Article
Pharmacology & Pharmacy
Fangliang Guo, Xiaolong Zheng, Ziyu He, Ruoying Zhang, Song Zhang, Minghuan Wang, Hong Chen, Wei Wang
Summary: The study found that long-term treatment with NMD helps to improve locomotion, pain-related behaviors, and spasticity-like symptoms in rats with SCI, but has less effect on open-field activity, hind limb grip strength, and bladder function. Additionally, NMD-treated rats showed greater tissue preservation, reduced lesion areas, and increased perilesional neuronal sparing, suggesting a potential therapeutic strategy for SCI treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Taoyang Yuan, Yu Shao, Xu Zhou, Qian Liu, Zhichao Zhu, Bini Zhou, Yuanchen Dong, Nicholas Stephanopoulos, Songbai Gui, Hao Yan, Dongsheng Liu
Summary: Researchers have developed a DNA hydrogel to repair spinal cord gap in rats, promoting proliferation and differentiation of stem cells for functional recovery. This hydrogel system shows great potential in clinical trials and could be adaptable to other tissue regeneration applications.
ADVANCED MATERIALS
(2021)
Article
Biotechnology & Applied Microbiology
Sisi Mi, Xue Wang, Jiaxin Gao, Yu Liu, Zhongquan Qi
Summary: After spinal cord injury (SCI), the microenvironment inhibits neural regeneration due to the abundance of inhibitory factors and lack of factors promoting nerve regeneration. This study developed a bioactive material, hp-SHED sheet, to mimic the natural spinal cord structure and enhance nerve cell attachment and migration. Implantation of hp-SHED sheet in SCI rats promoted nerve regeneration, axonal remyelination, and inhibited glial scarring, leading to the restoration of sensory and motor functions.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Clinical Neurology
Alice Lin, Elias Shaaya, Jonathan S. Calvert, Samuel R. Parker, David A. Borton, Jared S. Fridley
Summary: This review assesses the efficacy of spinal cord stimulation for individuals with chronic spinal cord injury. The results show that spinal cord stimulation can improve sensorimotor and autonomic function. However, further research and optimization are needed before clinical translation.
Article
Medicine, General & Internal
Md Akhlasur Rahman, Niraj Singh Tharu, Sylvia M. Gustin, Yong-Ping Zheng, Monzurul Alam
Summary: Spinal cord injury (SCI) is a debilitating injury with severe complications, but recent development of noninvasive electrical neuromodulation treatments offers hope for rehabilitation. Trans-spinal direct current stimulation (tsDCS) and trans-spinal pulsed current stimulation (tsPCS) have shown promising results in improving sensorimotor and autonomic functions.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Shiva Hashemizadeh, Zeinab Gharaylou, Saereh Hosseindoost, Maryam Sardari, Ameneh Omidi, Hassan Hosseini Ravandi, Mahmoudreza Hadjighassem
Summary: This study found that early administration of bumetanide after spinal cord injury can promote recovery of locomotor function. The results showed that bumetanide can reduce the expression of NKCC1 gene and increase GAP protein levels, thereby having neuroprotective and regenerative effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Nicholas O. Jensen, Brooke Burris, Lili Zhou, Hunter Yamada, Catrina Reyes, Zachary Pincus, Mayssa H. Mokalled
Summary: Adult zebrafish are capable of anatomical and functional recovery following severe spinal cord injury. Axon growth, glial bridging, and adult neurogenesis are hallmarks of cellular regeneration during spinal cord repair. However, the correlation between these cellular regenerative processes and functional recovery remains to be elucidated.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Yiyoung Kim, Eun Ji Roh, Hari Prasad Joshi, Hae Eun Shin, Hyemin Choi, Su Yeon Kwon, Seil Sohn, Inbo Han
Summary: BZA has shown neuroprotection and remyelination effects in central nervous system injuries. Research demonstrated that BZA could suppress inflammatory response, promote oligodendrocyte precursor cell differentiation, and reduce blood-spinal cord barrier disruption. BZA also improved locomotor recovery in rats with spinal cord injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Materials Science, Multidisciplinary
Xuelian Wei, Yunhang Wang, Botao Tan, Enyang Zhang, Baocheng Wang, Hong Su, Lehua Yu, Ying Yin, Zhong Lin Wang, Zhiyi Wu
Summary: TENG-driven EA treatment using soft-contact FR-TENG improved the gait performance and BBB score of rats with spinal cord contusion for up to 4 weeks, while also enhancing neuron survival and inhibiting astrocyte activation.
