Review
Clinical Neurology
Nina P. T. Jacobs, Petra J. W. Pouwels, Marjolein M. van Der Krogt, Pieter Meyns, Kangdi Zhu, Lois Nelissen, Linda J. Schoonmade, Annemieke I. Buizer, Laura A. van de Pol
Summary: This study aimed to investigate altered structural and functional connectivity as well as network organization in different clinical subtypes of cerebral palsy (CP). The results showed differences in connectivity between CP subtypes and typically developing individuals. Future research should focus on underrepresented CP subtypes and methodologies, assess the prognostic potential of specific connectivity measures in neonates, and explore the effects of therapeutic interventions on brain connectivity.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Article
Health Care Sciences & Services
Jungsoo Lee, Won Hyuk Chang, Yun-Hee Kim
Summary: Understanding the interaction between the corticospinal tract (CST) and corticocerebellar tract (CCT) can enhance the individualized rehabilitative strategies and predictive accuracy for stroke patients. The study found that the CCT was significantly associated with high CST FA, indicating a conditional role of CCT depending on CST status in upper extremity recovery after stroke.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ken Muramatsu, Satoshi Shimo, Toru Tamaki, Masako Ikutomo, Masatoshi Niwa
Summary: The study reveals a decrease in conduction velocity of the corticospinal tract in the lumbar spinal cord of diabetic animals, along with atrophy of fibers and an increased g-ratio.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuanhao Li, Su Yan, Guiling Zhang, Nanxi Shen, Di Wu, Jun Lu, Yiran Zhou, Yufei Liu, Hongquan Zhu, Li Li, Shun Zhang, Wenzhen Zhu
Summary: A novel method was used to evaluate the prognostic value of corticospinal tract (CST) injury in patients with ischemic stroke. The results showed that this method is effective in assessing CST injury and predicting functional outcomes for patients.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Neurosciences
Yue Qin, Xin Li, Yanqiang Qiao, Huili Zou, Yifan Qian, Xiaoshi Li, Yinhu Zhu, Wenli Huo, Lei Wang, Ming Zhang
Summary: This study investigated the relationship between brain glymphatic activity and motor dysfunction in subacute ischemic stroke (IS) patients using diffusion tensor image analysis. The results showed that glymphatic dysfunction is involved in subacute IS, and the DTI-ALPS index could be a potential magnetic resonance biomarker of motor dysfunction in subacute IS patients.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Noriyuki Oka, Masaharu Sakoh, Misato Hirayama, Mayu Niiyama, Albert Gjedde
Summary: The signal intensity differences between the left and right corticofugal tracts (CFT) are related to differences in hand motor function. This difference can be quantified using T2WI images. The signal intensity ratio of each CFT structure can serve as a biological marker for assessing manual dexterity.
SCIENTIFIC REPORTS
(2023)
Article
Geriatrics & Gerontology
Jingchun Liu, Caihong Wang, Jingliang Cheng, Peifang Miao, Zhen Li
Summary: In chronic subcortical stroke, there is increased interhemispheric resting-state functional connectivity (rsFC) between the bilateral primary motor cortex (M1) to compensate for corticospinal tract (CST) impairment, facilitating motor recovery. The FA of the affected M1 fiber in the acute stage showed the most significant correlation with long-term motor recovery, and the compensatory role of M1-M1 rsFC enhancement may start from the subacute stage in stroke patients with CST impairment.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
David Emanuel Vetter, Christoph Zrenner, Paolo Belardinelli, Tuomas Petteri Mutanen, Gabor Kozak, Laura Marzetti, Ulf Ziemann
Summary: This study investigated the relationship between functional connectivity in the motor network and corticospinal excitability using real-time EEG-TMS experiment. The findings suggest that high functional connectivity predicts high corticospinal excitability, but should be considered along with mu-power and stimulus interval.
Article
Anatomy & Morphology
Prajwal Ghimire, Jose Pedro Lavrador, Asfand Baig Mirza, Noemia Pereira, Hannah Keeble, Marco Borri, Luciano Furlanetti, Christian Brogna, Jozef Jarosz, Richard Gullan, Francesco Vergani, Ranjeev Bhangoo, Keyoumars Ashkan
Summary: A supplemental clinical cortical and a novel subcortical motor map are proposed based on data from a retrospective cohort study of patients undergoing craniotomy for motor eloquent lesions. These maps are essential for improving the safety and outcome of patients undergoing resection of motor eloquent brain lesions.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Neurosciences
Frances S. Hausmann, John M. Barrett, Megan E. Martin, Huiqing Zhan, Gordon M. G. Shepherd
Summary: This study used MAPseq to investigate the diversity of brainstem branching patterns of the pyramidal tract projections from the forelimb-related areas of the motor cortex. The results showed high yet systematic diversity in PT axons at the level of brainstem projection patterns. The projections from M1 and M2 were qualitatively similar, but with quantitative differences in subclasses and clusters.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Clinical Neurology
Karim Fouad, Phillip G. Popovich, Marcel A. Kopp, Jan M. Schwab
Summary: Lesion size is considered a reliable predictor of outcome after central nervous system injury, but lesions of comparable size can lead to different levels of functional impairment and recovery, contributing to failed replication in animal models. A clinical-radiological paradox may explain why individuals with similar injuries respond differently to rehabilitation in humans.
