules among far-flung bodily cells. These advantages and the accomplishment of favorable in vivo results convincingly show the value of ECVs in medication delivery. The usage of ECVs is constantly being improved, as it might be difficult to develop a consistent biochemical strategy that is in line with their useful clinical therapeutic uses.
Article
Pharmacology & Pharmacy
Krishnashis Chatterjee, Naciye Atay, Daniel Abler, Saloni Bhargava, Prativa Sahoo, Russell C. Rockne, Jennifer M. Munson
Summary: This study applied a novel image analysis method to measure fluid flow and diffusion in GBM patients, finding strong correlations between flow rates and patient outcomes. The analysis of standard DCE-MRI in patients offers more information regarding IFF and transport within and around the tumor, indicating a significant correlation with patient prognosis.
Article
Chemistry, Multidisciplinary
Xiuxiu Yue, Tao Guo, Hankun Zhang, Benhua Wang, Minhuan Lan, Xiangzhi Song
Summary: In this study, a red-absorbing photosensitizer (NBS-ER) with specific targeting ability toward estrogen receptors (ER) was developed. NBS-ER could specifically bind to the overexpressed ER in breast cancers, increasing its accumulation and enhancing the photodynamic therapeutic effect. Imaging-guided therapy could be achieved with the aid of red fluorescence from NBS-ER.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Hang Zhang, Shujuan Guan, Tianxiang Wei, Tianyou Wang, Junxia Zhang, Yongping You, Zhaoyin Wang, Zhihui Dai
Summary: In this study, gold nanorods were cloaked with GBM patient-derived tumor cell membrane (GBM-PDTCM) to achieve efficient blood-brain barrier (BBB) crossing and selective glioblastoma (GBM) targeting. Fluorescence and Raman signals generated by GBM-PDTCM@AuNRs were used to guide precise tumor resection, improving surgical treatment for advanced GBM. Additionally, intravenous injection of GBM-PDTCM@AuNRs enabled photothermal therapy for early GBM, doubling the median survival time of orthotopic xenograft mice.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Kai Nishimura, Hideki Kashiwagi, Taiki Morita, Yusuke Fukuo, Satoshi Okada, Kazuki Miura, Yoshitaka Matsumoto, Yu Sugawara, Takayuki Enomoto, Minoru Suzuki, Kei Nakai, Shinji Kawabata, Hiroyuki Nakamura
Summary: In this study, a novel boron agent, PBC-IP, was developed for efficient targeting and accumulation in glioblastoma cells. PBC-IP showed higher accumulation and tumor growth suppression compared to L-4-boronophenylalanine (BPA) in animal models. When delivered via convection-enhanced delivery (CED), PBC-IP achieved high tumor accumulation and significantly improved survival rate in the glioma model.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Oncology
Antonio Omuro, Gordana Vlahovic, Michael Lim, Solmaz Sahebjam, Joachim Baehring, Timothy Cloughesy, Alfredo Voloschin, Shakti H. Ramkissoon, Keith L. Ligon, Robert Latek, Ricardo Zwirtes, Lewis Strauss, Prashni Paliwal, Christopher T. Harbison, David A. Reardon, John H. Sampson
Article
Biochemistry & Molecular Biology
Pakawat Chongsathidkiet, Christina Jackson, Shohei Koyama, Franziska Loebel, Xiuyu Cui, S. Harrison Farber, Karolina Woroniecka, Aladine A. Elsamadicy, Cosette A. Dechant, Hanna R. Kemeny, Luis Sanchez-Perez, Tooba A. Cheema, Nicholas C. Souders, James E. Herndon, Jean-Valery Coumans, Jeffrey Everitt, Brian Nahed, John H. Sampson, Michael D. Gunn, Robert L. Martuza, Glenn Dranoff, William T. Curry, Peter E. Fecci
Review
Oncology
Bryan D. Choi, Marcela V. Maus, Carl H. June, John H. Sampson
CLINICAL CANCER RESEARCH
(2019)
Article
Oncology
