Review
Nutrition & Dietetics
Rut Fado, Anna Molins, Rocio Rojas, Nuria Casals
Summary: In recent years, traditional eating habits have been replaced by a more globalized diet rich in saturated fatty acids and simple sugars. Extensive evidence shows that this diet contributes to cognitive health impairment and increases the incidence of metabolic diseases such as obesity and diabetes. However, the mechanisms through which these nutrients modulate synaptic function and neuroplasticity are not well understood. This review focuses on the effects of Western, ketogenic, and paleolithic diets on cognition and their correlations with synaptic changes, primarily in animal models, to understand the molecular alterations that may contribute to impaired human cognition.
Article
Neurosciences
Belal Mosaferi, Yahya Jand, Ali-Akbar Salari
Summary: The study found that antibiotic treatment impaired object recognition memory in healthy mice, while significantly exacerbating spatial memory impairment in mice with Alzheimer-like disease. There were significant correlations between the behavioral tests conducted. Antibiotic treatment also led to a reduction in brain IL-6 levels in healthy animals and decreased cytokines TNF-alpha and IL-6 in Alzheimer's disease-induced mice, showing that gut microbiota manipulation from early adolescence to adulthood may negatively impact cognitive functions.
BRAIN RESEARCH BULLETIN
(2021)
Article
Neurosciences
Jamie S. Church, Jane A. M. Bannish, Leighelle A. Adrian, Kimberly Rojas Martinez, Asari Henshaw, Jared J. Schwartzer
Summary: Dietary components, such as prebiotic fiber, impact brain chemistry via the gut-brain axis. Short chain fatty acids (SCFAs) generated from excessive soluble fiber consumption are thought to influence neuroimmune signaling and brain function. A high soluble fiber diet in mice leads to increased SCFA levels, decreased neuroinflammation, and increased BDNF production in the hippocampus, suggesting the beneficial effects of fiber-induced molecular changes on mood and cognition-related behaviors. These findings highlight the importance of dietary composition in mental health management plans.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Oncology
Ding Quan Ng, Daniella Chan, Parisa Agrawal, Weian Zhao, Xiangmin Xu, Munjal Acharya, Alexandre Chan
Summary: This systematic review assessed the relationship between BDNF biomarkers and neurocognitive outcomes in cancer patients and survivors. The results suggest that BDNF is a potential monitoring biomarker and druggable target for CRCI.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Review
Cell Biology
Laura Bellingacci, Jacopo Canonichesi, Andrea Mancini, Lucilla Parnetti, Massimiliano Di Filippo
Summary: The modern view recognizes the immune system as a sensitizing and modulating mechanism of the central nervous system. The immune system and the central nervous system interact subtly to control cognitive function and behavior. Pro-inflammatory cytokines play a dual role in modulating brain network connections, and maintaining a balance between pro- and anti-inflammatory molecules is essential for synaptic functioning and neural network performance.
NEURAL REGENERATION RESEARCH
(2023)
Article
Food Science & Technology
Leila Nazari, Somayeh Komaki, Iraj Salehi, Safoura Raoufi, Zoleikha Golipoor, Masoumeh Kourosh-Arami, Alireza Komaki
Summary: Oxidative stress is an important factor in the development of Alzheimer's disease (AD). This study found that lutein, a carotenoid with antioxidant properties, has protective effects on memory and learning. Lutein reduces oxidative stress, improves memory and learning, and shows potential as a therapeutic agent for the treatment and prevention of AD.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Neurosciences
Renli Qi, Minshu Wang, Qian Zhong, Lanlin Wang, Xinwang Yang, Baihui Huang, Zhengsheng Yang, Cong Zhang, Xin Geng, Cheng Luo, Wei Wang, Jinghui Li, Hualin Yu, Jingkuan Wei
Summary: Inflammatory processes play a role in the pathogenesis of epilepsy. Vagus nerve stimulation (VNS) is an effective adjunctive therapy that may exert its antiepileptic effect by inhibiting inflammation.