NATURE REVIEWS NEUROLOGY
(2021)
Article
Neurosciences
Shinya Suzuki, Tsuyoshi Nakajima, Shun Irie, Ryohei Ariyasu, Hiroyuki Ohtsuka, Tomoyoshi Komiyama, Yukari Ohki
Summary: The study found that MEPs in specific muscles are modulated during switching movements, potentially mediated by presumed cervical interneuronal systems. In patients with cortical hemianopsia, MEPs were facilitated just before the switching activities.
Article
Neurosciences
Safiye Cavdar, Busra Kose, Damlasu Altinoz, Mazhar Ozkan, Yasin Celal Gunes, Oktay Algin
Summary: This study investigates the afferent and efferent connections of the supplementary motor area (SMA) with brainstem structures and clarifies its relationship with the corticospinal tract (CST). The results show that the SMA has both afferent and efferent connections with various brainstem structures, which contribute to its motor and non-motor functions. These findings provide new insights into the role of the SMA in brainstem networks.
NEUROSCIENCE LETTERS
(2023)
Article
Neurosciences
J. Ibanez, A. Del Vecchio, J. C. Rothwell, S. N. Baker, D. Farina
Summary: This study investigates the transmission speeds of cortical beta rhythms to arm and leg muscles during mild contractions in humans. Two improvements for estimating corticomuscular beta transmission delays are proposed, leading to the discovery that descending corticomuscular beta transmission is only slightly slower than expected from the fastest corticospinal pathways. Simulation results suggest two possible scenarios to explain fast corticomuscular transmission, with implications for our understanding of corticomuscular interactions.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Giorgio Leodori, Marco Mancuso, Davide Maccarrone, Matteo Tartaglia, Antonio Ianniello, Francesco Certo, Viola Baione, Gina Ferrazzano, Leonardo Malimpensa, Daniele Belvisi, Carlo Pozzilli, Alfredo Berardelli, Antonella Conte
Summary: This study aimed to investigate the mechanisms of central motor fatigue in multiple sclerosis (MS) patients and found that central motor fatigue is associated with abnormal primary motor cortex (M1) output and connectivity within the sensorimotor network. The results showed that MS patients exhibited higher levels of central and supraspinal fatigue in contraction.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Computer Science, Interdisciplinary Applications
Wonhee Lee, Beomki Yoo, Dongho Park, Juntaek Hong, Dain Shim, Joongon Choi, Dong-wook Rha
Summary: This study compared the foot kinematics of toe walking and heel-toe walking in healthy individuals, finding increases in forefoot plantarflexion and hindfoot internal rotation during toe walking compared to heel-toe walking. These results may aid in distinguishing the pathologic mechanism of equinus gait in various disorders.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Young Hee Sung, Joong-Seok Kim, Sang-Won Yoo, Na-Young Shin, Yoonho Nam, Tae-Beom Ahn, Dallah Yoo, Kyung Mi Lee, Hyug-Gi Kim, Seong-Beom Koh, Jinhee Kim, Ilsoo Kim, Do-Young Kwon, Younghen Lee, Chulhan Kim, Sun Ju Chung, Sungyang Jo, Seung Hyun Lee, Sang Joon Kim, Minjae Kim, Chul Hyoung Lyoo, Min Seok Baek, Suk Yun Kang, Suk Ki Chang, Sang-Won Jo, Seun Ah Lee, Hyeo-il Ma, Young Eun Kim, Eun Soo Kim, Yun Joong Kim, Hyun Sook Kim, Min-Hee Woo, Hye Jeong Choi, Eung Yeop Kim
Summary: This study compared the diagnostic performance of susceptibility map-weighted imaging (SMwI) using different MRI machines with N-3-fluoropropyl-2-beta-carbomethoxy-3-beta-(4-iodophenyl)nortropane (F-18-FP-CIT) PET in the diagnosis of neurodegenerative parkinsonism. The results showed that SMwI had a high diagnostic sensitivity, specificity, and accuracy, and there was no significant difference between the results of SMwI and F-18-FP-CIT PET. The study demonstrated the generalisability of SMwI for determining nigrostriatal degeneration in patients with parkinsonism in a multi-centre setting.
EUROPEAN RADIOLOGY
(2022)
Article
Neurosciences
Dain Shim, Dongho Park, Beomki Yoo, Joong-on Choi, Juntaek Hong, Tae Young Choi, Eun Sook Park, Dong-wook Rha
Summary: This study aimed to compare the center-of-pressure (CoP) measurements using force plates during standing and sitting trials with the Pediatric Balance Scale (PBS) in children with spastic CP. The results showed that the mediolateral CoP parameters in the sitting position and the anteroposterior CoP parameters in the standing position may better reflect the balance control in children with spastic CP.