Carter M. Suryadevara, Rupen Desai, S. Harrison Farber, Bryan D. Choi, Adam M. Swartz, Steven H. Shen, Patrick C. Gedeon, David J. Snyder, James E. Herndon, Patrick Healy, Elizabeth A. Reap, Gary E. Archer, Peter E. Fecci, John H. Sampson, Luis Sanchez-Perez
CLINICAL CANCER RESEARCH
(2019)
Correction
Biochemistry & Molecular Biology
Pakawat Chongsathidkiet, Christina Jackson, Shohei Koyama, Franziska Loebel, Xiuyu Cui, Harrison Farber, Karolina Woroniecka, Aladine A. Elsamadicy, Cosette A. Dechant, Hanna R. Kemeny, Luis Sanchez-Perez, Tooba A. Cheema, Nicholas C. Souders, James E. Herndon, Jean-Valery Coumans, Jeffrey I. Everitt, Brian V. Nahed, John H. Sampson, Michael D. Gunn, Robert L. Martuza, Glenn Dranoff, William T. Curry, Peter E. Fecci
Review
Pharmacology & Pharmacy
Kendra L. Congdon, Luis A. Sanchez-Perez, John H. Sampson
PHARMACOLOGY & THERAPEUTICS
(2019)
Review
Oncology
William Tomaszewski, Luis Sanchez-Perez, Thomas F. Gajewski, John H. Sampson
CLINICAL CANCER RESEARCH
(2019)
Review
Oncology
Kenneth Aldape, Kevin M. Brindle, Louis Chesler, Rajesh Chopra, Amar Gajjar, Mark R. Gilbert, Nicholas Gottardo, David H. Gutmann, Darren Hargrave, Eric C. Holland, David T. W. Jones, Johanna A. Joyce, Pamela Kearns, Mark W. Kieran, Ingo K. Mellinghoff, Melinda Merchant, Stefan M. Pfister, Steven M. Pollard, Vijay Ramaswamy, Jeremy N. Rich, Giles W. Robinson, David H. Rowitch, John H. Sampson, Michael D. Taylor, Paul Workman, Richard J. Gilbertson
NATURE REVIEWS CLINICAL ONCOLOGY
(2019)
Article
Oncology
Landon J. Hansen, Ran Sun, Rui Yang, Simranjit X. Singh, Lee H. Chen, Christopher J. Pirozzi, Casey J. Moure, Carlee Hemphill, Austin B. Carpenter, Patrick Healy, Ryan C. Ruger, Chin-Pu J. Chen, Paula K. Greer, Fangping Zhao, Ivan Spasojevic, Carole Grenier, Zhiqing Huang, Susan K. Murphy, Roger E. McLendon, Henry S. Friedman, Allan H. Friedman, James E. Herndonll, John H. Sampson, Stephen T. Keir, Darell D. Bigner, Hai Yan, Yiping He
Article
Biochemical Research Methods
Teilo H. Schaller, Matthew W. Foster, J. Will Thompson, Ivan Spasojevic, Deimante Normantaite, M. Arthur Moseley, Luis Sanchez-Perez, John H. Sampson
JOURNAL OF PROTEOME RESEARCH
(2019)
Letter
Oncology
Kenneth Aldape, Kevin M. Brindle, Louis Chesler, Rajesh Chopra, Amar Gajjar, Mark R. Gilbert, Nicholas Gottardo, David H. Gutmann, Darren Hargrave, Eric C. Holland, David T. W. Jones, Johanna A. Joyce, Pamela Kearns, Mark W. Kieran, Ingo K. Mellinghoff, Melinda Merchant, Stefan M. Pfister, Steven M. Pollard, Vijay Ramaswamy, Jeremy N. Rich, Giles W. Robinson, David H. Rowitch, John H. Sampson, Michael D. Taylor, Paul Workman, Richard J. Gilbertson
NATURE REVIEWS CLINICAL ONCOLOGY
(2019)
Review
Clinical Neurology
Peter E. Fecci, John H. Sampson
JOURNAL OF NEUROSURGERY
(2019)
Review
Oncology
Kelly M. Hotchkiss, John H. Sampson
Summary: GBM is difficult to eradicate with immunotherapy and chemotherapy, and different doses and timing of chemotherapy may affect tumor eradication efficacy.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Yaoying Wu, Hanning Wen, Zachary J. Bernstein, Kelly M. Hainline, Tykia S. Blakney, Kendra L. Congdon, David J. Snyder, John H. Sampson, Luis Sanchez-Perez, Joel H. Collier
Summary: The study demonstrates the potential clinical benefit of vaccine-induced antibody responses for tumor treatments when combined with simultaneous CD8(+) and CD4(+) responses, using a nanofiber vaccine design approach. Additionally, the study highlights the importance of supramolecular nanomaterials in developing multiepitope cancer vaccines.
Review
Oncology
John H. Sampson, Michael D. Gunn, Peter E. Fecci, David M. Ashley
NATURE REVIEWS CANCER
(2020)