Article
Behavioral Sciences
Kathryn A. McNaughton, Lauren L. Williamson
Summary: In learning and memory tasks, immune activation plays a role in performance. Peripheral immune stimulation impairs context-object discrimination memory in male rats, but its effects on females and the potential for rescue are unclear. Male rats showed memory impairment in response to immune stimulation, whereas female rats did not. Treatment with IL-1ra improved memory in females, but not in males. Specific cytokine signals may be altered in impaired males. Understanding sex differences in response to inflammatory challenges is important for understanding memory impairments.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Licheng Yan, Jinghua Yang, Miao Yu, Wenchang Sun, Yarao Han, Xiaobo Lu, Cuihong Jin, Shengwen Wu, Yuan Cai
Summary: This study examined the effect of lanthanum on learning and memory in mice and found that lanthanum can impair learning and memory by overactivating microglia.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Vincent Pretre, Dimitrios Papadopoulos, Jean Regard, Marc Pelletier, Janghee Woo
Summary: Inflammation plays a significant role in the development and progression of cancer. Inflammation in the tumor microenvironment alters the adaptability of tumor cells, promoting their survival and progression. Recent studies have shown that inhibiting interleukin-1 beta (IL-1 beta) can significantly decrease the risk of lung cancer. This article reviews the role of IL-1 beta and its upstream regulator NLRP3 in solid tumor and hematologic malignancies, and discusses the pharmacologic tools used to evaluate the effects of blocking tumor-promoting inflammation.
Article
Neurosciences
Fernanda Cardoso Teixeira, Mayara Sandrielly Pereira Soares, Eduardo Bierhaus Blodorn, William Borges Domingues, Karine Paula Reichert, Adriana Maria Zago, Fabiano Barbosa Carvalho, Jessie Martins Gutierres, Relber Aguiar Goncales, Marilda da Cruz Fernandes, Vinicius Farias Campos, Maria Rosa Chitolina, Francieli Moro Stefanello, Roselia Maria Spanevello
Summary: This study found that inosine can prevent memory deficits, reduce the immunoreactivity of the brain A2A adenosine receptor, increase levels of brain anti-inflammatory cytokines, enhance brain-derived neurotrophic factor expression, and attenuate changes in the hippocampus induced by STZ in rats with AD.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Reine Khoury, Joelle Saad, Vanessa Jabre, Litsa Maria Ghayad, Mohamad Khalifeh, Rouba Houbeika, Perla El Ahmad, Amar Mezher, Diala El Masri, Zena Haddad, Fady Eid, Nour Barmo, Patrick Nasrallah, Sama F. Sleiman, Joseph S. Stephan
Summary: Exercise enhances learning and memory recall and counteracts cognitive decline associated with aging. The positive effects of exercise are mediated by circulatory factors, specifically Brain Derived Neurotrophic Factor (BDNF) signaling in the hippocampus. Identifying the mechanisms behind the release of these factors and their effects on hippocampal Bdnf expression will help harness the therapeutic potential of exercise.
Article
Behavioral Sciences
Rodrigo Orso, Kerstin Camile Creutzberg, Francisco Sindermann Lumertz, Luis Eduardo Wearick-Silva, Eduardo Farias Sanches, Regis Gemerasca Mestriner, Gregers Wegener, Rodrigo Grassi-Oliveira
Summary: This study demonstrates that early environmental enrichment is effective in recovering memory impairments and hippocampal volume loss caused by hypoxia-ischemia. However, the expression of Bdnf was not associated with the improvement in memory performance observed in animals exposed to EE after a hypoxic-ischemic event.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Multidisciplinary Sciences
Larry R. Squire, Jennifer C. Frascino, Charlotte S. Rivera, Nadine C. Heyworth, Biyu J. He
Summary: One-trial, long-lasting perceptual learning relies on hippocampus-independent (nondeclarative) memory, independent of any requirement to consciously remember. Patients with hippocampal lesions or larger medial temporal lobe (MTL) lesions show intact perceptual learning but impaired memory for the images presented.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Wan-Ling Huang, Ming-Heng Hsiung, Wen Dai, Sherry Shu-Jung Hu
Summary: This study found that rottlerin impairs the consolidation of aversive memory in mice by enhancing BDNF signaling in the hippocampus, without affecting the reconsolidation process. This suggests that rottlerin could be used in combination with exposure therapy to facilitate the forgetting of maladaptive aversive memories.
