Article
Immunology
Haiyan Deng, Pingping Zhang, Xianxian Gao, Weiyi Chen, Jianing Li, Fuyan Wang, Yiyue Gu, Xin Hou
Summary: This review summarizes the trophic activities of mesencephalic astrocyte-derived neurotrophic factor (MANF) in tissue repair and regeneration, as well as the underlying molecular mechanisms. The structural motifs and immune modulation of MANF are also discussed. The authors propose that MANF could be a promising therapeutic target for tissue repair.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Immunology
Tineke Vanderhaeghen, Rudi Beyaert, Claude Libert
Summary: Glucocorticoid-induced and hypoxia-induced transcriptional responses play crucial roles in maintaining tissue homeostasis and regulating cellular stress and inflammatory responses. Cells respond rapidly to hypoxia to prevent metabolic shutdown and death through hypoxia inducible factors (HIFs). The crosstalk between the glucocorticoid receptor (GR) and HIFs has been investigated, and the therapeutic effects of GCs on HIF-mediated diseases have been discussed.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Maximilian Lassi, Archana Tomar, Gemma Comas-Armangue, Rebekka Vogtmann, Dorieke J. Dijkstra, David Corujo, Raffaele Gerlini, Jonatan Darr, Fabienne Scheid, Jan Rozman, Antonio Aguilar-Pimentel, Omry Koren, Marcus Buschbeck, Helmut Fuchs, Susan Marschall, Valerie Gailus-Durner, Martin Hrabe de Angelis, Torsten Plosch, Alexandra Gellhaus, Raffaele Teperino
Summary: Disruption of paternal circadian rhythm at conception has significant effects on offspring health, including feeding behavior, metabolic health, and oscillatory transcription. Research suggests that the impact of paternal circadian disruption is not directly transferred to offspring via germ cells, but initiated by corticosterone-based parental communication at conception.
Article
Medicine, Research & Experimental
Anamika Gupta, Manju N. Jayakumar, Mohamed A. Saleh, Meganathan Kannan, Rabih Halwani, Rizwan Qaisar, Firdos Ahmad
Summary: Growth factors play differential roles in the pathogenesis of COVID-19, with most of them being upregulated at the moderate stage of the disease. The induction of growth factors likely occurs due to endothelial dysfunction and may counter the adverse effects of cytokine storms.
Review
Pharmacology & Pharmacy
Shuyuan Yi, Xinyi Tao, Yin Wang, Qianqian Cao, Zhixia Zhou, Shoushi Wang
Summary: Macrophages, along with monocytes and dendritic cells, make up the monocyte immune system, which plays a crucial role in immune response. Propofol, a commonly used anesthetic, has various effects including anti-inflammatory and anti-oxidation properties. This article summarizes the effects of propofol on macrophage functions in inflammation, infection, tumors, and organ reperfusion injury, and discusses its impact on pathology and prognosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Agronomy
Daniela Eliza Marin, Gina Cecilia Pistol, Cristina Valeria Procudin, Ionelia Taranu
Summary: Food and feed safety is a major concern for both animal and human health, as contamination with pathogens can occur frequently. This study investigated the effects of simultaneous contamination with mycotoxins and bacterial toxins on cell viability, oxidative stress, and inflammation. The results showed significant additive/synergistic effects of co-exposure to fungal and bacterial toxins, suggesting that the concomitant contamination with bacteria and mycotoxins could lead to higher toxicity.