Article
Neurosciences
Wu Jiang, Fan He, Guoming Ding, Junsong Wu
Summary: This study aimed to investigate the protective effect of the novel mitochondria-targeted peptide EPT in spinal cord injury (SCI). The results showed that EPT improved locomotor functional recovery and reduced neuronal loss. EPT also inhibited NLRP3 inflammasome activation and elevated levels of pro-inflammatory cytokines. Furthermore, EPT alleviated mitochondrial dysfunction and reduced mitochondrial reactive oxygen species level. Therefore, EPT may protect against SCI by inhibiting pyroptosis.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Neurosciences
Rakib Uddin Ahmed, Chase A. Knibbe, Felicia Wilkins, Leslie C. Sherwood, Dena R. Howland, Maxwell Boakye
Summary: Animal models are important for spinal cord injury research. Small animal models have advantages in terms of management and cost, but their neurologic and anatomical differences may limit their translation to humans. In contrast, large animal models are more similar to humans and have greater translational value in studying spinal cord injury.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jian Zhao, Ailang Pang, Saige Yin, Meifeng Yang, Xuemei Zhang, Rong Zhang, Jingfei Liu, Yuanqi Gu, Shanshan Li, Yan Hu, Yue Zhang, Yingchun Ba, Buliang Meng, Xinwang Yang
Summary: OM-LV20 promotes structural and functional recovery of spinal cord injury by increasing neuronal survival, enhancing BDNF and TrkB expression, and regulating oxidative stress balance.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Microbiology
Jingjie Du, Ahmed A. Zayed, Kristina A. Kigerl, Kylie Zane, Matthew B. Sullivan, Phillip G. Popovich
Summary: Metagenomic analysis revealed changes in gut microbial population dynamics after SCI, with decreases in beneficial bacteria and increases in potentially pathogenic bacteria. The study also identified reductions in microbial genes related to essential pathways for central nervous system function and an expansion of known murine gut viral species sequence space after SCI.
Article
Neurosciences
Siyi Liu, Ge Lin, Qiao Yang, Penghui Wang, Chao Ma, Xiaowei Qian, Xiaomei He, Zhangji Dong, Yan Liu, Mei Liu, Ronghua Wu, Liu Yang
Summary: This study aimed to evaluate the effects of SASH1 knockdown on functional recovery after SCI and investigate its mechanism in facilitating axonal growth. The results show that SASH1 downregulation improved hindlimb motor function and reduced glial activation. In cultured spinal astrocytes, SASH1 knockdown decreased interferon-gamma release and increased BDNF release, leading to increased axonal growth. Furthermore, SASH1 depletion maintained high levels of Nestin protein and increased BDNF release in differentiated NSCs.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Benita Jin, Monzurul Alam, Alexa Tierno, Hui Zhong, Roland R. Roy, Yury Gerasimenko, Daniel C. Lu, V. Reggie Edgerton
Summary: Serotonergic agents, specifically buspirone and fluoxetine, have shown to improve forelimb motor function recovery after spinal cord injury in adult female rats. Buspirone treatment led to rapid improvement in reaching and grasping success rates, while fluoxetine treatment resulted in a more progressive improvement in forelimb performance over time. However, both treatments did not significantly improve quadrupedal locomotion.