PSYCHOPHARMACOLOGY
(2021)
Review
Immunology
Andrew Schrepf, Susan K. Lutgendorf, Leah M. Pyter
BRAIN BEHAVIOR AND IMMUNITY
(2015)
Review
Psychology, Biological
Leah M. Pyter
PHYSIOLOGY & BEHAVIOR
(2016)
Article
Multidisciplinary Sciences
Leah M. Pyter, Yasmin Husain, Humberto Calero, Daniel B. McKim, Hsin-Yun Lin, Jonathan P. Godbout, John F. Sheridan, Christopher G. Engeland, Phillip T. Marucha
Article
Endocrinology & Metabolism
Savannah R. Bever, Xiaoyu Liu, Ning Quan, Leah M. Pyter
NEUROIMMUNOMODULATION
(2017)
Article
Surgery
Leah M. Pyter, Daniel B. McKim, Yasmin Husain, Humberto Calero, Jonathan P. Godbout, John F. Sheridan, Phillip T. Marucha, Christopher G. Engeland
JOURNAL OF SURGICAL RESEARCH
(2018)
Article
Immunology
Brian J. Prendergast, Erin J. Cable, Priyesh N. Patel, Leah M. Pyter, Kenneth G. Onishi, Tyler J. Stevenson, Norman F. Ruby, Sean P. Bradley
BRAIN BEHAVIOR AND IMMUNITY
(2013)
Article
Immunology
Leah M. Pyter, Sean D. Kelly, Constance S. Harrell, Gretchen N. Neigh
BRAIN BEHAVIOR AND IMMUNITY
(2013)
Article
Neurosciences
Leah M. Pyter, Sarah El Mouatassim Bih, Husain Sattar, Brian J. Prendergast
Article
Endocrinology & Metabolism
Brian J. Prendergast, Leah M. Pyter, August Kampf-Lassin, Priyesh N. Patel, Tyler J. Stevenson
Article
Neurosciences
J. C. Walton, Z. Chen, Z. M. Weil, L. M. Pyter, J. B. Travers, R. J. Nelson
Article
Psychology, Biological
Leah M. Pyter, Linglan Yang, Jose M. da Rocha, Christopher G. Engeland
PHYSIOLOGY & BEHAVIOR
(2014)
Article
Multidisciplinary Sciences
James C. Walton, Leah M. Pyter, Zachary M. Weil, Randy J. Nelson
Article
Endocrinology & Metabolism
Leah M. Pyter, Brian J. Prendergast
PSYCHONEUROENDOCRINOLOGY
(2013)
Article
Behavioral Sciences
Leah M. Pyter, Linglan Yang, Cassandra McKenzie, Jose M. da Rocha, C. Sue Carter, Bin Cheng, Christopher G. Engeland
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2014)
Article
Behavioral Sciences
Leah M. Pyter, Lorena P. Suarez-Kelly, William E. Carson, Jasskiran Kaur, Joshua Bellisario, Savannah R. Bever
BEHAVIOURAL BRAIN RESEARCH
(2017)
Letter
Immunology
Wan-Ju Cheng, Hong-Mo Shih, Kuan-Pin Su, Po-Ren Hsueh
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Felipe Kenji Sudo, Talita P. Pinto, Fernanda G. Q. Barros-Aragao, Ivanei Bramati, Theo F. Marins, Marina Monteiro, Fernanda Meireles, Rejane Soares, Pilar Erthal, Victor Calil, Naima Assuncao, Natalia Oliveira, Joana Bondarovsky, Camila Lima, Beatriz Chagas, Alana Batista, Julia Lins, Thais L. Pinheiro, Felippe Mendonca, Andrea Silveira de Souza, Fernanda C. Rodrigues, Gabriel R. de Freitas, Pedro Kurtz, Paulo Mattos, Erika C. Rodrigues, Fernanda G. De Felice, Fernanda Tovar-Moll
Summary: Post-COVID-19 Condition (PCC) is a multisystemic syndrome that persists for months after SARS-CoV-2 infection, affecting cognitive function and neuropsychiatric features. A study on COVID-19 survivors in Brazil found that these patients experienced significant difficulties in overall cognition, memory, working memory, and inhibitory control, as well as fatigue, anxiety, and depressive symptoms. In addition, elevated levels of inflammatory markers in the blood were associated with brain microstructural damage and cognitive impairments.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Letter
Immunology
Tieh-Cheng Fu, Juei-Chao Chen, Ching-Mao Chang
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Aastha Dheer, Dale B. Bosco, Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Koichiro Haruwaka, Min-Hee Yi, Abhijeet Barath, Dai-Shi Tian, Long-Jun Wu