Article
Neurosciences
Dain Shim, Ja Young Choi, Sook-Hee Yi, Eun Sook Park, Seungki Kim, Beomki Yoo, Dongho Park, Hye-Rin Park, Dong-Wook Rha
Summary: This study investigated whether new parameters derived from 3D motion analysis reflect upper limb function in children with cerebral palsy (CP), compared to clinical measurements. The index of curvature and number of movement units showed fair to good correlation with accuracy and fluency of upper limb function.
Article
Clinical Neurology
Yoon-Chul Kim, Jong-Won Chung, Oh Young Bang, Mihee Hong, Woo-Keun Seo, Gyeong-Moon Kim, Eung Yeop Kim, Jin Soo Lee, Ji Man Hong, David S. Liebeskind, Jeffrey L. Saver
Summary: This study developed a DL model to grade collateral status in patients with LVO acute ischemic stroke and compared its performance with expert manual grading. The DL model showed good agreement with expert grading and was associated with clinical outcomes. The study highlights the potential of DL in assessing collateral status and guiding treatment decisions.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Muhammad Asaduddin, Hong Gee Roh, Hyun Jeong Kim, Eung Yeop Kim, Sung-Hong Park
Summary: This study successfully extracted perfusion maps using deep learning methods from a single dose of contrast agent. Testing showed that U-net with multiple decoders and enhanced encoders performed the best, demonstrating strong agreement between the generated perfusion maps and the ground truth.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Haejoon Lee, Jun-Ho Kim, Seul Lee, Kyu-Jin Jung, Woo-Ram Kim, Young Noh, Eung Yeop Kim, Koung Mi Kang, Chul-Ho Sohn, Dong Young Lee, Mohammed A. Al-masni, Dong-Hyun Kim
Summary: This study proposes a new end-to-end CMBs detection network that integrates CNNs on multiple planes, improving precision and sensitivity. This approach is clinically feasible and is expected to provide better results in detecting lesions in clinical practice.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Clinical Neurology
So Youn Choi, Minjung Seong, Eung Yeop Kim, Michelle Sojung Youn, Soohyun Cho, Hyemin Jang, Mi Ji Lee
Summary: The study found that epidural blood patch showed significant treatment response in patients with suspected spontaneous intracranial hypotension, even when brain and spinal imaging results were negative.
Article
Clinical Neurology
Han-Kyeol Kim, Tae Won Kim, Min Seok Baek, Eung Yeop Kim, Young Hee Sung, Jae Hoon Lee, Young Hoon Ryu, Sung Jun Ahn, Han Soo Yoo, Chul Hyoung Lyoo
Summary: In this study, the visibility of NG1 in SMwI was found to be associated with the degree of nigrostriatal degeneration in PD patients. It was concluded that SMwI can be used for diagnosing PD only after the onset of motor symptoms.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Minjung Seong, Seongbeom Park, Young Hee Sung, Eung Yeop Kim
Summary: Significant differences were found between early-stage IPD patients and HCs using CR measurements based on the NM-MRI template. The CR values of the left N1 + N2 showed the highest diagnostic performance.
BMC MEDICAL IMAGING
(2023)
Article
Pediatrics
Ja Young Choi, Sook-hee Yi, Dain Shim, Beomki Yoo, Eun Sook Park, Dong-wook Rha
Summary: This study investigated the feasibility and effectiveness of a home-based VR-enhanced rehabilitation program on upper limb functions in children with brain injury. Findings showed that although the VR training had limited impact on improving upper limb function, it could help improve social cognitive function, movement pattern, and efficiency, and serve as an effective means of extending clinical therapy to the home.
FRONTIERS IN PEDIATRICS
(2023)
Article
Chemistry, Analytical
Yongjin Ahn, Juntaek Hong, Dain Shim, Joong-on Choi, Dong-wook Rha
Summary: This study compared the muscle activation patterns of real and simulated walking in children with spastic cerebral palsy and found differences between the two conditions, which should be taken into account for gait training using an end-effector-type robot.
Review
Clinical Neurology
Juntaek Hong, Dong-wook Rha
Summary: Technological advances have improved survival rates in preterm babies, but intraventricular hemorrhage remains a major complication. It is associated with neurodevelopmental disorders and requires multidisciplinary rehabilitation throughout the patient's life cycle.
JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
(2023)
Article
Clinical Neurology
Seongbeom Park, Young Hee Sung, Woo Ram Kim, Young Noh, Eung Yeop Kim
Summary: There were significant correlations between CR values in the SNpc on NM-MRI and striatal SUVR values on DAT PET on both sides in early-stage PD.
JOURNAL OF CLINICAL NEUROLOGY
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Inhwa Han, Boah Kim, Eung Yeop Kim, Jong Chul Ye
Summary: This study proposes a method to synthesize NECT images from CECT using cycle-consistent generative adversarial network (cycleGAN) with adaptive instance normalization. By utilizing histogram equalization of CECT and NECT images, the single generator in our framework effectively learns image contrast. Experimental results demonstrate that the proposed method provides high-quality synthetic NECT images compared to the original cycleGAN.
2022 IEEE INTERNATIONAL CONFERENCE ON ARTIFICIAL INTELLIGENCE CIRCUITS AND SYSTEMS (AICAS 2022): INTELLIGENT TECHNOLOGY IN THE POST-PANDEMIC ERA
(2022)