Article
Clinical Neurology
Anh K. Vo, Fred Geisler, Lukas Grassner, Jan Schwab, Gale Whiteneck, Catherine Jutzeler, John L. K. Kramer
Summary: This secondary analysis study found a significant association between serum albumin concentration and long-term neurological outcomes in individuals with spinal cord injury. However, after adjusting for initial motor scores and injury severity, the significance of serum albumin was reduced. Serum albumin could potentially serve as a crude prognostic biomarker in cases where injury severity assessment is challenging.
Article
Oncology
Trisha Jogia, Tom Luebstorf, Esther Jacobson, Elissa Scriven, Sridhar Atresh, Quan H. Nguyen, Thomas Liebscher, Jan M. Schwab, Marcel A. Kopp, James Walsham, Kate E. Campbell, Marc J. Ruitenberg
Summary: The study found that the extent of acute neutrophilia in SCI patients is positively correlated with injury severity scores but inversely with neurological outcomes. Acute SCI-induced neutrophilia is an independent predictor of AIS grade conversion failure, while lymphopenia is identified as an independent predictor of better recovery.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Microbiology
Jingjie Du, Ahmed A. Zayed, Kristina A. Kigerl, Kylie Zane, Matthew B. Sullivan, Phillip G. Popovich
Summary: Metagenomic analysis revealed changes in gut microbial population dynamics after SCI, with decreases in beneficial bacteria and increases in potentially pathogenic bacteria. The study also identified reductions in microbial genes related to essential pathways for central nervous system function and an expansion of known murine gut viral species sequence space after SCI.
Article
Clinical Neurology
Marcel A. Kopp, Tom Lubstorf, Christian Blex, Jan M. Schwab, Ulrike Grittner, Thomas Auhuber, Axel Ekkernkamp, Andreas Niedeggen, Erik Prillip, Magdalena Hoppe, Johanna Ludwig, Martin Kreutztraeger, Thomas Liebscher
Summary: The study found that older patients (>= 75 years) had a longer injury to surgery interval, mainly due to secondary referrals and multimorbidity. A shorter time span to surgery (<= 12 hours) was associated with higher rates of neurological improvement after traumatic spinal cord injury.
EUROPEAN SPINE JOURNAL
(2022)
Article
Urology & Nephrology
Christopher S. Elliott, Marcel A. Kopp, Argyrios Stampas, Jan M. Schwab, Yuying Chen, Kazuko Shem, James Crew
Summary: Early infections after spinal cord injury can significantly affect long-term bladder function recovery, especially during the early recovery period. The severity of injury and lower extremity motor scores also play a role in this effect.
JOURNAL OF UROLOGY
(2022)
Article
Clinical Neurology
Thomas Liebscher, Johanna Ludwig, Tom Lubstorf, Martin Kreutztraeger, Thomas Auhuber, Ulrike Grittner, Benedikt Schaefer, Grit Wuestner, Axel Ekkernkamp, Marcel A. Kopp
Summary: This study investigated the effects of spinal surgical adverse events (SSAE) on clinical and functional outcome, length of stay, and treatment costs after traumatic cervical spinal cord injury (SCI). The results showed that SSAE had significant impacts on neurological recovery, functional outcome, and healthcare costs. Reducing SSAE is important for protecting the limited intrinsic capacity for recovery from SCI.
Article
Emergency Medicine
Martin Kreutztraeger, Tom Lubstorf, Axel Ekkernkamp, Christian Blex, Jan M. Schwab, Marcel A. Kopp, Thomas Auhuber, Grit Wuestner, Thomas Liebscher
Summary: This study compared the outcomes of patients with and without spinal cord injury in terms of diagnostic algorithm, therapy, and complications. The results showed that patients with spinal cord injury had higher risks of longer hospital stay, disease-associated complications, and mortality. However, survival rates were similar between the two groups. Age and extent of infection were identified as significant risk factors for mortality.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Article
Neurosciences
Yixing Du, Faith H. Brennan, Phillip G. Popovich, Min Zhou
Summary: This study investigates the role of microglia in regulating the structure and function of astrocytes in the mouse hippocampus, revealing that depletion of microglia disrupts astrocyte syncytial isopotentiality and dye coupling, leading to reduced synaptic transmission in neurons. Activation of microglia enhances synaptic transmission, while leaving astrocyte network function unaffected.