Summary: Microglial activation plays a crucial role in the pathology of epilepsy, with both acute and prolonged activation affecting seizure severity and neuronal loss.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Julie B. Rosenberg, Jens Richardt Mollegaard Jepsen, Parisa Mohammadzadeh, Astrid Sevelsted, Rebecca Vinding, Mikkel E. Sorensen, David Horner, Kristina Aagaard, Birgitte Fagerlund, Susanne Brix, Nilofar Folsgaard, Ann -Marie M. Schoos, Jakob Stokholm, Bo Chawes, Christos Pantelis, Soren Dalsgaard, Birte Y. Glenthoj, Niels Bilenberg, Klaus Bonnelykke, Bjorn H. Ebdrup
Summary: Clinical data demonstrates a strong association between prenatal maternal inflammation assessed by hs-CRP and a diagnosis of ADHD by age 10. Maternal inflammation is also associated with ADHD symptom load in the entire cohort.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Suzanne M. Green-Fulgham, Michael J. Lacagnina, Kendal F. Willcox, Jiahe Li, Michael E. Harland, Adriano Polican Ciena, Igor R. Correia Rocha, Jayson B. Ball, Renee A. Dreher, Younus A. Zuberi, Joseph M. Dragavon, Marucia Chacur, Steven F. Maier, Linda R. Watkins, Peter M. Grace
Summary: Regular aerobic activity, specifically voluntary wheel running, can reduce the risk of chronic pain by inhibiting MAC and preserving myelin integrity at the site of peripheral nerve injury.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
India Boyton, Stella M. Valenzuela, Lyndsey E. Collins-Praino, Andrew Care
Summary: Neuronanomedicine is a multidisciplinary field that aims to develop innovative nanotechnologies for the treatment of neurodegenerative disorders. Nanoparticles are an important component of neuronanomedicine, as they can improve drug properties and enhance safety and delivery across the blood-brain barrier. However, a major challenge for neuronanomedicine translation is the poor understanding of bio-nano interactions, partly due to inconsistent reporting in published works. This review provides specific recommendations to guide researchers in harnessing the unique properties of nanoparticles for breakthrough treatments of Alzheimer's and Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Celine De Looze, Cathal McCrory, Aisling O'Halloran, Silvia Polidoro, Rose Anne Kenny, Joanne Feeney
Summary: Our study found that subjective measures of stress and biological metrics may be independently associated with cognitive function over time in older adults, hinting at potential different underlying mechanisms.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Beatrice Bravi, Elisa Maria Teresa Melloni, Marco Paolini, Mariagrazia Palladini, Federico Calesella, Laura Servidio, Elena Agnoletto, Sara Poletti, Cristina Lorenzi, Cristina Colombo, Francesco Benedetti
Summary: Depressed patients show changes in immune-inflammatory markers in their blood and cerebrospinal fluid. The Choroid Plexus, located at the base of the brain ventricles, plays a key role in regulating the exchange of substances between the brain and immune cells. Patients with bipolar disorder or major depressive disorder have larger Choroid Plexus volumes compared to healthy controls. Age and levels of circulating cytokines are associated with Choroid Plexus volumes in the clinical groups.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Mingxuan Zheng, Huaiyu Ye, Xiaoying Yang, Lijun Shen, Xuemei Dang, Xiaoli Liu, Yuying Gong, Qingyuan Wu, Li Wang, Xing Ge, Xiaoli Fang, Benchi Hou, Peng Zhang, Renxian Tang, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