Article
Pharmacology & Pharmacy
Raffaella Belvedere, Nunzia Novizio, Mariangela Palazzo, Emanuela Pessolano, Antonello Petrella
Summary: The combination of heparan sulfate, growth factors, and heparinase shows a significant pro-healing activity in treating skin wounds. This combination enhances the motility and activation of key cell populations involved in tissue regeneration and promotes the highest closure of wounds compared to other combinations. It also allows the formation of a well-structured matrix with new vessels, indicating its potential as a new therapy for skin wound healing.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Psychology, Multidisciplinary
Anem Iftikhar, Mohammad Islam, Simon Shepherd, Sarah Jones, Ian Ellis
Summary: Lifestyle factors, including alcohol consumption and smoking, play a significant role in the development of head and neck cancers. Promoting healthy lifestyle choices is crucial for improving health and preventing diseases. Stress is known to contribute to the adoption of unhealthy habits such as alcohol and smoking. Understanding the impact of stress on lifestyle choices and exploring the underlying mechanisms can facilitate the development of prevention measures.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Crystal S. Shin, Fernando J. Cabrera, Richard Lee, John Kim, Remya Ammassam Veettil, Mahira Zaheer, Aparna Adumbumkulath, Kirti Mhatre, Pulickel M. Ajayan, Steven A. Curley, Bradford G. Scott, Ghanashyam Acharya
Summary: The development of an inflammation modulating biomaterial scaffold for soft tissue repair has shown promising results in inhibiting visceral adhesions formation and minimizing postsurgical complications. In vivo evaluation in a rat ventral hernia model confirmed that the bioscaffold acts as an inflammation trap, capturing proinflammatory cytokines and modulating local inflammation effectively without the need for exogenous anti-inflammatory agents.
ADVANCED MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
David A. Hart, Norimasa Nakamura
Summary: After injuries to musculoskeletal tissues, an inflammatory response occurs to promote endogenous repair, but it often results in functionally inferior scar tissue. Injuries in adults no longer have the anabolic processes that contribute to growth and maturation, which can lead to degenerative conditions such as osteoarthritis. Researchers have been exploring cellular therapies, such as Platelet-rich Plasma and mesenchymal stem/medicinal signaling cells, to enhance tissue repair and regeneration. However, implanting these cells or engineered constructs into an inflammatory adult environment may compromise their potential for regeneration. Therefore, it may be necessary to neutralize the inflammatory environment and create an anabolic environment for optimal outcomes.
Review
Medicine, Research & Experimental
Hui Cheng, Haoyan Huang, Zhikun Guo, Ying Chang, Zongjin Li
Summary: PGE2 plays a crucial role in tissue regeneration by promoting the regeneration of various organ systems through activation of endogenous stem cells, immune regulation, and angiogenesis. Understanding the modulation of tissue regeneration by PGE2 and enhancing its regenerative efficiency are crucial for tissue repair and regeneration processes.
Article
Endocrinology & Metabolism
Assel Sarsenbayeva, Priya Dipta, Martin Lundqvist, Kristina E. Almby, Boaz Tirosh, Giada Di Nunzio, Jan W. Eriksson, Maria J. Pereira
Summary: The study found that co-culturing different types of macrophages with adipocytes can induce the expression of pro-inflammatory cytokines in adipocytes but does not affect the expression of genes related to metabolism. Dexamethasone significantly reduces the expression of pro-inflammatory cytokines in macrophages and prevents macrophage-induced inflammatory response in adipocytes.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Immunology
Juan Manuel Ortiz Wilczynski, Hebe Agustina Mena, Martin Manuel Ledesma, Cinthia Mariel Olexen, Enrique Podaza, Mirta Schattner, Soledad Negrotto, Andrea Emilse Errasti, Eugenio Antonio Carrera Silva
Summary: Monocytes are plastic cells that differentiate into macrophages and play a crucial role in inflammation resolution and tissue regeneration. They exhibit dynamic switching from pro-inflammatory to pro-reparative phenotypes depending on the wound environment. Promoting tissue repair program switching is a promising strategy for chronic inflammatory wounds.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Ashti M. Shah, Ali Mubin Aral, Ruben Zamora, Nitin Gharpure, Fayten El-Dehaibi, Fatih Zor, Yalcin Kulahci, Huseyin Karagoz, Derek A. Barclay, Jinling Yin, Warren Breidenbach, Dmitry Tuder, Vijay S. Gorantla, Yoram Vodovotz