Article
Multidisciplinary Sciences
Christian Blex, Martin Kreutztraeger, Johanna Ludwig, Claus Peter Nowak, Jan M. Schwab, Tom Luebstorf, Axel Ekkernkamp, Marcel A. Kopp, Thomas Liebscher
Summary: This study found that specific comorbidities, such as kidney or liver diseases, have a significant impact on in-hospital mortality after traumatic spinal cord injury, and end-of-life decisions are also an important consideration factor.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Nicole Pukos, Christina M. Marion, W. David Arnold, Benjamin T. Noble, Phillip G. Popovich, Dana M. McTigue
Summary: Our previous study found that a large number of new oligodendrocytes (OLs) are generated in the injured spinal cord of mice, with peak oligodendrogenesis occurring between 4 and 7 weeks post-injury. We also observed new myelin formation up to 2 months post-injury. Our current research expands on these findings, quantifying new myelin formation up to 6 months post-injury and investigating indices of demyelination. We discovered that remyelination reaches its peak during the third month post-injury and continues for at least 6 months. Additionally, we observed chronic demyelination through the expression of Nav1.2 and nodal protein disorganization. Our study also revealed a potential mechanism for initiating post-injury myelination, showing that oligodendrocyte progenitor cells (OPCs) make contact with glutamatergic axons in an activity-dependent manner. Increasing OPC/axon contacts through chemogenetic activation of axons may serve as a therapeutic target for enhancing post-spinal cord injury myelin repair.
Article
Clinical Neurology
Marcel A. Kopp, Christian Meisel, Thomas Liebscher, Ralf Watzlawick, Paolo Cinelli, Oliver Schweizerhof, Christian Blex, Tom Luebstorf, Erik Prilipp, Andreas Niedeggen, Claudia Druschel, Klaus-Dieter Schaser, Guido A. Wanner, Armin Curt, Gertraut Lindemann, Natalia Nugeva, Michael G. Fehlings, Peter Vajkoczy, Mario Cabraja, Julius Dengler, Wolfgang Ertel, Axel Ekkernkamp, Kerstin Rehahn, Peter Martus, Hans-Dieter Volk, Nadine Unterwalder, Uwe Koelsch, Benedikt Brommer, Rick C. Hellmann, Elias Baumgartner, Julian Hirt, Laura-Christin Geurtz, Ramin Raul Ossami Saidy, Harald Pruess, Ines Laginha, Vieri Failli, Ulrike Grittner, Ulrich Dirnagl, Jan M. Schwab
Summary: Infections are a leading cause of death after spinal cord injury (SCI). The study shows that SCI can cause a secondary neurogenic immune deficiency syndrome (SCI-IDS) characterized by reduced monocytic HLA-DR expression. The findings indicate the importance of assessing immune suppression in SCI patients to stratify infection risk.
Correction
Clinical Neurology
Karim Fouad, Phillip G. Popovich, Marcel A. Kopp, Jan M. Schwab
NATURE REVIEWS NEUROLOGY
(2023)
Meeting Abstract
Clinical Neurology
Markus Harrigan, Marcel Kopp, Juan Peng, YuYing Chen, Clayton Peterson, Jan Schwab
Article
Immunology
Katherine A. Mifflin, Faith H. Brennan, Zhen Guan, Kristina A. Kigerl, Angela R. Filous, Xiaokui Mo, Jan M. Schwab, Phillip G. Popovich
Summary: Pulmonary infection is a common and serious complication after spinal cord injury (SCI). This study shows that SCI not only impairs the immune system in the lung, but also decreases the tissue-specific defense mechanisms against infection. Moreover, the current drug AMD3100 is only partially effective in overcoming this immune suppression. Novel strategies are needed to prevent lung infection after SCI.
JOURNAL OF IMMUNOLOGY
(2022)