Summary: Obesity is linked to cognitive dysfunction and neurodegenerative disease. The connection between the gut microbiota and the brain is altered in obesity. The probiotic Clostridium butyricum can improve cognitive impairment caused by obesity and prevent gut microbiota dysbiosis and inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Edward Drydale, Phalguni Rath, Katie Holden, Gregory Holt, Laurissa Havins, Thomas Johnson, James Bancroft, Lahiru Handunnetthi
Summary: This study created a novel three-dimensional neurosphere assay using induced pluripotent stem cell differentiation and live cell imaging techniques to investigate the effect of a simulated viral infection on cortical development. The findings demonstrated that the infection led to reduced radial glial growth and neural migration.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Yuancheng Weng, Ningting Chen, Rui Zhang, Jian He, Xukai Ding, Guo Cheng, Qianqian Bi, Ying-mei Lu, Xiao Z. Shen, Shu Wan, Peng Shi
Summary: This study reveals that microglia is the primary cellular source of PDGFB in adults, and microglial PDGFB is crucial for maintaining BBB integrity in adult mice.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Evan A. Bordt, Haley A. Moya, Young Chan Jo, Caitlin T. Ravichandran, Izabella M. Bankowski, Alexis M. Ceasrine, Christopher J. Mcdougle, William A. Carlezon Jr, Staci D. Bilbo
Summary: There is a strong male bias in many neurodevelopmental disorders such as autism spectrum disorder, but the mechanisms behind this bias are unknown. Infection during the perinatal period increases the risk of neurodevelopmental disorders. Using a mouse model, researchers found that early-life immune activation only induced deficits in social behaviors in male mice. These behavioral changes were associated with alterations in microglial immune signaling, mitochondrial morphology, gene expression, and function specifically in microglia, the brain's innate immune cells. Furthermore, the vulnerability to early-life immune activation and its effects on behavior and microglial mitochondria were programmed by the male-typical perinatal gonadal hormone surge. These findings highlight the role of microglia-specific mechanisms shaped by early developmental events in regulating male social behavior throughout lifespan.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Maria Amalia Di Castro, Stefano Garofalo, Alessandro Mormino, Laura Carbonari, Erika Di Pietro, Eleonora De Felice, Myriam Catalano, Laura Maggi, Cristina Limatola
Summary: Cytokines, such as interleukin-15 (IL-15), play important roles in modulating the central nervous system (CNS). In this study, the authors found that exposure to IL-15 enhances GABA release and reduces glutamatergic currents in hippocampal slices. Chronic treatment with IL-15 has negative effects on memory formation. Serotonin is involved in mediating these effects, as a selective 5-HT3A receptor antagonist prevents the effects on inhibitory neurotransmission and improves performance in a memory test.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Nikhitha Sreenivas, Michael Maes, Hansashree Padmanabha, Apoorva Dharmendra, Priyanka Chakkera, Saptamita Paul Choudhury, Fazal Abdul, Thrinath Mullapudi, Vykuntaraju K. Gowda, Michael Berk, John Vijay Sagar Kommu, Monojit Debnath
Summary: Neurodevelopmental disorders (NDDs) are a spectrum of conditions with both common and differing characteristics in terms of phenome, symptomatome, neuropathology, risk factors and underlying mechanisms. This study investigates the possibility of a shared immune etiology among three early-onset NDDs, namely Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD) and Intellectual Disability Disorder (IDD).
BRAIN BEHAVIOR AND IMMUNITY
(2024)