Summary: Vascularized composite allotransplantation (VCA) is often complicated by inflammation spanning multiple tissues. In this study, nerve repair and immunosuppressive therapy were found to potentially lead to dysregulated and mis-compartmentalized inflammation, calling for mitigation strategies.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Laiba Jamshed, Amrita Debnath, Shanza Jamshed, Jade Wish, Jason C. Raine, Gregg T. Tomy, Philippe J. Thomas, Alison C. Holloway
Summary: Tryptophan metabolism plays a critical role in various physiological processes and can be influenced by environmental factors and chemical contaminants. Understanding this pathway may have broader implications for the health of organisms and ecosystems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Andrew Schrepf, Susan K. Lutgendorf, Leah M. Pyter
BRAIN BEHAVIOR AND IMMUNITY
(2015)
Review
Psychology, Biological
Leah M. Pyter
PHYSIOLOGY & BEHAVIOR
(2016)
Article
Multidisciplinary Sciences
Leah M. Pyter, Yasmin Husain, Humberto Calero, Daniel B. McKim, Hsin-Yun Lin, Jonathan P. Godbout, John F. Sheridan, Christopher G. Engeland, Phillip T. Marucha
Article
Endocrinology & Metabolism
Savannah R. Bever, Xiaoyu Liu, Ning Quan, Leah M. Pyter
NEUROIMMUNOMODULATION
(2017)
Article
Surgery
Leah M. Pyter, Daniel B. McKim, Yasmin Husain, Humberto Calero, Jonathan P. Godbout, John F. Sheridan, Phillip T. Marucha, Christopher G. Engeland
JOURNAL OF SURGICAL RESEARCH
(2018)
Article
Immunology
Brian J. Prendergast, Erin J. Cable, Priyesh N. Patel, Leah M. Pyter, Kenneth G. Onishi, Tyler J. Stevenson, Norman F. Ruby, Sean P. Bradley
BRAIN BEHAVIOR AND IMMUNITY
(2013)
Article
Immunology
Leah M. Pyter, Sean D. Kelly, Constance S. Harrell, Gretchen N. Neigh
BRAIN BEHAVIOR AND IMMUNITY
(2013)
Article
Neurosciences
Leah M. Pyter, Sarah El Mouatassim Bih, Husain Sattar, Brian J. Prendergast
Article
Endocrinology & Metabolism
Brian J. Prendergast, Leah M. Pyter, August Kampf-Lassin, Priyesh N. Patel, Tyler J. Stevenson
Article
Neurosciences
J. C. Walton, Z. Chen, Z. M. Weil, L. M. Pyter, J. B. Travers, R. J. Nelson
Article
Multidisciplinary Sciences
James C. Walton, Leah M. Pyter, Zachary M. Weil, Randy J. Nelson
Article
Endocrinology & Metabolism
Leah M. Pyter, Brian J. Prendergast
PSYCHONEUROENDOCRINOLOGY
(2013)
Article
Behavioral Sciences
Leah M. Pyter, Linglan Yang, Cassandra McKenzie, Jose M. da Rocha, C. Sue Carter, Bin Cheng, Christopher G. Engeland
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2014)
Article
Behavioral Sciences
Leah M. Pyter, Lorena P. Suarez-Kelly, William E. Carson, Jasskiran Kaur, Joshua Bellisario, Savannah R. Bever
BEHAVIOURAL BRAIN RESEARCH
(2017)
Article
Psychology, Biological
Umit Yilmaz, Kevser Tanbek
Summary: This study investigated the effects of intracerebroventricular administration of Spexin on the hypothalamus-pituitary-thyroid axis and energy expenditure in rats. The results showed that Spexin reduced food consumption and body weight, increased thyroid hormones, and enhanced energy metabolism.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Kuei-Yu Chien, Yun-Ju Chen, Kuo-Jen Hsu, Chiao-Nan Chen
Summary: This study investigated the effects of a high-protein diet and high-intensity interval training on appetite and weight loss in obese middle-aged individuals. The results showed that consuming a high-protein drink and following a high-protein diet after exercise can reduce post-exercise appetite and the frequency of late-night snacking.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Melissa Alves Braga Oliveira, Ana Carolina Odebrecht Vergne de Abreu, Debora Barroggi Constantino, Andre C. Tonon, Antoni Diez-Noguera, Fernanda Gaspar Amaral, Maria Paz Hidalgo
Summary: Biological processes in living organisms exhibit strong rhythmicity and are regulated by internal timing systems. Understanding the influence of biological rhythms is crucial for experimental design and reporting.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Yanqun Cao, Hao Chen, Yinna Tan, Xu-Dong Yu, Chuli Xiao, Yin Li, James Reilly, Zhiming He, Xinhua Shu
Summary: There is evidence to suggest that chronic stress impacts neurochemical homeostasis and contributes to mental disorders. This study investigates the therapeutic potential of p-coumaric acid (p-CA), a natural compound found in vegetables and fruits, against stress-associated mental disorders. The findings suggest that p-CA could alleviate cognitive deficits and depression-like behavior in mice exposed to chronic restraint stress (CRS) by regulating the PKA-CREB-BDNF signaling pathway.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Mai O. Spaulding, Jessica R. Hoffman, Grace C. Madu, Magen N. Lord, Caroline Soares Iizuka, Kevin P. Myers, Emily E. Noble
Summary: Food insecurity is associated with obesity and disordered eating behaviors. Studying a rodent model, researchers found that adolescent food insecurity may increase susceptibility to obesity and altered eating behaviors during adulthood.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
K. Oberman, B. L. van Leeuwen, M. Nabben, J. E. Villafranca, R. G. Schoemaker
Summary: The present study investigated the post-operative complications and therapeutic potential of J147 in male Zucker rats, and found that J147 treatment had positive effects on behavioral and metabolic parameters, but did not affect neuroinflammation. The results suggest that a combination of acute and chronic J147 treatment may be optimal for treatment.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Mathieu Cournoyer, Alice Maldera, Alexandre-Charles Gauthier, Fabien Dal Maso, Marie-Eve Mathieu
Summary: This article provides a comprehensive view of the literature on the effect of different odors on physical activity through a systematic review. It was found that pleasant odors have a positive impact on participants' physical activity. However, better methodological consistency is needed in studies to produce more meaningful results.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Gabriel R. Gilmore, Jeff Dyche
Summary: This study examined sleep, sleep/wake regularity, and cognition in college students diagnosed with depression and using serotonergic antidepressants, comparing them to those without a depression diagnosis. The results showed that students using antidepressants had slightly longer wake after sleep onset and lower sleep efficiency, but these differences were likely not noticed by the participants. There were no differences in sleep regularity or cognition between the two groups.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Erica A. Cross, Kim L. Huhman, H. Elliott Albers
Summary: Social stress plays a significant role in the development of neuropsychiatric disorders and can lead to behavioral deficits such as social withdrawal. This study investigates the impact of social stress on social reward in Syrian hamsters. The results show that subordinate and socially defeated males have reduced motivation for social interactions compared to dominant males. Additionally, winning males exhibit greater activation in the mesolimbic dopamine system compared to losers. In females, there were no differences in social entries between winners and losers, but winning females display more activation in the NAc shell.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Daniel A. R. Cabral, Maria L. M. Rego, Eduardo B. Fontes, Vagner D. O. Tavares
Summary: This study examined the association between body mass index (BMI) and negative emotional states (NES) in men with substance use disorders (SUD) undergoing treatment. The findings showed a positive correlation between BMI and stress, anxiety, and depression. These results suggest that reducing body fat accumulation may contribute to improving mental health in individuals with SUD during recovery.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Elizabeth Agbor Epse Muluh, Jessica C. McCormack, Yunfan Mo, Michael Garratt, Mei Peng
Summary: This PROSPERO pre-registered systematic review and meta-analysis evaluated the olfactory and gustatory changes in pregnant individuals. The meta-analysis revealed that pregnant individuals performed poorer in odour identification, rated olfactory stimuli to be more intense during the second and third trimester, and had increased pleasantness for sweet taste in the first trimester. No major difference was observed in terms of gustatory functions between pregnant and non-pregnant subjects.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Renee Spiteri Douglas, Mackenzie R. Hartley, J. Renee Yang, Tamara B. Franklin
Summary: The expression of Hdac2 in the hippocampus is associated with social status, while the expression of closely related genes Hdac1 and HDAC2 protein is not associated with social rank in the hippocampus.
PHYSIOLOGY & BEHAVIOR
(2024)